• 대한소아치과학회지
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• 제11권1호
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• pp.103-112
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• 1984

Eighty children, aged from 2 years 8 months to 5 years 1 month old, were examined to study the relationship between the preschool children's response at dental visit and the influencing factors. The results were as follows: 1, There was no significant relationship between the sexes and the children's response. 2. Children who experienced the painful dental treatment demonstrated significantly more negative dental response. 3. Children who stowed negative dental behavior at last dental visit demonstrated significantly more negative dental response. 4. Children of mothers with high anxiety scores demonstrated significantly more negative dental response. 5, Children who were unpleasant at hospitaization demonstrated significantly more negative dental response. 6. Children who thought they had dental problems demonstrated significantly the most negative dental response. 7. Children who abhorred the medical treatment demonstrated significantly more negative dental response.

• BMB Reports
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• 제41권4호
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• pp.267-277
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• 2008

Insects mount a robust innate immune response against a wide array of microbial pathogens. The hallmark of the Drosophila humoral immune response is the rapid production of anti-microbial peptides in the fat body and their release into the circulation. Two recognition and signaling cascades regulate expression of these antimicrobial peptide genes. The Toll pathway is activated by fungal and many Gram-positive bacterial infections, whereas the immune deficiency (IMD) pathway responds to Gram-negative bacteria. Recent work has shown that the intensity and duration of the Drosophila immune response is tightly regulated. As in mammals, hyperactivated immune responses are detrimental, and the proper down-modulation of immunity is critical for protective immunity and health. In order to keep the immune response properly modulated, the Toll and IMD pathways are controlled at multiple levels by a series of negative regulators. In this review, we focus on recent advances identifying and characterizing the negative regulators of these pathways.

• Earthquakes and Structures
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• 제25권6호
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• pp.399-415
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• 2023

In this study, we investigate the use of a negative stiffness tuned inerter damper system to improve the performance of a base-isolated structure. The negative stiffness tuned inerter damper system consists of a tuned inerter damper connected in parallel with a negative stiffness element. To find the optimal parameters for the base-isolated structure with negative stiffness tuned inerter damper system, we develop an optimization method based on performance criteria. The objective of the optimization is to minimize the superstructure acceleration response ratio, while ensuring that the base displacement response ratio remains below a specified target value. We evaluate the proposed method by conducting numerical analyses on an eight-story building. The structure is modeled using both a simplified 3-degree-of-freedom system and a more detailed story-by-story shear-beam model. Lastly, a comparative analysis using time history analysis is performed to compare the performance of the base-isolated structure with negative stiffness tuned inerter damper system with that of the base-isolated structure and base-isolated structure with tuned inerter damper systems. The results obtained from the comparative analysis show that the negative stiffness tuned inerter damper system outperforms the tuned inerter damper system in reducing the dynamic seismic response of the base-isolated structure. Overall, this study demonstrates that the negative stiffness tuned inerter damper system can effectively enhance the performance of base-isolated structures, providing improved seismic response reduction compared to other systems.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.807-813
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• 2016

Triple-negative breast cancers constitute about 15% of all cases, but despite their higher response to neoadjuvant chemotherapy, the tumors are very aggressive and associated with a poor prognosis as well as a higher risk of early recurrence. This study was retrospectively performed on 101 patients with stage II and III invasive breast cancer who received 6-8 cycles of neo-adjuvant chemotherapy. Out of the total, 23 were in the triple negative breast cancer subgroup. Nuclear Ki-67 expression in both the large cohort group (n=101) and triple negative breast cancer subgroup (n=23) and its relation to the pathological response were evaluated. The purpose of the study was to identify the predictive value of nuclear protein Ki-67 expression among patients with invasive breast cancers, involving the triple negative breast cancer subgroup, treated with neoadjuvant chemotherapy in correlation to the rate of pathological complete response. The proliferation marker Ki-67 expression was highest in the triple negative breast cancer subgroup. No appreciable difference in the rate of Ki-67 expression in triple negative breast cancer subgroup using either a cutoff of 14% or 35%. Triple negative breast cancer subgroup showed lower rates of pathological complete response. Achievement of pathological complete response was significantly correlated with smaller tumor size and higher Ki-67 expression. The majority of triple negative breast cancer cases achieved pathological partial response. The study concluded that Ki-67 is a useful tool to predict chemosensitivity in the setting of neoadjuvant chemotherapy for invasive breast cancer but not for the triple negative breast cancer subgroup.

