• Tuberculosis and Respiratory Diseases
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• 제43권4호
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• pp.623-629
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• 1996

기관지 비정형 카르시노이드 종양은 임파절 및 다른 장기로의 전이율이 높은 질환으로 특별한 증상 없이 우연히 방사선학적 검사상 발견되어 지는 드문 질환으로 알려져 있으며, 수술적 절제술이 우선적 치료로 되어 있다. 저자들은 흥부 방사선적 검사 및 조직 검사로 진단되어 수술적 절제술을 시행한 간전이를 동반한 폐기관지 비정형 카르시노이드 종양 1예를 경험하였기에 보고한다.

• 원예과학기술지
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• 제33권2호
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• pp.227-232
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• 2015

수출용 스프레이 장미 차광방법(차광률 50%와 70% 알루미늄 차광 전용 스크린 및 부직포)에 따른 고온기 기상환경, 절화품질 및 생산성을 조사하였다. 차광방법에 따른 일일 최고와 적산 일사량은 부직포보다 알루미늄 전용 차광에서 높았고, 70%보다 50% 차광처리에서 더 높았다. 대기온도 및 근권 온도는 부직포보다 알루미늄 전용 차광에서 낮았고, 차광률 70%에서 더 낮은 경향이었으며, 대기습도는 처리 간 차이가 없었다. 엽온과 엽록소 함량(SPAD)은 알루미늄 차광, 특히 50% 차광처리에서 약간 더 높았다. 차광방법별 상품수량 및 수출가능 수량은 'Lovely Lydia'를 제외한 시험품종 모두가 알루미늄 차광처리에서 높았으며, 특히 50% 차광처리에서 더 높았다. 절화장, 경경 및 마디 수, 7매 엽수, 소화수 및 소화폭도 알루미늄 차광처리에서 우수하였다. 절화장의 경우는 50%보다 70% 알루미늄 차광처리에서 더 우수한 경향이었다. 꽃잎 색도의 경우 부직포 차광보다 알루미늄 차광처리에서 a, b값이 증가하였고, 절화 수명도 품종에 따라 0.5-2.5일 더 길었다.

• 한국전산구조공학회논문집
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• 제17권1호
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• pp.21-30
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• 2004

본 연구에서는 유한요소법을 이용한 채널단면을 갖는 복합재료 적층 구조물의 자유진동을 다룬다. 복합적층 절판구조물에 고차항 판이론을 적용하기 위하여 개발된 유한요소 프로그램은 Lagrangian 및 Hermite 보간함수를 병용하여 면내회전각 자유도를 포함한 절점 당 8개의 자유도를 갖는다. 전단보정계수의 가정을 필요로 하지 않고 전단변형의 3차항 비선형 특성이 고려된 본 논문의 절판 요소는 국부좌표계와 전체좌표계에 대한 좌표변환행렬에 의하여 요소 당 32×32의 국부요소행렬로 구성된다. 본 해석 프로그램의 결과는 기존의 고전적 이론 및 일차항 이론에 의한 문헌 결과와 비교ㆍ분석하였으며, 화이버 보강각도, 길이-두께비, 기하학적 형상 변화 등의 다양한 매개변수 연구를 수행하였다. 본 연구에서는 특히 경계조건 및 길이-두께비 변화에 따라 예측하기 힘든 복잡한 거동을 보이는 복합적층 채널단면 구조물의 자유진동에 대하여 정밀한 고차항 이론 적용에 의한 엄밀 해석의 필요성을 제기하였다.

• 대한두경부종양학회지
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• 제17권2호
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• pp.205-209
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• 2001

