• 한국강구조학회 논문집
• /
• 제19권6호
• /
• pp.599-610
• /
• 2007

이 연구에서는 박벽 뼈대 구조물의 3차원 기하 비선형 해석을 위한 Corotational 정식화를 유도하였으며, 특히 변형 후 부재좌표계 결정에서 모호했던 기존의 이론을 단면의 물리적 적합 조건을 이용하여 해결하였다. 부재 양단의 순수 비틀림 회전값이 서로 크기는 같고 방향은 반대가 되는 상태를 적합조건으로 적용하고, 이를 특별히 ZTSC(Zero Twisted Section Condition)이라고 명명하였다. 개발된 방법의 타당성을 검증하기 위하여 기존의 다른 연구자가 사용한 방법과 비교하여 대회전변위가 발생한 경우에 대한 순수회전변위 결과를 검토하였으며, 개발된 Corotational 정식화를 이용하여 3차원 대변위가 발생하는 세장한 구조물의 후좌굴 해석을 성공적으로 수행하였다.

• Journal of Pharmaceutical Investigation
• /
• 제32권4호
• /
• pp.299-303
• /
• 2002

The oral bioavailability of itraconazole is variable and low in fasting state. This is mainly due to the low solubility of this drug. Bioavailability can be improved by changing the formulation and it is general that the liquid preparations show greater bioavailability than the solid dosage forms such as tablets and capsules do. Benzyl alcohol-water binary mixture showed the excellent solubilizing capacity for itraconazole but the release of the drug from the preparation needs to be enhanced. In this study, various nonionic surfactants and hydrophilic polymers, poloxamers, were screened to investigate their effects on the releasε of itraconazole from the liquid preparations. Poloxamer 407 showed the most enhancing effect on the drug release and the release rate was proportional to thε amount of poloxamer 407 added. A liquid preparation of itraconazole, consisting of benzyl alcohol/water/poloxamer 407 ternary solvent system, releasεd more than 80% of the total drug amount at 5 min and showεd the possibility of a new formulation development.

• 한국자원식물학회:학술대회논문집
• /
• 한국자원식물학회 2018년도 춘계학술발표회
• /
• pp.71-71
• /
• 2018

The aim of this study was to prepare a new functional food with enriched bioactive compound by the combination of Tartary buckwheat and bean flour mixes. Two types of bean such as: black bean and white bean with the ratio of 5, 10, 15 % were used to develope a food formulation. The solid formulation of functional food was prepared by the hot melt extrusion process (HME) at the temperature of 60, 90, $120^{\circ}C$. Total phenolic content (TPC), total flavonoid (TF) and DPPH were analysed of the prepared food by the use of spectrophotometer. Results demonstrated that TPC (254 mg/g), TF (18.22 mg/g) and DPPH (88%) were significanlty increased in the receipe of 10% black bean and 90% Tartary buckwheat mixes among the formulation at $90^{\circ}C$. As therefore, it is concluded that the optimum ratio of bean and Tartary buckwheat flour mixes should be considerd for the preparation of high quality functional food.

• Advances in nano research
• /
• 제4권4호
• /
• pp.251-264
• /
• 2016

In this paper, a simple and refined nonlocal hyperbolic higher-order beam theory is proposed for bending and vibration response of nanoscale beams. The present formulation incorporates the nonlocal scale parameter which can capture the small scale effect, and it considers both shear deformation and thickness stretching effects by a hyperbolic variation of all displacements across the thickness without employing shear correction factor. The highlight of this formulation is that, in addition to modeling the displacement field with only two unknowns, the thickness stretching effect (${\varepsilon}_z{\neq}0$) is also included in the present model. By utilizing the Hamilton's principle and the nonlocal differential constitutive relations of Eringen, the equations of motion of the nanoscale beam are reformulated. Verification studies demonstrate that the developed theory is not only more accurate than the refined nonlocal beam theory, but also comparable with the higher-order shear deformation theories which contain more number of unknowns. The theoretical formulation proposed herein may serve as a reference for nonlocal theories as applied to the static and dynamic responses of complex-nanobeam-system such as complex carbon nanotube system.

• Smart Structures and Systems
• /
• 제5권1호
• /
• pp.23-42
• /
• 2009

In order to reduce vibration or to control shape of structures made of metal or composites, piezoelectric materials have been extensively used since their discovery in 1880's. A recent trend is also seen to apply piezoelectric materials to flexible structures made of rubber-like materials. In this paper a non-linear finite element model using updated Lagrangian (UL) approach has been developed for static analysis of rubber-elastic material with surface-bonded piezoelectric patches. A compressible stain energy function has been used for modeling the rubber as hyperelastic material. For formulation of the nonlinear finite element model a twenty-node brick element is used. Four degrees of freedom u, v and w and electrical potential ${\varphi}$ per node are considered as the field variables. PVDF (polyvinylidene fluoride) patches are applied as sensors/actuators or sensors and actuators. The present model has been applied to bimorph PVDF cantilever beam to validate the formulation. It is then applied to study the smart rubber components under different boundary and loading conditions. The results predicted by the present formulation are compared with the analytical solutions as well as the available published results. Some results are given as new ones as no published solutions available in the literatures to the best of the authors' knowledge.

