• Brain Tumor Research and Treatment
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• 제6권2호
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• pp.60-67
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• 2018

Background Recently, modern technology such as diffusion tensor imaging (DTI), neuro-navigation and intraoperative neurophysiological monitoring (IOM) have been actively adopted for the treatment of thalamic tumors. We evaluated surgical outcomes and efficacy of the aforementioned technologies for the treatment of pediatric thalamic tumors. Methods We retrospectively reviewed clinical data from 37 children with thalamic tumors between 2004 and 2017. There were 44 operations (27 tumor resections, 17 biopsies). DTI was employed in 17 cases, neuro-navigation in 23 cases and IOM in 14 cases. All diagnoses were revised according to the 2016 World Health Organization Classification of Tumors of the Central Nervous System. Progression-free survival (PFS) and overall survival (OS) rates were calculated, and relevant prognostic factors were analyzed. The median follow-up duration was 19 months. Results Fifteen cases were gross total resections (GTR), 6 subtotal resections (STR), and 6 partial resections (PR). Neurological status did not worsen after 22 tumor resections. There were statistically significant differences in terms of the extent of resection between the groups with DTI, neuro-navigation and IOM (n=12, GTR or STR=12) and the group without at least one of the three techniques (n= 15, GTR or STR=9, p=0.020). The mean PFS was $87.2{\pm}38.0$ months, and the mean OS $90.7{\pm}36.1$ months. The 5-year PFS was 37%, and the 5-year OS 47%. The histological grade ($p{\leq}0.001$) and adjuvant therapy (done vs. not done, p=0.016) were significantly related to longer PFS. The histological grade (p=0.002) and the extent of removal (GTR/STR vs. PR/biopsy, p=0.047) were significantly related to longer OS. Conclusion Maximal surgical resection was achieved with acceptable morbidity in children with thalamic tumors by employing DTI, neuro-navigation and IOM. Maximal tumor resection was a relevant clinical factor affecting OS; therefore, it should be considered the initial therapeutic option for pediatric thalamic tumors.

• Journal of Power Electronics
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• 제4권1호
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• pp.28-38
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• 2004

In this paper, the position control of a detuned indirect field oriented control (IFOC) induction motor drive is studied. A proposed Simple-Neuro-Controllers (SNCs) are designed and analyzed to achieve high-dynamic performance both in the position command tracking and load regulation characteristics for robotic applications. The proposed SNCs are trained on-line based on the back propagation algorithm with a modified error function. Four SNCs are developed for position, speed and ｄ-ｑ axes stator currents respectively. Also, a synchronous proportional plus integral-derivative (PI-D) two-degree-of-freedom (2DOF) position controller and PI-D speed controller are designed for an ideal IFOC induction motor drive with the desired dynamic response. The performance of the proposed SNCs and synchronous PI-D 2DOF position controllers for detuned field oriented induction motor servo drive is investigated. Simulation results show that the proposed SNCs controllers provide high-performance dynamic characteristics which are robust with regard to motor parameter variations and external load disturbance. Furthermore, comparing the SNC position controller with the synchronous PI-D 2DOF position controller demonstrates the superiority of the proposed SNCs controllers due to attain a robust control performance for IFOC induction motor servo drive system.

• 생약학회지
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• 제48권1호
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• pp.31-37
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• 2017

Glutamate-induced oxidative stress results in neuro-degenerative disorders in many central nervous system (CNS) such as Alzheimer's disease, ischemia, Huntington's disease, and Parkinson's disease. Our study was performed to investigate neuroprotective effects of Allium hookeri extracts (leaf, root, and whole) on glutamate-induced HT22 cells. In this study, ethanol extract of A. hookeri showed the outstanding neuroprotective effect in HT22 cells. In addition, we found that ethanol extract of A. hookeri root increased heme oxygenase (HO)-1 in HT22 cells. Moreover, ethanol extract of A. hookeri root also upregulated nuclear accumulation of nuclear factor E2-related factor 2 (Nrf2) in HT22 cells. These results demonstrate that ethanol extract of A. hookeri root contributes neuroprotective effects against glutamate-induced oxidative stress in HT22 cells, via Nrf2-mediated HO-1 expression. Our study suggests that ethanol extract of A. hookeri root could be the potential agent for the treatment of many neuro-degenerative diseases.

