• 대한세포병리학회지
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• 제6권2호
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• pp.148-155
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• 1995

Urinary cytology has become an essential element in the diagnosis and management of transitional ceil carcinoma(TCC) of the urinary tract. It has the advantage of being noninvasive, inexpensive, and easily accessible. Besides that it can even detect malignancy when unsuspected at cystoscopy. We report a retrospective review of urine cytology un the diagnosis of 83 TCC cases that underwent 295 cytologic evaluation. All patients had biopsy-proven TCC of the bladder, ureter and renal pelvis, The overall incidence of the positive cytology cases was 66.2%. To define the cytologic features of tumor cells, we tried to use three cytologic gradings such as "grade 1", "grade 2", and "grade 3" according to the cytologic degree of anaplastic neoplastic cells. These cytologic gades of TCC were relatively well correlated with the histologic grade and tumor invasiveness. This result suggests that the recognition of characteristic cellular features of TCC can suspect the histologic grade and tumor stage. The false negative TCC cases were 78.9%. They showed severe inflammatory or bloody background and a few neoplastic cells. Therefore, a cautious approach for accurate interpretation, personal experience, and proper fixation and processing could expand the role of urinary cytology.

• 대한세포병리학회지
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• 제10권2호
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• pp.185-189
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• 1999

The diagnosis of peripheral T cell lymphoma is difficult due to the varying size and shape of the neoplastic lymphoid cells and the frequent admixture of nonneoplastic mature lymphyocytes, histiocytes, eosinophils, and plasma cells. We report a case of peripheral T cell lymphoma, lymphoepithelioid ceil type, which was difficult to differentiate from tuberculous lymphadenitis due to the aggregates of epithelioid histlocytes mimicking granuloma and the past history of pulmonary tuberculosis. Fine needle aspiration cytology of the inguinal lymph node in a 63-year-old male was characterized by hypercellular aspirates composed of a mixture of small and intermediate-size lymphoid cells and large lymphoid cells with background of confluent epithelioid histiocytes. The neoplastic lymphocytes demonstrated significant nuclear irregularity with protrusion and indentations of the nuclear membrane, prominent nucleoli, and frequent mitotic figures. The diagnosis of peripheral T cell lymphoma was confirmed by histological and immunohistochemical studios.

• 한국임상수의학회지
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• 제35권4호
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• pp.141-143
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• 2018

A 6-year-old spayed female Turkish Angora cat presented with sneezing, nasal discharge, and decreased appetite lasting for 21 days. Skull radiography revealed slightly increased density of soft tissue in the left nasal cavity. Computed tomography (CT) scan revealed an extensive mass with nasal septum destruction and moderate contrast enhancement in the left nasal cavity. After surgical biopsy, histopathological examination confirmed that the mass was an infiltrative round cell neoplasm, composed of sheets of large neoplastic cells. Immunohistochemical analysis revealed that most of the neoplastic cells were strongly positive for CD79a and weakly positive for PAX5. Additionally, numerous mature lymphocytes were found to be positive for CD3. This is the first reported case of nasal diffuse large B-cell lymphoma (DLBCL) in a Turkish Angora cat in Korea.

• 한국수의병리학회지
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• 제3권1호
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• pp.55-59
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• 1999

Metastatic squamous cell carcinoma was described in two female Pere David's deer reared at Everland zoo. Both deer with chronic emaciation had the mass on right maxilla(9$\times$11$\times$15cm or 20$\times$17cm) which was composed of miliary tan creamy contents and encapsulated by connective tissue. The undulating contents in the mass was a1so extended in the underlying or adjacent soft palate, maxillary and frontal sinus causing severe bone destruction. In one deer, two fistula were also noted in the right periocular area. Histologically, the neoplastic masses of both deer consist of anastomosing cords or nests of squamous epithelial cells with intercellular bridge or keratin pearl formation. The neoplastic cells invade deep into the subcutis and bony tissue. Mitotic figure was rare. Multifocal areas of necrosis and hemorrhages were also noted in the dermis. Metastasis to maxilla and ethmoid bones and/or to submandibular lymph node was noted in both cases. The diagnosis was based on the results of histopathology.

• 대한의용생체공학회:의공학회지
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• 제15권4호
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• pp.419-427
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• 1994

본 연구는 인간의 갑상선 세포를 대상으로 암세포의 식별을 위하여 새로운 디지털 영상기술을 적용하여 해석한 것으로 이를 위하여 세포영상해석에 필요한 개선된 처리방법들을 제안하였다. 실험대상으로 정상세포와 암세포로 확진된 갑상선세포의 현미경 영상을 사용하였다. 세포영상으로부터 세포핵을 구분하기 위하여 기존의 방법을 개선한 방향각을 갖는 Contour Following법을 시도하여 세포핵의 영상을 매우 효과적으로 얻을 수 있음을 입증하였고, 세포핵의 특징추출을 위하여 16개의 특징파라미터들을 사용하였고 식별율을 높이기 위하여 우세특징파라미터를 선택하여 식별을 향상을 꾀하였다. 실험 결과 평균 91.11%의 식별률을 얻음으로서 효과적으로 갑상선의 암세포를 식별할 수 있음을 증명하였다.

