• Journal of Yeungnam Medical Science
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• 제15권2호
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• pp.371-380
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• 1998

저자들은 최근 루푸스가 뇌 혈관계를 침범하여 신경 정신과적 이상 증상을 보였으며 면역 검사, 뇌파 검사 및 뇌 자기공명사진에서 중추 신경 루푸스의 소견에 부합되는 양상을 보였고 고용량의 부신피질 호르몬 충격 요법에 반응이 좋았던 2례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Psychiatry investigation
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• 제15권12호
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• pp.1168-1173
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• 2018

Objective After the Sewol ferry disaster, bereavement with suicidal ideation was a critical mental health problem that was accompanied by various neuropsychological symptoms. This study examined the frontal alpha asymmetry (FAA), heart rate variability (HRV), and several psychological symptoms in bereaved family members (BFM) after the Sewol ferry disaster. Methods Eighty-three BFM after the Sewol ferry disaster were recruited. We assessed FAA, HRV, and psychological symptoms, including depression, post-traumatic stress, post-traumatic growth factor, anxiety, grief, and positive resources, between BFM with the presence and absence of current suicidal ideation. Results Compared to BFM without suicidal ideation, BFM with suicidal ideation showed a higher FAA with right dominance. Significant differences in psychological symptoms were observed between the groups. In BFM with suicidal ideation, the low: high frequency (LF:HF) ratio correlated with social resources and support. Conclusion The FAA and LF:HF ratio may be biomarkers that represent the pathological conditions of BFM with suicidal ideation. If researched further, they may shed light on the interaction between bereavement with suicidal ideation and social resources for therapeutic intervention.

• BMB Reports
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• 제49권9호
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• pp.457-458
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• 2016

Recent studies have strongly implicated postsynaptic scaffolding proteins such as SAPAP3 or Shank3 in the pathogenesis of various mood disorders, including autism spectrum disorder, bipolar disorder (BD), and obsessive-compulsive disorders. Neural Abelson-related gene-binding protein 2 (nArgBP2) was originally identified as a protein that interacts with SAPAP3 and Shank3. Recent study shows that the genetic deletion of nArgBP2 in mice leads to manic/bipolar-like behavior resembling symptoms of BD. However, the function of nArgBP2 at synapse, or its connection with the synaptic dysfunctions, is completely unknown. This study provides compelling evidence that nArgBP2 regulates the spine morphogenesis through the activation of Rac1/WAVE/PAK/cofilin pathway, and that its ablation causes a robust and selective inhibition of excitatory synapse formation, by controlling actin dynamics. Our results revealed the underlying mechanism for the synaptic dysfunction caused by nArgBP2 downregulation that associates with analogous human BD. Moreover, since nArgBP2 interacts with key proteins involved in various neuropsychiatric disorders, our finding implies that nArgBP2 could function as a hub linking various etiological factors of different mood disorders.

• 신경정신의학
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• 제57권3호
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• pp.235-243
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• 2018

Treatment of schizophrenia has as its ultimate goals, the functional recovery of the patients and improvement of their quality of life. While antipsychotic medication is the fundamental method for treating schizophrenia, it has certain limitations in terms of treating the illness beyond its positive symptoms. Therefore, psychosocial intervention should be used in tandem with pharmacological methods in treating schizophrenia. The efficacy of several modes of psychosocial intervention for improving outcomes in schizophrenia is well attested. Approximately 10 modes of psychosocial intervention have been recommended based on existing evidence, including family intervention, cognitive behavioral therapy, supported employment, early intervention services, lifestyle intervention for physical health enhancement, treatment of comorbid substance abuse, assertive community treatment, cognitive remediation, social skills training, and peer support. Ideally, these interventions are offered to patients in combination with one another. Over the last decade, increased emphasis has been placed on early detection and intervention, with particular focus on long-term recovery. Early intervention with comprehensive psychosocial interventions should be enacted promptly from the initial detection of schizophrenia.

