• Journal of the Korean Society of Radiology
• /
• v.15 no.4
• /
• pp.555-564
• /
• 2021

Thalamus is known to play an important role in the regulation of nerve function. Thalamus, located in the center of the brain, is involved in sleep, arousal, and emotional regulation, and has been reported to be associated with multiple sclerosis, essential tremors, and neurodegenerative diseases such as Parkinson's disease. In addition, it has been reported that iron deposits in the thalamus can cause depressive symptoms with age. Although there are discrepancies between studies, it can be deduced that the thalamus region has a clear effect on neurological disorders due to a strong relationship between the thalamus and neurological functions such as emotional control and processing. Through tractography analysis, the connectivity between the detailed areas of each subcortical region was investigated in the form of a matrix, showing strong connectivity and weak interhemispheric connectivity. In the 59> group, the WM connectivity of thalamus was found to be weaker than those of the two groups. Comparisons between the two groups showed that the young groups (10-39 and 40-59) had higher connection intensity than the 59> group and that statistically significant differences in 3 connection pathways were found in each hemisphere. A decrease in thalamus-related connection strength in aging has shown that it can affect emotional and neurological disorders such as anxiety and depression, and network measurements can help assess cognitive impairment across clinical conditions.

• Therapeutic Science for Rehabilitation
• /
• v.10 no.2
• /
• pp.53-74
• /
• 2021

Objective : The purpose of this study was to examine foreign literature on the evaluation and interventions for motor functions in children. Methods : Studies in this review were identified by searching the PubMed, Cochrane Library (Embase) databases from those published form January 2010 to March 2020 using the following keywords: "motor function test" or "motor function measure" or "movement assessment" or "motor proficiency test" or "motor scale" or "motor skill" and children. Results : Of the total 37 identified studies, 14 analyzed evaluations, 23 analyzed interventions, all of which were randomized control trials. Studies on evaluations were increasingly more common, in contrast to studies on interventions for motor functions. The most frequent field of research was rehabilitation. The studies on evaluations included the AIMS and MABC-II, and GMFM was the most frequently used intervention. Interventions were most commonly used in task-oriented training (six studies). Conclusion : This study aimed to provide a basis for therapists to choose effective motor function evaluation and interventions for clinical trials by analyzing studies related to interventions for and evaluation of motor function in children.

• Journal of Music and Human Behavior
• /
• v.19 no.2
• /
• pp.81-103
• /
• 2022

The effects of therapeutic instrumental music performance (TIMP) using a ukulele were examined in adults with central nervous system damage and impaired hand functions. The participants were three adults with neurological damage who participated in 30-min sessions twice a week over 6 weeks. Changes in hand function was measured by the Box and Block Test (BBT), the 9-Hole Peg Test (9-HPT), and the Jebsen-Taylor Hand Function Test (JTHFT). Following the intervention, all three participants showed increases in the BBT and 9-HPT scores, indicating positive changes in fine motor coordination and dexterity. In terms of the JTHFT, all three participants showed increases in the "writing" and "card flipping" subtask scores, indicating that the intervention was effective in improving more coordinated finger movements. All participants reported the satisfaction with the intervention. They also pointed out that they were motivated to play the ukulele and that following the intervention used their affected hand more frequently in daily activities. These findings suggest that TIMP with a ukulele for patients with central nervous system damage can have positive effects on their functional hand movements and motivate these patients to practice their rehabilitation exercises.

• Journal of Oriental Neuropsychiatry
• /
• v.17 no.1
• /
• pp.129-136
• /
• 2006

Objective : Audio-evoked potential is technique used for measuring brain functions such as memory, attention, and concentration. Although a number of studies on acupuncture for pain, there are few reports on the effect of acupuncture cognitive function. Methods : Fifteen healthy volunteers with no neurological condition took part of the study. $(23.27{\pm}2.09)$. In this study, we examined the changes in auditory P300 by acupuncture stimulation to 'Oegwan' on the left hand. Auditory P300 was recorded before, during and after acupuncture. The amplitude and latency of P300 at Fz, Cz, Pz point were calculated. Results : Auditory P300 amplitude decreased during and after acupuncture, but there was no statistical significance.(P< .05) Auditory P300 latency significantly decreased during and after acupuncture.(P< .05) Conclusions : The decrease of Auditory P300 latency time suggests that acupuncture at Oegwan has some effects on the cognitive function.

• BMB Reports
• /
• v.56 no.9
• /
• pp.488-495
• /
• 2023

Mitochondrial transplantation is a promising therapeutic approach for the treatment of mitochondrial diseases caused by mutations in mitochondrial DNA, as well as several metabolic and neurological disorders. Animal studies have shown that mitochondrial transplantation can improve cellular energy metabolism, restore mitochondrial function, and prevent cell death. However, challenges need to be addressed, such as the delivery of functional mitochondria to the correct cells in the body, and the long-term stability and function of the transplanted mitochondria. Researchers are exploring new methods for mitochondrial transplantation, including the use of nanoparticles or CRISPR gene editing. Mechanisms underlying the integration and function of transplanted mitochondria are complex and not fully understood, but research has revealed some key factors that play a role. While the safety and efficacy of mitochondrial transplantation have been investigated in animal models and human trials, more research is needed to optimize delivery methods and evaluate long-term safety and efficacy. Clinical trials using mitochondrial transplantation have shown mixed results, highlighting the need for further research in this area. In conclusion, although mitochondrial transplantation holds significant potential for the treatment of various diseases, more work is needed to overcome challenges and evaluate its safety and efficacy in human trials.

