• Asian Pacific Journal of Cancer Prevention
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• v.15 no.15
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• pp.6263-6267
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• 2014

Background: It is standard treatment to combine chemotherapy (CT) and thoracic radiotherapy (TRT) in treating patients with limited stage small cell lung cancer (LS-SCLC). However, optimal timing of TRT is unclear. We here evaluated the survival impact of early versus late TRT in patients with LS-SCLC. Materials and Methods: Follow-up was retrospectively analyzed for seventy consecutive LS-SCLC patients who had successfully completed chemo-TRT between January 2006 and January 2012. Patients received TRT after either 1 to 2 cycles of CT (early TRT) or after 3 to 6 cycles of CT (late TRT). Survival and response rates were evaluated using the Kaplan-Meier method and comparisons were made using the multivariate Cox regression test. Results: Median follow-up was 24 (5 to 57) months. Carboplatin+etoposide was the most frequent induction CT (59%). Median overall, disease free, and metastasis free survivals in all patients were 15 (5 to 57), 5 (0 to 48) and 11 (3 to 57) months respectively. Late TRT was superior to early TRT group in terms of response rate (p=0.05). 3 year overall survival (OS) rates in late versus early TRT groups were 31% versus 17%, respectively (p=0.03). Early TRT (p=0.03), and incomplete response to TRT (p=0.004) were negative predictors of OS. Significant positive prognostic factors for distant metastasis free survival were late TRT (p=0.03), and use of PCI (p=0.01). Use of carboplatin versus cisplatin for induction CT had no significant impact on OS (p=0.634), DFS (p=0.727), and MFS (p=0.309). Conclusions: Late TRT appeared to be superior to early TRT in LS-SCLC treatment in terms of complete response, OS and DMFS. Carboplatin or cisplatin can be combined with etoposide in the induction CT owing to similar survival outcomes.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.42 no.3
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• pp.399-407
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• 2022

Energy absorption facilities installed on roads should follow the performance standards of the real-car crash test of 'Installation and Maintenance Guidelines for Roadside Safety Facilities'. However, due to different installation conditions, such as differing structure widths on roads, some energy absorption facilities do not provide adequate performance. In order to apply varied environments on roads, an energy absorption structure was designed in this study with 150 mm height and four layers of W-shape guardrail at 200 mm intervals, and the performance was verified using LS-DYNA computer simulation. Through a real-car crash test, the performance of the facility designed by LS-DYNA was tested and was found to meet the performance of the CC2 category for crash cushions. The conclusion of the comparison demonstrates that the simulation and the real-car crash tests are both significant.

• Journal of the Korean Wood Science and Technology
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• v.51 no.6
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• pp.493-508
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• 2023

Round timber materials of 600 mm length, cut from large-cross-section round timber of red pine (Pinus densiflora S. et Z.) of 450 mm width and 4.2 m length, were prepared as the target of kiln drying in this study. After treating the target materials through end sealing (ES), end sealing - kerfing (ES-K), lateral sealing - end sealing - boring (LS-ES-B), or lateral sealing - partial end sealing (LS-PES), the effects of the treatment on the incidence of drying defects were determined. The target materials with exposed lateral surface and sealed cross surface were steamed at the initial temperature of 65℃ above the official pest control temperature of 56℃, followed by kiln drying toward the final temperature of 75℃. The target materials with sealed lateral surfaces, on the other hand, were dried at the initial temperature of 90℃ at almost the maximum temperature of conventional kiln drying, as there is no risk of early check formation caused by surface moisture evaporation. The final temperature was set at approximately 100℃. The drying time, taken for the target materials with initial moisture content of 70%-80% to reach the target moisture content of 19%, varied across treatment conditions. The measured drying time was 1,146 hours (approximately 48 days) for the timber with sealed cross surface and 745 hours (approximately 31 days) for the timber with sealed lateral surface, until the moisture content reached the target level. The formation of surface checks could not be prevented in the control and ES groups, but a definite preventive effect was obtained for the LS-ES-B and LS-PES groups.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.34 no.5
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• pp.311-319
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• 2012

