• Title/Summary/Keyword: New Prescription

Search Result 215, Processing Time 0.02 seconds

Targeting Catecholamines to Develop New Drugs for Attention Deficit Hyperactivity Disorder (주의력결핍 과잉행동장애 치료제 개발을 위한 카테콜아민계 표적화)

  • Sung-Cherl Jung;Chang-Hwan Cho;Hye-Ji Kim;Eun-A Ko;Min-Woo Ha;Oh-Bin Kwon
    • Journal of Medicine and Life Science
    • /
    • v.18 no.3
    • /
    • pp.41-48
    • /
    • 2021
  • The prevalence of attention deficit hyperactivity disorder (ADHD), a developmental neuropsychiatric disorder, is high among children and adolescents. The pathogenesis of ADHD is mediated with genetic, biological, and environmental factors. Most therapeutic drugs for ADHD have so far targeted biological causes, primarily by regulating catecholaminergic neurotransmitters. However, ADHD drugs that are clinically treated have various problems in their addictiveness and drug stability; thus, it is recommended that efficacy and safety should be secured through simultaneous prescription of multiple drugs rather than a single drug treatment. Accordingly, it is necessary to develop drugs that newly target pathogenic mechanisms of ADHD. In this study, we attempt to confirm the possibility of developing new drugs by reviewing dopamine-related developmental mechanisms of neurons and their correlation with ADHD. Histone deacetylase inhibitors (HDACi) can regulate the concentration of intracellular dopamine in neurons by expressing vesicular monoamine transporter 2 and inducing the exocytosis of neurotransmitters to the synaptic cleft, thereby promoting the development of neurons and signal transmission. This cellular modulation of HDACi is expected to treat ADHD by regulating endogenous catecholamines such as dopamine. Although studies are still in the preclinical stage, HDAC inhibitors clearly have potential as a therapeutic agent with low addictiveness and high efficacy for ADHD treatment.

The Comparative Study of Oriental Medicine in Korea, Japan and China (한국(韓國)과 일본(日本) 및 중국(中國)의 동양의학(東洋醫學)에 대한 비교연구(比較硏究))

  • Cho, Ki-Ho
    • The Journal of Korean Medicine
    • /
    • v.19 no.1
    • /
    • pp.271-298
    • /
    • 1998
  • During these days of new understanding, western medicine has developed remarkably and a revaluation of traditional medicine has been achieved. This appears to have resulted from the sound criticisms of what western medicine has achieved up to now; excessive subdivisions of clinical medicine, severe toxicity of chemical drugs, lack of understanding about patients complaints which cannot be understood objectively, and etc. It is thought that the role of traditional medicine will be more important in the future than it is now. Someone said that the research methods of traditional medicine depends on the way of experimental science too much. That there was no consideration of a system for traditional medicine and the critic also went so far as to assert that in some cases the characteristics of eastern ideas is to permit irrationalism itself. In view of this thinking, the term traditional medicine seems to have been used somewhat too vaguely. However, traditional medicine is a medical treatment which has existed since before the appearance of modern medicine and it was formed from a traditional culture with a long history. One form of traditional medicine, oriental medicine based upon ancient Chinese medicine, was received in such countries as Korea, Japan, Thailand, Vietnam, Tibet, and Mongolia. Oriental medicine then developed in accordance with its own environment, race, national characteristics, and history. Although there are some simultaneous differences between them, three nations in Eastern Asia; Korea, Japan, and China, have especially similar features in their clinical prescriptions and medical literature. These three nations are trying to understand each others unique traditional medicines through numerous exchanges. Even though many differences in their ways of studying have developed over history exist, recent academic discussions have been made to explore new ways into oriental medicine. Therefore a comparative study of oriental medicine has gradually been thought to be more important. In Korea the formation of a new future-oriented paradigm for oriental medicine is being demanded. The purpose of the new paradigm is to create a new recognition of traditional culture which creates an understanding of oriental medicine to replace the diminished understanding of oriental medicine that was brought about by the self-denial of traditional culture in modem history and cultural collisions between oriental and occidental points of view. Therefore, to make a new paradigm for oriental medicine which is suitable for these days, and fortifies the merit of oriental medicine while compensating its defects, the author has compared the characteristics of oriental medicines in Korea, Japan, and China. The conclusions of this research are as follows: 1. The fundamental differences of the traditional medicines of these three nations are caused by the differences in the systems of Naekyung and Sanghannon. 2. The pattern-identification of illnesses is generally divided into two categories; the pattern identification of Zang-Fu and the pattern identification of prescription. 3. There are many differences in the definition of terms, such as Yin and Yang, Deficiency and Excess, and etc. 4. Chinese traditional medicine has some new concepts about pattern identification and epidemic febrile disease. 5. Japanese traditional medicine has some characteristics about pattern identification of the whole bodys condition and signs of abdominal palpation. 6. In terms of the effects of herbal drugs, Chinese traditional medicine attaches great importance to the experiential efficacy of the herb, and Japanese traditional medicine is taking a serious view of the effects of experimental medical actions.

