• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제30권3호
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• pp.193-202
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• 2004

Distraction osteogenesis(DO) is defined as a gradual mechanical process of mechanical stretching two vascularized bone surface apart with a critical rate and rhythm such that new bone forms within the expanding gap, reliably bridges the gap, and ultimately remodels to normal structure. DO has become a mainstay in bone tissue engineering and has significantly improved our armamentarium for reconstructive craniomaxillofacial procedures. But the molecular and biological mechanisms that regulate the formation of new bone during distraction osteogenesis are not completely understood. BMPs are potent osteoinductive agents. Our hypothesis was that BMPs, especially BMP-2 and BMP-4, might play an importent role in the signaling pathways that link the mechanical forces created by distraction to biological responses and in promting new bone formation. Using a rabbit's mandible, we investigated the expression of BMP-2, -4 at different time points during distraction osteogenesis. The purpose of this study is to research the pattern of expression of BMP-2, -4 in new bone formation during distraction osteogenesis of the rabbit mandible. The experimental group was applied gradual distraction (0.7mm a day by twice a day, 4.9mm in total, for 7 days) and the control group was carried out osteotomy alone. They were examined clinically, histologically, and by RT-PCR analysis. On 3 days after osteotomy, the high level of expression of BMP-2, -4 was detected. But, the expression of BMP-4 was decreased during latency period. As distraction was started, its expression was increased and maintained till postoperative 28days. In control group, the expression of BMP-4was remarkably decreased till postoperative 14 days. On the other hand, the expression of BMP-2 was no difference between experimental group and control group. The expression of BMP-4 was maintanined at high level during the entire experimental period in both group. These findings suggested that excellent bone formation during distraction osteogenesis is associated with enhanced expression of BMP-4 genes by mechanical tension stress.

• 응용통계연구
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• 제30권3호
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• pp.363-376
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• 2017

보험 시장은 포화되고 그 성장 동력은 소진되어 보험 산업이 저성장에 머물러 있는 가운데 보험사들은 치열한 경쟁 환경에 놓여있다. 이러한 상황에서 보험 상품에 대한 보험수리적 계산의 기초가 되는 보험 청구액의 흐름을 잘 설명할 수 있는 확률분포를 찾아내는 것은 중요한 쟁점이 될 것이다. 보험 청구액의 분포는 일반적으로 두꺼운 꼬리를 가지면서 왼쪽으로 치우친 로그정규분포나 파레토 분포로 잘 설명된다고 알려져 있으나 최근에는 기운 정규분포나 기운 t 분포가 보험 청구액 분포로 적절한 것으로 고찰되었다. Cooray와 Ananda (2005)는 로그정규분포와 파레토 분포의 장점을 모두 가진 로그정규-파레토 복합분포를 제시하고 단일분포보다 더 높은 적합도를 가짐을 확인하였다. 본 논문에서는 기운 정규분포와 기운 t 분포를 머리 부분으로 결합한 새로운 복합분포를 소개하고 덴마크의 화재보험 청구액 데이터와 미국의 배상 지불금 데이터에 적용하여 기존의 다른 복합분포들을 포함하여 여러 단일분포들과 그 성능을 비교한다.

• 한국식품영양학회지
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• 제22권4호
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• pp.560-569
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• 2009