Purpose: The aim of this study is to evaluate the vertical changes of the lip and perioral soft tissue, following orthognathic surgery in skeletal class III patients by a cephalometric analysis of a cone beam computed tomography (CBCT). Methods: A total of 20 skeletal class III patients, who had bimaxillary surgery with Le Fort 1 osteotomy and bilateral sagittal split ramus osteotomy, were included in this study. The surgical plan for maxilla was posterosuperior impaction with the anterior nasal spine, as the rotation center. Further, the surgical plan for mandible was also posterosuperior movement. The soft tissue changes between lateral cephalogram and CBCT were compared. And the correlations between independent variables and dependent variables were evaluated. Results: There were no significant differences of the soft tissues changes between lateral cephalogram and CBCT. Upper lip philtrum length (SnLs), nasolabial angle increased and upper lip vermilion length (LsStms), lower lip length (StmiB'), lower lip vermilion length (StmiLi), lower lip philtrum length (LiB') and soft tissue lower facial height (SnMe') decreased after surgery. Change of SnLs (${\Delta}$SnLs) was influenced by vertical change of menton (${\Delta}$MeV), and change of LsStms (${\Delta}$LsStms) was influenced by upper lip thickness (ULT). Change of StmiLi' (${\Delta}$StmiLi') were influenced by preoperative overjet. Change of StmiB' (${\Delta}$StmiB') were influenced by preoperative overjet, vertical change of lower incisor (${\Delta}$L1V) and horizontal change of posterior nasal spine (${\Delta}$PNSH). Change of LiB' (${\Delta}$LiB') was influenced by ${\Delta}$L1V and ${\Delta}$PNSH. Change of SnMe' (${\Delta}$SnMe') was influenced by ${\Delta}$MeV, horizontal change of upper incisor (${\Delta}$U1H) and horizontal change of lower incisor (${\Delta}$L1H). ${\Delta}$Nasolabial angle was influenced by change of ULT (${\Delta}$ULT). Conclusion: Both soft tissues and hard tissues can be evaluated by CBCT. Posterosuperior rotation of maxillomandibular complex resulted in increase of upper lip philtrum length and nasolabial angle, while the upper lip vermilion length, lower lip philtrum length, lower lip vermilion length, and soft tissue lower facial height showed a decrease.

• Korean Journal of Radiology
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• v.23 no.2
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• pp.180-188
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• 2022

Objective: To validate the performance of 3T spin-echo echo-planar imaging (SE-EPI) magnetic resonance elastography (MRE) for staging hepatic fibrosis in a large population, using surgical specimens as the reference standard. Materials and Methods: This retrospective study initially included 310 adults (155 undergoing hepatic resection and 155 undergoing donor hepatectomy) with histopathologic results from surgical liver specimens. They underwent 3T SE-EPI MRE ≤ 3 months prior to surgery. Demographic findings, underlying liver disease, and hepatic fibrosis pathologic stage according to METAVIR were recorded. Liver stiffness (LS) was measured by two radiologists, and inter-reader reproducibility was evaluated using the intraclass correlation coefficient (ICC). The mean LS of each fibrosis stage (F0-F4) was calculated in total and for each etiologic subgroup. Comparisons among subgroups were performed using the Kruskal-Wallis test and Conover post-hoc test. The cutoff values for fibrosis staging were estimated using receiver operating characteristic (ROC) curve analysis. Results: Inter-reader reproducibility was excellent (ICC, 0.98; 95% confidence interval, 0.97-0.99). The mean LS values were 1.91, 2.41, 3.24, and 5.41 kPa in F0-F1 (n = 171), F2 (n = 26), F3 (n = 38), and F4 (n = 72), respectively. The discriminating cutoff values for diagnosing ≥ F2, ≥ F3, and F4 were 2.18, 2.71, and 3.15 kPa, respectively, with the ROC curve areas of 0.97-0.98 (sensitivity 91.2%-95.9%, specificity 90.7%-99.0%). The mean LS was significantly higher in patients with cirrhosis (F4) of nonviral causes, such as primary biliary cirrhosis (9.56 kPa) and alcoholic liver disease (7.17 kPa) than in those with hepatitis B or C cirrhosis (4.28 and 4.92 kPa, respectively). There were no statistically significant differences in LS among the different etiologic subgroups in the F0-F3 stages. Conclusion: The 3T SE-EPI MRE demonstrated high interobserver reproducibility, and our criteria for staging hepatic fibrosis showed high diagnostic performance. LS was significantly higher in patients with non-viral cirrhosis than in those with viral cirrhosis.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2004.05a
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• pp.47-52
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• 2004

Springback comes from the release of residual stress after forming. The control of phenomenon is especially important in the sheet metal forming since there are no other practical methods available to correct the dimensional inaccuracy from springback. Therefore the accurate predication before the die machining has been a long goal in the Held of sheet metal forming. The aim of the present study is to enhance the prediction capability of finite element(FE) analysis for the springback phenomenon. For this purpose FE analysis for V-bending has been carried out with the commercial programs, LS-DYNA. The FE analysis results have been validated through the comparison of experimental. The experimental results measured directly by the strain gauge have given the confidence to FEA.

