• 약학회지
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• 제52권4호
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• pp.252-258
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• 2008

The cytotoxic effect of benzoic acid and related compounds on the growth of normal cell lines and human oral epithelioid cell line was evaluated by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and 2,3-bis-[2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-caboxanilide (XTT) methods. 3,4,5-Trihydroxybenzoic acid decreased the cell viability of human oral epithelioid cells and the cell adhesion activity of human oral epithelioid cells. Under the light microscopy, 100 ${\mu}M$ 3,4,5-trihydroxybenzoic acid showed the highest cytotoxic activity. From these results, we can propose that 3,4,5-trihydroxybenzoic acid has a potential anticancer activity.

• 한국환경과학회:학술대회논문집
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• 한국환경과학회 2007년도 춘계 학술발표회 발표논문집
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• pp.518-521
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• 2007

생활하수처리장과 농공단지폐수처리장 방류수의 화학분석과 in vitro bio-assay를 통한 세포독성의 결과를 통해 다음과 같은 결론을 얻었다. 1) 다성분 동시분석법을 통해 다양한 성상을 가진 9곳의 방류수에서는 phenol, aliphatic compounds, polycyclic compounds, phthalate, pesticides, aromatic amines, benzens, nitro compounds이 주오염물질로 검출이 되었다. 2) 세포독성을 나타내는 TU값이 생활하수에서는 화학분석에 결과 다종고농도의 유기오염물질이 검출된 A지점과 농공폐수의 F지점에서 높게 나타났다. 즉, 화학분석결과와 in vitro bio-assay에 의한 상관관계를 유추해 볼 수 있다. 3) S9 mixture에 따른 대사활성으로 난분해성, 소수성 유기오염물질에 대한 세포독성에 악영향을 미침을 알 수 있다.

• 생약학회지
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• 제28권2호
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• pp.80-83
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• 1997

The methanol extract of aerial part of Angelica keiskei Koidzumi exhibited a strong antimutagenic activity against aflatoxin $B_1\;(AFB_1)$. N-methyl-N'-nitro-N-nitrosoguanidine and 4-nitroquinoline-1-oxide in the Ames test with Salmonella typhimurium TA100. Cynaroside, isolated front ethylacetate fraction of the methanol extract Over silica gel, inhibited the mutagenicity of $AFB_1$ with an inhibition value of 96% at 1.0 mg/plate concentration and 87% at 0.5 mg/plate concentration. Other compounds, hyperoside, sucrose and luteolin-7-rutinoside, isolated from ethylactate or n-butanol fraction, also showed antimutagenic effect.

• 약학회지
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• 제47권5호
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• pp.293-299
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• 2003

Structure-activity relationship studies of allylamine type of antimycotics were carried out to evaluate the effect of naphthyl and methyl portion of naftifine. Compounds with 4-fluorophenyl(2a-5a), 2-fluorophenyl(2b-5b), 2,4-dichlorophenyl(2c-5c), 2,6-dichlorophenyl(2d-5d), 4-nitrophenyl(2e-5e), and 2,3-dihydro-benzo[1,4]dioxan-6-yl( 2f-5f) instead of naphthyl group with hydrogen(3a-3f), methyl(4a-4f), and ethyl(5a-5f) in the place of methyl in naftifine were synthesized and tested their in vitro anti-fungal activity against five different fungi. Eight compounds(3a, 5a, 3c, 4c, 4d, 5d, 5e, and 4f) showed significant antifungal activity against T. mentagrophytes. (E)-N-Ethyl-(3-phenyl-2-propenyl)-4-nitro-benzenemethaneamine(5e) displayed moderate antifungal activity against all five different fungi.

• 대한화학회지
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• 제21권2호
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• pp.108-120
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• 1977

수소화붕소리튬-테트라히드로푸란용액의 환원특성에 대한 계통적인 연구가 52가지의 대표적인 작용기를 가진 유기화합물을 가지고 표준조건($0^{\circ}$, 테트라히드로 푸란)에서 대략의 반응속도 및 정량 관계를 알아봄으로서 이루어 졌다.

• 대한화학회지
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• 제9권4호
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• pp.185-189
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• 1965

韓國産 酸性白土類 및 silica gel을 aniline yellow, o-nitro aniline, oil orange 色素 benzene 溶液과 작용시켜 非水溶液에서의 色素吸着率을 측정하였다. 그 吸着率은 silica gel이 酸性白土類보다 컸으며 酸性度에는 무관하였다. 또 上記 色素溶液에 각 10%의 添加溶劑 amine, alcohol, halogen類 化合物등을 加하여 高體酸의 色素吸着率의 변화(吸着阻害率)에 대하여 조사한 결과 위에 적은 順으로 그 영향이 적어지고, 同族體에서는 分子量이 적을 수록 그 영향이 커짐을 알았다. 따라서 非水溶液에서의 吸着은 amine基, 水酸基등과 같은 陰性基를 갖는 化合物은 選擇吸着하고 界面張力에 무관계하여 Traulbe系列의 逆轉現象을 나타내었다. 그 逆轉現象(吸着潮害現象)은 그 順位가 添加溶制의 雙極子能率과 대체적으로 일치하는 것으로 보아 固體酸模體인 活性硅酸과 被吸着體사이의 極盛的化學吸着에 의한 것이라 推定된다. 本實驗結果로부터 固體酸의 非水溶液에서의 吸着메카니즘, Traube 系列의 逆轉現象에 관하여 考察하게 되었다.

