• Annals of Clinical Neurophysiology
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• 제4권1호
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• pp.78-80
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• 2002

A 32-year-old man who had worked at aluminum processing plant for 4 months visited us. He complained of numbness and paresthesia of both foot and hands and weakness of all extremities. Electrophysiologic study showed motorsensory polyneuropathy of diffuse axonal type with focal conduction block. And we discovered higher concentration of n-Hexane in his workplace. On sural nerve biopsy, bubbly enlarged nerve fibers in light microscope and thick myelin sheath and axonal degeneration on electron microscope were found. We diagnosed it as n-Hexane induced neuropathy.

• 대한한방내과학회지
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• 제38권5호
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• pp.675-680
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• 2017

A diabetic neuropathy patient was treated with Korean medicine for 2 weeks. In this case report, we report the efficacy of a complex treatment comprising various Korean medicine methods by evaluating the differences in pain scores. The patient reported improvement in both pain score and glucose index. Korean medicine could therefore be effective for the treatment and prevention of diabetic neuropathy.

• Journal of Yeungnam Medical Science
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• 제16권1호
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• pp.114-118
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• 1999

LHON은 사립체 DNA의 점돌연변이에 의해서 유발되며 11778, 3460, 14484의 세 부위가 주된 사립체 DNA 점돌연변이의 위치로 알려져 있다. 이에 저자들은 점진적인 시력 저하를 호소하면서 사립체 DNA 분석 결과 11778 점돌연변이가 확인된 LHON환자 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 대한한의학방제학회지
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• 제9권1호
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• pp.386-386
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• 2001

경산대학교 부속 대구한방병원에 당뇨병성 신경병증으로 인한 兩下肢 冷痺症, 無力感을 주소로 내원한 환자 1例에 대하여 2000년 7월 3일부터 2000년 7월 16일까지 漢藥治療 및 鍼灸治療 등을 시행하여 下肢의 증상 및 당뇨병으로 인한 전신증상의 호전에 도움이 되었으므로 치료내용과 경과를 문헌고찰과 함께 보고하는 바이다.

• 대한한의학방제학회지
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• 제9권1호
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• pp.387-395
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• 2001

경산대학교 부속 대구한방병원에 당뇨병성 신경병증으로 인한 양하지(兩下肢) 냉비증(冷痺症), 무력감(無力感)을 주소로 내원한 환자 1례(例)에 대하여 2000년 7월 3일부터 2000년 7월 16일까지 한약치료(漢藥治療) 및 침구치료(鍼灸治療) 등을 시행하여 하지(下肢)의 증상 및 당뇨병으로 인한 전신증상의 호전에 도움이 되었으므로 치료내용과 경과를 문헌고찰과 함께 보고하는 바이다.

• Annals of Clinical Neurophysiology
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• 제7권2호
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• pp.88-92
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• 2005

Blink reflex could be a useful tool to differentiate facial synkinesis as one of complications of facial neuropathy, from volitional associated movements. We had performed applied blink reflex test for 23 patients with objective evidence of hemifacial weakness in which orbicularis oculi muscle(zygomatic branch) and mentalis muscle(mandibular branch) are electrophysiologically evaluated in response to supraorbital stimulation of trigeminal nerve. For an unaffected side of face there is no evidence of positive blink reflex from the mentalis muscle. We concluded that a positive blink reflex from mentalis muscle is almost always suggestive of chronic facial neuropathy even in clinical silence of facial synkinesis, or an aberrant reinnervation after peripheral facial neuropathy, and does not electrophysiologically correlate with the severity of facial palsy.

