• Journal of Korean Biological Nursing Science
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• v.19 no.2
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• pp.60-68
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• 2017

Purpose: The purpose of this study was to analyze the relationship between lower urinary tract symptoms and urodynamic parameters to investigate the characteristics of mixed urinary incontinence (MUI) and stress urinary incontinence (SUI). Methods: The subjects were 318 women with MUI and 128 women with SUI. Data were collected retrospectively from electronic medical records including Bristol Female Lower Urinary Tract Symptoms-Scored Form (BFLUTS-SF), Incontinence Quality of Life Instrument (I-QOL), voiding diaries, and urodynamic parameters. Results: Compared with the SUI group, the MUI group was older and showed lower I-QOL and more severe urinary tract symptoms. The MUI group had more urinary frequency, more nocturia, and a higher urgency score than the SUI group. In the correlation analysis, the greatest difference between the two groups was that urgency was associated with Qmax, maximal cystometric capacity, and detrusor overactivity only in the MUI group (r = -.175, p= .004; r = -.281, p< .001; r= .232, p< .001, respectively). Conclusion: As a result of this study, we propose that a customized management program that emphasizes the control of urgency for the MUI group, and one that effectively strengthens the weak pelvic floor for the SUI group.

• Korean Journal of Clinical Pharmacy
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• v.18 no.1
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• pp.28-37
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• 2008

Objectives: Overactive bladder(OAB), defined as 'urgency, with or without urge incontinence, usually with frequency and nocturia', is a major burden for patients and impairs quality of life. The aim of this study is to evaluate the cost-effectiveness of antimuscarinic agents for the treatment of overactive bladder including quality of life in societal perspective. Methods: A decision-analysis model was developed to compare the cost-effectiveness of solifenacin and tolterodine IR over 12 weeks. We used data from the published literature to develop the framework for the model. Resource utilization and costs were calculated with public institutional data and supplemented this information with clinical expert opinion, where necessary. Results: The expected costs per patient for solifenacin were 48,762 KRW less expensive than tolterodine IR over 12 weeks. Also, all outcomes including quality of life for solifenacin were more effective than tolterodine IR over 12 weeks. In conclusion, solifenacin dominates tolterodine IR and appears to be cost-effective options for the management of overactive bladder.

• Journal of Korean Biological Nursing Science
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• v.17 no.1
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• pp.71-77
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• 2015

Purpose: This study was performed to identify lower urinary tract symptoms (LUTS), and to evaluate the factors affecting LUTS in patients with type 2 diabetes mellitus (T2DM). Methods: The cross sectional study was used with a structured questionnaire to collect data through interviews with 181 T2DM patients and their clinical data from a university hospital diabetes clinic from October 2010 to April 2012. LUTS were measured using the International Prostate Symptom Score (IPSS), depression using the Center for Epidemiologic Studies Depression Scale (CES-D), and glycosylated hemoglobin (HbA1c) from the clinical data. Results: Of all patients with T2DM, the mean IPSS of LUTS was $9.34{\pm}6.86$. Concerning the reported severity of LUTS, 53.6% of the subjects were in the moderate and severe group. In each symptom score of LUTS (range 0-5), nocturia was the highest 2.04, weak stream 1.62, and frequency 1.45. LUTS was significantly predicted by HbA1c and depression, and 14.3% of the variance in LUTS was explained. Conclusion: HbA1c and depression were found to be very important factors associated with LUTS in T2DM patients.

• Journal of Veterinary Clinics
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• v.19 no.1
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• pp.55-60
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• 2002

The Allium tuberosum is a perennial herb. From the ancient times, it has been used for food or medical purpose. Allium tuberosum is widely distributed in Korea, China, Japan and other countries. As herbal medicine, the Allium tuberosum has medical effects on lumbago, sthenia, diuresis, nocturia, hematemesis, anemia, haemorrhoid, hiccups, diarrhea, eczema, sunstroke, pollution and so on. Recently, the Allium tuberosum has been studied on its components, anti-microorganism action, anti-fungal action, anti-arteriosclerosis action, anti-cancer action. However, there has not been any study on hematological effect of allium tuberosum extract on the blood in large dogs whereas the effects of excess garlic and onion on the blood of cattle, horses, dogs, cats and sheep has been reported by many researchers. Thus, this study was performed to observe the hematological effect of excessive Allium tuberosum extract administrated in large dogs. 1. The Red Blood Cell(R3C) count was significantly decreased(p<0.05), Packed Cell Volume (PCV) count were significantly decreased(P<0.05), and Reticulocyte count was significantly increased(p<0.05) 2. The White Blood Cell(WBC) count was significantly increased(p<0.05).3. The Hemoglobin concentration was significantly decreased(p<0.05) and Mean Corpuscular Hemoglobin Concentration (MCHC) was increased. and Mean Corpuscular Volume(MCV) was significantly increased.(p<0.05). 4. The Reduced glutathione(GSH) and Met-Hemoglobin were significantly increased (p<0.05).

• The Journal of Internal Korean Medicine
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• v.24 no.2
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• pp.380-386
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• 2003

Patients with neurogenic bladder undergo morphometric and functional changes of their bladder and urethra. As a result, voiding symptoms such as frequency, nocturia, urgency and incontinence appear. We experienced two cases of the urinary incontinence treated with Samboo-tang(Sanfu-tang). In the point of Differentiation of Syndrome, two cases were diagnosed as Deficiency Syndrome of Yang of the kidneys. After Samboo-tang(Sanfu-tang) administration, the frequency of the urinary incontinence were decreased and the accompanied symptoms also improved. So, we report two cases with a brief view of related literatures.

