• 동의생리병리학회지
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• 제20권6호
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• pp.1664-1671
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• 2006

Cisplatin is a anti-neoplastic agent which is commonly used for the treatment of solid tumor. Cisplatin activates multiple signal transduction pathways involved in the stress-induced apoptosis in a variety of cell types. Cytotoxicity of cisplatin was detected in rat mesangial cells and the value of $IC_{50}$ is about 20 ${\mu}M$. The treatment of cisplatin to rat mesangial cells showed the apoptotic bodies and DNA fragmentation. The activation of caspase-3, -8, and -9 and proteolytic cleavage of PARP were observed in the rat mesangial cells treated time-dependently with cisplatin. The activation of ERK, p38 and JNK was also observed in the apoptosis induced by cisplatin in rat mesangial cells. The ethanol extract of Bojungbangam-tang (EBJT), a new hergal prescription composed of nine crude drugs, inhibited cisplatin-induced apoptosis in rat mesangial cells. EBJT reduced sub-G1 peak (apoptotic peak) in cisplatin-treated rat mesangial cells. The cisplatin-induced ERK and JNK activation in rat mesangial cells were blocked by EBJT, but EBJT had no effect on p38 activation. Taken together, these results con suggest that EBJT prevents cisplatin-induced apoptotic cell death in rat mesangial cells through inhibition of ERK and JNK activation.

• 동의생리병리학회지
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• 제20권1호
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• pp.235-244
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• 2006

There is much confusion in the field of Rhinitis regarding how to best measure disease severity objectively, Therefore, we aimed to establish a new adequate scoring system for Rhinitis, that should be based on comparison analysis of various scoring systems. We report as follows. We researched for data relating to severity scoring systems for rhinitis in Entrez PubMed from 1995 to 2005 and in Kiss Kstudy. Results and Conclusions: Properties of severity scoring systems were validity, sensitivity of change and ease of use. The essential items of severity scoring systems were subjective symptoms. The criterion of severity were divided into subjective symptoms and complication and Quality of Life. Intensity items are nasal obstruction, rhinorrhea, sneezing, itching, Postnasal drip, nasal mucosa swelling, nasal mucosa color, complication. Subjective symptoms is difficulty of Life. The significant items of severity scoring system are nasal symptoms. The whole score does with the maximum 30 scores. As it were, we assumed nasal symptoms accounted for around 80% of each total score, with complication and difficulty of Life representing 20%.

• 약학회지
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• 제44권5호
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• pp.470-477
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• 2000

WooHwangChungSimWon is a traditional medicine for treatment of hypertension, arteriosclerosis, coma, and stroke in China, Korea, and Japan. In the new prescription of WooHwangChungSimWon, the civet is substituted for the musk, the major component of WooHwangChungSimwon, because of the prohibition law about the musk. We have made a comparative study of the effects on the central nervous system between the musk containing and civet containing WooHwangChungSimWon. In order to investigate the effects on the central nervous system, we have examined spontaneous motor activities, anti-convulsion activities induced by chemicals or electric shock, sleep induced by hexobarbital, and antistress effects. In the examination of anti-convulsion effects against the electric shock and injection of pentetrazol, only the civet containing WooHwangChungSimWon showed the anti-convulsion effects, i.e. the duration of convulsion by electric shock was decreased (control: 104.0 seconds, low dose of civet containing WooHwangChungSimWon: 60.7 seconds) and the duration of suppression against pentetrazol induced convulsion was increased (control: 392.3 seconds, low dose of civet containing WooHwangChungSimWon: 574.0 seconds, high dose of civet containing WooHwangChungSimWon: 561.4 seconds). In the other examinations, all kinds of WooHwangChungSimWon showed sedation, anti-convulsion activities, and induction of sleeping. These results suggest that there are no significant differences between the musk containing and civet containing WooHwangChungSimWon except the anti-convulsion effects against the convulsions induced by electric shock and pentetrazol.

