• 자동차안전학회지
• /
• 제9권3호
• /
• pp.19-23
• /
• 2017

This paper presents a lateral driver model with neuromuscular system to evaluate the performance of electric power steering (EPS). Output of most previously developed driver models is steering angle. However, in order to evaluate EPS system, driver model which results in steering torque output is needed. The proposed lateral driver model mainly consists of 2 parts: desired steering angle calculation and conversion of steering angle into steering torque. Desired steering angle calculation part results in steering angle to track desired yaw rate for path tracking. Conversion of steering angle into torque is consideration with neuromuscular system. The proposed driver model is investigated via actual driving data. Compared to other algorithms, the proposed algorithm shows similar pattern of steering angle with human driver. The proposed driver can be utilized to efficiently evaluate EPS system in simulation level.

• 한국자동차공학회논문집
• /
• 제10권3호
• /
• pp.245-253
• /
• 2002

A driver model with nervous neuromuscular system was developed to steer a vehicle along the prescribed path during handling simulations. A 3-dimensional vehicle model with 10 DOF and 3 DOF steering handle are used to perform a computer simulation. PID and fuzzy controller are used to perform single and double lane change, and their tracking abilities were compared. The effects of time delay and preview distance are also investigated, and it is demonstrated that the driver model developed can be an aid far objective evaluation of vehicle handling simulation.

• Molecules and Cells
• /
• 제45권4호
• /
• pp.231-242
• /
• 2022

The neuromuscular junction (NMJ), which is a synapse for signal transmission from motor neurons to muscle cells, has emerged as an important region because of its association with several peripheral neuropathies. In particular, mutations in GARS that affect the formation of NMJ result in Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. These disorders are mainly considered to be caused by neuronal axon abnormalities; however, no treatment is currently available. Therefore, in order to determine whether the NMJ could be targeted to treat neurodegenerative disorders, we investigated the NMJ recovery effect of HDAC6 inhibitors, which have been used in the treatment of several peripheral neuropathies. In the present study, we demonstrated that HDAC6 inhibition was sufficient to enhance movement by restoring NMJ impairments observed in a zebrafish disease model. We found that CKD-504, a novel HDAC6 inhibitor, was effective in repairing NMJ defects, suggesting that treatment of neurodegenerative diseases via NMJ targeting is possible.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2007년도 춘계학술대회A
• /
• pp.855-860
• /
• 2007

This paper describes a human driver model developed based on finite preview optimal control method. The human driver steering model is constructed to minimize a performance index which is a quadratic form of lateral position error, yaw angle error and steering input. Simulation studies are conducted using a vehicle simulation software, Carsim. The Carsim vehicle model is validated using vehicle test data. In order to validate the human driving steering model, the human driver steering model is compared to the driving data on a virtual test track(VTT) and the actual vehicle test data. It is shown that human driver steering behaviors can be well represented by the human driver steering model presented in this paper

• Maxillofacial Plastic and Reconstructive Surgery
• /
• 제33권2호
• /
• pp.120-127
• /
• 2011

Purpose: This study was designed to examine whether the use of neuromuscular electrical stimulation (NMES) after mandibular distraction osteogenesis accelerated bone formation and consolidation. Methods: Eight adult dogs underwent mandibular left body osteotomy. After a 3 day latency period, a distraction rod device was activated at a rate of 1.0 mm once per day for 10 days. After the completion of mandibular lengthening, NMES group was treated twice daily with 2 hours of NMES for 14, and 28 days, while non-NMES group did not receive NMES. The distracted segment was evaluated radiolgraphically histologically and than immunohistochemically for osteopontin (OPN) to evaluate new bone formation and consolidation. Results: Radiography, did not demonstrate significantly different images between the group and the NMES group. Histological examination however, showed that the new bone formation 14 and 28 days after distraction was better in the NMES group when compared to non-NMES group. Immunohistochemical analysis demonstrated that the staining intensity of OPN increased more in the NMES group than in non-NMES group during early consolidation. Conclusion: The results of this study demonstrated that the use of NMES can promote bone formation and consolidation.

• PNF and Movement
• /
• 제7권1호
• /
• pp.17-23
• /
• 2009

Purpose : To provide a convenient framework for PNF practice, we reviewed the relationship between ICF framework and PNF framework. Methods : We reviewed literatures related with ICF and PNF. Results : ICF model is useful tool for physical therapist who is working in PNF to identify the interactions the components of individual's health, especially the relationship between functioning and disability. A framework for PNF is philosophy which included the concept, functional approach. It is essential to identify primary activity limitation and causal impairment in PNF field and evaluate the their relationship. The ICF model can be used to classify the examination information. Next step is to prioritize the activity limitation and then evaluate the interrelationships among each components of the ICF framework. Conclusions : ICF model guides physical therapist in PNF practice to identify patient problems and evaluate the interrelationship of components of their health. This model is logical framework to directs functional approach as PNF philosophy to be approached the goal.