• 대한의료기공학회지
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• 제15권1호
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• pp.23-43
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• 2015

Objects : The purpose of this study is to evaluate Korean medicine treatment as an active postpartum care for women with San-Hu-Byung. Methods : We examined 35 patients(39 cases) with San-Hu-Byung who had hospitalized at the M Korean medicine hospital in Gyeonggi Province between January 1st, 2006 and March 31th, 2015. Based on medical records and questionnaires, we analyzed the general characteristics, main symptoms, duration of hospitalization, treatment satisfaction, etc. We also reviewed and analyzed the results using multifaceted questions. Results : 1. The patients were divided into four age groups; 30-34 years old(46%), 35-39 years old(33%), 27-29 years old(13%), more than 40 years old(5%) and less than 26 years old(3%) in the order. 2. Patients appealed musculoskeletal symptoms(44.05%), reproductive and breast symptoms(21.43%), circulatory symptoms(10.12%), neuropsychiatric symptoms(8.33%), digestive symptoms(7.14%), the other symptoms(5.95%), urinary symptoms(1.79%) and respiratory symptoms(1.19%) in the order. 3. Duration of hospitalization were; within 2 months(33.33%), more than 3 months(25.64%), within 1 month(17.95%), within 3 weeks(12.82%), within 3 months(5.13%) in the order. 4. The improvement of musculoskeletal symptoms including back pain was measured by VAS. After 6 weeks, the pain fell to less than half. After 12 weeks, the pain fell to less than 1. 5. Average satisfaction with Korean medicine treatment is a 4.51 out of 5. Conclusions : As an active postpartum care, Korean medical treatment had significant effect on San-Hu-Byung and patients found the treatment satisfying.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제12권1호
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• pp.149-156
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• 2001

베타 용혈성 A군 연구균(group A beta-hemolytic streptococcus)에 의한 류마치스성 열 이후에 Sydenham 무도병이 발현되는 환자 군에서 강박 증상 또는 틱 증상이 나타난다는 보고가 있은 후, A군 연구균 감염과 강박 장애 또는 틱 장애 사이의 관계가 주목받게 되었다. A군 연구균 감염 후에 강박 증상 또는 틱 증상이 유발되는 환자들은 갑작스런 발병과 극적인 증상 악화를 보이고 사춘기 이전에 발병하며 무도병 모양의 운동 및 독특한 양상의 운동 과잉 등의 신경학적 이상을 보이고 또 그 경과가 악화 및 완화를 반복하는 양상을 보인다. 이런 임상적 특징을 보이는 소아 환자 군을 PANDAS(pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections)라고 부르게 되었다. 이후 현재까지 강박 장애와 틱 장애뿐 아니라 주의력 결핍/과잉운동 장애, 신경성 식욕부전증, 신체이형장애 환자들이 PANDAS 범주에 속한다는 보고들이 있어 왔다. 본 증례는 7세까지 정상적인 발달을 보이다가 A군 연구균 감염 수개월 후부터, 인지 기능, 사회성, 언어 및 의사소통에 장애를 보이고 틱 증상과 함께 얼굴과 손발에 이상 운동을 보이는 환자를 기술하였다. 이에 저자들은 본 증례가 소아기 붕괴성 장애의 양상을 보이는 PANDAS 증례라고 생각되어 이를 문헌 고찰과 함께 보고함으로써, PANDAS가 틱 장애, 강박 장애, 주의력 결핍/과잉운동 장애, 신경성 식욕부전증, 그리고 신체이형장애 등의 양상을 보일 뿐 아니라 소아기 붕괴성 장애의 양상을 보일 수 있다는 사실을 보고하고자 한다.

• 대한한방부인과학회지
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• 제34권4호
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• pp.111-130
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• 2021

Objectives: The purpose of this study was to identify the current status of Korean medicine clinical practice for pregnant patients. Methods: The study is conducted by searching medical records of 209 pregnant patients using Korean Standard Classification of Diseases related pregnancy at the Korean Gynecology Clinic of traditional Korean medicine hospital from March 1, 2016 to February 28, 2021. We retrospectively investigated characteristics, symptoms, pregnancy outcomes of the patients and treatments for the patients. Results: The most frequent symptoms of pregnant patients were musculoskeletal symptoms (60.63%) followed by neuropsychiatric symptoms (14.55%) and genital symptoms (10.82%). The most common contributory factor of the symptoms was the motor vehicle accident (74.64%). Acupuncture (94.94%) and moxibustion (90.91%) were performed to most pregnant patients. Cupping (86.60%), herbal medicine (52.63%), Chuna therapy (30.62%), and pharmacopuncture (21.05%) were performed to the patients. Normal pregnancy maintenance and delivery were reported by 147 patients (91.30%). Premature birth was reported by 11 patients (6.83%), and miscarriage was reported by 3 patients (1.86%). Conclusions: Most patients were the patients with musculoskeletal symptoms injured by motor vehicle accidents. Various Korean medicine treatments were performed during pregnancy with safety outcomes. This study could be used as basic data to provide instructions for the development of traditional Korean medicine in the obstetric clinical fields.

