• IMMUNE NETWORK
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• 제6권4호
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• pp.185-191
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• 2006

Background: Based on outstanding progresses in animal experiments, vaccines for some human tumors have been developed. However, clinical effects of these vaccines have been far below than expected. This discrepancy might come from differences between animal models and human patients with respect to immunocompetency. The immune status of mice after tumor inoculation has not been well studied, which make us cautious in interpreting and applying the results from mice to human. We evaluated cell-mediated immune responses in mice after tumor cell inoculation. Methods: Mice were inoculated with TA3Ha, CT26, or 4T1. Delayed-type hypersensitivity (DTH) responses were induced 2-4 weeks after inoculation using 2,4-dinitro-1-fluorobenzene as an antigen. The relationships between the severity of DTH responses and the duration of tumor inoculation or the size of tumor mass were analyzed. Results: In T A3Ha groups, DTH response was elevated 2 weeks after inoculation, but depressed after 4 weeks, compared to the control group. When analyzed based on the sizes of tumor masses elicited, DTH responses were inversely related to the mass size, especially in those greater than 10 mm in diameter. In CT26 groups, while the duration after inoculation did not affect the severity of DTH responses, those with large mass showed depressed responses regardless the duration of inoculation. 4T1 cells grew so slowly that the size of tumor mass was small even 4 weeks after inoculation, and this group showed much higher DTH responses compared to that of tumor-free group. Conclusion: At least in an experimental setting where tumor model was induced by inoculating tumor cell lines into immunologically competent mice, the host immune response was elevated in early stage, and then depressed in late stage when the mass grew over a critical size.

• 상하수도학회지
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• 제26권5호
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• pp.669-683
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• 2012

The water supply pipes are buried across wide range of areas, so it is hard to spot them using excavation and takes a large amount of expense. Thus, there is a high risk for direct research and application, accompanying many difficulties in implementation of them. Therefore, it is more economical and convenient to use indirect evaluation variables than direct evaluation of the buried pipes in assessing the degree of pipe deterioration. To assess the degree of pipe deterioration using the indirect evaluation variables, it should be done first to identify how and to what extent they affect the degree of deterioration. This study measured the evaluation variables for pipe deterioration using the pipe endoscope and analyzed the measurement results and the degree of impact on the pipes. In addition, this study attempted to evaluate the adequateness of the pipe deterioration evaluation using the indirect variables based on the analysis results. The evaluation variables measured through the pipe endoscope were the thickness of sediments, size of scale, degree of desquamation and condition of connections. For the indirect evaluation variables, the data such as the property data from GIS pipe network map as well as the material, diameter, age and pipe lining material of the pipe, road type, leakage frequency, average water velocity and water pressure using the leakage repair records was collected. Using the collected data, this study comparatively analyzed the indirect evaluation variables for the degree of pipe deterioration and the results from the pipe endoscope to choose appropriate variables for pipe deterioration evaluation and calculated the weights of the indirect variables on the degree of deterioration. The results showed that the order of the impact of indirect variables on deterioration was pipe age > pipe lining material > road type > leakage frequency > average water velocity with their weights of 0.45, 0.20, 0.15, 0.10, and 0.10, respectively. Conclusively, the results suggest that the measures of sediment thickness, scale size, degree of desquamation and condition of connections are appropriate for the evaluation of pipe deterioration and sufficient for the analysis of the impact of the indirect variables on deterioration.

• Archives of Plastic Surgery
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• 제35권1호
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• pp.28-35
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• 2008

