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Isolation, Physico-chemical Properties, and Biological Activity of New Thiopeptide Antibiotics, Kimorexins

  • Yeo, Woon-Hyung;Kim, Si-Kwan;Kim, Sang-Seock;Yu, Seung-Hun
    • Journal of Microbiology and Biotechnology
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    • v.4 no.4
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    • pp.349-353
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    • 1994
  • An isolate 90-GT-302, identified as Kitasatosporia kimorexae, was found to produce antibiotics that induce mycelial swelling in Magnaporthe grisea, and Fusarium solani. The strain produced at least 5 antibiotics. Among them, the main active compound designated as kimorexin A was isolated and its physico-chemical properties and biological activities were examined, and as a result was found to be of the thiopeptide antibiotic. A comparison between the properties of kimorexin A and those of the known thiopeptide antibiotics led us to conclude that kimorexin A was a new thiopeptide polythiazolyl antibiotic. Kimorexin A showed a narrow antimicrobial spectrum against very limited genus of phytopathogenic fungi. It prevented host plants from infections of Rhizoctonia solani and absolute parasitic fungi, such as Sphaerotheca fuliginea and Puccinia recondita, almost completely at the treatment concentration of approximately 20 ppm.

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Development of an autonomous biped walking robot

  • hyeung-sik choi;Oh, jeong-min;Kim, young-sik;Baek, chang-yul
    • 제어로봇시스템학회:학술대회논문집
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    • 2002.10a
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    • pp.105.6-105
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    • 2002
  • Contents 1We developed a new type of lower part of the human-sized BWR (biped walking robot) driven by a new actuator based on the ball screw which has high strength and high gear ratio. Each leg of the robot is composed of three pitch Joints and one roll joint. In all, a 8 degree-of-freedom robot was developed. A new type of actuator for the robot is proposed, which is composed of four bar link mechanism driven by the ball screw. The BWR was designed to walk autonomously by adapting small DC motors for the robot actuators and has an embeded controller system including host computer, batteries and motor drivers. In the performance test, we had basic stable walking data so far, but we f...

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A New Mobile-IPv6 based Buffering Scheme in the All-IP Network

  • Park, Byoung-Seob;Lim, Cheol-Su
    • Proceedings of the IEEK Conference
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    • 2002.07b
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    • pp.1094-1097
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    • 2002
  • Realtime applications like VoIP(Voice over IP) in All-IP networks need smooth handoffs in order to minimize or eliminate packet loss as a Mobile Host(MH) transitions between network links. In this paper, we design a new dynamic buffering(DB) mechanism for IPv6 by which an MH can request that the router on its current subnet buffers packets on its behalf while the MH completes registration procedures with the router of a new subnet. Performance results show that our proposed buffering scheme with a dynamic buffer space allocation is quite appropriate for mobile Internet, or the All-IP environment in terms of the datagram loss rate.

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New Red Phosphor with the Improved Color Purity for PDP Applications

  • Mho, Sun-Il
    • 한국정보디스플레이학회:학술대회논문집
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    • 2002.08a
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    • pp.257-259
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    • 2002
  • As a new host material for a red phosphor for PDP applications, has studied (Y,Gd)$Al_3(BO_3)_4$ which gives non-centrosymmetric sites for $Eu^{3+}$ activators. Vacuum ultraviolet (VUV) excitation spectrum of new red phosphor (Y,Gd)$Al_3(BO_3)_4$:$Eu^{3+}$ has two broad bands. One band with the absorption edge at ca. 168 nm is the band-gap absorption of aluminoborate and the other broad band centered 240 nm is the charge transfer transition between $Eu^{3+}$ and the neighboring oxygen anions. The PL spectrum shows the strongest emission at 617 nm due to the electric dipole $^5D_0{\rightarrow}^7F_2$ transition of $Eu^{3+}$, whose luminescent chromaticity is (0.67, 0.33).

