• Transactions of the Korean Society of Mechanical Engineers A
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• v.29 no.2 s.233
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• pp.318-324
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• 2005

Theoretical efforts are performed to extend the formulation of NSLT(New Shear Lag Theory) for the prediction of the elastic modulus in short fiber composite. The formulation is based on the elastic stress transfer considering the stress concentration effects influenced by elastic modulus ratio between fiber and matrix. The composite modulus, thus far, is calculated by changing the fiber aspect ratio and volume fraction. It is found that the comparison with FEA(Finite Element Analysis) results gives a good agreement with the present theory (NSLT). It is also found that the NSLT is more accurate than the SLT(Shear Lag Theory) in short fiber regime when compared by FEA results. However, The modulus predicted by NSLT becomes similar values that of SLT when the fiber aspect ratio increases. Finally, It is shown that the present model has the capability to predict the composite modulus correctly in elastic regime.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2004.04a
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• pp.365-372
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• 2004

A new finite element model will be presented to analyze the nonlinear behavior of not only RC beams and slabs, but also RC beams strengthened by a patch repair. The numerical approach is based on the p-version degenerate shell element including theory of anisotropic laminated composites, theory of materially and geometrically nonlinear plates. In the nonlinear formulation of this model, the total Lagrangian formulation is adopted with large deflections and moderate rotations being accounted for in the sense of von Karman hypothesis. The material model is based on hardening rule, crushing condition, plate-end debonding strength model and so on. The Gauss-Lobatto numerical quadrature is applied to calculate the stresses at the nodal points instead of Gauss points. The validity of the proposed p-version finite element model is demonstrated through several numerical examples for the load-deflection curves, the ultimate loads, and the failure modes of reinforced connote slabs and RC beams bonded with steel plates or FRP plates compared with available experimental and numerical results.

• 한국생물공학회:학술대회논문집
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• 2000.04a
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• pp.541-545
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• 2000

For the sustained release formulation of recombinant human growth hormone (rhGH), dissociable rhGH aggregates were microencapsulated within poly(D,L-lactic-co-glycolic acid) [PLGA] microparticles. rhGH aggregates with 2 - 3 m Particle diameter were first produced by adding a small volume of aqueous rhGH solution into a partially water miscible organic solvent phase(ethyl acetate) containing PLGA. These rhGH aggregates were then microencapsulated within PLGA polymer phase by extracting ethyl acetate into an aqueous phase pre-saturated with ethyl acetate. The resultant microparticles were 2 - 3 m in diameter similar to the size of rhGH aggregates, suggesting that PLGA polymer was coated around the protein aggregates. Release profiles of rhGH from these microparticles were greatly affected by changing the volume of the incubation medium. The release rhGH species consisted of mostly monomeric form with having a correct conformation. This study reveals that sustained rhGH release could be achieved by microencapsulating reversibly dissociable protein aggregates within biodegradable polymers.

• Journal of Mechanical Science and Technology
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• v.15 no.5
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• pp.555-561
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• 2001

A new approach to analyze the multi-domain acoustic system divided and enclosed by flexible structures is presented in this paper. The boundary element formulation of the Helmholtz integral equation is used for the internal fields and the finite element formulation for the structures surrounding the fields. We developed a numerical analysis program for the structural-acoustic coupling problems of the multi-domain system, in which boundary conditions such as the continuity of normal particle velocity and sound pressure in the structural interfaces between Field 1 and Field 2 are not needed. The validity of the numerical analysis program is verified by comparing the numerical results with the experimental ones. Example problems are included to investigate the characteristics of the coupled multi-domain system.

