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Analysis of Indicated Points and Main Factors Affecting the Quality of Clinical Research for the Development of Internal Audit Tools (자체점검 도구 개발을 위한 지적사항 및 임상연구의 품질에 작용하는 요인 분석)

  • Hye Yun Jang;Jung-Hee Jang;Yoon Jin Lee
    • The Journal of KAIRB
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    • v.5 no.1
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    • pp.14-20
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    • 2023
  • Purpose: To obtain fundamental data on selection tools for an internal audit and develop a new guideline. We scored the indicated points from the internal audit, identified the research progress and problems that occurred, and confirmed the validity of the risk factors involved. Methods: Of the 63 internal audits conducted by Keimyung University Dongsan Hospital from 2014 to 2021, we analyzed 55 clinical trials with an inspection checklist. We excluded 8 that failed to transfer data and refused to comply with the internal audit. The statistical summary of the collected data was verified and interpreted by using frequency analysis and a chi-square test. Result: Of total 55 cases included in the internal audit, sponsor-initiated trial (SIT) was 63.6% (vs. investigator-initiated trial [IIT]), clinical trial for investigational drug was 71.0% (vs. nonclinical or clinical trial for investigational device), domestic multicenter trial was 60.0% (vs. single center or multinational multicenter trial), and trial requisition for MFDS approval was 69.1% (vs. exception for MFDS approval). The 10 areas of the clinical trial inspection checklist (reports, protection of subjects, compliance with protocols, records, management of investigational drug and/or device, delegation of duties, qualification of investigators, management of specimen, contract-agreement and approval of protocols, and preservation of recorded documents) were weighted between 2 to 5 points. The average of the total points was 16.09±13.2 and 20 clinical trials were above the average. As a result of comparing the average of the total points weighted by year, the highest score was in 2020. The 4 factors that play significant roles in determining the internal quality were (1) principal subjects that initiated the clinical trials (p=0.049), (2) type (p=0.003), (3) phase of clinical trials (p=0.024), and (4) number of registered subjects reported at the time of continuing deliberation (p=0.019). Of the 10 areas of the clinical trial inspection checklist, 'record' was the most inappropriate and insufficient. We found more indicated points; the quality of performance declined in IIT, nonclinical trials, and other clinical trials that were not in phase I1-IV4, and the study of more than 30 registered subjects at the time of continuing review. Conclusion: If an institution has an internal audit selection tool that reflects the aforementioned risk factors, it will be possible to effectively manage high-risk studies; thereby, contributing to an efficient internal audit and improving the quality of clinical trials.

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The Results of the Application of a Real-time Chemical Exposure Monitoring System in a Workplace (스마트 센서 세트를 활용한 화학물질 상시모니터링 시스템의 작업현장 적용 결과)

  • Wook Kim;Jangjin Ryoo;Jongdeok Jung;Gwihyun Park;Giyeong Kim;Jinju Kang;Kihyo Jung;Seunghon Ham
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.33 no.2
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    • pp.215-229
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    • 2023
  • Objectives: To validate the effectiveness of a real-time chemical exposure monitoring system developed by KOSHA (Korea Occupational Safety and Health Agency), we applied the system to a workplace in the electronics industry for 153 days. Methods: The monitoring system consisted of a PID chemical sensor, a LTE communication equipment, and a web-based platform. To monitor chemical exposure, four sets of sensors were placed in two manufacturing tasks - inspection and jig cleaning - which used TCE as a degreasing agent. We reviewed previous reports of work environment measurements and conducted a new work environment measurement on one day during the period. The PID sensor systems detected the chemical exposure levels in the workplace every second and transmitted it to the platform. Daily average and maximum chemical exposure levels were also recorded. Results: We compared the results from the real-time monitoring system and the work environment measurement by traditional methods. Generally, the data from the real-time monitoring system showed a higher level because the sensors were closer to the chemical source. We found that 28% of jig cleaning task data exceeded the STEL. Peak exposure levels of sensor data were useful for understanding the characteristics of the task's chemical use. Limitations and implications were reviewed for the adoption of the system for preventing poisoning caused by chemical substances. Conclusions: We found that the real-time chemical exposure monitoring system was an efficient tool for preventing occupational diseases caused by chemical exposure, such as acute poisoning. Further research is needed to improve the reliability and applicability of the system. We also believe that forming a social consensus around the system is essential.