• 한국임상수의학회지
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• 제26권5호
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• pp.511-513
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• 2009

This report deals with a 3-year-old male Yellow-crowned Amazon (Amazona orcrocephala) that died after twenty five days history of cloacal prolapse. On necropsy, multiple to occasionally coalescing well-demarcated tan nodules were scattered throughout the entire liver lobes. The nodules were firm and slightly elevated from the surface. The neoplastic nodules were also recognized on cut sections of the liver. Histologically, the nepatic nodules consisted of cuboidal to low columnar cells forming tubular to acinar pattern with marked desmoplasia. The neoplastic cells had small to moderate amounts of eosinophilic cytoplasm and round nucleus with one to two prominent nucleoli. Based on these results, hepatic nodules was diagnosed as primary cholangiocellular carcinoma.

• 한국임상수의학회지
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• 제27권4호
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• pp.491-493
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• 2010

Granular cell tumor was described in a 7-year-old male Miniature Pinscher. Sublingual mass was surgically removed and submitted for diagnosis. The mass was about 1.8 cm in diameter, firm, tan, and ulcerated. On histopathology, the mass was unencapsulated and infiltrated adjacent tissue and consisted of nest or sheet of round to polygonal, and occasional spindle-shaped cells. The neoplastic cells contain large amount of eosinophilic granular materials in the cytoplasm. Immunohistochemically, the neoplastic cells were positive to neuron-specific enolase but were negative to S-100. The cytoplasmic eosinophilic granules were positive to PAS but were negative to PTAH methods. Based on these results, the mass was diagnosed as sublingual granular cell tumor. No recurrence or metastasis was noted so far since surgery.

• 한국임상수의학회지
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• 제19권4호
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• pp.450-454
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• 2002

A five-year-old, female Great Dane dog with edema, localized trauma, mild pain, and lameness of the right hind limb was referred to the Veterinary Medical Teaching Hospital of Chungbuk National University. This dog had a history of mammary tumor excisions 6 months ago. Abnormal changes were not seen in the values of complete blood count and serum biochemical tests. But pedal direct lymphangiography using aqueous-based radiographic agent showed the obstructed lymph flow in right popliteal lymph node. Based on these observations, the dog was suspected as lymphedema resulted from lymph drainage flilure without any other possibilities of inflammation or other causes. Although recommended chemotherapy and physiotherapy had been applied for resolvinr presented problems for one month, there was no improvement on edema of damaged region and any other clinical signs. Therefore, the necropsy was performed after euthanasia under agreement of the owner of patient. In histopatholofical examination, the most characteristic lesions in the mass of femoral region were diffuse edema fibrosis and neoplastic cells in the lymphatics. Also, the neoplastic cells were very similar to those found in the tumor mass of mammary gland, which had diagnosed as fibrosing carcinoma. These facts suggested that the cause of obstructed lymph flow was the neoplasia in lymphatics of the right hind limb. With these results, a diagnosis of malignant lymphedema was made in this dog.

• 대한수의학회지
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• 제49권1호
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• pp.63-66
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• 2009

Cutaneous leiomyomas (leiomyosarcomas) are smooth muscle tumors that occur single or as multiple lesions. They usually arise from the arrector pili muscles (piloleiomyomas) and less commonly from the muscle of veins (angioleiomyomas). This report describes histologic and immunohistochemical features of one cutaneous piloleiomyoma and two angioleiomyosarcomas. Three 7-12-year-old female dogs were presented with single or double cutaneous nodules. Histologically, the neoplastic masses were composed of densely or loosely arranged interlacing bundles. The neoplastic cells were ovoid to elongate, and had eosinophilic cytoplasms and perinuclear cytoplasmic vacuolation. Nuclei were central to eccentric, cigar shaped, oval to elongate. In two cases, high mitotic index in high power field, multifocal necrosis and local invasion were also noted. Masson's trichrome and van Gieson staining revealed muscle origin tumors in these cases. Immunohistochemically, the tumor cells were strongly positive for smooth muscle actin. In our best knowledge, this is the first report of cutaneous smooth muscle tumors in dogs in Korea.

• 치과방사선
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• 제26권2호
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• pp.109-120
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• 1996

Nine cases presented with a calcifying odontogenic cyst to the Dental Hospital of the College of Dentistry, Yonsei University. from January 1987 to September June, 1996, Clinical or histopathological findings were observed according to each radiologic criteria. The results obtained are as follows : 1. The male to female ratio was 2 : 1 with a mean age of 25 years. 2. The radiographic appearences of nine cases were well-defined radiolucent lesions in which eight cases were shown unilocular lesions and only one lesion was seen multilocular lesion. 3. Radiologically. three of nine cases were pure radiolucent lesions and others, six cases were radiolucent contained a variable amount of radiopaque material. 4. Histologically, two cases were classified simple cyst, five were cyst associated odonoma, two were neoplastic type. 5. Histological findings according to the radiological classification, two of three radiolucenct lesions were simple cysts; another was a cyst associated with odontoma. While, four of six radiologic mixed lesions turned out to be a cyst associated with odontoma, two was the neoplastic type.