• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2005.10a
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• pp.231-234
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• 2005

The high temperature deformation behavior of AZ 31 Mg alloy was investigated by designing a back propagation neural network that uses a gradient descent-learning algorithm. A neural network modeling is an intelligent technique that can solve non-linear and complex problems by learning from the samples. Therefore, some experimental data have been firstly obtained from continuous compression tests performed on a thermo-mechanical simulator over a range of temperatures $(250-500^{\circ}C)$ with strain rates of $0.0001-100s^{-1}$ and true strains of 0.1 to 0.6. The inputs for neural network model are strain, strain rate, and temperature and the output is flow stress. It was found that the trained model could well predict the flow stress for some experimental data that have not been used in the training. Workability of a material can be evaluated by means of power dissipation map with respect to strain, strain rate and temperature. Power dissipation map was constructed using the flow stress predicted from the neural network model at finer Intervals of strain, strain rates and subsequently processing maps were developed for hot working processes for AZ 31 Mg alloy. The safe domains of hot working of AZ 31 Mg alloy were identified and validated through microstructural investigations.

• Geomechanics and Engineering
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• v.1 no.1
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• pp.75-84
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• 2009

Artificial neural networks (ANNs) are a new type of information processing system based on modeling the neural system of human brain. The prediction of swell pressures from easily determined soil properties, namely, initial dry density, initial water content, and plasticity index, have been investigated by using artificial neural networks. The results of the constant volume swell tests in oedometers, performed on statically compacted specimens of Bentonite-Kaolinite clay mixtures with varying soil properties, were trained in an ANNs program and the results were compared with the experimental values. It is observed that the experimental results coincided with ANNs results.

• Animal cells and systems
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• v.6 no.1
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• pp.69-74
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• 2002

Recent evidence has suggested that trunk neural crest cell generally assumed to have equivalent differentiation potentials, demonstrate differentiation bias along the anterior/posterior axis. In amphibian and fish, neural crest cells give rise to three chromatophore types, melanophores, xantho-phores, and iridophores. Each pigment cell type has distinct characteristics but there is speculation about the cellular plasticity that exists among them. Neural crest cells migrate along specific routes, ventromedially and dorsolaterally. Neural crest cells that travel dorsolaterally are the first cells to begin migration in the axolotl and are the major contributors to the visible pigment pattern. Many factors and mechanisms that are responsible for guiding migratory neural crest cells along potential pathways or determining their fate remain unknown. A single lineage of the crest, which becomes restricted to one of the three pigment cell types, gives us the opportunity to examine the existence of neural crest stem cell populations and cellular plasticity. Study presented here showed results from recent in vitro studies designed to identify parameters influencing differentiation events of individual neural crest-derived pigment cell lineages. Melanophore production from neural crest explants originating from different levels along the anterior/posterior axis of wild type-axolotl embryos were compared and demonstrate that the differentiation of melanophores is enhanced in subpopulation of neural crest treated with forskolin. Forskolin (an adenylate cyclase activator) increases intracellular CAMP concentration and eventually activates the protein kinase-A signaling pathway. Melanophore number, melanin content, and tyrosinase activity in explants taken from the anterior-most region of the crest increased significantly in response to forskolin treatment. This study suggests implications of region specific influences and developmental regulation in the development of pigment pattern.

• The Journal of Korean Physical Therapy
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• v.16 no.2
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• pp.90-98
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• 2004

Traumatic brain injury is an insult to the brain caused by an external physical force, that may product a diminished or altered state of consciousness, which results in impairment of cognitive abilities or physical function. The purposes of this study were to overview injury mechanism and neural plasticity of traumatic brain injury. Injury mecanism includes exitotoxicity, production free radical, inflammation and apoptosis. Furthermore traumatic brain injury has protective mechanisms includes production of neural growth factor, heat shock protein, anti-inflammatory cytokines.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2004.08a
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• pp.145-152
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• 2004

The flow stress value was calculated by comparing predicted and measured roll force. Using basic on-line roll force model and logged mill data the flow stress equation of high strength steel for automobile was derived. The flow stress equation consists of the flow stress equation of carbon steel and flow stress factor calculated by neural network with input parameters not only carbon contents, strip temperature, strain, and strain rate, but also compositions such as Mn, p, Ti, Nb, and Mo. Using the flow stress equation and basic roll force model, precision roll force model of high strength steel for automobile was derived. Using test set of logged mill data the flow stress equation was verified.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 1999.08a
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• pp.429-437
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• 1999

Width variation of the top and bottom ends of steel at finishing rolling in a plate, has been investigated. It was found that width variation after finishing rolling is affected by edging, broadside rolling ratio, longitudinal rolling ratio, width shape after broadside rolling, temperature, width-to-thickness ratio, and so on. A neural network modelling of back propagation has been conducted on the width variation during rolling. Based on these prediction models, a width control system, by which the roll opening and closing of the hydraulic AWC edger can be adjusted during edge rolling in finishing rolling passes, has been developed. Compared to conventional width model, the neural network model is much accurate in a model. The width control system is applied to a newly built production mill.