• 대한화학회지
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• 제47권4호
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• pp.345-353
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• 2003

6-Chloro-3-methoxycarbonylmethylene-2-oxo-1,2,3,4-tetrahydroquinoxaline(5) 또는 3-methoxycarbonylmethylene- 6-nitro-2-oxo-1,2,3,4-tetrahydroquinoxaline(6)을 hydrazine hydrate와 반응시켜 3-hydrazinocarbonylmethylene-2-oxo-1,2,3,4-tetrahydroquinoxaline류(7, 8)를 합성하였다. 화합물 7 또는 8을 치환 벤즈알데히드류 및 헤테로고리 알데히드류와 반응시켜 quinoxaline류(9-14)를 각각 합성하였다. 합성한 화합물들은 dimethyl sulfoxide 용액에서 enamine형, methylene imine형 또는 enamine형, methylene imine형, enaminol형 사이에 토토머화 현상을 나타내었는데, 이들의 토토머 비를 1H NMR로서 측정하였다.

• Bulletin of the Korean Chemical Society
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• 제16권10호
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• pp.912-915
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• 1995

Ornidazole, C7H10ClN3O3, crystallizes in the triclinic, space group P1^, with a=13.605(2), b=14.054(1), c=8.913(5) Å, α=71.59(2), β=78.73(2), γ=64.86(1)°, μ=3.26 cm-1, Dc=1.499 g/cm3, Dm=1.497g/cm3, F(000)=684, and z=6. Intensities for 2693 unique reflections were measured on a CAD4 diffractometer with graphite-monochromated Mo-Kα radiation. The structure was solved by direct method and refined by block-diagonal least squares to a final R of 0.081 (Rw=0.047) for 1952 reflections with Fo>3σ (Fo). The asymmetric unit contains three independent molecules of the title compound. The bond lengths and bond angles are comparable with the values found in the other nitro-substituted compounds. The nitro groups are rotated (6.9°, 6.6°, 2.6° for the three independent molecule, respectively) about the C-N axes from the imidazole planes. The crystal structures are linked by two intermolecular hydrogen bonds of O-H---N type and one intermolecular hydrogen bond of O-H---O type.

• 대한예방한의학회지
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• 제13권2호
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• pp.1-18
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• 2009

Objectives : In order to evaluate the cytotoxicity of hexavalent chromium, the cytoprotective effect of phenolic compounds against hexavalent chromium-induced cytotoxicity, cell viability, cell adhesion ability, lactate dehydrogenase(LDH) activity, and morphological changes of cells were examined. Methods : We measured the cytotoxicity of hexavalent chromium with 3-[4,5-dimethyl-thiazol-2-yl]-2,5-diphenyltetrazolium bromide(MTT), 2,3-bis-[2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-caboxanilide (XTT), LDH and DPPH methods. Results : The cytotoxicity of hexavalent chromium($IC_{50}$, $44.0-51.0{\mu}M$) was high according to the toxic criteria. Cytoprotective effect of phenolic compounds against $IC_{50}$ value of hexavalent chromium in cell morphology increased in a concentration-dependent manner. Conclusions : These results suggest that 3,4,5-trihydroxybenzoic acid may be used as a cytoprotective agent against chromium(IV)-mediated cytotoxicity.

• Bulletin of the Korean Chemical Society
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• 제18권8호
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• pp.890-895
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• 1997

The approximate rates and stoichiometry of the reaction of excess lithium tripiperidinoaluminum hydride (LTPDA), an alicyclic aminoaluminum hydride, with selected organic compounds containing representative functional groups under the standardized conditions (tetrahydrofuran, 25°) were examined in order to define the reducing characteristics of the reagent for selective reductions. The reducing ability of LTPDA was also compared with those of the parent lithium aluminum hydride (LAH) and lithium tris(diethylamino)aluminum hydride (LTDEA), a representative aliphatic aminoaluminum hydride. In general, the reactivity of LTPDA toward organic functionalities is weaker than LTDEA and much weaker than LAH. LTPDA shows a unique reducing characteristics. Thus, benzyl alcohol, phenol and thiols evolve a quantitative amount of hydrogen rapidly. The rate of hydrogen evolution of primary, secondary and tertiary alcohols is distinctive. LTPDA reduces aldehydes, ketones, esters, acid chlorides and epoxides readily to the corresponding alcohols. Quinones, such as p-benzoquinone and anthraquinone, are reduced to the corresponding diols without hydrogen evolution. Tertiary amides and nitriles are also reduced readily to the corresponding amines. The reagent reduces nitro compounds and azobenzene to the amine stages. Disulfides are reduced to thiols, and sulfoxides and sulfones are converted to sulfides. Additionally, the reagent appears to be a good partial reducing agent to convert primary carboxamides into the corresponding aldehydes.