This study was conducted to investigate the annual differences in food habits and dietary attitudes of new female college students enrolled in the department of food and nutrition for 6 years by questionnaire. The results were as follows: age, height, weight and body mass index(BMI) were no significant annual differences over study period. The average ratios of underweight, normal weight and above overweight groups classified by the BMI standard were 19.4%, 64.4% and 16.2%, respectively. There were no significant annual differences in the scores of food habits and dietary attitudes. The intake of milk showed the lowest scores among all the food habit items and the same annual tendencies for 6 years. Among food groups items, the mean intake scores of milk(p<0.01), fats and oils(p<0.001) and vegetables(p<0.05) differed significantly by year. Specifically, the intake scores of milk and vegetables decreased gradually throughout the study period and were significantly lower in 2008 than in 2003. Among dietary habits, the mean intake scores of sweets were significantly lower in 2003 and 2007 than in other years(p<0.001), and the mean intake scores of instant frozen foods were significantly higher in 2006 than during other years(p<0.05). The sum of health related items in 2007 was significantly lower than those during other years, and this was likely due to the lowest scores both of eating-out and alcohol intake in 2007 than in other years. Among dietary attitudes, the mean score of item 'Price of food is more important than nutrition.' was significantly lower in 2005(p<0.05). Food habit scores showed significantly positive correlation with dietary habits(r=0.733, p<0.01), food groups related habits(r=0.720, p<0.01), lifestyle related disease related habits(r=0.518, p<0.01), health related habits(r=0.422, p<0.01). Food habits and dietary attitudes showed highly significantly positive linear correlations each other(r=0.426, p<0.01). Dietary habits and food groups related habits showed highly significantly positive linear correlations(r=0.366, p<0.01). These results showed the same annual tendency with respect to food habit and dietary attitudes in newly enrolled college female students for 6 years. It is expected that food habit and dietary attitudes will be improved if systemic and proficient nutrition education is provided during their college period.

• 호스피스학술지
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• 제5권1호
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• pp.42-49
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• 2005

To determine which are the culturally specific factors of Korean bereavement, this chapter focuses on the view of death and the traditional mourning process which reflect Korean values and norms. The formation of the Korean view and understanding of death has been strongly influenced by three of its major traditional religions: Shamanism, Buddhism, and Confucianism (Park:1994: Hao:1999) and Christianity more recently. Each religion has a different view of death and the appropriate expression of mourning. Korea accommodates funeral customs and rules strictly as a cultural system and has retained these traditions over a long period; hence, some of the traditional funeral rituals still remain in modern Korean life, although some of the rites have been simplified. We have looked at the various ways in which grief and mourning is displayed and shared in a collective manner over a long period of time. This fits in well within the other Eastern cultures that are collectively organized, and contrary to the Eurocentric models do not hastily seek to detach the living from the dead and recognize that grief is a long process, and different individuals may take different amounts of time to recover from the grief. The view of death and bereavement in Korea has sprung from the roots of three Korean religions, together with the recent addition of Christianity, although they mainly result from the three earlier religions. The beliefs of these religions are still closely linked together in the rituals of Korean bereavement on both conscious and unconscious levels. The influence of these religions is evident in practice through the bereaved family's mourning reactions, funeral rites and customs and its views about death. Korea used to have a period of mourning for three years, following traditional mourning rites; then the chief mourner and the bereaved families could return to their normal life. In spite of this long mourning process for the bereaved family, once the funeral ceremony is finished, people expect the bereaved family not to express their grief in public; even the bereaved family does not like to talk about death. The process for bereaved people is related to mourning processes in terms of detachment from the deceased in order to start a new life. Relatives and the community recommend the performance of the kut ceremony for relieving the grief of the bereaved. When one family member dies in an unlucky way, the bereaved family may have some fear or other psychological reactions of grief such as pain, depression, insomnia and nightmares, hallucinations or other physical reactions. Unlucky deaths give the bereaved a very painful time and these types of reactions are often more serious than reactions to natural death. But through the kut ceremony, the bereaved family can start to make a new relationship with the deceased. The taboo of this type of death and death generally remains a crucial aspect of the isolation that bereaved people might face and the collective nature of mourning(even where it is still present) is unable to address this aspect of the privatization of grief.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제32권4호
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• pp.317-326
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• 2006