• 동의생리병리학회지
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• 제19권1호
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• pp.279-283
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• 2005

After initial recovery from acute carbon monoxide(CO) intoxication, some patients occasionally undergo severe neuropsychiatric deterioration, which is called postanomic delayed encephalopathy(sequelae). This is the clinical study about one patient, a 53-year-old woman, diagnosed with delayed encephalopathy after acute CO intoxication. The patient's symptoms were mental dysfunction including memory impairment and disorientation, aphasia, atrophy and weakness throughtout the body. She had completely recovered after an anomic episode, but the neurological symptoms that developed were preceded by an interval of apparent nomality.(the 'lucid interval'). She was characterized as suffering deficiency syndrome of the heart(心虛) and was prescribed for her an Ansinschungnoi-tang(安神淸腦湯), and thereafter her symptoms improved remarkably. For the evaluation of clinical improvement, we use the Modified Barthel Index(MBI).

• 생물정신의학
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• 제14권1호
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• pp.48-54
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• 2007

Objectives : This study aimed to examine the relationship between behavioral and psychological symptoms of dementia(BPSD) and patient and caregiver QOL in Alzheimer's disease(AD). Methods : Fifty-one AD patients and their caregivers participated. Measures about patients were Neuropsychiatric Inventory(NPI), Korean version of QOL-Alzheimer's Disease(KQOL-AD), Activities of Daily Living(ADL), Clinical Dementia Rating(CDR), and Korean version-Mini Mental State Examination(K-MMSE). Caregiver QOL was assessed with KQOL-AD and General Health Questionnaire/Quality of Life-12(GHQ/QOL-12). Results : Patient QOL-AD on patient ratings was negatively correlated with appetite/eating change and NPI scores. Patient QOL-AD on caregiver ratings was negatively correlated with hallucinations, depression/dysphoria, and NPI scores. Caregiver QOL assessed by the GHQ/QOL-12 was negatively correlated with agitation/aggression, depression/dysphoria, and NPI scores and was negatively correlated with distress related to agitation/aggression, depression/dysphoria, and NPI scores. Conclusion : BPSD of AD patients was associated with low QOL of both patients and caregivers. Thus, interventions of BPSD were needed to improve both patient and caregiver QOL.

• 대한지역사회작업치료학회지
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• 제2권1호
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• pp.85-96
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• 2012

목적 : 본 연구는 배회가 있는 치매 노인에게 신체 그룹 작업치료 참여가 인지기능, 심리행동증상 및 사회적 행동기능에 어떠한 영향을 미치는지 알아보고자 하였다. 연구방법 : 본 연구는 대전 ${\bigcirc}{\bigcirc}$요양원에 거주하고 있는 노인 중 고도의 치매(MMSE-K 9점 이하)를 가지고 있는 노인 13명을 대상으로, 2010년 7월부터 2010년 9월까지 주 1회 총 9회 실시하였다. 평가도구는 배회유형과 정도를 알아보기 위해 Algase Wandering Scale-V2를 사용하였고, 인지기능을 알아보기 위해서 인지기능 척도를 사용하였고, 심리정신행동을 알아보기 위해서 Neuropsychiatric Inventory-Questionnaire (NPI-Q)를 사용하였으며, 사회행동기능을 알아보기 위해 사회행동 척도를 사용하였다. 결과 : 대응표본 t-test를 이용하여 신체그룹 작업치료를 시행하기 전과 후를 살펴본 결과 인지도 기능손상정도와 심리행동증상은 감소되었으나, 유의한 결과(p>0.05)를 얻지는 못하였고, 사회적 행동기능, 심리행동증상의 심각정도, 배회의 정도는 유의하게 감소(p<0.05)된 것을 보여주었다. 결론 : 신체 그룹 작업치료를 한 결과 고도의 치매노인도 향상되었으며, 특히 사회적 행동기능, 심리행동증상의 정도, 배회의 정도가 향상되었음을 볼 수 있었다. 치매를 가지고 있는 노인에게도 꾸준한 치료가 필요하며, 앞으로 충분한 대상자와 대조군 그리고 치매노인의 다양한 변수를 고려한 지속적인 프로그램 개발이 필요하다.