• Nuclear Engineering and Technology
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• 제54권10호
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• pp.3841-3848
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• 2022

The effect of modifiers on the optical features and radiation defying ability of the Eu³⁺ ions doped multi constituent glasses was examined. XRD has established the amorphous nature of the specimen. The presence of various functional/fundamental groups in the present glasses was analyzed through FTIR spectra. The physical, structural and elastic traits of the glasses were explored. The variation in the structural compactness of the glass structure according to the incorporated modifier was enlightened to describe their suitability for a better shielding media. For the examined glasses, the metallization criterion value varied in the range 0.613-0.692, indicating the non-metallic character of the glasses with possible nonlinear optical applications. The computed elastic moduli expose the Li-containing glass (BTLi:Eu) to be tightly packed and rigid, which is a requirement for a better shielding channel. Furthermore, the optical bandgap and the Urbach energy values are calculated based on the optical absorption spectra. The evaluated bonding parameters revealed the nature of the fabricated glasses covalent. In addition, we investigated the radiation attenuation attributes of the prepared Eu³⁺ ions doped multi constituent glasses using Phy-X software. We determined the linear attenuation coefficient (LAC) and reported the influence of the five oxides Li₂O₃, CaO, BaO, SrO, and ZnO on the LAC values. The LAC varied between 0.433 and 0.549 cm^-1 at 0.284 MeV. The 39B₂O₃-25TeO₂-15Li₂O₃-10Na₂O-10K₂O-1Eu₂O₃ glass has a much smaller LAC than the other glasses.

• Genomics & Informatics
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• 제21권1호
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• pp.8.1-8.19
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• 2023

Cancer of the stomach is the second most frequent cancer-related death worldwide. The survival rate of patients with gastric cancer (GC) remains fragile. There is a requirement to discover biomarkers for prognosis approaches. Helicobacter pylori in the stomach is closely associated with the progression of GC. We identified the genes associated with poor/favorable prognosis in H. pylori-induced GC. Multivariate statistical analysis was applied on the Gene Expression Omnibus (GEO) dataset GSE54397 to identify differentially expressed miRNAs (DEMs) in gastric tissues with H. pylori-induced cancer compared with the H. pylori-positive with non-cancerous tissue. A protein interaction map (PIM) was built and subjected to DEMs targets. The enriched pathways and biological processes within the PIM were identified based on substantial clusters. Thereafter, the most critical genes in the PIM were illustrated, and their prognostic impact in GC was investigated. Considering p-value less than 0.01 and |Log2 fold change| as >1, five microRNAs demonstrated significant changes among the two groups. Gene functional analysis revealed that the ubiquitination system, neddylation pathway, and ciliary process are primarily involved in H. pylori-induced GC. Survival analysis illustrated that the overexpression of DOCK4, GNAS, CTGF, TGF-b1, ESR1, SELE, TIMP3, SMARCE1, and TXNIP was associated with poor prognosis, while increased MRPS5 expression was related to a favorable prognosis in GC patients. DOCK4, GNAS, CTGF, TGF-b1, ESR1, SELE, TIMP3, SMARCE1, TXNIP, and MRPS5 may be considered prognostic biomarkers for H. pylori-induced GC. However, experimental validation is necessary in the future.

• 한국미생물생명공학회:학술대회논문집
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• 한국미생물생명공학회 2001년도 Proceedings of 2001 International Symposium
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• pp.83-89
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• 2001