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Three Copepod Parasites (Crustacea) of the Surfperch Ditrema temmincki bleeker (Pisces) from Korea (망상어에 기생하는 요각류 신종 및 희귀종의 기재)

  • Il-Hoi Kim
    • Animal Systematics, Evolution and Diversity
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    • v.11 no.3
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    • pp.301-314
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    • 1995
  • New and rare species of copepod parasites of the sufperch Ditrema temmincki Bleeker are reported from Korean seas. Two of them, each belonging to Colobomatus of Poecilostomatoida and Caligus of Siphonostomatoida, are described as new speices. The latter species is very peculilar in bearing the single-segmented exopod ini leg 4. Caligus tanago Yamaguti, an incompletely known species, is also described from the same fish host.

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Three Species of the Subfamilies, Lithocolletinae and Ornixolinae (Lepidoptera, Gracillariidae), New to Korea

  • Da-Som Kim;Ji-Young Lee;Bong-Kyu Byun
    • Animal Systematics, Evolution and Diversity
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    • v.39 no.4
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    • pp.212-217
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    • 2023
  • The subfamilies Lithocolletinae and Ornixolinae belong to the family Gracillariidae (Lepidoptera). In this study, one species in the subfamily Lithocolletinae, Neolithocolletis hikomonticola Kumata, 1963 and two species in the subfamily Ornixolinae, Conopomorpha flueggella Li, 2011 and Epicephala nudilingua Kawakita & Kato, 2016 are reported for the first time from Korea. Also, two genera, Neolithocolletis Kumata, 1963 and Conopomorpha Meyrick, 1885 are reported as new to Korea. All available information of these taxa, including details on their host plants and distributional regions are provided with the descriptions and illustrations of the adults, male and female genitalia of these taxa.

Suppressors for Human Epidermal Growth Factor Receptor 2/4 (HER2/4): A New Family of Anti-Toxoplasmic Agents in ARPE-19 Cells

  • Kim, Yeong Hoon;Bhatt, Lokraj;Ahn, Hye-Jin;Yang, Zhaoshou;Lee, Won-Kyu;Nam, Ho-Woo
    • Parasites, Hosts and Diseases
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    • v.55 no.5
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    • pp.491-503
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    • 2017
  • The effects of tyrosine kinase inhibitors (TKIs) were evaluated on growth inhibition of intracellular Toxoplasma gondii in host ARPE-19 cells. The number of tachyzoites per parasitophorous vacuolar membrane (PVM) was counted after treatment with TKIs. T. gondii protein expression was assessed by western blot. Immunofluorescence assay was performed using Programmed Cell Death 4 (PDCD4) and T. gondii GRA3 antibodies. The TKIs were divided into 3 groups; non-epidermal growth factor receptor (non-EGFR), anti-human EGFR 2 (anti-HER2), and anti-HER2/4 TKIs, respectively. Group I TKIs (nintedanib, AZD9291, and sunitinib) were unable to inhibit proliferation without destroying host cells. Group II TKIs (lapatinib, gefitinib, erlotinib, and AG1478) inhibited proliferation up to 98% equivalent to control pyrimethamine ($5{\mu}M$) at $20{\mu}M$ and higher, without affecting host cells. Group III TKIs (neratinib, dacomitinib, afatinib, and pelitinib) inhibited proliferation up to 98% equivalent to pyrimethamine at $1-5{\mu}M$, but host cells were destroyed at $10-20{\mu}M$. In Group I, TgHSP90 and SAG1 inhibitions were weak, and GRA3 expression was moderately inhibited. In Group II, TgHSP90 and SAG1 expressions seemed to be slightly enhanced, while GRA3 showed none to mild inhibition; however, AG1478 inhibited all proteins moderately. Protein expression was blocked in Group III, comparable to pyrimethamine. PDCD4 and GRA3 were well localized inside the nuclei in Group I, mildly disrupted in Group II, and were completely disrupted in Group III. This study suggests the possibility of a vital T. gondii TK having potential HER2/4 properties, thus anti-HER2/4 TKIs may inhibit intracellular parasite proliferation with minimal adverse effects on host cells.