Purpose : The aim of this study was to evaluate the effect of recombinant human bone morphogenetic protein-7 (rhBMP-7) injected on the rate of new-bone formation for distraction osteogenesis on dogs. Materials & Methods : Twelve adult dogs were randomly selected into two groups of six dogs on each. Unilateral osteotomies were performed on the body of the mandible and an intraoral distractor was mounted to the mandible on dogs. One group was treated with injection of rhBMP-7 and the other group served as the control. RhBMP-7 was administered on the day of surgery by single injection into the medullary bone at the osteotomy gap. Distraction was performed five days after osteotomy as a rate of 0.5 mm twice per day for 10 days. The animals were then sacrificed at 2, 4, and 8 weeks after completion of the distraction. Two dogs in each group, totaling four dogs, were killed at 2 weeks, 4 weeks, and 8 weeks after completion of distraction, respectively. The lengthened mandibles were harvested and processed for radiographic and histological examinations. In addition, immunohistochemical examination using osteocalcin expression was studied. Results : Radiographs showed accelerated regenerate ossification with maturation of new bone in the rhBMP-7 group comparing with the control group at the 4 weeks of the consolidation. There was no significant difference in the radiographic findings at the 2 weeks and 8 weeks of the consolidation period. Histological findings demonstrated increased bone healing pattern in the rhBMP-7-treated group during all observation period. The expression of osteocalcin immunoreactivity was hardly detected in the normal mandible of dog, but the expression was detected in all experimental rhBMP-7 treated specimens. There were also significant increasing in number of positive immunostaining cells and staining intensity of osteocalcin expression in the rhBMP-7 treated group compared with those of the control group on 2-weeks and 4-weeks. There was a significant decreasing in staining intenstiy of all both two groups on 8 weeks of consolidation period, but significant differences of immunostaining was not seen in two groups. Conclusions : A single injection of rhBMP-7 at the time of osteotomy may stimulate the rate of regenerate ossification and increase callus maturation during distraction osteogenesis. In addition, it may shorten the distraction osteogenesis procedure and decrease the prevalence of complications associated with mandibular distraction osteogenesis.

• BMB Reports
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• 제36권1호
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• pp.78-81
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• 2003

The prevention of cancer is one of the most important public health and medical practices of the $21^{st}$ century. We have made much progress in this new emerging field, but so much remains to be accomplished before widespread use and practice become common place. Cancer chemoprevention encompasses the concepts of inhibition, reversal, and retardation of the cancer process. This process, called carcinogenesis, requires 20-40 years to reach the endpoint called invasive cancer. It typically follows multiple, diverse and complex pathways in a stochastic process of clonal evolution. These pathways appear amenable to inhibition, reversal or retardation at various points. We must therefore identify key pathways in the evolution of the cancer cell that can be exploited to prevent this carcinogenesis process. Basic research is identifying many genetic lesions and epigenetic processes associated with the progression of precancer to invasive disease. Many of these early precancerous lesions favor cell division over quiescence and protect cells against apoptosis when signals are present. Many oncogenes are active during early development and are reactivated in adulthood by aberrant gene promoting errors. Normal regulatory genes are mutated, making them insensitive to normal regulatory signals. Tumor suppressor genes are deleted or mutated rendering them inactive. Thus there is a wide range of defects in cellular machinery which can lead to evolution of the cancer phenotype. Mistakes may not have to appear in a certain order for cells to progress along the cancer pathway. To conquer this diverse disease, we must attack multiple key pathways at once for a predetermined period of time. Thus, agent combination prevention strategies are essential to decrease cancer morbidity. Furthermore, each cancer type may require custom combination of prevention strategies to be successful.

• 대한물리치료과학회지
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• 제9권2호
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• pp.99-109
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• 2002

We designed the experiments to elucidate the anti-inflammatory effect of low power laser stimulation on acupoint or non-acupoint using arthrogenic solution induced poly arthritis animal model. In order to achieve the experimental purpose, change in body weight paw edema, pathological changes in inflammed pint and the serum interlukin-6 level were measured after arthritis induction in acupoint later stimulated group, non acupoint laser stimulated group and non treated control animal. The results were summerized as follows: 1. The consistent increase in body weight was observed in the normal animal during whole experimental period, while the induction of arthritis significantly suppressed increase in body weight from the 15 day after arthritis induction. Especially, non treated animal group showed more suppressive effect on increase in body weight as compared to that of low power laser stimulated groups (P<0.05). 2. Low power laser stimulation on acupoint (Zusanli) significantly inhibited edema in the left side paw from the 12th day after arthritis induction as compared to that of non treated animals. This suppressive effect on paw edema was maintained until the end of experiment. 3. Laser treatment on acupoint dramatically suppressed the radiological change (i.e. new bone proliferation and soft tissue swelling) caused by arthritis as compared to that of non treated group animals. 4. Low power laser treatment reduced the increase in serum interlukin-6 caused by arthritis induction to levels observed in the normal animals. In conclusion, the results of the present study demonstrated that low power laser stimulation on acupoint has potent anti-inflammatory effect on arthritis. Thus it is recommended that low power laser be used for long term treatment of arthritis induced inflammation. However, further study is necessary to clarify the possible side effect of laser treatment depending upon intensity and duration of stimulation.