• 가정∙방문간호학회지
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• 제24권2호
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• pp.189-199
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• 2017

Purpose: This study aimed to investigate the effects of foot bath therapy on the symptom intensity, distress, and interference with usual activities due to chemotherapy-induced peripheral neuropathy (CIPN) in patients with metastatic and recurrent cancer. Methods: Foot bath therapy was administered to the experimental group for >8 sessions in 2 weeks, and the chemotherapy-induced peripheral neuropathy assessment tool (CIPNAT) was used to measure its effects on the symptom intensity, distress, and interference with usual activities due to CIPN. SPSS was used to perform data analyses including descriptive statistics, chi-square test, Fisher's exact test, t-test, paired t-test, and repeated measures ANCOVA. Results: A statistically significant difference in the variation of the symptom intensity, distress, and interference with usual activities due to CIPN was observed between the two groups; however, a statistically insignificant difference was observed between the groups and time of interaction. Conclusion: Foot bath therapy can be used as a simple and effective clinical or home care nursing intervention to improve the symptom intensity, distress and interference with usual activities due to CIPN.

• The Korean Journal of Pain
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• 제20권2호
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• pp.208-212
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• 2007

Although Churg-Strauss syndrome (CSS) is a rare disease that is generally associated with vasculitis, nerve involvement is also common in cases of CSS. A 48-year old man was diagnosed with a herniated disc at L4-5 and an annular tear at L5-S1 after complaining of pain and numbness in the left lower leg. Peripheral edema was observed during physical examination and the patient was diagnosed with CSS after a biopsy was conducted. In addition, electromyography and nerve conduction velocity revealed the presence of multiplex mononeuropathy, which indicated the pain and numbness was due to peripheral neuropathy caused by CSS. The symptoms were relieved after oral administration of prednisolone. This case indicates that when symptoms of peripheral neuropathy do not match the radiographic evidence other causes, such as CSS, must be considered.

• 사상체질의학회지
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• 제33권3호
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• pp.171-180
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• 2021

Objectives This case report is about a Taeyangin patient with Acute Motor Axonal Neuropathy identified as Hae-Yeok pattern using Ogapijangchuk-tang. In this study, we report the significant improvement of lower extremity weakness and pain of this patient after Sasang Constitutional medicine treatment. Methods The patient was identified as Taeyangin Hae-Yeok pattern and treated with Ogapijangchuk-tang. Guillain-Barre Syndrome disability scale was used to assess the overall function of the patient. The Numeral Rating Scale was used to assess the change of lower extremity pain. Also the change of lower extremity weakness was measured by patient's expression and graded by Manual Muscle Test. Result and Conclusion After treatment with Ogapijangchuk-tang, patient's symptoms were improved. And there was not any side effect. In conclusion, this study shows that Sasang Constitutional medicine can be effective treatment for Taeyangin patient with Acute Motor Axonal Neuropathy.

• The Korean Journal of Pain
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• 제35권2호
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• pp.160-172
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• 2022

Background: The authors established an in vitro model of diabetic neuropathy based on the culture system of primary neurons and Schwann cells (SCs) to mimic similar symptoms observed in in vivo models of this complication, such as impaired neurite extension and impaired myelination. The model was then utilized to investigate the effects of insulin on enhancing neurite extension and myelination of diabetic neurons. Methods: SCs and primary neurons were cultured under conditions mimicking hyperglycemia prepared by adding glucose to the basal culture medium. In a single culture, the proliferation and maturation of SCs and the neurite extension of neurons were evaluated. In a co-culture, the percentage of myelination of diabetic neurons was investigated. Insulin at different concentrations was supplemented to culture media to examine its effects on neurite extension and myelination. Results: The cells showed similar symptoms observed in in vivo models of this complication. In a single culture, hyperglycemia attenuated the proliferation and maturation of SCs, induced apoptosis, and impaired neurite extension of both sensory and motor neurons. In a co-culture of SCs and neurons, the percentage of myelinated neurites in the hyperglycemia-treated group was significantly lower than that in the control group. This impaired neurite extension and myelination was reversed by the introduction of insulin to the hyperglycemic culture media. Conclusions: Insulin may be a potential candidate for improving diabetic neuropathy. Insulin can function as a neurotrophic factor to support both neurons and SCs. Further research is needed to discover the potential of insulin in improving diabetic neuropathy.