• Title/Summary/Keyword: Neurophysiology

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Updates in postural tachycardia syndrome

  • Moon, Jangsup
    • Annals of Clinical Neurophysiology
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    • v.23 no.1
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    • pp.1-6
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    • 2021
  • Postural tachycardia syndrome (POTS) is the most common form of orthostatic intolerance in young people. However, it is still considered an underrecognized disorder and so deserves more attention from clinicians. This review covers the diagnostic challenges, correlations between the symptoms, evidence of autoimmune involvement in the pathogenesis, and treatment strategies in POTS.

Potential risks of nerve conduction studies and needle electromyography

  • Yoon, Byung-Nam;Ahn, Suk-Won;Kim, Jee-Eun;Seok, Jin Myoung;Kim, Kwang-Kuk;Kwon, Ki-Han;Park, Kee Duk;Suh, Bum Chun;Lim, Young Min;Korean Society of Clinical Neurophysiology Education Committee
    • Annals of Clinical Neurophysiology
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    • v.20 no.2
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    • pp.66-70
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    • 2018
  • Electrodiagnostic studies such as nerve conduction studies (NCS) and needle electromyography (EMG) provide important and complementary information for evaluating patients with suspected neuromuscular disorders. NCS and needle EMG are reasonably safe diagnostic investigations and are generally associated with only mild transient discomfort when performed by experienced physicians. However, there is the risk of complications in some patients, because NCS involve the administration of electric current and EMG involves inserting a needle percutaneously into muscle tissue. This article reviews the potential risks of NCS and needle EMG.

Methionyl-tRNA Synthetase Regulates Lifespan in Drosophila

  • Suh, Yoon Seok;Yeom, Eunbyul;Nam, Jong-Woo;Min, Kyung-Jin;Lee, Jeongsoo;Yu, Kweon
    • Molecules and Cells
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    • v.43 no.3
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    • pp.304-311
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    • 2020
  • Methionyl-tRNA synthetase (MRS) is essential for translation. MRS mutants reduce global translation, which usually increases lifespan in various genetic models. However, we found that MRS inhibited Drosophila reduced lifespan despite of the reduced protein synthesis. Microarray analysis with MRS inhibited Drosophila revealed significant changes in inflammatory and immune response genes. Especially, the expression of anti-microbial peptides (AMPs) genes was reduced. When we measured the expression levels of AMP genes during aging, those were getting increased in the control flies but reduced in MRS inhibition flies age-dependently. Interestingly, in the germ-free condition, the maximum lifespan was increased in MRS inhibition flies compared with that of the conventional condition. These findings suggest that the lifespan of MRS inhibition flies is reduced due to the down-regulated AMPs expression in Drosophila.