• Therapeutic Science for Rehabilitation
• /
• v.6 no.2
• /
• pp.47-58
• /
• 2017

Objective : The purpose of this study is to observe effects of Occupation-Based bilateral UE training for chronic stroke. Methods : 4 patients with hemiplegic stroke were divided into two groups: experimental group and control group. From May to August 2016, we conducted a occupation - based bilateral UE training and a traditional bilateral UE training for 5 weeks, 3 times a week, and 60 minutes per session for each subject. EMG, accelerometer, ARAT, Y-BAT, SIS, and COPM were performed before and after the intervention. Results : The experimental group showed a large changes before and after intervention in ECR, DA and all items except for hand function and memory of SIS, compared with the control group. Also, the experimental group showed a large change before and after the intervention compared to the control group in the accelerometer measuring the amount used of bilateral hand and grasp, pinch, and gross movement items of ARAT and COPM, Y-BIT. Conclusions : Occupation-based bilateral upper extremity training was effective in the recovery of upper limb function and social participation through neurological changes. Future research will be required development studies to ensure a high content validity of the Occupation-based bilateral upper extremity training protocol.

• Journal of the Korean Society of Physical Medicine
• /
• v.5 no.2
• /
• pp.193-201
• /
• 2010

Purpose : This study achieved to search the effect of the circuit exercise and conventional exercise on walking ability(walking speed, endurance, dynamic balance, speed, endurance and pedestrian crossing) in chronic stroke. Methods : Since is diagnosed by stroke, to 30 chronic stroke patients who more than 1 year past the 15 circuit exercise group, the 15 conventional exercise group random the circuit exercise group applied circuit exercise 3th 8 weeks each week after neurological treatment because assigning and the conventional exercise group executed round trip walk exercise in parallel bar 3th 8 weeks each week after neurological treatment. The data of 25 patients who complete experimental course were statistically analysed. Results : The results of this dissertation were as following : 1) There were significantly increased after experimental of 10 meter walk test, 6 minutes walk test and Timed "Up and Go" test in circuit exercise group (p<.001). 2) There were significantly increased after experimental of 2, 4 and 6 lane road crossing mobility in Walking circuit exercise group(p<.01). 3) There were significantly differences after experimental of 10 meter walk test, 6 minutes walk test and Timed "Up and Go" test change quantity between circuit exercise group and conventional exercise group(p<.05). 4) There were correlations were found between the TUG test and 2, 4 and 6 lane road (2 lane road; r=.463, p<.01., 4 lane road; r=515, p<.01., 6lane road; r=.710, p<.01), and there were correlations were found between the 10 meter walk test and 6 minutes walk test(r=.595, p<.01), TUG test(r=.662, p<.01) and 6 lane road(r=.527, p<.01). Conclusion : Even if improvement of walk function through training consists in room, transfer of actuality pedestrian crossing is no change outside the room. Because it is much variable of the weather, seasonal factor, temperature, pedestrian number, state of underneath etc. outside the room. Then, in room after direction promotion of walk function to be promotion of walk function in actuality life and need development of connectable training method consider.

• Therapeutic Science for Rehabilitation
• /
• v.5 no.2
• /
• pp.23-33
• /
• 2016

Objectives: The aim of this study was to investigate the association between cognitive function and upper extremity function in the elderly. The articles were analyzed based on patient, intervention, comparison, and outcome using the P.I.C.O. principle. Methods: We systematically examined papers from January, 2000 to November, 2015 published papers through the foreign journals which were Medline & Pubmed for three months. mainly used key words were elderly, dementia, Alzheimer's disease, Mild cognitive impairment, age-related, aging, cognitive, upper extremity function, hand function, hand-grip strength, grip force, complex motor function, bimanual, dexterity, UE performance, and coordination. Results: The number of discovered outcomes for association between cognitive function and upper extremity function in the elderly was 7; grip strength & sex are impact on manipulation object, 1. The results show that cognitive function is associated with upper extremity function in the elderly. Conclusion: This study is expected to help selecting intervention, assessment tools according to the individual's degree of cognitive level and upper extremity function. In future domestic research, variety assessment tools need to be used and more qualitative level experiment will be carried out.

• Therapeutic Science for Rehabilitation
• /
• v.3 no.2
• /
• pp.59-69
• /
• 2014

Objective : This study was done to see that upper limb reaching task have an effect on stroke patient's upper limb function and self-efficacy. Methods : The object of the study was done to see for diagnosed with stroke man on the thirty-ninth of this month. upper limb reaching task was done to see three times a for 6 week and by a per for thirty minutes. To find changing upper limb function and self-efficacy before-after upper limb reaching task, they were measured using Box & block test and self-efficacy scale. Results : Box & block test and self- efficacy scale were increased mark of revaluation, evaluation result than one of early evaluation result. Conclusion : Through this study, upper limb reaching task applied to stroke patient was found that it improved stroke patient's upper limb function and self-efficacy.

• Therapeutic Science for Rehabilitation
• /
• v.1 no.2
• /
• pp.35-40
• /
• 2012

The purpose of this review was to investigate feasibility of intensive virtual reality training to improve upper extremity function with brain plasticity of individuals with stroke through the literature. The recovery of the paretic upper extremity depends on regularity and intensity of training as use-dependent plasticity. In resent, virtual reality program has been widely used in the occupational therapy field of augmented stroke rehabilitation. There is a growing body of evidence that virtual reality training of the paretic extremity induces brain plasticity associated with motor improvement. In terms of therapeutic feasibility to improve paretic upper extremity, recent research has explored several important factors of virtual reality training for recovery of upper extremity motor function. These factors include high repetition intensity, high motivation like type of game, enhanced multisensory feedback regarding performance, and interactive task-oriented training. Therefore, occupational therapy combined with intensive and repetitive virtual reality training will enhance recovery of upper extremity motor function after stroke.