  • PDF

Medical Care Environment and the Productivity Change in Korean Tertiary Hospitals. (Malmquist 생산성 지수를 이용한 종합전문요양기관의 생산성 변화 분석)

  • Kim, Young-Hee;Cho, Woo-Hyun;An, Dong-Hwan;Park, Sang-Woo;Chung, Woo-Jin
    • Korea Journal of Hospital Management
    • /
    • v.10 no.4
    • /
    • pp.51-74
    • /
    • 2005
  • This paper presents an analysis of the current status of domestic hospital industry which went trough the time of new hospitals operated by chaebols from 1994 to 2003 and the dramatic changes of medical service environment such as IMF relief loan in 1997 and the separation of prescription and dispensing (SPD) in 2000. For the sake of righteous policy-making in the future, this paper presents a productivity analysis of the management and administration of 38 tertiary hospitals nationwide in the past 10 years. The analysis is based on the Malmquist index approach using linear programming. d prepare a productivity index that measures not merely efficiency but the technological evolution and adjustment to changing environments.

  • PDF

Cytoprotective effect of Bojungbangam-tang on cisplatin-induced nephrotoxocity (Cisplatin 유도 신장독성에 대한 보정방암탕 에탄올층의 보호효과)

  • Lee, Hyo-Jung;Kim, Kwan-Hyun;Lee, Jae-Ho;Jang, Yu-Sung;Lee, Eun-Ok;Shim, Beom-Sang;Ahn, Kyoo-Seok;Lee, Kyung-Tae;Kim, Sung-Hoon
    • Journal of Physiology & Pathology in Korean Medicine
    • /
    • v.21 no.1
    • /
    • pp.28-32
    • /
    • 2007
  • Cisplatin, an antitumor agent widely used in the treatment of cancers, has nephrotoxicity. This side effect is closely related to oxidative stress. In the present study, we studied to protective effect of ethanol extract of Bojungbangam-tang (EBJT) on cisplatin-induced nephrotoxicity. Bojungbangam-tang is a new herbal prescription composed of nine crude drugs. Pretreatment of EBJT prevented cisplatin-induced cytotoxicity and generation of ROS. Also, cellular GSH content and gluathione peroxidase activity were recovered by EBJT. EBJT also decreased cisplatin-induced expression of HO-1 via inhibition of ERK activation. Taken together, these results suggest that EBJT has a cytoprotective effect against cisplatin-induced nephrotoxicity through anti-oxidant activity.

A Study for The Pharmaceutical Pricing Standard of the National Health Insurance in Japan (일본의 건강보험 약가 산정기준에 관한 연구)