• Childhood Kidney Diseases
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• v.17 no.2
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• pp.29-34
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• 2013

Urine production is vital for the removal of certain waste products produced by metabolism in the body and for the maintenance of homeostasis in the body. The kidneys produce urine by the following three precisely regulated processes: filtration, reabsorption, and secretion. Urine is composed of water, certain electrolytes, and various waste products that are filtered out of the blood through the glomeruli. The physical features of urine are evaluated carefully to detect any abnormal findings that may indicate underlying diseases in the genitourinary system. A change in urine color may indicate an underlying pathological condition, although many of the causes of abnormal urine color are benign effects of medications and foods. A characteristic and specific odor may be the result of a metabolic disease rather than a concentrated specimen or a simple urinary tract infection. Although transient changes in urine output and nocturia are usually benign conditions, persistent abnormal findings require further workup, with a thorough medical history taking. This article presents many of the conditions that physicians may encounter and will help them in the diagnosis and in establishing a treatment plan.

• Journal of Sasang Constitutional Medicine
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• v.32 no.4
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• pp.96-106
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• 2020

Objectives The purpose of this case study was to report that San-syndrome patient was treated by diagnosing as Greater Yang Disease Reverting Yin Pattern. Methods The patient was administered with Insamosuyu-tang. Numeral Rating Scale (NRS) and National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) was used to assess the improvements of symptoms. Results and Conclusions The perineal region discomfort was reduced from NRS 4 to NRS 1. NIH-CPSI score was reduced from 23 to 11, which means symptom relief. Nocturia and sleep disorder were resolved, and general weakness was relieved accordingly.

• Childhood Kidney Diseases
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• v.25 no.1
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• pp.35-39
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• 2021

Bartter syndrome is an autosomal recessive hypokalemic salt-losing tubulopathy, and classic Bartter syndrome is associated with mutations in the CLCNKB gene. While chronic hypokalemia is known to induce renal cyst formation in different renal diseases, renal cyst formation in Bartter syndrome is rarely reported. Russian six-year-old identical male twins were referred to our hospital for the evaluation of renal cysts, which were incidentally detected on abdominal sonography due to diarrhea. Both twins had shown symptoms of polydipsia, polyuria, and nocturia since they were one year olds. Vital signs including blood pressure were normal in both twins. Renal sonography revealed nephromegaly, increased echogenicity of renal cortex, and various sized multiple cysts in both kidneys for both twins. Laboratory findings included hyponatremia, hypokalemia, hypochloremia, and metabolic alkalosis. Bartter syndrome with renal cysts were suspected. Genetic analysis for both twins confirmed a homozygous c.1614delC deletion on exon 15 of the CLCNKB gene, which was confirmed as a previously unreported variant to the best of our knowledge. They were managed with potassium chloride, nonsteroidal anti-inflammatory drugs, and angiotensin-converting-enzyme inhibitors. Metabolic alkalosis, hypokalemia, hypochloremia, and polyuria partially improved during the short course of treatment. This is the first report of a homozygous mutation in the CLCNKB gene in an identical twin, presenting with renal cysts.

• The Journal of Internal Korean Medicine
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• v.43 no.5
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• pp.795-808
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• 2022

Objectives: The purpose of this study is to report two cases of prostate cancer patients whose side effects after surgery were treated with traditional Korean medicine. Methods: Two prostate cancer patients underwent robot-assisted laparoscopic prostatectomy, and both patients were treated with traditional Korean medicine. Subjective discomfort symptoms were evaluated using the Numerical Rating Scale. Adverse events were evaluated using the National Cancer Institute Common Terminology Criteria for Adverse Events, version 5.0. Daily life vitality was evaluated by the Eastern Cooperative Oncology Group. Results: After treatment with traditional Korean medicine, discomfort symptoms that occurred after surgery, such as frequent urination, nocturia, insomnia, and depression, all gradually improved, and Eastern Cooperative Oncology Group scores also improved from two points to one point. Additionally, there were no hematologic side effects from the traditional Korean medicine treatment. Conclusions: This case study suggests that traditional Korean medicine may contribute to the improvement of side effects caused by robot-assisted laparoscopic prostatectomy, quality of life, and immunity.

• Journal of Sasang Constitutional Medicine
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• v.34 no.4
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• pp.38-48
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• 2022

This study was aimed to report an significant improvement of urinary disturbance in overactive bladder patient using Soeumin's Sibimigwanjung-tang based on Sasang constitutional medicine. Methods A female overactive bladder patient with urinary disturbance including urgency, frequency, nocturia, tenesmus, weak stream was enrolled in this study. The patient was diagnosed as Soeum type greater-yin pattern and medicated with Sibimigwanjung-tang three times a day. Clinical improvement was evaluated with urination diary, International Prostate Symptom Score, Overactive Bladder Symptom Score, Numeric Rating Scale, and percentage of improvement compared to the day of hospitalization. Results Significant improvement was seen in urinary disturbance after 26 days of admission treatment. Also, symptoms of dyspepsia, coldness of hands and feet, and facial edema were improved. Conclusions This clinical case suggests that Sibimigwanjung-tang can be valuable option in treating urinary disturbance in overactive bladder within Soeum type greater-yin pattern.