• Nuclear Engineering and Technology
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• 제27권6호
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• pp.870-876
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• 1995

해석함수전개 노달방법에 기초한 새로운 3차원 노달확산 코드가 개발되었다. 이 방법은 균질화된 노드내의 해를 노드내에서 중성자확산방정식을 만족하는 해석적인 18개의 기저함수들과 1개의 상수로 전개한후 노달연관방정식을 노드에 대한 중성자의 균형, 경계면에서의 중성자류의 연속, 모서리주위의 무한히 작은 체적소에 대한 중성자누출의 균형이 만족되도록 유도한다. 이 코드의 정확성을 검증한기 위해 잘 알려진 LMW 표준문제와 IAEA 3차원 문제와 동일한 물질을 가지는 작은 노심문제에 적용하여 QUANDRY코드 및 VENTURE코드의 결과와 비교하였다. 계산결과들은 본 연구에서 개발된 코드가 출력분포 및 유효중배계수를 매우 정확하게 예측함을 보여준다.

• Nuclear Engineering and Technology
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• 제54권2호
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• pp.764-769
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• 2022

The United Arab Emirates is currently building and operating four units of the APR-1400 developed by a South Korean vendor, Korea Electric Power Corporation (KEPCO). This paper attempts to perform APR-1400 reactor core analysis by using the well-known two-step method. The two-step method was applied to the APR-1400 first cycle using the open-source nodal diffusion code, KOMODO. In this study, the group constants were generated using CASMO-4 fuel transport lattice code. The simulation was performed in Hot Zero Power (HZP) at steady-state and transient conditions. Some typical parameters necessary for the Nuclear Design Report (NDR) were evaluated in this paper, such as effective neutron multiplication factor, control rod worth, and critical boron concentration for steady-state analysis. Other parameters such as reactivity insertion, power, and fuel temperature changes during the Reactivity Insertion Accident (RIA) simulation were evaluated as well. The results from KOMODO were verified using PARCS and SIMULATE-3 nodal core simulators. It was found that KOMODO gives an excellent agreement.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제30권6호
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• pp.529-539
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• 2008

Background and Purpose : Oral squamous cell carcinoma (OSCC) is one of the most aggressive tumors of the head and neck area. OSCC is known to preferentially metastasize via lymphatic system, and resulting cervical lymph node metastasis is the most reliable of treatment failure. But the biological mechanism of the regional nodal metastasis is not clear. So, we determined metastasis-related factors in orthotopic nude mouse models of OSCC. Experimental Design : Two cell lines-KB and YD-10B cells, established from human oral mucosal squamous cell carcinoma, were xenografted into the tissue space of athymic murine mouth floor. The mice were followed for tumor development and growth, the murine tumors were examined histopathologically for local invasion or regional or distant metastasis. Finally, we performed immunohistochemical assays with antiepithelial growth factor (EGF), EGF receptor (EGFR), phosphorylated EGFR (pEGFR), and anti-vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)-2, phosphorylated VEGFR-2/3 (pVEGFR-2/3) antibodies. We also determined the microvessel density. Results : Transplantation of human OSCC tumor cells into the mouth floor successfully resulted in the formation of orthotopic tumors. KB cell line showed significantly higher tumor proliferation and higher nodal metastatic potential than YD-10B cell line. Furthermore, immunohistochemical staining demonstrated higher expression of EGFR/pEGFR, VEGF, and pVEGFR-2/3 as well as higher microvessel density in KB murine tumors than in YD-10B murine tumors. Conclusion : An orthotopic model of OSCC in athymic mice was established which copies the cervical lymph nodal metastasis of human OSCC. Our mouth floor model should facillitate the understanding of the molecular pathogenesis of cervical nodal metastasis of OSCC.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제35권2호
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• pp.55-65
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• 2009