Purpose: The pedicle of transverse rectus abdominis myocutaneous(TRAM) flap and deep inferior epigastric arterial perforator flap is deep inferior epigastic artery (DIEA) and accurate anatomic knowledge about perforator of DIEA is very important for the elevation of these flap. The authors investigated a detailed vascular network of perforator of DIEA in Koreans. Methods: 24 fresh cadavers were studied. Among them, 15 were examined based on the plain X-ray examination for the distribution and location of perforator of DIEA. And 9 fresh cadavers were examined based on the 3-dimensional computed tomography(CT) study for the distance between ending point of perforator of DIEA and mother artery, the distance between most medial mother artery and midline, the distance between most lateral mother artery and midline, and the running type of perforators of DIEA. Results: Based on the plain X-ray examination, suitable(external diameter$${\geq_-}0.5mm$$) perforators of DIEA are located between the level of umbilicus and 8 cm below it. Based on the 3D-CT study, average distance between the ending point of perforator of DIEA and the mother artery is 30.26 mm on the left, 28.62 mm on the right, respectively. The average distance between most medial mother artery and midline is 17.13 mm on the left, 15.76 mm on the right, respectively. The average distance between most lateral mother artery and midline is 56.31 mm on the left, 50.90 mm on the right, respectively. The main running course of suitable perforators of DIEA is type a, which is a direct musculocutaneous perforator vessel from main vascular axis passing outward to join the subdermal plexus, directly. Conclusion: 3-dimensional computed tomography study as well as plain X-ray examination provided more accurate and detail informations about perforators of DIEA in Koreans. These informations will help us understand the detailed vascular anatomy and operation with ease and safe in the lower abdomen of Koreans.

• 대한약침학회지
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• 제19권3호
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• pp.197-206
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• 2016

Introduction: This study aims to investigate the effects of acupuncture stimulation on the radial artery's pressure pulse wave, along with various hemodynamic parameters, and to explore the possible underlying mechanism of pulse diagnosis in healthy participants in their twenties. Methods and analysis: This study is a prospective, single-arm, exploratory clinical study. A total of 25 healthy participants, without regard to gender, in their twenties will be recruited by physicians. Written informed consent will be obtained from all participants. The participants will receive acupuncture once at ST36 on both sides. The radial arterial pulse waves will be measured on the left arm of the subjects by using an applicable pulse tonometric device (KIOM-PAS). On the right arm (appearing twice), electrocardiogram (ECG), photoplethysmogram (PPG), respiration and cardiac output (CO) signals, will be measured using a physiological data acquisition system (Biopac module), while the velocity of blood flow, and the diameter and the depth of the blood vessel will be measured using an ultrasonogram machine on the right arm (appearing twice). All measurements will be conducted before, during, and after acupuncture. The primary outcome will be the spectral energy at high frequencies above 10 Hz ($SE_{10-30Hz}$) calculated from the KIOM-PAS device signal. Secondary outcomes will be various variables obtained from the KIOM-PAS device, ECG, PPG, impedance cardiography modules, and an ultrasonogram machine. Discussion: The results of this trial will provide information regarding the physiological and the hemodynamic mechanisms underlying acupuncture stimulation and clinical evidence for the influence of acupuncture on the pressure pulse wave in the radial artery. Ethics and dissemination: This study was approved by the Institutional Review Board (IRB) of Kyung Hee University's Oriental Medical Center, Seoul, Korea (KOMCIRB-150818-HR-030). The study findings will be published in peer-reviewed journals and presented at national and international conferences. Trial registration number: This trial was registered with the Clinical Research Information Service (CRIS) at the Korea National Institute of Health (NIH), Republic of Korea (KCT0001663), which is a registry in the World Health Organization's (WHO's) Registry Network.

• 환경정책연구
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• 제11권2호
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• pp.3-16
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• 2012

