• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제14권2호
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• pp.181-186
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• 2011

저자들은 구토, 설사와 같은 비특이적인 증상과 복수가 발생한 13세 남아에서 말초혈액의 호산구 증가 소견이 있고 IgE는 정상범위이며, 내시경 생검상 식도, 소장, 대장 및 직장에서 특징적인 호산구 침윤 소견이 관찰되어 비 IgE 매개성 호산구성 위장관염으로 진단된 1예를 경험하였으며 스테로이드 투여로 증상 호전을 보였기에 문헌고찰과 함께 보고하는 바이다.

• Molecules and Cells
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• 제42권4호
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• pp.345-355
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• 2019

Eosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most challenging problems in clinical rhinology. FZD5 is a receptor for Wnt5A, and its complex with Wnt5A contributes to activating inflammation and tissue modification. Nasal polyps and eosinophil/non-eosinophil counts are reported to be directly correlated. This study investigated the expression and distribution of FZD5, and the role of eosinophil infiltration and FZD5 in eosinophilic CRSwNP pathogenesis. The prognostic role of eosinophil levels was evaluated in seven patients with CRSwNP. Fifteen patients with CRS were classified based on the percentage of eosinophils in nasal polyp tissue. Methylated genes were detected using methylCpG-binding domain sequencing, and qRT-PCR and immunohistochemistry were used to detect FZD5 expression in nasal polyp tissue samples. The results showed that mRNA expression of FZD5 was upregulated in nasal polyps. FZD5 expression was significantly higher in nasal polyp samples from patients with eosinophilic CRSwNP than in those from patients with non-eosinophilic CRSwNP, as indicated by immunohistochemistry. Furthermore, inflammatory cytokine levels were higher in eosinophilic CRSwNP-derived epithelial cells than in normal tissues. In conclusion, FZD5 expression in nasal mucosal epithelial cells is correlated with inflammatory cells and might play a role in the pathogenesis of eosinophilic CRSwNP.

• Imaging Science in Dentistry
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• 제43권2호
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• pp.117-122
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• 2013

Eosinophilic granuloma is a common expression of Langerhans cell histiocytosis and corresponds with typical bone lesions. The radiographic appearance of eosinophilic granuloma in the jaw is variable and not specific. It may resemble periodontitis, radicular cyst, or malignancies. The purpose of this report is to describe the characteristic radiographic features of eosinophilic granuloma of a 39-year-old male. The lesion in the anterior mandible was first diagnosed as radicular cyst because the radiographic findings were ovoid radiolucent lesion with well-defined border. However, careful interpretation revealed a non-corticated border and floating tooth appearance that were the characteristic radiographic features for the differential diagnosis. Early clinical signs of eosinophilic granuloma can occur in the jaw and a bony destructive lesion might be mistaken for periodontitis or an odontogenic cystic lesion; therefore, careful interpretation of radiographs should be emphasized.

• 대한두경부종양학회지
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• 제26권2호
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• pp.243-246
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• 2010

Purpose : Eosinophilic granuloma is a rare benign tumor that is characterized histologically by the presence of destructive granulomas containing numerous Langerhans, cells. The most common presentation of eosinophilic granuloma is a painful, immobile scalp mass in the frontal and parietal bones occurring predominantly in children and adolescents or young adults. We report a representative case of eosinophilic granuloma. Methods : A 16-year-old woman complained of an enlarging fixed scalp mass without pain and tenderness which measured $3{\times}4.5cm$ at the frontal area, which had been found incidentally 2 months before. Plain skull x-ray showed a punched-out bone lesion. Computed tomography and magnetic resonance imaging showed a non-enhancing osteolytic lesion. The tumor and surrounding bony edges were completely removed via a bicoronal approach. The bony defect was reconstructed with bone cement. Results : The tumor was involved frontal bone and dura mater. We confirmed the tumor by the documentation of Birbeck's granules by electron microscopy. There is no evidence of local recurrence during postoperative 1.5 years. Conclusion : The present case shows the characteristic feature of frontal bone involvment of the eosinophilic granuloma. The prognosis of eosinophilic granuloma depend on age at diagnosis and number of bones involved. We consider that best choice of treatment for eosinophilic granuloma is surgical excision.

• Nuclear Medicine and Molecular Imaging
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• 제42권3호
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• pp.253-255
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• 2008

A 61-year-old man had a F-18 FDG PET/CT scan for evaluation of a common bile duct cancer identified on CT. The PET/CT image showed a hypermetabolic mass in the common bile duct, and a focal area of increased F-18 FDG uptake in segment IV of the liver, which corresponded to a hypoattenuated lesion on non-enhanced CT, and was consistent with hepatic metastasis. The patient underwent choledochojejunostomy with hepatic resection, and pathologic findings were compatible with an eosinophilic abscess in the liver. This case demonstrates that F-18 FDG uptake by an eosinophilic abscess can mimic hepatic metastasis in a patient with a malignancy.