• Biomolecules & Therapeutics
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• v.26 no.2
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• pp.93-100
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• 2018

Carbon monoxide (CO) is a gaseous molecule produced from heme by heme oxygenase (HO). Endogenous CO production occurring at low concentrations is thought to have several useful biological roles. In mammals, especially humans, a proper neurovascular unit comprising endothelial cells, pericytes, astrocytes, microglia, and neurons is essential for the homeostasis and survival of the central nervous system (CNS). In addition, the regeneration of neurovascular systems from neural stem cells and endothelial precursor cells after CNS diseases is responsible for functional repair. This review focused on the possible role of CO/HO in the neurovascular unit in terms of neurogenesis, angiogenesis, and synaptic plasticity, ultimately leading to behavioral changes in CNS diseases. CO/HO may also enhance cellular networks among endothelial cells, pericytes, astrocytes, and neural stem cells. This review highlights the therapeutic effects of CO/HO on CNS diseases involved in neurogenesis, synaptic plasticity, and angiogenesis. Moreover, the cellular mechanisms and interactions by which CO/HO are exploited for disease prevention and their therapeutic applications in traumatic brain injury, Alzheimer's disease, and stroke are also discussed.

• PNF and Movement
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• v.6 no.3
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• pp.37-51
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• 2008

Purpose : This paper focuses on the emerging concept that adult central nervous system neurogenesis can be regulated by various physical activity, enriched environment, and pathological conditions. Neurogenesis-the production of new neuron-is an ongoing process that persists in the adult brain of mammalian, including humans. Result : The adult brain was thought be limited in its regenerative function. However, this concepts changed, recent evidence of neurogenesis in certain adult brain areas such as SVZ(subventricular zone) and SGZ(subgranular zone) in hippocampus, raised possibility for improved treatment for patient with stroke. Neural plasticity has an adaptive purpose, because an ability of the brain to change in response to peripheral stimulation, physical activity, experience, and injury. Conclusions : The major function of the neurogenesis in adult brain seems to be replacing the neuron that die regularly in discrete adult brain regions. These cells are capable of functionally integrating into neighboring neural cells, and reconnecting to the correct neural networks. This review suggest that various intervention, including physical activity, voluntary movement training, skilled forelimb reaching training, and enriched environment, induced neural cell production in certain adult brain, and associated with functional recovery after stroke.

• PNF and Movement
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• v.6 no.2
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• pp.39-50
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• 2008

Purpose : This article reviewed the advances in the understanding of the effect of motor rehabilitation and brain plasticity on functional recovery after CNS damage. Methods : This is literature study with Pubmed, Medline and Science journal. Results : The inability of CNS neurons to regenerate is largely associated with nonneuronal aspects of the CNS environment. Especially, this neuronal growth inhibition is mediated by myelin associated glycoprotein, olygodendrocyte-myelin glycoprotein, and NOGO. Enriched environment, motor learning, forced limb use have been utilized in scientific studies to promote functional reorganization and brain plasticity. Especially, enriched environment and motor enrichment may prime the brain to respond more adaptively to injury, in part by expressed neurotrophic factors. Conclusions : These reviews suggest that activity-induced neural plasticity occur in damaged brain areas in order to functional reorganization, where it could contribute to motor recovery, and represent a target for stroke rehabilitation.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2009.10a
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• pp.76-79
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• 2009

The current understanding for phase/grain boundary sliding and low-temperature/high-strain rate superplasticity of two-phase titanium alloys is summarized. The quantitative analysis on boundary sliding revealed increased sliding resistance on the order of $\alpha/\beta\;\ll\;\alpha/\alpha\;\approx\;\beta/\beta$ boundary, hence, led to the conclusion that approximately 50% alpha(or beta) volume fraction and/or grain refinement is beneficial for obtaining large superplastic elongation at low temperature and/or high strain rate. To predict the temperature for 50% alpha volume in various alpha/beta Ti, artificial neural network was applied. Finally, much enhanced superplasticity was achieved through grain refinement utilizing dynamic globularization.