Exploring Picture Book Reding Ecperiences of 2-Year-Olds Using Sensuous Reading Media (감각적 읽기 매체를 활용한 만2세의 그림책 )

  • Nam, Ki-won;Lee, su-jung
    • The Journal of the Convergence on Culture Technology
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    • v.9 no.3
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    • pp.359-370
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    • 2023
  • The purpose of this study is to analyze the meaning of picture book reading experience for 2-year-old children using sensory reading media and to suggest a plan to support language ability through meaningful reading. For this study, 35-month-old boys were selected, and data collection was conducted based on participant observation and field record notes at home and analyzed qualitatively. In this study, for about two months from March 20th to April 30th, 2021, all the time of exploring picture books and playing were recorded and the data were collected. The recording time was about 20 hours, and the collected data and field records were transcribed on 108 pages of A4 paper. The results of the study showed that 2-year-old infants were immersed in exploring new media through the experience of reading picture books using sensory reading media, comparing with similar media, and reading picture books using media. In addition, it was found that the emergence of leading reading that selects and reads books by Hans himself, exploration using reading media, and play linked to picture books in everyday life.This can be seen as a result of suggesting that the picture book reading experience of 2-year-olds using sensory reading media is meaningful to the reading experience of infants.

Investigation on the History of the Muck (Traditional Starch Jelly) and Its Processing Methods Reviewed in the Ancient and the Modern Culinary Literatures (고문헌(1400년대~1800년대) 및 근대문헌(1900년대~1960년대)에 나타난 묵의 변천과 묵 쑤는 방법에 대한 고찰)

  • Cha, Jin-A;Cha, Gyung-Hee;Chung, La-Na;Kim, Soo-Youn;Chung, Yoo-Sun;Yang, Il-Sun
    • Journal of the Korean Society of Food Culture
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    • v.23 no.1
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    • pp.73-89
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    • 2008
  • Muck (Korean traditional starch jelly) is very unique and the one of the oldest starch processing traditional food. The typical ingredients for making muck such as acorns, mungbean and buckwheat have been eaten since the new stone age or even before that era. This study was for investigation on the history of muck and its processing methods in the ancient and the modern culinary literatures from the 1400’s to 1900’s. The summary of the reviews was as follows. In the ages from the 1400’s to 1700’s, using starch powder, Se-myon and Chang-myon were made and their shape were like noodles instead of cubical shape. It was after the 1700’s that muck making methods were revealed in the literature, like ${\ulcorner}Gyeong-do-jabji{\lrcorner}$ (1730) and${\ulcorner}Go-sa-sib-e-jib{\lrcorner}$ (1737). The naming of muck might be from the time after 1800’s, in${\ulcorner}Myoung-mul-kiryak {\lrcorner}$ (around 1870) the basis of the names of Choeng-po (white mungbean jelly) and Whang-po (yellow mungbean jelly) could be found. One of the most well-known muck dish, Tang-pyeong-chae, was recorded many old literatures, so it was found that Tang-pyeong-chae was very popular and governmental policy of Tang-pyeong-chak influenced the food of the common people. In ${\ulcorner}Shi-eui-jeon-seo{\lrcorner}$ (late 1800’s) there were records of several types of muck and starch powder making methods in detail which were handed down to the modern ages.

BuddyMirror: A Smart Mirror Supporting Image-Making Service (BuddyMirror: 이미지 메이킹 서비스를 지원하는 스마트 미러)

  • Jo, Yeon-Jeong;Sim, Chae-Lin;Jang, Hyo-Won;Jin, Jae-Hwan;Lee, Myung-Joon
    • Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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    • v.9 no.5
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    • pp.811-821
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    • 2019
  • Image making for a person is a way to improve various factors that can express oneself, such as appearance, impression, and confidence. In general, people use mirror or camera as a traditional method to make their own image or perform presentation exercises. Recently, as smart mirrors are widely used in various fields, attempts to use smart mirrors as image making tools instead of mirrors have been frequently made. Smart Mirror is considered as a suitable tool to provide image making service because it can attach various devices such as a camera and a microphone in addition to the main advantage of a mirror that it is easily accessible. In this paper, we present BuddyMirror - a smart mirror software that provides image-making service to users, and a dedicated mobile app for flexibly running the mirror software. BuddyMirror provides functions for presentation, mock interview, and styling service at the request of users, interworking with the dedicated mobile app. We also describe the techniques developed for implementing and activating each of the new services as a module of MagicMirror, a widely used smart mirror development platform. The developed mobile app enables users to deliver presentations to BuddyMirror or to download the recorded video for image-making services.