• 한국항해항만학회지
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• 제38권6호
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• pp.689-694
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• 2014

The Korean government has introduced and enforced maritime traffic safety assessment to secure traffic safety since 2010. The maritime traffic safety assessment is needed by law to design a new port or modify an existing one. According to Korea Maritime Safety Act, in the assessment the propriety of marine traffic system consists of the safety of channel transit and berthing/unberthing maneuver, safety of mooring, and safety of marine traffic flow. The safety of channel transit and berthing/unberthing maneuver can be evaluated only by ship-handling simulation. The ship-handling simulation is carried out by sea pilots working with the port concerned. The vessel's proximity measure is an important factor to evaluate traffic safety. The proximity measure is composed of vessel's closest distance to channel boundary and probability of grounding/collision. What is more, the probability of grounding becomes important. According to central limit theorem, a sample has a normal distribution on condition that its size is more than 30. However, more than 30 simulation runs bring about the increase of assessment period and difficulty of employing sea pilots. Therefore this paper is to find out minimum sample size for evaluating vessel's proximity. First sample sets of size of 3, 5, 7, 9 etc. are selected randomly on the basis of normal distribution. And then KS test for goodness of fit and t-test for confidence interval are applied to each sample set. Finally this paper decides the minimum sample size. As a result this paper suggests the minimum sample size of 5, that is, the simulation of more than five times.

• Archives of Plastic Surgery
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• 제41권4호
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• pp.403-406
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• 2014

Background Perforations in the nasal septum (NSP) give rise not only to disintegration of the septum anatomy but also impairment in normal nasal physiology. The successes of these surgical techniques are usually equated to anatomical closure of the perforation. The goal of this study is to evaluate the subjective and objective results of our surgical technique for septal perforation surgery. Methods All NSPs in the six patients were closed by inferior turbinate flap. The Nasal Obstruction Symptom Evaluation (NOSE) instrument was used to evaluate the preoperative and postoperative subjective sensation of nasal obstruction. Measurement of preoperative and postoperative nasal airway resistance was performed using active anterior rhinomanometry which is an objective test. Wilcoxson signed rank test and Spearman correlation test were used to analyze correlation between NOSE scores and rhinomanometric measurements. Results The full closure of the septal perforations was noted in 100% of patients. The total NOSE score was 14 preoperatively and one postoperatively. The improvement in NOSE scores was statistically significant ($P{\leq}0.002$). The mean preoperative total resistance (ResT150) value was $0.13Pa/cm^3s^{-1}$, which is below the normal range ($0.16-0.31Pa/cm^3s^{-1}$), while the mean postoperative ResT150 value was $0.27Pa/cm^3s^{-1}$. The correlation between the improvement in NOSE scores and improvements in ResT150 values was statistically significant. Conclusions Surgical approaches should aim to solve both the anatomical and physiological problems of NSP. The application of subjective and objective tests in the postoperative period will help surgeons assess the applied techniques.

• 동의생리병리학회지
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• 제26권1호
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• pp.19-25
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• 2012

This study was designed to investigate the effects of a new herbal medicine named CWS-A on the changes in regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats, and further to determine the mechanism of action. Also, this study was designed to investigate the effects of CWS-A on the changes in rCBF in cerebral ischemic rats and the safety examination of CWS-A in rats regared to body weight change, renal and liver function test, CBC, $LD_{50}$ and histological observation in rats. The rCBF was significantly and stably increased and MABP was significantly decreased by CWS-A during the period of cerebral reperfusion in normal rats. However, there were no here were no significant changes of rCBF in ischemic rats. In additional, there were no significant changes on the safety examination. In conclusion, these results suggest that medication of CWS-A is effective for the improve the cerebral blood flow and CWS-A can be prescribed as vertigo(眩暈) symptoms treatment.