• 한국지능시스템학회논문지
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• 제14권5호
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• pp.533-538
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• 2004

본 논문은 뉴로-퍼지 모델의 구조 학습을 이용하여 단기 전력 수요 예측시스템을 개발하기 위한 체계적인 방법을 제안한다. 제안된 단기 수요 예측시스템은 1시간, 24시간, 168시간의 예측 리드 타임을 갖고 예측을 수행하기 위해서 요일 유형과 시간 별로 총 96개의 초기 구조를 미리 생성하고, 이를 초기 구조 뱅크에 저장한다. 예측이 수행되는 시점에 해당하는 초기구조를 선택하여 뉴로-퍼지 모델을 초기화하고, 학습하고, 예측을 수행한다. 제안된 예측시스템은 단지 2개의 입력 변수만을 이용하기 때문에 간단한 모델 구조를 가질 뿐 아니라 학습된 퍼지 규칙을 해석하는 것이 매우 용이하다는 장점을 갖는다. 제안된 방법의 실효성을 검증하기 위해 1996년과 1997년의 한극전력의 실제 전력 수요 데이터를 이용하여 1시간, 24시간, 168시간 앞의 전력 수요를 예측하는 모의 실험을 수행한다. 실험 결과 제안된 방법은 단지 2개의 입력 변수를 사용함에도 불구하고, 기존의 예측 방법과 비교하여 예측의 정확도와 신뢰도 측면에서 우수한 성능을 얻는다.

• 대한의용생체공학회:의공학회지
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• 제25권1호
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• pp.5-10
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• 2004

체동은 수면 분석에 있어서 중요한 변수중의 하나이다. 본 연구에서는 수면 중에 발생하는 체동을 비접촉 방식으로 검출하기 위하여 4채널의 써모파일 검출기를 구현하였으며, 써모파일 센서를 이용한 방식의 체통 검출 가능성을 확인하기 위해 열적외선 카메라를 통해 획득한 영상을 써모파일의 수학적 모델에 적용하였다 합성된 체동 신호는 Haar 웨이브렛을 이용하여 변환함으로써 체통이 발생한 시점과 움직임의 크기를 상체 및 하체로 나누어 순간 체동을 검출하였다. 또한 뉴로-퍼지 알고리즘인 ANFIS를 이용하여 발생한 체동이 상체만 움직인 것인지 또는 하체만 움직인 것인지 또는 몸 전체가 움직인 것인지에 대한 부위별 체동을 검출하였고, 총 3명의 피험자에 대해 60분간의 데이터를 획득하여 실험한 결과 순간 체동과 부위별 체통에 대해 각각 평균 96.3％와 39.2％ 의 검출률을 나타냈다.

• Journal of International Society for Simulation Surgery
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• 제2권2호
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• pp.58-63
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• 2015

Image-guided neurosurgery (IGN) is a technique for localizing objects of surgical interest within the brain. In the past, its main use was placement of electrodes; however, the advent of computed tomography has led to a rebirth of IGN. Advances in computing techniques and neuroimaging tools allow improved surgical planning and intraoperative information. IGN influences many neurosurgical fields including neuro-oncology, functional disease, and radiosurgery. As development continues, several problems remain to be solved. This article provides a general overview of IGN with a brief discussion of future directions.

• 대한토목학회논문집
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• 제32권2D호
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• pp.137-145
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• 2012

경찰청 발표 자료에 따르면 2010년 우리나라에서 발생한 교통사고 건수는 226,878건으로 전체 교통사고 중 교차로가 차지하는 비중이 44.8%로 교차로 사고는 교통사고 중 많은 부분을 차지하고 있다. 이 중 신호교차로 교통사고에 대한 연구는 지속적으로 이루어지고 있는 반면에 비신호교차로에 대한 연구는 아직 부족한 실정이다. 본 연구는 환경적 요인으로 퍼지적 성격을 가진 교통량, 차로폭, 시거를 입력변수로 비신호교차로에서의 사고건수예측을 위한 ANFIS(Adaptive Neuro-Fuzzy Inference System) 모형을 구축하였다. 이렇게 구축된 모형의 예측력은 검증자료를 이용한 실측치와 추론치를 비교함으로써 평가되었다. 본 모형의 예측력은 결정계수인 $R^2$와 평균절대오차(MAE), 평균제곱근오차(MSE)를 통하여 적합성을 평가하였으며, 이들은 각각 평가 결과 0.9817, 0.4773, 0.3037로 나타나 모형의 설명력이 우수한 것으로 평가된다. 본 연구의 비신호 교차로 사고예측분석 연구결과는 비신호교차로의 안전 대책 수립 및 교통사고 개선사업을 위한 기초자료를 제공할 것으로 사료된다.