  • Ryu, Chung-Kul
    • Korea Journal of Hospital Management
    • /
    • v.14 no.4
    • /
    • pp.52-70
    • /
    • 2009
  • This study is to analyse the reimbursement prices of drugs in Japan. Japan has the world's second-largest pharmaceutical market, and the world's largest price-controlled pharmaceutical market. The reimbursement prices of new drugs in Japan are determined by confidential negotiations between the manufacturer and the Japanese Ministry of Health, Labor, and Welfare. Pharmaceuticals account for a larger share of total healthcare expenditures in Japan than in most other major pharmaceutical markets such as France, Germany, United Kingdom and United States. Prescription drugs' share of total healthcare spending has slightly increased in recent years, from 20.2% in 2000 to 21.5% in 2004, the most recent year for which data are currently available. This trend is attributable to the effect of the Japanese rapidly aging population that stimulates demand for healthcare services. There are several method of price setting for drugs as below. First, on the initial pricing of branded drugs, is the similar-efficacy pricing method and cost calculation method. Second is postmarketing price changes which are biennial price revisions under the rule of National Health Insurance. Third is the rule of the generics price. Recently, the generics market is expanded because there are increasing numbers of hospitals by DPCs(Diagnosis-procedure Combinations).

  • PDF

A Study of Application of Exercise Treatments according to Sasangin (사상인의 운동요법 적용에 관한 연구)

  • 이의주;이재구
    • The Journal of Korean Medicine
    • /
    • v.24 no.1
    • /
    • pp.84-91
    • /
    • 2003
  • Sasang Constitutional Medicine (SCM) is based on the theory of Sasang (Taeyang, Soyang, Taeum, Soeum) in Traditional Korean Medicine (TKM). It is hypothesized that all of the things in the material world can be divided into the four categories of SCM. We made a new attempt to combine nutritive components, and patterns in physical activities with SCM. At first, we hypothetically divided the nutrients into 4 compartments according to SCM theory, and human body composition as well. These factors could be basically related to Sasangin Exercise Treatment (SET). Therefore, we applied sasangin theory to exercise prescription. As a research method, we hypothesized that human beings' types can be distinguished by mind and body. Mind was focused on exercise psychological aspects, and body also handled by nutrients, body compositions, body shapes, and exercise physiological aspects. For application of sasang theory to the exercise prescriptions, Taeumin as a sample sasangin was selected in this study. We concluded that in perspective of general traits, Taeumin have to reduce their carbohydrate intake volume, but greatly increase their intake of vitamins, minerals, and water in daily diet. They are also recommended exercises that can increase cardiorespiratory function and make them sweat, like endurance running, hiking, swimming, cycling, etc.

  • PDF

온라인과 오프라인의 적절한 통합을 위한 의사결정 로드맵에 관한 실증연구

  • 김인재;황경태;지홍구
    • Proceedings of the Korean Operations and Management Science Society Conference
    • /
    • 2001.10a
    • /
    • pp.79-82
    • /
    • 2001
  • The wide use of Information Technology(IT), especially the rapid diffusion of the internet, brings us a new paradigm, called "Electronic Commerce", or "Digital Economy." The paradigm is regarded as a business strategy essential to organization's competitive advantage. Because very few studies have been performed in the area of e-strategy, especially in the combined strategy of clicks and mortars, a research on this area is needed. The main questions of this study are empirically to validate the usefulness and the applicability of a decision roadmap and to analyze the situation of Korean firms based on the decision roadmap. Major results of this study are as follows; First, there is an evidence that the roadmap can be applied to firms regardless of its industry and size. Second, usefulness of the roadmap is proved since companies that followed the prescription of the decision roadmap showed high degree of satisfaction with online sales amount. Third, Korean firms in general do not achieve the ideal degree of integration (or separation), especially in terms of management and operation. In conclusion, this study provides e-business strategy planners some guidelines about how to achieve right mix of on-line and off-line business.

  • PDF

A study on the Uigamsanjeonyogyul written by Seopa Lee-yidoo (서파(西坡) 이이두(李以斗)의 『의감산정요결(醫鑑刪定要訣)』 연구(硏究))