• Steel and Composite Structures
• /
• 제38권4호
• /
• pp.463-476
• /
• 2021

The concept of using Steel-concrete (SC) composite walls as retaining walls has recently been introduced by the authors and their effectiveness of resisting out-of-plane loads has also been demonstrated. In this paper, an improved analytical formulation based on partial interaction theory, which has previously been developed by the authors, is presented. The improved formulation considers a new loading condition and also accounts for cracking in concrete to simulate the real conditions. Due to a limited number of test specimens, further finite element (FE)simulations are performed in order to verify the analytical procedure in more detail. It is observed that the results from the improved analytical procedure are in excellent agreement with both experimental and numerical results. Moreover, a detailed parametric study is conducted using the developed FE model to investigate effects of different parameters, such as distance between shear connectors, shear connector length, concrete strength, steel plate thickness, concrete cover thickness, wall's width to thickness ratio, and wall's height to thickness ratio, on the behavior of SC composite walls subjected to out-of-plane loads.

• Earthquakes and Structures
• /
• 제25권5호
• /
• pp.325-342
• /
• 2023

The damping modification factor (DMF) is used to modify the 5%-damped response spectrum to produce spectral values that correspond to other necessary damping ratios for seismic design. The DMF has been the subject of numerous studies, and it has been discovered that seismological parameters like magnitude and distance can have an impact on it. However, DMF formulations incorporating these seismological parameters cannot be directly applied to seismic design because these parameters are not specified in the present seismic codes. The goal of this study is to develop a formulation for the DMF that can be directly applied in seismic design and that takes the effects of magnitude, distance, and site conditions into account. To achieve this goal, 16660 ground motions with magnitudes ranging from 4 to 9 and epicentral distances ranging from 10 to 200 km are used to systematically study the effects of magnitude, distance, and site conditions on the DMF. Furthermore, according to the knowledge that magnitude and distance affect the DMF primarily by changing the spectral shape, a spectral shape factor is adopted to reflect influences of magnitude and distance, and a new formulation for the DMF incorporating the spectral shape factor is developed. In comparison to the current formulations, the proposed formulation provides a more accurate prediction of the DMF and can be employed directly in seismic design.

• 한국도서관정보학회지
• /
• 제38권3호
• /
• pp.425-454
• /
• 2007

이 연구는 한국 전통음악 녹음자료의 통일표제 기술원칙에 관한 모형안을 제시한 것이다. 주요부분을 중심으로 그 결과를 요약하여 보면 다음과 같다. 비악곡형식의 경우에는 구국악의 아악은 속명을, 민속악은 일반화된 표제를, 신국악은 작곡자가 최초로 표현한 원표제를 통일표제로 하여 각 괄호 속에 기입하되 식별적 요소를 제외하고는 연주수단 등을 생략한다. 그러나 기악곡의 악곡형식의 경우에는 악곡형식, 연주수단 축차번호, 작품번호, 조, 기타 한정어구나 설명구의 순으로 통일표제를 구성하여 각 괄호 속에 기술한다. 그리고 구국악의 성악곡 중 합창곡의 연주수단은 남성, 여성, 혼성합창으로만, 독창곡은 남성, 여성독창으로만 기술하고, 신국악은 양악의 형식을 따른다. 이 밖에 상이한 작품이 동일한 통일표 제를 가질 경우는 연주수단, 축차번호 조 한정어구나 설명구, 발행사명, 발행년 등을 부가하여 구별하도록 한다.

• Archives of Pharmacal Research
• /
• 제26권12호
• /
• pp.1002-1008
• /
• 2003

Ferulic acid (3-methoxy, 4-hydroxy cinnamic acid) is a flavoid component possessing antioxidant property. The compound is currently under development as a new drug candidate for the treatment of the dementia. The objective of this preformulation study was to determine the physicochemical properties of ferulic acid. The n-octanol to water partition coefficients of ferulic acid were 0.375 and 0.489 at the pHs of 3 and 10, respectively. Accelerated stability study for ferulic acid indicated that the t 90 value for the drug was estimated to be 459 days at $25^{\circ}C$. Ferulic acid was also found to be unstable under the relative humidity of more than 76%, probably because of the hygroscopic nature of the drug. In order to study compatibility of ferulic acid with typical excipients, potential change in differential scanning calorimetry spectrum was studied in 1: 1 binary mixtures of ferulic acid and typical pharmaceutical excipients (e.g., Aerosil, Avicel, CMC, Eudragit, lactose, PEG, PVP, starch and talc). Avicel, CMC, PVP and starch were found to be incompatible with ferulic acid, indicating the addition of these excipients may complicate the manufacturing of the formulation for the drug. Particle size distribution of ferulic acid powder was in the size range of 10-190 $\mu$m with the mean particle size of 61 $\mu$m. The flowability of ferulic acid was apparently inadequate, indicating the granulation may be necessary for the processing of the drug to solid dosage forms. Two polymorphic forms were obtained by recrystallization from various solvents used in formulation. New polymorphic form of ferulic acid, Form II, was obtained by recrystallization from 1,4-dioxane. The equilibrium solubility for Form I was approximately twice of that for Form II. The dissolution rate of Form II was higher than that of Form I in the early phase (<6 min). Therefore, these physicochemical information has to be taken in the consideration for the formulation of ferulic acid.

• 한국식물병리학회:학술대회논문집
• /
• 한국식물병리학회 2002년도 총회 및 추계학술발표회
• /
• pp.62.1-62
• /
• 2002