• Journal of Nutrition and Health
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• 제41권8호
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• pp.691-700
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• 2008

본 연구는 착상 후 단계의 쥐 배아와 난황낭을 대상으로 구리 결핍이 NO 하부 신호전달체계에 영향을 주는지를 알아보기 위한 것으로, 연구 결과는 다음과 같이 요약할 수 있다. 첫째, 구리 결핍은 정상적인 배아 및 난황낭 발달을 억제하고, NO의 생물학적 이용도와 아세틸콜린에 대한 NO dose-response를 낮추었다. 둘째, 구리 결핍은 NO의 하부 신호전달 물질인 cGMP 수준을 감소시켰으나, NO/cGMP 하부 신호전달체계 표적 중 하나인 P-VASP에는 영향을 미치지 않았다. 셋째, 구리 결핍 배양액에 NO donor를 첨가하는 것은 구리 결핍 배아와 난황낭의 기형 발생 빈도를 구리 정상군과 비슷한 수준으로 개선시켰다. 넷째, NO donor 첨가는 구리 결핍군에서 감소되었던 cGMP의 농도를 유의적으로 증가시켰지만, P-VASP에는 영향을 미치지 않았다. 상기 연구 결과들은 구리 결핍으로 인한 NO의 생물학적 이용도의 감소가 기형발생의 주요 발생 기전이라는 것을 뒷 받침하고 있다. 또한, 임상적으로 임신 기간 중 적절한 구리 섭취의 중요성을 강조한다.

• 한국강구조학회 논문집
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• 제12권5호통권48호
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• pp.581-593
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• 2000

본 연구는 지진하중을 받는 현수교의 수직 동적 해석방법을 발전시켰다. 시간 영역해석, 불규칙 진동 해석 및 스펙트럼 해석의 이론을 체계적으로 정립하였다. 불규칙 진동 해석을 다시 수치적분을 이용하는 방법과 수학적 적분식 및 상관계수를 이용한 방법으로 나누고 각각은 다시 지진하중을 white noise로 가정한 경우와 filtered white noise로 가정한 경우에 대해 CQC 방법과 SRSS 방법을 사용하였다. 현수교의 모델링은 빔, 트러스 및 프레임요소를 사용하였고 케이블과 주탑은 사하중에 의한 기하학적 강성을 고려하였다.

• BMB Reports
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• 제49권12호
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• pp.687-692
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• 2016

We recently reported the anti-inflammatory effects of 3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride (KHG26792) on the ATP-induced activation of the NFAT and MAPK pathways through the P2X7 receptor in microglia. To further investigate the underlying mechanism of KHG26792, we studied its protective effects on hypoxia-induced toxicity in microglia. The administration of KHG26792 significantly reduced the hypoxia-induced expression and activity of caspase-3 in BV-2 microglial cells. KHG26792 also reduced hypoxia-induced inducible nitric oxide synthase protein expression, which correlated with reduced nitric oxide accumulation. In addition, KHG26792 attenuated hypoxia-induced protein nitration, reactive oxygen species production, and NADPH oxidase activity. These effects were accompanied by the suppression of hypoxia-induced protein expression of hypoxia-inducible factor 1-alpha and NADPH oxidase-2. Although the clinical relevance of our findings remains to be determined, these data results suggest that KHG26792 prevents hypoxia-induced toxicity by suppressing microglial activation.

• 한국산업융합학회 논문집
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• 제6권1호
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• pp.73-80
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• 2003

We report herein synthetic results obtained six new types of bis-benzocrown ethers containing imine group. Bis crown ethers1~3 are aminobenzo-15-crown-5-ether linked with terephthalaldehyde, isophthalaldehyde, phthaldehyde respectively by imine reaction. Bis crown ethers1~3 are different distances in each crown ether rings. Bis crown ether 4 has large cavity in crown ethers. Functionalized crown ether 5 is synthesized amonobenzo-15-crown-5-ether and terephthaladehyde same ratio at one to one. Bis crown ether 6 has photosensitive linkage between crown ethers. Bis crown ether 7 is prepared by amonobenzo-15-crown-5-ether and triethyl ortho formate. 4'-Nitrobenzo-crown ethers and 3',4'-dinitrobenzo-crown ethers were prepared by nitration of benzo crown ethers, obtained from the reaction of catechol and oligoethylene glycol ditosylate. Crown ethers containing aldehyde group were synthesized from the reaction of 3,4-dihydroxybenzaldehyde and corresponding ditosylate respectively. The synthesized crown ethers were characterized respectively by IR, NMR, GC-Mass.

• 한국소음진동공학회논문집
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• 제13권8호
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• pp.605-611
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• 2003

A simply supported pipe conveying fluid and two moving masses upon it constitute this nitration system. The equation of motion is derived by using Lagrange's equation. The influence of the velocities of two moving masses, the distance between two moving masses, and the velocities of fluid flow in the pipe have been studied on the dynamic behavior of a simply supported pipe by numerical method. The velocities of fluid flow are considered with in its critical values of a simply supported pipe without moving masses upon It. Their coupling effects on the transverse vibration of a simply supported pipe are inspected too. As the velocity of two moving masses increases, the deflection of a simply supported pipe is increased and the frequency of transverse vibration of a simply supported pipe is not varied. In case of small distance between two masses, the maximum deflection of the pipe occur when the front mass arrive at midspan. Otherwise as the distance get larger, the position of the front masses where midspan deflection is maximum moves beyond the midpoint of a simply supported pipe. The deflection of a simply supported pipe is increased by coupling of the velocities of moving masses and fluid flow.