• 대한화장품학회지
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• 제31권4호
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• pp.285-287
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• 2005

주관적인 관능평가와 밀접한 관계가 있었던 표준화된 측정법을 이용하여 립스틱에서의 광택 및 광택지속성의 영향인자를 도출하였고 이를 분석하였다. 일부인자들을 분석하면서 립스틱의 광택에 영향을 주는 인자로서 스틱경도, 휘발성 실리콘 오일의 양, 왁스의 종류 등이 유효한 인자로 도출할 수 있었다. 그리고 립스틱의 광택지속성에서는 주요인자로 휘발성 실리콘 오일의 양, 스틱경도, 폴리머의 함량 등을 도출할 수 있었다. 이러한 결과는 립스틱의 일반적인 특성에 대해서 6-Sigma라는 새로운 분석기법을 이용하여 분석하는데 성공하였으며, 본 연구를 통하여 광택을 향상시키는 제품을 설계하는데 초석이 될 것이다.

• 대한방사선기술학회지:방사선기술과학
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• 제44권5호
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• pp.535-543
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• 2021

The purpose of this study is to investigate various opinions on changes and revisions in the Medical Technician Act, to compare the curriculum of radiological technologist and physicians or dentists, and to compare the definitions and scope of work of radiological technologist in Korea and abroad. From the information, The goal is to review whether the phrase 'guidance of a doctor or dentist' specified in the definition of the 'Act on Medical Technicians, etc.' is realistically appropriate. radiological technologist receive specialized college education on radioligical science & medical imaging. The training hours for radiolgical science student are greater than medical students. In addition, radiological technologists are continuously developing their competencies for new knowledge and skills through continuing education in clinical fields. In particular, radiological technologist are making steady research efforts to reduce patient exposure and improve medical image quality. As a result of this investigation, it is considered that the term "guided by a doctor or dentist" as currently defined in the 'Act on Medical Technicians, etc.' may need to be revised in consideration of the professionalism of the radiological technologist.

• 융합정보논문지
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• 제10권12호
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• pp.166-174
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• 2020

화장품 기능성 원료는 감성 융합 기술의 산물이다. 의약품과는 다르게 효능을 발휘하는데 제한이 있는 생활용품이기 때문에 원료에 감성적인 매력 요소가 담겨 있는 것이 매우 중요하다. 인삼은 오랫동안 인류 건강을 위해 동양의학의 주요 처방으로 활용됐다. 인삼의 기원 및 전파 등의 상세한 기록들은 K-뷰티의 자산으로서 인삼의 정통성과 우수성을 활용한 감성 융합 소재로서 인삼의 다양한 제품화로 이어질 수 있다. 인삼 활용 최초의 기록들이 중국 고서에 의존하고 있다는 안타까운 현실에서 뷰티의 영역에서 활용된 기록들을 서술하여 남기고 이를 활용하는 것은 그 의미가 매우 크다고 할 수 있다. 본 연구에서는 인삼의 화장품 응용 연구에 필요한 일반적인 역사적 기록들과 피부 기능성 영역에서의 인삼 진세노사이드 성분에 관한 최근의 연구결과들을 고찰해보고 신규 화장품 개발연구에 응용할 수 있는 기초 자료를 제공하였다.

• 사상체질의학회지
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• 제34권3호
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• pp.50-68
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• 2022

Objectives The purpose of this study is to review the current Sasang constitutional research on obesity and to provide basic data for further development in the direction of better research. Methods Clinical research articles on obesity of the Sasang Constitutional Medicine were extracted from five database. Published year, published journals, and subjects of studies were classified. Clinical methods for the classification of Sasang type and diagnostic criteria for obesity were summarized. Results A total of 36 selected research articles were published from 1998 to 2020. And 20 articles(55.6%) have been published in Journal of Sasang Constitutional Medicine and Journal of Oriental Rehabilitation Medicine. Most of the clinical study subjects were studies that identified independent factors that were correlated with obesity by Sasang constitution type. But these studies have not sufficiently reflected the distinctive characteristics of Sasang Constitution Medicine. Discussion Through this study, it was confirmed to the necessity of developing new research designs for obesity by Sasang constitution and researching on obesity treatment through improvement of symptoms by using the already developed questionnaires that have proven reliability and validity, away from the research biased towards Taeeumin and Taeeumin's prescription. If additional research based on this study is accompanied, it is expected that it can be utilized in typed obesity treatment fields.