  • Jeon, Jong-wook
    • Journal of Korean Medical classics
    • /
    • v.31 no.1
    • /
    • pp.139-156
    • /
    • 2018
  • Objectives : This paper provides a general introduction of a person Seopa Lee-yidoo and the contents of his medical text, Uigamsanjeonyogyul. The paper then investigates how this text summarized and recomposed Donguibogam. Methods : The paper first reviews the activities and academic leanings of Lee-yidoo, the author of Uigamsanjeonyogyul, as described in his book Seopa-munjip. Furthermore, the paper compares Donguibogam and Uigamsanjeonyogyul's process of summarizing Donguibogam. Based on this the paper divides these comparisons and introduces examples. Results : When the overall composition, formation, and the original contents of Uigamsanjeonyogyul were compared with the texts of Donguibogam, it was discovered that the former wholly accepted the composition of the latter but made bold summarizations. Meanwhile, Uigamsanjeonyogyul added a detailed list of contents at the beginning of the book, and its original contents provided integration, relocation, and detailed explanations of Donguibogam two sections. It gave changes to bogam's prescription configuration and explanations on the mechanism of diseases, and it also added a section for new prescriptions. Like this, Uigamsanjeonyogyul showed a great deal of knowledge regarding the clinical field. Conclusions : Uigamsanjeonyogyul which was published as a summary of Donguibogam, faithfully follows the texts of Donguibogam. At the same time, it provides summary, improvement, and rearrangement based on the author's academic leanings.

A Review on "Kimoonbirok" II ("기문비록(岐門秘錄)" 에 대(對)한 고찰(考察) (하(下)))

  • Choi, Kyung-Suk;Kim, Sang-Un;Song, Ji-Chung;Lee, Si-Hyeong
    • Journal of the Korean Institute of Oriental Medical Informatics
    • /
    • v.16 no.2
    • /
    • pp.51-88
    • /
    • 2010
  • An empirical formula that has been empirically shown to be effective for a particular condition can be said to add medical materials to an exciting formula or to make a new prescription by Korean medical doctors' empirical clinic. This dissertation aims to study the prescriptions according to A Confidential Document of A Distinguished Medical Family and to contribute to the development of Korean medicine. A Confidential Document of A Distinguished Medical Family is a medicinal recipe that is an heirloom of the Gyeongju Kim family for the eighth generation. And the date and the writer of the book are unknown. The contents of the book consist of 18 parts and are made up of about 300 medical recipes. Of these, 153 formulas and indications of roundworm, cholera, puffy swelling, abdominal distension, phlegm-rheum, woman, child, summerheat, dryness-heat, eye, and blood are found in the book. From among these, 26 formulas are directly quoted out of The Precious Mirror of Oriental Medicine, 93 formulas are adjusted in proportion or combined and 34 formulas are empirical ones. By the parity of reasoning of the above, I think that this book was published after The Precious Mirror of Oriental Medicine.

  • PDF

A study of how proprietary medicines during the Japanese colonial period led to transforms in Korean medicine and Korean medicine prescriptions (일제강점기 매약을 통해 본 한약의 제형 변화와 새로운 한약 처방의 경향성에 대한 고찰)

  • Hwang, Jihye;Kim, Namil
    • The Journal of Korean Medical History
    • /
    • v.33 no.1
    • /
    • pp.99-112
    • /
    • 2020
  • In this study, we examine the changes to Korean medicine that occurred when 'proprietary medicines' (賣藥) swept through the pharmaceutical market during the Japanese occupation (1910-1945 C.E.). Proprietary medicine during the Japanese colonial period took various forms including ready-made, over-the-counter, patent, and nostrum type pharmaceuticals. This paper examines how Korean medicine, which was the dominant form of medicine during the Joseon Dynasty, was forced to adapt to the rise of proprietary medicines. We found that the prescription of Korean medicine herbal decoctions became more like proprietary medicine in the way that they were formulated. In addition, prescriptions in Korean medicine books were reformulated with prescriptions and medicines from outside the tradition. Proprietary medicines, many of which were made with secret recipes handed down in a family, also attracted attention. Such prescriptions were made famous through advertisements and further influenced future Korean medicine doctors. New prescriptions took advantage of the trust and authority existing in traditional Korean medicine by introducing ginseng and traditional medicinal herbs such as deer antler velvet (鹿茸, Cervi Parvum Cornu). This paper argues that proprietary medicine of the Japanese colonial period distorted the concept of traditional herbal medicine.