• Transactions of the Korean Society of Mechanical Engineers
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• v.16 no.7
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• pp.1314-1321
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• 1992

In analyzing the plastic flow of axisymmetric tube extrusion a new method of formulation using the stream function approach and upper-bound theorem is proposed which permits the prediction of plastically deformed zone in analytic expression as well as metal flow. It is shown that the formulation proposed in this work covers the solid extrusion and tube extrusion in axisymmetric case. The effect of some process parameters such as area reduction, the ratio of radii(inner radius to outer radius) and friction factor on extrusion pressure, deformation zone and plastic flow through stream-lined dies has been studied. The presented theoretical analysis can be effectively used for the prediction of deformation zone and plastic flow.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1993.10a
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• pp.212-217
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• 1993

A 2-dimensional FEM/GEM program was developed for analyzing forming processes of an arbitrarily shaped draw-die, in which plane strain condition is assumed and linear line elements are employed. FEM formulation adopted a new algorithm for solving force equilibrium as well as non-penetration condition simultaneously. For the case of numerical divergence at nearly final forming stages and the initial guess in Newton-Raphson iterations, geometric force equilibrium method(GEM) is also introduced. The developed program was tested with the simulation of stamping processes of automotive bonnet inner pannel in order to verify the usefulness and validity of FEM/GEM formulation.

• Journal of Pharmaceutical Investigation
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• v.22 no.3
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• pp.17-34
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• 1992

A novel drug delivery system, detergent-phospholipid mixed micelles as proliposomes, for water-insoluble compounds was developed by investigating (i) spontaneous formation of small unilamellar vesicles (SUV) from bile salt-egg phosphatidylcholine mixed micelles, (ii) the molecular mechanism of micelle-to-vesicle transition in aqueous mixtures of detergent-phospholipid, (iii) preparation and screening of a suitable liposomal formulation for a lipophilic drug: solubilization of the drug within the lipid bilayer, evaluation of the solubility limit, and characterization of the resulting product with respect to the physical properties and stability of the drug in the system, and (iv) testing antitumor activity in vitro. The results showed that the new carrier had a strong possibility to be a biocompatible universal formulation for water-insoluble drugs.

• Journal of Pharmaceutical Investigation
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• v.33 no.1
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• pp.61-65
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• 2003

Silybin is the main component of Cardus marianus extracts originated from Silybum marianum and has a hepato-protective effect. It is a water-insoluble compound and poorly absorbed from the gastrointestinal tract, resulting in very low oral bioavailability(BA). Polymeric mixed-micelle precursor formulation was made to enhance the dissolution rate of silybin, showing the results of pH-independent release profile with increased dissolution. Oral BA of different preparations in rats was evaluated, revealing that the new formulation showed increased BA more than 2-fold and 4-fold compared to the marketed product and Cardus marianus extracts itself, respectively.

• Journal of Pharmaceutical Investigation
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• v.33 no.3
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• pp.163-169
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• 2003

In order to develop a film-forming transdermal drug delivery system, polyurethane (PU) based on poly(ethylene glycol) and poly(tetramethylene oxide) was synthesized and characterized. The synthesized PU was blended with Gantrez ES 225 (GT) to improve the adhesion property of film-forming agent to the skin. When film-forming gel formulation containing 3% ketoprofen (KP) was applied, transparent thin film was obtained within 5 minutes and adhered to the skin for 8 hours. In vitro percutaneous absortion studies were performed to determine the rate of ketoprofen absorption through guinea pig skin. A prominent effect of limonene on the skin permeability of ketoprofen was observed among the various skin permeation enhancers investigated. Considering mechanica properties of film and skin permeability of ketoprofen, 2% of limonene was optimal content in the film forming transdermal formulation.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.7
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• pp.2078-2086
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• 1996

This paper introduces two three-dimensional eight-node hexagonal elements obtained by using multivariable variational mehtod. Both of them are based on the modified hellinger-reissner principle to employ incompatible displacements and assumed stresses of assumed strains. The internal functions of element are introduced to as element formulation through two different methods : the first one uses the functions determined directly from the element boundary condition of the incompatible displacements ; while the second, being a kind of B-bar mehtod, employs the modification technique of strain-displacement matrix to pass the patch test. The elements are evaluated on the selective problems of bending and material incompressibility with regular and distorted meshes. The results show that the new elements perform with good accuracy in both of deformation and stress calculation and they are insensitive to distorted geometry of element.