• The Journal of the Korean dental association
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• v.23 no.6 s.193
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• pp.527-538
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• 1985

The purpose of this study is to evaluate the chronologic changes of the soft tissue profile in 6 to 11 years children. The author analyzed 174 cephalometric roentgenograms of 13 boys and 16 girls taken from the ages of 6 to 11 to assess the growth changes of the soft tissue profile. The results were obtained as follow: 1. Means, standard deviation and coefficient of variation of children were obtained. 2. Items which showed difference between males and females in longitudinal study were prn. Sn. A', and Ls that were greater than females variation. 3. With age, thickness of the soft tissue were increased except Ls. 4. Nasolabial angle and facial convexity had no significant change with age and sex.

• Structural Engineering and Mechanics
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• v.48 no.2
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• pp.207-220
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• 2013

In this study, the vulnerability of two existing asymmetric steel building frames to Progressive Collapse (PC) is assessed. The buildings have different frame systems, steel sections and number of stories (nine and six). An alternate path method (APM) with a linear static analysis (LS) is carried out according to General Services Administration (GSA) 2003 guidelines. The Demand Capacity Ratio (DCR) of each primary element (beams and columns) is given with its specific details for all frames. The results show that the nine-story building with a dual frame system (moment frame with bracing system) has a lower susceptibility and greater resistance to PC than the six-story building with a simple building frame system (gravity system with bracing system). Implementing built-up box-shaped sections for columns is a better choice than using built-up I-shaped sections because there is no weak axis for the box section.

• Journal of electromagnetic engineering and science
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• v.7 no.4
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• pp.195-200
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• 2007

Doubly-selective channel estimator for orthogonal frequency division multiplexing(OFDM) systems is proposed in this paper. Based on the generalized complex exponential basis expansion model(GCE-BEM), we describe the time-variant channel with time-invariant coefficients over multiple OFDM blocks. The time variation of the channel destroys the orthogonality between subcarriers, and the resulting channel matrix in the frequency domain is no longer diagonal, but the main interference comes from the near subcarriers. Based on this, we propose a channel estimator with low pilot ratio. We first develop a least-square(LS) estimator under the assumption that only the maximum Doppler frequency and the channel order are known at the receiver, and then verify that the correlation matrix of inter-channel interference(ICI) is a scaled identity matrix based on which we derive an optimal pilot insertion scheme for the LS estimator in the sense of minimum mean square error. The proposed estimator has the advantages of low pilot ratio and robustness against inter-carrier interference.

• Parasites, Hosts and Diseases
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• v.45 no.3
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• pp.165-174
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• 2007

Toxoplasma gondii GRA10 expressed as a GFP-GRA10 fusion protein in HeLa cells moved to the nucleoli within the nucleus rapidly and entirely. GRA10 was concentrated specifically in the dense fibrillar component of the nucleolus morphologically by the overlap of GFP-GRA10 transfection image with IFA images by monoclonal antibodies against GRA10 (Tg378), B23 (nucleophosmin) and C23 (nucleolin). The nucleolar translocalization of GRA10 was caused by a putative nucleolar localizing sequence (NoLS) of GRA10. Interaction of GRA10 with TATA-binding protein associated factor 1B (TAF1B) in the yeast two-hybrid technique was confirmed by GST pull-down assay and immunoprecipitation assay. GRA10 and TAF1B were also co-localized in the nucleolus after co-transfection. The nucleolar condensation of GRA10 was affected by actinomycin D. Expressed GFP-GRA10 was evenly distributed over the nucleoplasm and the nucleolar locations remained as hollows in the nucleoplasm under a low dose of actinomycin D. Nucleolar localizing and interacting of GRA10 with TAF1B suggested the participation of GRA10 in rRNA synthesis of host cells to favor the parasitism of T. gondii.