• Neonatal Medicine
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• v.28 no.2
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• pp.72-76
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• 2021

Ectopic pancreas is defined as an abnormally located pancreatic tissue not sufficiently connected with the normal pancreas, which rarely occurs in neonates. To our knowledge, only a few cases of ectopic pancreas have been reported in newborns in South Korea. We report a case of ectopic pancreas as the cause of intussusception and jejunal atresia in a newborn. This clinical association is extremely rare, and this is the first report in South Korea.

• Neonatal Medicine
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• v.28 no.1
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• pp.1-6
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• 2021

Persistent pulmonary hypertension of the newborn (PPHN) is a consequence of the failure of a decrease in the elevated pulmonary vascular resistance after birth. Pulmonary vasodilators, including inhaled nitric oxide (iNO), have been the mainstream of targeted therapy for PPHN, but no drugs have been proven to be effective in preterm infants with PPHN. The fetus remains hemodynamically stable despite lower arterial oxygen tension and pulmonary blood flow as compared to full-term newborns. This adaptation is due to the lower oxygen requirement and high oxygen-carrying capacity of fetal circulation. The immature lungs of preterm infants are more vulnerable to reactive oxygen species, and the response of pulmonary vascular dilatation to blood oxygen tension is blunted in preterm infants. Recently, iNO has been reported to be effective in a selected group of preterm infants, such as those with prolonged preterm rupture of membrane-oligohydramnios-pulmonary hypoplasia sequence. PPHN in preterm infants, along with maximum supportive treatment based on fetal physiology and meticulous assessment of cardiovascular function, is in dire need of new treatment guidelines, including optimal dosing strategies for pulmonary vasodilators.

• Journal of Genetic Medicine
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• v.15 no.2
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• pp.115-119
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• 2018

The 16p11.2 microdeletion has been reported in patients with developmental delays and intellectual disability. The distal 220- kb deletion in 16p11.2 is associated with developmental delay, autism spectrum disorder, epilepsy, and obesity at a young age. We have reported a case of distal 16p11.2 deletion syndrome in a preterm infant with unusual facial morphology and congenital heart disease. We suggest using chromosome microarray analysis to detect chromosomal abnormalities in newborns, especially preterm infants with unusual morphologies.

• Archives of Craniofacial Surgery
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• v.20 no.4
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• pp.265-269
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• 2019

Congenital hypoplasia of the depressor anguli oris muscle is a rare cause of asymmetrical crying facies in newborns. The clinical manifestations range from mild to severe asymmetry and may persist up to adulthood. In the current case, the patient did not exhibit other congenital anomalies or paralysis of other branches of the facial nerve. This adult patient presented with severe asymmetrical lower lip deformity during full mouth opening since birth. A chromosomal study for the detection of 22q gene deletion yielded negative results. The electromyography findings of the lower lip were insignificant. Depressor labii inferioris muscle resection was not effective, but bidirectional (horizontal and vertical) fascia lata grafting improved the aesthetic appearance of the asymmetrical lower lip. The patient showed improved lower lip symmetry during full mouth opening at 1 year after the surgery. Therefore, the details of this rare case are reported herein.

• Molecules and Cells
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• v.42 no.6
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• pp.441-447
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• 2019

RAS gene mutations are frequently found in one third of human cancers. Affecting approximately 1 in 1,000 newborns, germline and somatic gain-of-function mutations in the components of RAS/mitogen-activated protein kinase (RAS/MAPK) pathway has been shown to cause developmental disorders, known as RASopathies. Since RAS-MAPK pathway plays essential roles in proliferation, differentiation and migration involving developmental processes, individuals with RASopathies show abnormalities in various organ systems including central nervous system. The frequently seen neurological defects are developmental delay, macrocephaly, seizures, neurocognitive deficits, and structural malformations. Some of the defects stemmed from dysregulation of molecular and cellular processes affecting early neurodevelopmental processes. In this review, we will discuss the implications of RAS-MAPK pathway components in neurodevelopmental processes and pathogenesis of RASopathies.

• Sleep Medicine and Psychophysiology
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• v.27 no.2
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• pp.33-40
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• 2020

An infant's sleep varies considerably from that of adults in terms of structure, amount, and breathing pattern. After birth, sleep becomes evenly distributed throughout the day and night. Nighttime sleep gradually increases with the maturation of circadian rhythm, and sleep is gradually consolidated. Electroencephalography characteristics change with age, from early and dominant active (REM) sleep in newborns to increasing NREM sleep. Similar to other elements of growth, the upper respiratory tract and ribcage gradually increase in size with age, and respiratory control also improves. With these changes, sleep patterns also change. At this time that various sleep disorders may appear. Improved understanding of age-dependent changes in infant sleep can help determine the etiology and facilitate diagnosis of infant sleep diseases.

• Medical Lasers
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• v.10 no.4
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• pp.238-241
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• 2021

Laryngomalacia is the most common laryngeal malformation that occurs mainly in newborns and children. Symptoms include inspiratory high pitched wheezing, dyspnea, and cyanosis. In most cases, symptoms aggravate until eight months and gradually disappear without any treatment as the patient grows older, but surgical treatment is required in severe cases. The surgical treatment options include epiglottoplasty, supraglottoplasty, aryepiglottoplasty, tracheostomy, and many others performing a resection of excessive mucosa in the larynx. Unlike conventional surgeries, the authors recently treated a case of a two-month-old infant with severe laryngomalacia using a CO₂ laser. After performing CO₂ laser surgery twice, the patient was cured without complications.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.48 no.6
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• pp.382-385
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• 2022

Congenital epulis (CE) is an extremely rare benign tumor of the gingiva that is found on the alveolar ridge of newborns, and the main treatment option is simple excision. Postoperative prognosis is very good, and spontaneous regression may occur despite incomplete excision. This report presented a rare case of CE and its healing process after surgery under local anesthesia. The treatment plan was decided upon through consultation between a medical team and the patient's family, with surgical excision for the main lesion, which benefitted from surgery, and follow-up for a very small-sized lesion, which was thought to be appropriate for a newborn. No recurrence was found after its removal, and favorable healing was observed.

• Proceedings of the Korea Information Processing Society Conference
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• 2021.11a
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• pp.1282-1285
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• 2021

만 1세 이하의 영유아가 사망하는 영아 돌연사 증후군은 매년 지속적으로 발생하고 있다. 그 중에서도 특히 질식사는 높은 비중을 차지한다. 이러한 위험이 다가오면 신생아는 울음으로 도움을 요청하지만, 청각장애인 부모의 경우에는 즉각적인 대응이 불가능하다. 따라서 청각장애인 부모의 귀가 되어주어 신생아의 다양한 위험을 방지하고, 육아에 도움을 주고자 한다.

• Proceedings of the Korea Information Processing Society Conference
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• 2022.11a
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• pp.1019-1021
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• 2022

본 연구는 산후조리원 내 신생아를 위한 원격 관리 시스템을 제안한다. 기존 시스템들은 공기질 문제만을 해결하거나, 모니터링 문제만을 해결하는 등 단순한 동작과 감시에 초점이 맞추어졌으나, 제안하는 시스템은 실내와 신생아 주변에 설치된 각각의 센서를 통하여 공기질을 포함한 실내 환경과 신생아를 모니터링하여 간호사와 산모가 쉽게 신생아의 건강을 웹과 엡으로 모니터링하고 원격으로 관리한다. 또한, OpenCV 라이브러리를 이용하여 신생아의 얼굴을 인식하고 표정별 이미지를 저장할 수 있도록 설계 및 구현하고 있다.