Purpose: Most cases of primary hyperparathyroidism are due to parathyroid adenoma or parathyroid hyperplasia. Parathyroid carcinoma is a very rare cause of hyperparathyroidism. Although the diagnosis of parathyroid carcinoma is usually established by pathologic criteria especially of vascular or capsular invasion, some clinical and biochemical features differentiate it from benign forms of hyperparathyroidism. We under-took a retrospective study in 6 patients with parathyroid carcinoma, with the aim of conveying experience from management for this rare cause of hyperparathyroidism. Methods: Clinical symptoms, biochemical laboratory, radiologic, and intraoperative findings, local recurrence and distant metastasis were analyzed in 6 patients diagnosed pathologically as a parathyroid carcinoma after operation from 1992 to 2001. Results: Mean age was 50.2 years (33.0-60.0 years) and male to female ratio was 1:1. Neck mass was found in 5 patients, multiple bone pain in 3 patients and renal stone in 1 patient. One case has suffered from chronic renal failure for 19 years. Although preoperative laboratory evaluations showed the aspects of hyperparathyroidism in all cases, mean serum calcium level was 11.2mg/dl(10.5-12.1mg/dl), slightly elevated. Laboratory values after surgery were within the normal range in 5 cases. However, in one case with chronic renal failure, serum PTH levels, serially checked, were above the normal range. Any of imaging methods failed to suggest a parathyroid carcinoma preoperatively. Parathyroid adenoma was suspected in 3 cases, thyroid cancer in the other cases before surgery. The extent of resection was radical resection of parathyroid lesion with more than unilateral thyroid lobectomy and central compartment neck node dissection and in 2 cases, the resection of recurrent laryngeal nerve or strap muscles was added. During follow-up period, any local or systemic recurrence were not evident in all the cases. Conclusion: Although parathyroid carcinoma is a rare disease and its preoperative diagnosis, in our experience, could not easily be made, the understanding of characteristic clinical and biochemical feature could help diagnosis at first surgery. Radical resection without remaining residual tumor is most important for the management of the parathyroid cancer.

• 한국정보과학회논문지:정보통신
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• 제34권6호
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• pp.475-482
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• 2007

이동 무선 애드-혹 네트워크에서 이동 노드들은 일반적인 호스트 기능뿐만 아니라 이동 노드의 위치 변화에 따른 네트워크 토폴로지가 변화는 상태에서 데이타 패킷 전달의 역할도 수행하는 라우팅 기능을 수행한다. 이런 애드-혹 네트워크를 위한 라우팅 프로토콜이 여러 가지 있다. 본 논문에서는 여러 제안된 프로토콜 중에서 네트워크에서 라우팅으로 인한 프로토콜 오버헤드가 작은 요구/응답 방식으로 동작하는 DSR 프로토콜을 대상으로 성능을 향상시키는 새로운 경로 축소 방법을 제안했다. 기존 경로 축소 방법은 소스 경로 상에 있는 노드만이 경로 축소에 참여하는데 반해, 본 논문에서 소스 경로 밖에 있는 인접 노드들도 청취한 패킷으로부터 수집한 정보를 경로 캐쉬로 관리해서. 저장된 캐쉬 경로 정보를 토대로 진행 중인 연결에 대해 더 짧은 경로를 발견한 경우에 기존 경로 대신 새 경로를 사용하도록 경로 축소 작업을 수행하는 방법을 제시했다. ns2를 이용한 시뮬레이션 결과, 제안한 방법이 이동 노드의 위치 변화가 활발한 경우에 기존 방법보다 경로 축소 횟수가 많이 발생했고, 또한 토폴로지의 변화에 대해 신속한 경로 축소를 수행해서 패킷 전송 성공률도 높아졌음을 확인했다. 즉, 약간의 프로토콜 오버헤드를 치루고 노드의 이등성에 따라 두 배에서 다섯 배 정도의 경로 축소로 신속한 패킷 전송과 전체적인 노드의 에너지 소모를 줄일 수 있음을 확인하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1169-1174
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• 2016