Histogram-Based Singular Value Decomposition for Object Identification and Tracking (객체 식별 및 추적을 위한 히스토그램 기반 특이값 분해)

  • Ye-yeon Kang;Jeong-Min Park;HoonJoon Kouh;Kyungyong Chung
    • Journal of Internet Computing and Services
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    • v.24 no.5
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    • pp.29-35
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    • 2023
  • CCTV is used for various purposes such as crime prevention, public safety reinforcement, and traffic management. However, as the range and resolution of the camera improve, there is a risk of exposing personal information in the video. Therefore, there is a need for new technologies that can identify individuals while protecting personal information in images. In this paper, we propose histogram-based singular value decomposition for object identification and tracking. The proposed method distinguishes different objects present in the image using color information of the object. For object recognition, YOLO and DeepSORT are used to detect and extract people present in the image. Color values are extracted with a black-and-white histogram using location information of the detected person. Singular value decomposition is used to extract and use only meaningful information among the extracted color values. When using singular value decomposition, the accuracy of object color extraction is increased by using the average of the upper singular value in the result. Color information extracted using singular value decomposition is compared with colors present in other images, and the same person present in different images is detected. Euclidean distance is used for color information comparison, and Top-N is used for accuracy evaluation. As a result of the evaluation, when detecting the same person using a black-and-white histogram and singular value decomposition, it recorded a maximum of 100% to a minimum of 74%.

Comparison and Analysis of Information Exchange Distributed Algorithm Performance Based on a Circular-Based Ship Collision Avoidance Model (원형 기반 선박 충돌 피항 모델에 기반한 정보 교환 분산알고리즘 성능 비교 분석)

  • Donggyun Kim
    • Journal of Navigation and Port Research
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    • v.47 no.6
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    • pp.401-409
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    • 2023
  • This study compared and analyzed the performance of a distributed area search algorithm and a distributed probability search algorithm based on information exchange between ships. The distributed algorithm is a method that can search for an optimal avoidance route based on information exchange between ships. In the distributed area search algorithm, only a ship with the maximum cost reduction among neighboring ships has priority, so the next expected location can be changed. The distributed stochastic search algorithm allows a non-optimal value to be searched with a certain probability so that a new value can be searched. A circular-based ship collision avoidance model was used for the ship-to-ship collision avoidance experiment. The experimental method simulated the distributed area search algorithm and the distributed stochastic search algorithm while increasing the number of ships from 2 to 50 that were the same distance from the center of the circle. The calculation time required for each algorithm, sailing distance, and number of message exchanges were compared and analyzed. As a result of the experiment, the DSSA(Distributed Stochastic Search Algorithm) recorded a 25%calculation time, 88% navigation distance, and 84% of number of message exchange rate compared to DLSA.

Face-to-Face and Non-Face-to-Face Student Counseling Experiences of Nursing Students During the COVID-19 (코로나 19시기 간호대학생의 대면과 비대면 학생상담 경험)

  • Woo-Young Chae;Eun-Young Jung;Hyun-Jin Kim
    • Journal of the Korean Applied Science and Technology
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    • v.40 no.6
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    • pp.1521-1532
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    • 2023
  • This study was done to identify the face-to-face and non-face-to-face student counseling experiences of nursing students during the COVID-19 period. Data were collected through interviews with 10 students at S Women's University in Gyeonggi-do from December 2022 to April 2023. All recorded data were analyzed using an inductive content analysis method. As a result of the study, two themes, four categories, and eight subcategories were found. Themes were 'factors promoting counseling' and 'Non-facilitating factors in counseling'. The first theme category was 'adaptation to new counseling methods' and 'pursuing convenience as the MZ generation', and the second theme category was 'resistance to counselling' and 'discrepancy from the desire for mutual relationships'. Through this study, it was helpful to understand that student counseling is essential for nursing students and what the most appropriate and useful counseling method is. Additionally, this study provided important evidence to lay the foundation for comparative research on face-to-face and non-face-to-face counseling among research participants according to gender and major. Further suggests research to develop a student counseling program for nursing students and confirm its effectiveness.