Purpose: We determined the therapeutic effects of blockade of epidermal growth factor(EGF) and vascular endothelial growth factor(VEGF) receptor tyrosine kinases on the growth of oral squamous cell carcinoma(OSCC) xenografted in athymic nude mice. Experimental Design: We investigated the in vivo antitumor effects of a tyrosine kinase inhibitor for EGFR and VEGFR-2, AEE788 in a mouth floor(orthotopic) tumor model. Nude mice with orthotopic tumors were randomized to receive AEE788, paclitaxel, a combination of AEE788 and paclitaxel, or control. Antitumor mechanisms of AEE788 were determined by immunohistochemical/immunofluorescent and apoptosis assays. Results: Tumors of mice treated with AEE788 demonstrated down-regulation of phosphorylated EGFR, phosphorylated VEGFR and their downstream mediators(pMAPK and pAkt), decreased proliferative index, decreased microvessel density(MVD). As a result, growth of the primary tumor and nodal metastatic potentials were inhibited by AEE788. Conclusion: These data show that EGFR and VEGFR can be molecular targets for the treatment of OSCC.

• Nuclear Engineering and Technology
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• 제32권3호
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• pp.235-243
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• 2000

A one-dimensional neutronics formulation is established within the framework of the nonlinear analytic nodal method such that it can result in consistent one-dimensional models that produce the same axial information as their corresponding reference three-dimension81 models. Consistency is achieved by conserving axial interface currents as well as the planar reaction rates of the three-dimensional case. For current conservation, flux discontinuity is introduced in the solution of the two-node problem. The degree of discontinuity, named the current conservation factor, is determined such that the surface averaged axial current of the reference three-dimensional case can be retrieved from the two-node calculation involving the radially collapsed group constants and the discontinuity factor. The current conservation factors are derived from the analytic nodal method and various core configurations are analyzed to show that the errors in K-eff and power distributions can be reduced by a order of magnitude by the use of the current conservation factor with no significant computational overhead.

• Radiation Oncology Journal
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• 제35권4호
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• pp.306-316
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• 2017

Purpose: To investigate the predictive role of maximum standardized uptake value ($SUV_{max}$) of 2-[$^{18}F$]fluoro-2-deoxy-D-glucose($^{18}F-FDG$) positron emission tomography/computed tomography (PET/CT) in nasopharyngeal cancer patients treated with intensity-modulated radiotherapy (IMRT). Materials and Methods: Between October 2006 and April 2016, 53 patients were treated with IMRT in two institutions and their PET/CT at the time of diagnosis was reviewed. The $SUV_{max}$ of their nasopharyngeal lesions and metastatic lymph nodes (LN) was recorded. IMRT was delivered using helical tomotherapy. All patients except for one were treated with concurrent chemoradiation therapy (CCRT). Correlations between $SUV_{max}$ and patients' survival and recurrence were analyzed. Results: At a median follow-up time of 31.5 months (range, 3.4 to 98.7 months), the 3-year overall survival (OS) and disease-free survival (DFS) rates were 83.2% and 77.5%, respectively. In univariate analysis, patients with a higher nodal pre-treatment $SUV_{max}$ (${\geq}13.4$) demonstrated significantly lower 3-year OS (93.1% vs. 55.5%; p = 0.003), DFS (92.7% vs. 38.5%; p < 0.001), locoregional recurrence-free survival (100% vs. 50.5%; p < 0.001), and distant metastasis-free survival (100% vs. 69.2%; p = 0.004), respectively. In multivariate analysis, high pre-treatment nodal $SUV_{max}$ (${\geq}13.4$) was a negative prognostic factor for OS (hazard ratio [HR], 7.799; 95% confidence interval [CI], 1.506-40.397; p = 0.014) and DFS (HR, 9.392; 95% CI, 1.989-44.339; p = 0.005). Conclusions: High pre-treatment nodal $SUV_{max}$ was an independent prognosticator of survival and disease progression in nasopharyngeal carcinoma patients treated with IMRT in our cohort. Therefore, nodal $SUV_{max}$ may provide important information for identifying patients who require more aggressive treatment.