Purpose: To review clinical characteristics, treatment outcomes and prognostic factors in patients with parotid gland tumors treated with surgery and postoperative radiotherapy. Materials and Methods: We retrospectively reviewed 69 patients with parotid gland tumors, with a median follow-up of 52 months (range, 2-228 months). and a median radiotherapy dose of 60Gy (range, 30-69 Gy). Results: There were 24 (35%) females and 45 (65%) males, at a ratio of 1/1.9. Median age at presentation was $58.9{\pm}17.2$ (range 13-88) years. The most common histology was adenoid cystic carcinoma (33%) and mucoepidermoid carcinoma (28%). The mean overall survival (OS) was $65.3{\pm}8$ (95% confidence interval [CI], 49.6-81.1) months and the median overall survival was $40.0{\pm}7$ (95% CI, 26.2-53.7) months. The -1, -3, -5 and -10 year OS rates were 78%, 52.4%, 35.3% and 19.6% respectively. The mean disease free survival (DFS) was $79.2{\pm}10$ (95% CI, 59.3-97.1) months and the median disease free survival was $38{\pm}13$ (95% CI, 7.05-88.7) months. The -1,-3,-5 and -10 year DFS rates were 71.9%, 50.1%, 43.7% and 30.1% respectively. On univariate analysis, the OS was significantly better with female sex (p<0.005), < 50 age (p<0.021), T stage (p<0.0001), absence of lymph node involvement (p<0.0001), lower tumor grade (p<0.0001), absence of lymphovascular invasion (p<0.002), absence of perineural invasion (p<0.0001), absence of extracapsuler extension (p<0.0001), surgical margin negativity (p<0.006), ${\leq}60Gy$ radiotherapy dose (p<0.0001) and absence of distant metastasis (p<0.027). Conclusions: Employing existing standards of postoperative radiotherapy is a possible treatment that was found to be mainly effective in patients with parotid gland carcinomas.

• 대한두경부종양학회지
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• 제14권1호
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• pp.54-60
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• 1998

Objectives: We'd like to give help in diagnosis and treatment of children's thyoid tumor through our clinical experiences and reference consideration. Materials and Methods: The authors report their experiences with 33 cases of thyroid tumor in patients younger than 16 years of age who were treated at Presbyterian Medical Center from 1979 to 1995. Results: 1) Girls were more predominant than boys by a ratio of 5.6:1. The peak incidence was in the 15 years old of age. 2) The final diagnosis in the 33 patients were thyroid carcinoma in 12 cases, nodular goiter in 6 cases, adenoma in 6 cases, Graves disease in 4 cases, Hasimoto's disease in 4 cases and cyst in 1 case. 3) All of 12 patients with thyroid cancer had nodular tumor. 4) In 5 of 6 patients with palpable cervical lymphadenopathy, the final diagnosis was thyroid carcinoma. 5) Delayed diagnosis arose in 6 of 12 thyroid carcinomas which were treated for long periods as benign disease. 6) The surgical procedures were total thyroidectomy in 3 cases, subtotal thyroidectomy in 13 cases and thyroid lobectomy in 17 cases. 7) 11 of 12 patients with thyroid carcinoma had subtotal or total thyroidectomy with lymphnode dissection and only one had lobectomy. 8) The overall rate of postoperative complication was 3%(1 of 33 patient). 9) Postoperative $^{131}I$ therapy was done in 7 case because of recurrence and distant metastasis in six and severe local invasion in one. 10) In thyroid cancer, the metastatic rate of lymph node at initial surgery was 81%(9/11) and rate of recurrence was 50%(6/12). 11) Patients with thyroid carcinoma were followed up for a mean of 12 years but only one died as a result of thyroid carcinoma 3.5 years later. Conclusion: The authors suggest that thyroid tumors in childhood should receive the benifit of joint management by endocrine pediatrician and experianced surgeons with an agreed protocol of diagnosis and management. We, also, recommend aggressive surgical and $^{131}I$ treatment as the most effective regimen for children with thyroid carcinoma.

• Journal of Chest Surgery
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• 제53권3호
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• pp.104-113
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• 2020