• 대한본초학회지
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• 제33권4호
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• pp.53-58
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• 2018

Objectives : Kaempferia parviflora Rhizome is black ginger indigenous to Laos and Thailand. It has been used as a folk medicine to improve blood flow and promote vitality and longevity with good health and well being. For these reasons, Kaempferia parviflora Rhizome has been focused on developing it as a food or food supplement. In addition, Kaempferia parviflora Rhizome could be under consideration of new prescription based on its characteristic compounds, polymethoxyflavonoids. However, it needs to be certified as safe before it can be used. Here, a single-oral toxicity test and safety classification was carried out to identity acute information of the toxicity of Kaempferia parviflora Rhizome powder and to make sure of its safety in clinical applications. Methods : Test substance was orally administered to male and female SD-rat at dose levels of 5000 mg/kg to estimate approximate lethal dose(ALD). Based on the acute information of the toxicity, the safety classification was estimated using the HED(human equivalent dose)-based MOS(margin of safety). Results : At 14 days after treatment with test substance. there were no of test substance related with mortalities and clinical signs. In addition, no changes in the body or organ weights and no gross or histopathological findings were observed. Thus, the ALD of Kaempferia parviflora Rhizome powder was considered over 5,000 mg/kg in both female and male mice. Conclusions : Based on the single oral toxicity test using the highest and limit dose, 5,000 mg/kg and the decision guideline for safety classification based on HED-based MOS, it was estimated that Kaempferia parviflora Rhizome powder is classified as "Specified class B" indicating that clinical dose is not limited to patients as safe as food.

• 대한한의학회지
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• 제42권4호
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• pp.120-132
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• 2021

Objectives: The prevalence of Parkinson's disease is on an upward trend along with an increase in the aging population but there is no available treatment that halts the progression of neurodegeneration. This study reports a numerical analysis on Donguibogam and suggests novel herbal drugs, which have never been researched before but found to be deemed effective in this study. Methods: Referring to 71 Korean medicine symptom terms that represent the symptoms of Parkinson's disease, 4170 prescriptions described in Donguibogam were classified into two groups based on whether their main effects were effective for Parkinson's disease or not. Comparing the two groups, the chi-square test was performed to select statistically significant herbs, while the t-test, Wilcoxon test, and descriptive statistics were performed to determine the appropriate dose. Results: One hundred and twenty-seven prescriptions effective for Parkinson's disease were identified. The chi-square test determined 17 herbs that are effective for symptomatic treatment. Among the medicinal herbs, the authors suggest Osterici seu Notopterygii Radix et Rhizoma, Ephedrae Herba, Aconiti Tuber, Myrrha, Sinomeni Caulis et Rhizoma, and Aconiti Kusnezoffii Tuber as herbal candidates that have never been studied for Parkinson's disease. Through the statistical tests, it was judged that the mean value of the dose of the entire prescription was the appropriate dose for each herb. Conclusions: Seventeen herbs were selected for Parkinson's disease and the appropriate daily dose were calculated. Furthermore, this study presented a new process that applies a statistical method to traditional medical literature and preselecting herbs deemed effective for specific diseases.

• 기독교교육논총
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• 제72권
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• pp.7-24
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• 2022

연구 목적 : 코로나 팬데믹 종식이 본격적으로 거론되는 시점에 이 논문은 팬데믹이 초래한 사회 변화를 집중적으로 살펴보고, 그것을 기초로 해서 향후 기독교교육의 방향을 가늠하고 제시하는 것을 목적으로 삼고 있다. 연구 내용 및 방법 : 코로나 팬데믹을 거치면서 진행된 사회 전반의 급속한 변화를 다섯 가지 관점, 즉 세계화, 디지털, 불평등, 교육체제, 교회 변화를 중심으로 검토한다(II장). 계속해서 코로나 이전에는 전혀 예상할 수 없었던 사회 변화를 충분히 고려해서 팬데믹 이후 세계에 필요한 기독교 교육의 향후 방향을 결론적으로 제시하고자 한다(III장, IV장). 결론 및 제언 : 코로나 이후 세계를 위한 기독교교육은 교회의 교육적 사명을 성취하도록 현재 상황을 위기 극복의 계기로 활용해야 한다. 추후 기독교교육은 팬데믹 시대의 사회 변화(지역 중심 세계화, 디지털 전환, 경제 불평등, 교육환경 변화)에 관심을 갖고 성찰하면서 모바일 교회학교, 거점 교회학교, 안전한 교회학교, 생태 교회학교로의 혁신적 전환이 시급하다.