• 소음진동
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• 제11권1호
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• pp.125-131
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• 2001

There is a clearance between the parts of a machine due to design tolerance, manufacturing error, wear, looseness, or misalignment. If the clearance is large, the vibration and noise of the machine is generally large. Therefore, the analysis on the nitration and noise of a machine can tell the clearance of the machine, which reveals the condition of the machine, i.e., the existence of faults and the safety of the machine. The investigation of this kind of research should be on the basis of experimental results. A link mechanism with a clearance at a joint between the coupler and locker is made for the investigation of the condition monitoring of a machine due to clearance. The vibration and sound are measured from the link driving system during the operation. The signals are clarified using line enhancement technique. The noise removed signals are used to develop the dynamic model of the system for a model based fault diagnosis. Also this study showed that the clarified signals can be used for the calculation of the joint forces between the coupler and rocker and for the correlation between the vibration and sound levels and the clearance sizes.

• 소음진동
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• 제11권2호
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• pp.249-256
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• 2001

In this paper the characteristics of vibration induced by subway trains running on track is discussed. The quantitative prediction of the vibration level and the countermeasure for reduction of necessary, is of importance for the better environment. It was made the constructed Bundang line as first step with the modified Young-Dan type to basis on the Japanese Young-Dan type. In this paper it was measured and analyzed to two region ($ \circled1$Susuh-Bokjung. $ \circled2$Chorim-Suhyun region) of this. at present, operational Bundang line when averaging velocity of train is 60 (km/h). As the response characteristics of frequency Induced by subway operation, it was confirmed that frequency band of neighborhood of 30~80 Hz in generally dominant. Also to assess the quantitative nitration as response level to be measured for each point of two region in subway operation, the vibrational response level was measured at the state to be not subway operation. And the level was approximately $\fraction one-fifth~\fraction one-ten$ level comparing to subway operation.

• 한국대기환경학회지
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• 제17권2호
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• pp.157-167
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• 2001

Although PAN has ong been considered to belong to one of the most characteristic photooxidants, its concentra-tions have rarely been measured in a systematic manner in Korea. The first in-situ Measurements of PAN were made in concert with simultaneous analysis of NO, NO$_2$, $O_3$ and UV-Visible radiation intensity from Seoul and dong-Hae during Spring and early Summer of 1999. The aim of our study was to evaluate the behavior of photo-chemical species in a highly polluted urban air and a relative clean one. PAN were determined using a semi-auto-mated gas chromatograph equipped with an electron captured detection system. Calibration of the PAN was done by synthesizing liquid standards using a strong acid nitration of the corresponding peracid. The PAN concentra-tions were found in the range of a few ppbv in the urban air ad persistently less than a ppbv in the clean rural airs. Diurnal variations of PAN and $O_3$ were also observed consistently during the experiment with maxima occurring during the late daylight hours. While the positive dependency of $O_3$ production and PAN concentrations were ob-served in most occasion, the dependency became deviated significantly under changes in air masses.

• 한국응용과학기술학회지
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• 제26권2호
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• pp.132-142
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• 2009

The benzophenone derivatives(4-$CH_3O$-4'-$NO_2$ and 3,4'-di-$NO_2$) are synthesized by the Fridel-Craft acylation and the nitration method. Electrochemical redox potentials of the benzophenone derivatives (4-$CH_3O$, H, 3-Cl, 3-$NO_2$, 4-$NO_2$, 4-$CH_3O$-4'-$NO_2$, 3,4'-di-$NO_2$) are measured by using cyclic voltammometry. In the relationship of summing Hammett value and redox potential, we find a proportional constant$(\rho)$ that shows a good relation with an electrochemical property and a reactivity of the benzophenone derivatives. The benzophenone substituted with the electron donating groups(4-$OCH_3$ and 4-$OCH_3-4'-NO_2$) are higher the energy in the LUMO level, then increasing a band-gap energy$(E_g)$, their $E_gs$ are obtained as a 3.94 eV and 3.59 eV, respectively.

• 한국응용과학기술학회지
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• 제30권1호
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• pp.57-63
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• 2013

Ammonium dinitramide (AND) is one of the most promising oxidizers in propellants without chlorinated pollution to the atmosphere in these days. Potassium sulfamate (PS) is a key substance in ADN synthesis as forming nitrates such as $-N(NO_2)_2$. In this paper, potassium sulfamate as a starting material for ADN synthesis was prepared in a lab scale through crystallization with ethanol solvent, and observed the effects on the yield and purity of KDN. The prepared potassium sulfamates were analyzed using FE-SEM, XRD, BET and TGA-DSC. The lab-made PS, which was ground to $20{\mu}m$ showed more beneficial than a commercial product achieving high yield and purity of the synthesized KDN. It would be associated closely with crystallinity, porosity and pore size of prepared PS.