국토환경성평가지도는 종합적인 환경정보를 이용하여 환경적 가치를 평가한 지도로서 친환경적인 토지이용 및 관리를 유도하기 위해 제작되었다. 2001년 평가항목 및 평가기준에 대한 연구를 시작으로 2003년부터 2005년까지 전국 국토환경성평가지도가 제작되었으며, 국토환경의 변화를 반영하여 매년 지도를 갱신하고 있다. 이처럼 지도의 정확도 개선을 위해 매년 타당성 연구를 기반으로 평가기준을 변경하였기 때문에 동일한 기준으로 국토의 환경성을 평가할 수 있는 모니터링 지표로서 국토환경성평가지도를 활용하기에 한계가 있는 상황이다. 따라서 본 논문은 2005년부터 현재까지 국토환경성평가지도에 사용된 데이터를 현재 평가기준으로 재평가하여 6년 동안의 국토환경성평가지도 변화 내역을 분석하고, 본 지도가 국토환경 모니터링 지표로 활용될 수 있는지 검토하였다. 분석 결과 국토환경성평가 1등급 지역은 꾸준히 증가하는 것으로 나타났다. 이러한 등급 변화는 10년 단위로 갱신되는 4차 임상도 갱신(2008), 백두대간 보호지역 등 신규 법정 보호지역 반영(2010), 광역생태축 등 환경생태적 평가항목 자료 추가(2009) 등에 의한 것으로 분석되었다. 이는 국토환경성평가지도가 산림지역의 지속적인 관리로 인한 영급 증가, 신규 환경생태적 보전지역 추가 지정 등과 같은 개별적인 환경지표를 통합적으로 평가하고 있다는 것을 의미한다. 따라서 지속적인 국토환경성평가지도 제작은 국토환경 및 정책 변화의 통합 모니터링 지표로서 활용 가능성이 높다. 향후 국토환경성 평가지도가 보다 정확한 모니터링 자료로 활용되기 위해서는 평가항목으로 활용되는 환경 주제도의 정확도 확보, 갱신주기 단축이 요구된다.

• 환경정책연구
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• 제12권3호
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• pp.21-47
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• 2013

GCI(Geospatial Correlative Integration) 중 Frequency ratio 모델을 적용하여 2006년 태풍 에위니아에 의하여 발생한 강원도 인제 가리산리 지역의 산사태 취약성도를 작성하였다. 또한 연구지역의 미래 확률강우량을 적용하여 미래 목표연도별 산사태 취약성도를 작성하였다. 산사태 취약성와 관련된 요인으로는 기후노출은 확률강우량, 민감도는 지질, 지형도(경사, 경사방향, 곡률도), 토양도(토양 지형, 토질, 토양 배수, 토양 모재 및 유효토심) 및 적응능력으로 는 임상도(영급, 경급, 소밀도 및 수종) 등을 GIS 기반의 공간 데이터베이스로 구축하였다. 전체 산사태 발생 위치는 470개소며 이 중 50%는 Frequency ratio 및 Neural network 모델의 산사태 발생 지역으로 적용하였으며, 나머지 50%는 취약성도 검증에 활용하였다. 산사태 발생 강우량 임계치는 3일 누적 449mm로 적용하였다. 확률강우량은 1973년부터 2006년까지의 실측 강우량을 정리하여 2106년까지 목표연도별(1년, 3년, 10년, 50년 및 100년) 산사태 취약성도를 작성하였다. 연구결과 연구지역은 경사도가 다른 항목에 비하여 산사태 발생에 높은 가중치를 나타냈으며 경사도 항목의 세부 항목의 산사태 발생과의 상관관계에서는 경사도 $25{\sim}30^{\circ}C$인 지역이 높은 상관관계를 나타냈다. 또한 강우량의 증가에 의하여 미래 산사태 발생 가능성이 매우 높은 지역이 2006년을 기준으로 2100년까지 약 110% 증가하였다. 앞으로 강우량의 변화에 의한 산사태 위험성 분석에 한 축을 차지할 수 있다는 점에서 중요성이 있다. 기존에 확률강우량 변화에 따른 산사태 발생의 불명확한 관계를 정량적으로 분석하였으며, 미래 기후변화 예측결과를 반영한 연구지역 내 산사태 발생 변화를 시-공간적으로 산정하고, 기존 산정 결과와의 비교를 통해, 향후 기후 변화를 고려한 국내 산사태 관리 방안 수립을 위한 방향을 제시하기 위한 연구라고 할 수 있다. 앞으로 분석모델의 고도화 방안 및 현장조사가 추가된다면 보다 정량적으로 기후변화와 산사태의 상관관계를 파악할 수 있으며, 산사태의 전반적인 관리 및 효율적인 운영 체제 구축을 위하여 기여할 수 있다는 점에서 그 중요성이 있다.