• 교육시설
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• 제10권3호
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• pp.37-43
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• 2003

This study investigates the physical characteristics of indoor rest zones using the Space Syntax Method. A conceptual framework is based on analysis of design works presented in competitions(544 rest zones of 24 buildings on 7 campuses). The analysis on the unit type of rest zones showed that they were mostly available as open type, followed by semi-open type and outdoor rest places. On the other hand, by classifying the shape of whole building into traffic lines and nodal points, it was found that the buildings with 3 or more traffic lines have lower availability than others, because the buildings required more nodal points along a little higher complexity and zoning formed at increased nodal points between building masses. The analysis on the location of rest zones on traffic lines showed that hall type was most excellent in the level of availability. Finally, the analysis on the floor height showed that hall-like open rest places and outdoor places like rooftop garden functioned as a factor to enhance the integration of different spaces. In conclusion, this research will help the follow-up studies make spatial creation planning that may enhance the spatial efficiency and availability of Indoor rest zones on the campus.

• 한국해양학회지:바다
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• 제12권3호
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• pp.234-238
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• 2007

현재까지 우리나라에선 연구자마다 각기 다른 세 가지 조석지각 기준(관측지점 경도 기준 지각, 표준시 자오선 기준 지각, 그리니치 자오선 기준 지각)을 사용하여 오고 있다. 이처럼 통일되지 않는 조석지각 정보체계는 전체적인 우리나라 조석의 특성이나 변화를 이해하는데 장애가 되고 있다. 이 연구에서는 올바른 조석지각 기준의 상호전환과 관련하여, 세 가지 지각기준에 관하여 자세히 살펴보았다. 이에 앞서 조석 조화분해 과정에서 분조의 지각이 어떻게 계산되며, 조석예측프로그램에선 계산된 지각이 어떻게 사용되게 되는지 살펴보았다. 또한 이것을 바탕으로 과거 일부 연구에서 불명확하게 기술된 조석지각의 정의에 관하여 논의하였다.

• Nuclear Engineering and Technology
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• 제24권3호
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• pp.252-262
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• 1992

시간 및 공간 종속형 중성자 수송 방정식으로부터 비균질 원자로 노심해석의 효율적인 방법을 개발하였다. 이를 위해 계산 시간을 단축하고 각 집합체 크기의 소격격자(coarse mesh)에 대한 평균 중성자속을 정확히 예측할 수 있도록 노달방법(nodal method)을 도입하였고, 노드 별 평균 중성자속과 노드 각 경계면의 평균 중성자속 및 유속(flux and current)과의 관계식을 얻기 위하여 조정 인자( correction factor)로서 불연속인자(discontinuity factor)를 사용하였으며, 이 인자는 이전 시간대(previous time step)의 노드 평균 중성자속, 확산계수, 그리고 불연속인자 등에 따라 새로이 계산(updating)된다. 본 논문에서 개발된 방법을 시간에 따라 비교적 단순히 변하는 과도 노심(TWIGL)과 급격한 중성자 거동의 변화를 모사하는 과도 노심(LRA)에 적용한 결과 정확성 및 효율성이 입증되었 다.

• Structural Engineering and Mechanics
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• 제10권1호
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• pp.27-36
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• 2000

The Oktalok nodal connection system is an aesthetic and efficient system. It has been widely used throughout Australia. The paper will briefly introduce the concept and application of the Oktalok nodal system. The existing design method is based on the assumption that the joints are pin-ended, i.e., the rotational stiffness of the joints is zero. However the ultimate capacity of the frame may increase significantly depending on the rotational stiffness of the joints. Stiffness tests and finite element simulations were carried out to determine the rotational stiffness of the Oktalok joints. Column buckling tests and non-linear finite element analyses were performed to determine the member capacity of columns with semi-rigid end conditions. A simple formulae for the effective length factor of column buckling is derived based on the above experimental and theoretical investigations.