Plant Viruses and Viral Host Plants Newly Reported in South Korea in 2020-2022 (2020-2022년 국내에서 새롭게 보고된 식물바이러스 및 기주 식물)

  • Myung-Hwi Kim;Seok-Yeong Jang;Ji-Soo Choi;Hee-Seong Byun;Hae-Ryun Kwak;Su-Heon Lee;Jang-Kyun Seo
    • Research in Plant Disease
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    • v.29 no.2
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    • pp.108-117
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    • 2023
  • With the development of advanced virus diagnostic technologies, numerous viruses, including novel viruses, have been identified explosively from various biological samples around the world over the last decade. For plant viruses, approximately 376 novel viruses have been reported in the last three years. Information on the occurrence and host ranges of plant viral diseases in a particular country or region is very important for diagnosis, quarantine, and control of the viral diseases. Recently, based on active research on the diagnosis and identification of plant viruses, a significant number of newly occurring viruses and new viral host plants have been reported in South Korea. This review paper provides integrated information on plant viruses and viral host plants newly reported in South Korea between 2020 and 2022 to help diagnose, control, and quarantine plant virus diseases in crop fields.

FDI and the Evolution of Directed Technological Progress Bias: New Evidence from Korean Outward Investment

  • Boye Li;Xiang Li;Yaokun Wu
    • Journal of Korea Trade
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    • v.27 no.5
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    • pp.1-22
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    • 2023
  • Purpose - Southeast Asia has been the focus of Korea's foreign investment. Korea has been helping developing countries in Southeast Asia achieve economic growth and win-win cooperation through capital exports. FDI is an important channel for technology diffusion. However, the impact of FDI on the bias of technological progress in the host country is dependent on the host country's own endowment structure and capital-labor factor substitution elasticity. Therefore, the central issue of this paper is to accurately evaluate the impact of Korea's FDI to the four Southeast Asian countries in various industries on their bias of technological progress. Design/methodology - The paper uses macroeconomic data for Korea and four East Asian countries to estimate capital-labor factor elasticities of substitution using nonlinear, seemingly uncorrelated regressions (NLSUR). Then, the biased technological change index (BTCI) is calculated for each country. Finally, panel data analysis is used to explore the impact of Korean FDI in various industries in the four Southeast Asian countries on their own directed technological progress, and a robustness test is conducted. Findings - There is a substitution relationship between capital and labor factors based on their elasticity in Korea, Singapore and the Philippines. There is a complementary relationship between capital and labor factors in Indonesia and Malaysia. According to the BTCI, there is a trend toward labor-biased technological progress in all countries. Korean investments in manufacturing, wholesale and retail trade in the host country trigger capital-biased technological change in the host country; investments in the finance, insurance and information and communication sectors trigger labor-biased technological change. In addition, this paper also confirms that directed technological progress can enable cross-country transmission. Originality/value - The innovation of this paper lies in three aspects. First, we estimate the BTCI for five countries and explore the trend and situation of directed technological progress in each country from each country's own perspective. Second, we explore the impact of Korean FDI in the host country on the bias to its technological progress at the industry level. Second, we explore the impact of Korean FDI in various industries in the four Southeast Asian countries on the four countries' own directed technological progress from a national perspective. Finally, we propose corresponding countermeasures for technological progress from the perspective of inverse factor endowment. These innovative points not only expand the understanding of technological progress and cross-country technology transfer in East Asia but also provide practical references for policy-makers and business operators.

Ferroelectric Cholesteric Suspension

  • Buchnev, Olesander;Reznikov, Yuri;Tereshchenko, Olexander;Grabar, A.;Kwon, Soon-Bum
    • 한국정보디스플레이학회:학술대회논문집
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    • 2004.08a
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    • pp.1236-1239
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    • 2004
  • We developed a new cholesteric material for bistable LCDs. The material consists of dispersion of sub-micron ferroelectric particles in cholesteric host. We found that the doping of the cholesteric with ferroelectric particles in small concentration (< 1% by weight) strongly improved basic characteristics of the transition between poly-domain planar texture and focal conic texture. Decrease of the driving voltage, increase of the reflection contrast and the steepness of the transition is associated with giant steady dipole and dielectric constant of the ferroelectric particles.

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