Background: Accurate intraoperative assessment of mediastinal lymph nodes is a critical aspect of lung cancer surgery. The efficacy and potential for upstaging implicit in these dissections must therefore be revisited in the current era of uniportal video-assisted thoracoscopic surgery (VATS). Methods: A retrospective study was conducted in which 544 patients with stage I (T1abc-T2a, N0, M0) primary lung cancer were analyzed. To assess risk factors for nodal upstaging and to limit any imbalance imposed by surgical choices, we constructed an inverse probability of treatment-weighted (IPTW) logistic regression model (in addition to non-weighted logistic models). We also evaluated risk factors for early locoregional recurrence using IPTW logistic regression analysis. Results: In the comparison of uniportal and multiportal VATS, the resected lymph node count (14.03±8.02 vs. 14.41±7.41, respectively; p=0.48) and rate of nodal upstaging (6.5% vs. 8.7%, respectively; p=0.51) appeared similar. Predictors of nodal upstaging included tumor size (odds ratio [OR], 1.74; 95% confidence interval [CI], 1.12-2.70), carcinoembryonic antigen level (OR, 1.11; 95% CI, 1.04-1.18), and histologically confirmed pleural invasion (OR, 3.97; 95% CI, 1.89-8.34). The risk factors for locoregional recurrence within 1 year were found to be number of resected N2 nodes, age, and nodal upstaging. Conclusion: Uniportal and multiportal VATS appear similar with regard to accuracy and thoroughness, showing no significant difference in the extent of nodal dissection.

• 한국환경보건학회지
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• 제38권6호
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• pp.541-549
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• 2012

Objectives: This study was undertaken in order to evaluate a potential mechanism involved in gastro-intestinal problems observed in autistic subjects and uses an animal model of autism investigation. Methods: BTBR T+tf/J, a mouse strain with typical socio-behavioral characteristics of autistic subjects and FVB mice with highly social behaviors as the control strain were used. Both genders of mice aged three weeks and six months were used from four separate litters for each strain. Serum was prepared following cardiac puncture, and mesenteric lymph nodes were collected for in vitro stimulation and enumeration of major immune cell proportion. Results: The level of serum IgA was significantly enhanced in six-month-old BTBR mice compared with three-week-old BTBR, which was not observed with the FVB control mice. The serum IgE level was also higher among BTBR mice than among age-sex matched FVB mice, respectively. Considering the ratio of interleukin-4 vs interferon-gamma production from mesenteric lymph node T cells, skewedness toward type-2 reactivities was observed. In addition, the proportion of B cells in mesenteric lymph nodes was significantly higher in BTBR mice than in FVB mice. Conclusion: Upregulation of mucosal immunity related with enhanced type-2 immune reactivity observed in BTBR mice could be involved with the etiology of gastro-intestinal abnormalities in autism.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5385-5388
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• 2015

Background: Gastric cancer is the most common gastrointestinal cancer and a leading cause of cancer mortality in Nepal. Survival of gastric cancer patients depends on the stage at which diagnosis is made. The aim of this study was to analyze the presentation and outcomes of gastric cancer patients treated at a tertiary care hospital in Nepal. Materials and Methods: A retrospective analysis of 140 consecutive histologically proven gastric adenocarcinoma cases managed at the Department of Surgery, Tribhuvan University Teaching Hospital, Kathmandu, Nepal for the period of January 2009 to December 2013 was carried out. Results: One hundred forty out of the total 186 patients with histologically proven gastric adenocarcinoma, were admitted for surgery. The mean age was $59.6{\pm}12.4yrs$ (range 29 to 78 yrs) and the male: female ratio was 2:1. Sixty three (45%) patients featured Tibeto-Burman descent though this ethnic group accounts for only 18% of the Nepalese population. Two-thirds or more patients presented with abdominal pain, anorexia, weight loss and/or vomiting. In 86 (61.5%) of the patients the tumor was located in the lower $3^{rd}$ of the stomach and in only 15% of the patients the tumor was located at the upper $3^{rd}$. Early gastric cancer was diagnosed postoperatively in only 4%. In 54%, the disease was locally advanced and metastatic lesions were found in 14% of the patients. Subtotal (73) or total (11) curative gastrectomies (D1, D1+ or D2) were performed in 84 (60%) patients with average lymph node retrieval of $16.6{\pm}8.2$. Palliative gastrectomies or procedures were performed in 23% of the patients and no intervention (open & close/biopsy) was employed in 15% of the patients. Perioperative morbidity was seen in 10% and mortality in 4%. Three, four and five year survival rates up to the recent follow-up were 17.9%, 11.9% and 8.3%, respectively. Conclusions: Gastric cancer in Nepal is usually diagnosed at an advanced stage and has a poor prognosis. Thus, early detection is the key to improve the survival of gastric cancer patients.