The distribution of Jeju coastal sand dune plants and its restoration implications (제주 해안사구 식물 분포와 복원을 위한 의미)

  • Kim, Kee Dae
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.27 no.1
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    • pp.31-44
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    • 2024
  • The coastal dune ecosystem is one of the ecosystems under the most development pressure in Korea. Therefore, it is necessary to study the ecological location and related ecological phenomena of coastal dune plants, but related studies are lacking. Through this study, we intend to conduct research on the structure and restoration of dune plants, focusing on the coastal dunes in Jeju Island, which are affected by artificial development pressure and the continuous increase in tourists among many coastal dunes in Korea. Ecosystems of coastal sand dunes for vegetation survey in Jeju Island are selected based on naturalness and preservation. In this study, 23 major coastal dunes on Jeju Island including Udo were selected. In the coastal dunes of Jeju Island, a whole species survey and quadrat survey were carried out. The vegetation survey at study sites were conducted on May to September 2022, when the vegetation is clearly visible. At the survey site, the dune area was identified at the beginning and the plant species were recorded until no more new species appeared. Vegetation survey in the field was performed by 103 quadrat establishments and was conducted using Braun-Blanquet method. A total of 277 species appeared, and the most common species were Vitex rotundifolia and Calystegia soldanella. The frequency of both Vitex rotundifolia and Calystegia soldanella was approximately over 90%. The proportion of woody and herbaceous in all emerging species was 7.2% and 92.8%, respectively. The total number of species found in the quadrat survey was 98. As a result of classifying plant communities based on species dominance in the quadrats, it was analyzed into 30 plant communities. The plant communities that appeared with a frequency of 2 or more on the main island of Jeju were Vitex rotundifolia, Imperata cylindrica var. koenigii, Ischaemum antephoroides, Wedelia prostrata, Elymus mollis, Calystegia soldanella, Artemisia scoparia, and Tetragonia tetragonoides. The DCCA(detrended canonical correspondence analysis) based on the vegetation and environment factor matrix showed that the height and covers of the dominant plant species explain significantly the variation and distribution of coastal sand dune species on Jeju island. Thus, we may propose a plan to restore the coastal dunes of Jeju island as helping colonization and establishment of mainly sand dune native perennials and trees, preserving native plant communities that are declining and preserving present tree strips of Pinus thunbergii, Litsea japonica, Pittosporum tobira and Vitex rotundifolia.

Effects of the interaction between seaweed consumption and the polygenic risk score on inflammation in Korean adults (한국 성인의 해조류 섭취와 다유전자 위험 점수 간의 상호작용이 염증에 미치는 영향)

  • Gayeon Hong;Dayeon Shin
    • Journal of Nutrition and Health
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    • v.57 no.2
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    • pp.211-227
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    • 2024
  • Introduction: Seaweed is a sustainable and underexplored source of bioactive compounds with potent anti-inflammatory activities. However, studies on the interaction between seaweed and genes on inflammation are limited. Purpose: We aimed to evaluate the relationships between seaweed consumption and the polygenic risk scores (PRS) and their interactions with high-sensitivity C-reactive protein (hs-CRP) levels. Methods: Information on seaweed consumption was collected using a food frequency questionnaire, which included laver, kelp, and sea mustard among the items consumed. A total of 31 hs-CRP-related single nucleotide polymorphisms (SNPs) were selected using genome-wide association studies and clumping analysis, and the individual PRS were calculated by weighting the effect size of each allele in the selected SNPs of 39,369 middle-aged (≥40 years) Koreans using the Korean Genome and Epidemiology Study (KoGES)-Health Examinees (HEXA) cohort data. To investigate the interaction between seaweed intake and the PRS on hs-CRP levels >1 mg/L, hazard ratios (HRs) and 95% confidence intervals (CIs) were assessed using multivariable Cox proportional hazards models. Results: During a mean follow-up period of 4.8 years, we recorded 436 patients with elevated hs-CRP levels. Women in the highest tertile of the PRS with the lowest quartile of seaweed intake had an increased incidence of elevated hs-CRP levels compared with women in the lowest tertile of the PRS with the lowest seaweed intake quartile (HR 2.34, 95% CI 1.23-4.45). No significant association was observed among the men. Conclusion: In conclusion, we identified a new interaction between the PRS, seaweed intake, and inflammation in Korean women, and this study suggests that the interaction between the identification of genetic predisposition and dietary seaweed intake may have an impact on determining the risk of developing hyperinflammation in the future.