• 전자공학회논문지SC
• /
• 제48권5호
• /
• pp.81-92
• /
• 2011

본 논문에서는 표면 근전도(surface electromyogram : SEMG)와 근육모델링을 이용하여 신경근육 접합부(neuromuscular junction, NMJ)의 종판(end plate) 폭(widths)과 분포(distribution)에 따른 운동단위(motor unit, MU)수를 추정하는 새로운 방법을 제안하였다. 이를 위하여 MU-시뮬레이터(motor unit simulator)와 EPZ-시뮬레이터(end plate zone simulator)를 설계하고, 본 연구에서 제안된 방법과 기존방법들을 비교하였다. 제안된 MU-시뮬레이터로 시뮬레이션 된 SMUAP(single motor unit action potential : 단일운동단위활동전위)와 CMAP(compound muscle action potential : 복합근활동전위)은 검출된 근신호와 유사하였다. EPZ-시뮬레이터는 신경근육 접합부의 종판 폭과 분포를 바꾸어 가면서 운동단위수를 추정하기 위하여 설계하였다. 실험결과 운동단위 수는 약 450 개, 근섬유수 약 340 개, 종판 폭은 약 6 mm이고, 종판분포는 불규칙하게 분포된 것 (randomly distributed)으로 추정되었다. 본 연구에서 제안된 방법은 인간 근육의 생체조직검사로 측정한 운동단위의 수와 비교 가능한 결과가 나왔다.

• Journal of Mechanical Science and Technology
• /
• 제20권8호
• /
• pp.1183-1194
• /
• 2006

The aim of this study was to identify the characteristics of the flexion withdrawal reflex modulated by the hip angle and hip movement in spinal cord injury (SCI). The influence of the hip position and passive movement were tested in 6 subjects with chronic SCI. Each subject placed in a supine position and lower leg was fixed with the knee at 5 -45 degree flexion and the ankle at 25-40 degree plantar flexion. A train of 10 stimulus pulses were applied at 200 Hz to the skin of the medial arch to trigger flexion reflexes. From results of the regression analysis, static properties of normalized muscle activation of flexor muscles have the linear relationship with respect to hip angle (P< 0.05). In order to verify the neural contribution of flexion reflex, we compared the static and dynamic gains of estimated muscle activations with measured EMG of ankle flexor muscle. Form this study, we postulate that the torque and muscle response of flexion withdrawal reflex have linear relationship with hip angle and angular velocity.

• Molecules and Cells
• /
• 제40권2호
• /
• pp.151-161
• /
• 2017

Proper synaptic function in neural circuits requires precise pairings between correct pre- and post-synaptic partners. Errors in this process may underlie development of neuropsychiatric disorders, such as autism spectrum disorder (ASD). Development of ASD can be influenced by genetic factors, including copy number variations (CNVs). In this study, we focused on a CNV occurring at the 16p11.2 locus in the human genome and investigated potential defects in synaptic connectivity caused by reduced activities of genes located in this region at Drosophila larval neuromuscular junctions, a well-established model synapse with stereotypic synaptic structures. A mutation of rolled, a Drosophila homolog of human mitogen-activated protein kinase 3 (MAPK3) at the 16p11.2 locus, caused ectopic innervation of axonal branches and their abnormal defasciculation. The specificity of these phenotypes was confirmed by expression of wild-type rolled in the mutant background. Albeit to a lesser extent, we also observed ectopic innervation patterns in mutants defective in Cdk2, Gq, and Gp93, all of which were expected to interact with Rolled MAPK3. A further genetic analysis in double heterozygous combinations revealed a synergistic interaction between rolled and Gp93. In addition, results from RT-qPCR analyses indicated consistently reduced rolled mRNA levels in Cdk2, Gq, and Gp93 mutants. Taken together, these data suggest a central role of MAPK3 in regulating the precise targeting of presynaptic axons to proper postsynaptic targets, a critical step that may be altered significantly in ASD.

• 대한의용생체공학회:학술대회논문집
• /
• 대한의용생체공학회 1993년도 추계학술대회
• /
• pp.145-150
• /
• 1993

It is an important component of the diagnosis to research the morphological changes of EMG in pathological conditions. In order to provide an EMG signal resulting from a predetermined neuromuscular pathophysiology, we have initially developed a mathmatical model of electromyographic interference pattern(IP). It can be used to study the variation of the IP resulting from morphological and electrophysiological changes occurring in disease states, because the model computes the IP from the underlying fiber and muscle structure. We performed quantative analysis or the model output, focusing on IPs resulting from simulations of dystrophic fiber loss and the MU denervation and reinnervation typical of neuropathies. To discribe the characteristics of IPs associated with these pathologies, a set of frequency domain discriptors, activity, mobility, and complexity were used, as well as several measures of the spectral density function. These discriptors demonstrate distinct patterns of variation corresponding to morphological changes observed in disease states, and closely with results obtained from the classical method, turn/amp technique.