• Journal of Korean Neurosurgical Society
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• 제43권6호
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• pp.304-306
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• 2008

Langerhans' cell histiocytosis (LCH) is a rare immunologic disorder characterized by histiocyte proliferation in multiple organ systems. Eosinophilic granuloma, a benign bone lesion, represents a focal form of LCH. We experienced a case of Langerhans' cell histiocytosis in a patient who presented with intracranial epidural hematoma and cyst on the midline of the frontal skull. A 10-year-old boy presented with a rapidly growing large scalp mass on the midline frontal area after mild head trauma. The scalp mass was painless and immobile. Plain skull x-ray showed a punched-out bone lesion. Computed tomography and magnetic resonance imaging showed a non-enhancing osteolytic lesion presenting with an epidural hematoma and cyst on the midline of the frontal skull. The lesion of the skull was completely resected and the patient's recovery was uneventful. The acute presentation of a solitary eosinophilic granuloma of skull with an epidural hematoma has been described in only five cases in the literature and we report the first case of LCH presenting as an intracranial epidural hematoma on frontal area.

• Allergy, Asthma & Immunology Research
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• 제10권6호
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• pp.698-715
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• 2018

Purpose: Hrd1 has recently emerged as a critical regulator of B-cells in autoimmune diseases. However, its role in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) remains largely unexplored. This study aimed to examine Hrd1 expression and B-cell accumulation and their possible roles in CRSwNP. Methods: Quantitative real-time polymerase chain reaction, immunohistochemistry, enzyme-linked immunosorbent assay and Western blotting were used to assess gene and protein expression in nasal tissue extracts. Cells isolated from nasal tissues and peripheral blood mononuclear cells were characterized by flow cytometry. Local antibody production was measured in tissue extracts with a Bio-Plex assay. Additionally, changes in Hrd1 expression in response to specific inflammatory stimuli were measured in cultured dispersed polyp cells. Results: Nasal polyps (NPs) from patients with eosinophilic CRSwNP (ECRS) had increased levels of Hrd1, B-cells and plasma cells compared with NPs from patients with non-eosinophilic CRSwNP (non-ECRS) or other control subjects (P < 0.05). The average Hrd1 levels in B-cells in NPs from ECRS patients were significantly higher than those from non-ECRS patients and control subjects (P < 0.05). NPs also contained significantly increased levels of several antibody isotypes compared with normal controls (P < 0.05). Interestingly, Hrd1 expression in cultured polyp cells from ECRS patients, but not non-ECRS patients, was significantly increased by interleukin-$1{\beta}$, lipopolysaccharide and Poly(I:C) stimulation, and inhibited by dexamethasone treatment (P < 0.05). Conclusions: Differential Hrd1 expression and B-cell accumulation between the ECRS and non-ECRS subsets suggests that they can exhibit distinct pathogenic mechanisms and play important roles in NP.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제5권1호
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• pp.91-95
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• 2002

저자들은 설사와 우복부통증 및 체중감소의 증상을 보인 11세 남아에서 말초혈액의 호산구수 증가와 IgE가 정상범위이며 대장내시경하에 채취한 S자결장 생검조직에서 특징적인 호산구침윤 소견이 관찰되어 비 IgE 매개성 호산구성 대장염으로 진단된 1례를 경험하였으며 부신피질 호르몬 투여로 증상 호전을 보여 문헌고찰과 함께 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제49권6호
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• pp.733-739
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• 2000

배경 및 방법 : 호산구성 흉막유출의 원인질환과 흉수 내 호산구의 진단적 의의에 대해 알아보고자 1999년 1월부터 12월까지 삼성서울병원에서 흉막유출로 첫번째 흉강천자를 시행 받은 446명을 대상으로 후향적 조사를 실시하여 다음과 같은 결과를 얻었다. 결과 : 1) 전체 환자의 남녀 비율은 3 : 2 였고 연령의 중앙값은 57.0세 였으며 전체 흉막유출 환자중 호산구성 흉막유출은 446명 중 24명(5.4%)에서 조사되었다. 전체 환자들의 질환 분포를 보면 악성종양에 의한 흉막유출 226명(50.7%), 폐렴성 76명(17.0%), 결핵성 53명(11.9%)순으로 상기 3개질환이 전체의 80%를 차지했다. 2) 호산구성 흉망유출 원인 중 악성종양으로 인한 경우는 13명(54%)에서 조사되었고 비호산구성 흉막유출과 비교시 의미있는 차이를 보이지 않았다(54.2% vs 50.5%, p=0.725). 3) 호산구성 흉막유출 환자들의 말초 혈액내 평균 호산구 수는 5.5%로 흉수 내 호산구 수와 연관이 없었고, 악성종양에 의한 흉수의 호산구 수는 31.2%로 양성질환에 의한 흉수의 호산구 26.1%와 비교하여 차이가 없었다(p=0.597). 4) 2번 이상 흉강 천자를 시행 받은 234명의 환자에서 반복 천자시 비호산구성 흉악유출에서 호산구성 흉막유출로 변하는 빈도는 6.4%(15명)로 조사되었다. 결론 : 호산구성 흉막유출은 전 흉막유출의 약 5%에서 발생하며, 원인 질환, 말초 혈액내 호산구 수, 반복적 천자와 무관하였다. 흉막유출에서 호산구가 증가하여도 특별한 진단을 시사하지 않을 것으로 생각된다.

• Tuberculosis and Respiratory Diseases
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• 제45권2호
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• pp.421-428
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• 1998

기흉과 미만성 간질성 폐질환의 소견을 보인 흡연력이 없는 젊은 여자 환자에서 개흉 폐생검후 면역조직화학염색을 통하여 폐 호산구성 육아종을 진단한 1예를 경험하였기에 보고하는 바이다.