• 반도체디스플레이기술학회지
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• 제12권2호
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• pp.57-61
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• 2013

This paper presents adaptive neuro-fuzzy inference based defect detection method for various defect types, such as micro-crack, fingerprint and contamination, in heterogeneously textured surface of polycrystalline solar wafers. Polycrystalline solar wafer consists of various crystals so the surface of solar wafer shows heterogeneously textures. Because of this property the visual inspection of defects is very difficult. In the proposed method, we use local binary feature and fuzzy reasoning for defect detection. Experimental results show that our proposed method achieves a detection rate of 80%~100%, a missing rate of 0%~20% and an over detection (overkill) rate of 9%~21%.

• 한국산학기술학회논문지
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• 제15권4호
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• pp.2436-2442
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• 2014

본 연구는 상대습도 50[RH%], 조도 1,000[Lux] 및 기류 속도 0.02[m/sec]의 동일한 조건의 항온 항습실에서 온도를 18, 23, 25, 28 및 $31[^{\circ}C]$로 변화를 주어 EEG, HRV 및 바이브라이미지를 비교 분석하였다. 실험 결과, 온도 $25[^{\circ}C]$에서 상대 $M{\alpha}$파, 상대 $M{\beta}$파, $\frac{SMR}{\theta}$ 및 SDNN은 활성화되었으며, ${\alpha}$파의 비대칭지수 $A_2$, HRT, 스트레스지수 및 피로도는 감소하였다. 따라서, 온도 $25[^{\circ}C]$가 쾌적성, 생산성 및 집중력 등과 같은 뉴로에너지 향상에 효과적인 것을 알 수 있었다.

• Journal of Korean Neurosurgical Society
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• 제63권1호
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• pp.80-88
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• 2020

Objective : Stent-assisted coil embolization (SAC) is commonly used for treating wide-neck intracranial aneurysms. In this study, we aimed to assess the clinical safety and efficacy of the NeuroForm Atlas Stent during SAC of intracranial aneurysms. Methods : We retrospectively analyzed data from patients with ruptured and unruptured cerebral aneurysms, who underwent SAC using the NeuroForm Atlas between February 2018 and July 2018. Favorable clinical outcomes and degree of aneurysm occlusion were defined as a modified Rankin scale score of ≤2 and a Raymond-Roy occlusion classification (RROC) class I/II during the immediate postoperative period and at the 6-month follow-up, respectively. Results : Thirty-one consecutive patients with 33 cases, including 11 ruptured and 22 unruptured cases were treated via NeuroForm Atlas SAC. Among the 22 unruptured cases with 24 unruptured aneurysms had favorable clinical outcome. Complete occlusion (RROC I) was achieved in 16 aneurysms (66.7%), while neck remnants (RROC II) were observed in six aneurysms (25%). Among the 11 patients with ruptured aneurysms, two died due to re-bleeding and diabetic ketoacidosis. In ruptured cases, RROC I was observed in eight (72.7%) and RROC II was observed in three cases (27.3%). At the 6-month follow-up, no clinical events were observed in the 22 unruptured cases. In the ruptured nine cases, five patients recovered without neurologic deficits, while four experienced unfavorable outcomes at 6 months. Of the 29 aneurysms examined via angiography at the 6-month follow-up, 19 (65.5%) were RROC I, eight (27.6%) were RROC II and two (6.9%) were RROC III. There were no procedure-related hemorrhagic complications. Conclusion : In this study, we found that stent-assisted coil embolization with NeuroForm Atlas stent may be safe and effective in the treatment of wide-neck intracranial aneurysms. NeuroForm Atlas SAC is feasible for the treatment of both ruptured and unruptured wide-neck aneurysms.