Recent advances in the structural and molecular biology uncovered that a set of translation factors resembles a tRNA shape and, in one case, even mimics a tRNA function for deciphering the genetic ：ode. Nature must have evolved this 'art' of molecular mimicry between protein and ribonucleic acid using different protein architectures to fulfill the requirement of a ribosome 'machine'. Termination of protein synthesis takes place on the ribosomes as a response to a stop, rather than a sense, codon in the 'decoding' site (A site). Translation termination requires two classes of polypeptide release factors (RFs)： a class-I factor, codon-specific RFs (RFI and RF2 in prokaryotes; eRFI in eukaryotes), and a class-IT factor, non-specific RFs (RF3 in prokaryotes; eRF3 in eukaryotes) that bind guanine nucleotides and stimulate class-I RF activity. The underlying mechanism for translation termination represents a long-standing coding problem of considerable interest since it entails protein-RNA recognition instead of the well-understood codon-anticodon pairing during the mRNA-tRNA interaction. Molecular mimicry between protein and nucleic acid is a novel concept in biology, proposed in 1995 from three crystallographic discoveries, one, on protein-RNA mimicry, and the other two, on protein-DNA mimicry. Nyborg, Clark and colleagues have first described this concept when they solved the crystal structure of elongation factor EF- Tu：GTP：aminoacyl-tRNA ternary complex and found its overall structural similarity with another elongation factor EF-G including the resemblance of part of EF-G to the anticodon stem of tRNA (Nissen et al. 1995). Protein mimicry of DNA has been shown in the crystal structure of the uracil-DNA glycosylase-uracil glycosylase inhibitor protein complex (Mol et al. 1995; Savva and Pear 1995) as well as in the NMR structure of transcription factor TBP-TA $F_{II}$ 230 complex (Liu et al. 1998). Consistent with this discovery, functional mimicry of a major autoantigenic epitope of the human insulin receptor by RNA has been suggested (Doudna et al. 1995) but its nature of mimic is. still largely unknown. The milestone of functional mimicry between protein and nucleic acid has been achieved by the discovery of 'peptide anticodon' that deciphers stop codons in mRNA (Ito et al. 2000). It is surprising that it took 4 decades since the discovery of the genetic code to figure out the basic mechanisms behind the deciphering of its 64 codons.

• Journal of Yeungnam Medical Science
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• 제5권1호
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• pp.23-32
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• 1988

저자는 1986년 3월부터 1988년 2월까지 2년동안 영남대학교 의과대학 부속병원 성형외과에 내원한 수지절단환자 75명, 102수지에 재해 수지재접합술을 시행하여 다음과 같은 결과를 얻었다. 1. 연령별분포에서는 20대에서 가장 많이 발생하였고, 남녀의 비율은 약 5:1로써 남자에서 현저히 많이 발생하였다. 2. 좌 우수의 발생빈도는 비슷한 분포를 보였으나 지배수와 비지배수의 비율에서는 지배수가 2배 이상 많이 발생하였다. 3. 수지별분포에서는 시지에서 가장 많이 발생하였고 그 다음으로는 중지에서 많이 발생하였다. 4. 손상의 원인으로는 압력기종류가 가장 흔하였고, 손상형태로는 좌멸창이 가장 많았다. 5. 마취방법에서는 국소마취와 전신마취가 비슷한 분포로 시행되었다. 6. zone II절단인 경우에는 77.8%의 성공률을, zone III의 절단인 경우에는 80%의 성공율을 나타내었다. 7. zone III절단인 경우보다 zone II절단인 경우에서 술후 수지기능이 더 좋았다. 8. 수지재접합술은 손상상태의 정도나 원인, 허혈시간에 관계없이 시행하였으며, 환자의 재접합술에 대한 요구도 무시할 수 없는 사항이었다.

• 한국컴퓨터정보학회논문지
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• 제17권12호
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• pp.169-177
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• 2012

응용 시스템 개발 과정에 있어서 중요하고 핵심을 이루는 작업은 분석과 설계 작업이며 아울러 대부분의 응용 시스템은 데이터베이스 기반으로 구축된다. 또한, IT 시스템들 간 상호 연결이 증가되면서 응용 시스템들은 외부공격에 쉽게 노출되어 지고 있기 때문에 보안과 관련된 처리 과정 역시 중요하다. 보안은 시스템에서 많은 부분과 상호작용을 하는 복잡한 비기능적 요구사항이다. 하지만 이러한 보안은 대부분 개발 마지막 과정에서 고려하기 때문에 보안에 취약한 응용 시스템이 개발될 가능성이 매우 높다. 따라서 개발 초기에 보안을 반영한 분석 및 설계 과정이 매우 중요하다. J2EE는 웹 응용 시스템을 위한 보안 방안을 제공하고, 아울러 객체-관계형 데이터베이스도 보안을 위하여 역할기반 접근제어를 지원하고 있지만 객체-관계형 데이터베이스 및 J2EE의 역할기반 접근제어를 활용하는, 요구사항 수집부터 구현까지 개발 단계 전체에 걸친 보안을 고려한 일관된 개발방법론은 전무한 실정이다. 따라서 본 논문에서는 보안 요구사항을 요구사항 수집부터 분석 및 설계 그리고 마지막 구현 단계까지 반영하여 J2EE 기반의 웹 응용 시스템을 개발하기 위한, 보안을 고려한 일관된 통합 분석 설계 방법론을 제안한다.