• Journal of Plant Biology
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• 제26권3호
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• pp.131-139
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• 1983

Temperature response of amoebae of thermotactic mutants have been investigated. Amoebae of the mutant strain HO 428 showed positive thermotaxs which is strong at lower temperaturs and drops sharply above the growth temperature of amoebae. The temperature response of HO 428 amoebae was not affected by the length of amoebae on the grdients. HO 596 amoebae seemed to have both positive and negative thermotactic responses shortly after food depletion. Longer exposure of these amoebae on the thermal gradients induced a stronger negative response at lower temperatures and an apparent positive response at higher temperatures. A similar changes could be observed in HO 1445 amoebae. Based on the steady positive thermotactic response by HO 428 amoebae and the mode of change in termperature response at higher temperatures, 24$^{\circ}C$ and $25^{\circ}C$, by HO 596 amoebae, a model for the temperature response of vegetative Dictyostelium discoideum amoebae, strain HL 50, has been proposed. The main features of the model are: a positive response at the thermal gradients with midpoint temperatures lower than the growth temperatures of amoebae and a negative response above it.

• 한국산업정보학회논문지
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• 제23권2호
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• pp.93-107
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• 2018

본 연구의 목적은 기업이 신제품의 실패로 인한 위기상황에서 실시하는 위기대응 전략에 대한 소비자의 부정적 구전에 대하여 알아보고자 한다. 이를 위해 가상의 기업을 사용하여 위기 시나리오 및 대응전략을 조작한 다음 실험을 실시하였다. 본 연구의 결과는 다음과 같다. 첫째, 대응유형 전략에 따르면, 위기 대응전략은 부정보다 사과를 실시하는 것이 부정적 구전을 더 완화시키는 것으로 나타났다. 둘째, 신제품 실패로 인한 위기 이전에 공익연계마케팅 활동을 실시한 회사는 소비자의 부정적 구전 완화에 더욱 효과적인 것으로 나타났다. 셋째, 기업이 실시하는 메시지 전략은 소비자의 부정적 구전에 영향을 미치지 않는 것으로 나타났다. 넷째, 위기대응전략과 공익연계 마케팅의 상호작용 효과는 유의하게 나타났지만 위기대응 전략과 메시지 전략 간의 상호작용효과는 유의하지 않은 것으로 나타났다.

• 한국조리학회지
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• 제22권6호
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• pp.61-70
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• 2016

The purpose of this study is to identify the effects of a company's response strategies (response type, communication style, and response sincerity) on customer's brand attitude and purchase intentions. A fictional Facebook fan page containing 6 separate scenarios was developed based on actual customer reviews and company responses observed on Facebook restaurant fan pages. Participants were recruited from Amazon's Mechanical Turk (MTurk). A total of 202 responses were obtained; 185 responses were analyzed after deleting insufficient responses. The results of MANOVA found that an accommodative response leads customers to have a more favorable attitude towards a brand and have stronger purchasing intentions. In addition, customers who perceive the company's response to a negative review as sincere are more likely to have a positive brand attitude and purchasing intentions, as compared to those who perceive it as either insincere or neutral.

• Archives of Pharmacal Research
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• 제11권1호
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• pp.65-73
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• 1988

The effects of clonidine on the negative chronotropic response induced by stimulation of vagus nerve were studied in the presence of propranolol in reserpinized and anesthetized rats. When the heart rate was decreased by stimulation of the vagus nerve, clonidine significantly inhibited vagally induced heart rate decrease (negative chronotropic response) in dose dependent manner. This inhibitory effect of clonidine was virtually abolished by phentolamine, ${\alpha}_1-\;and\;{\alpha}_2-adrenoceptor$ antagonist, and partially antagonized by prazosin, ${\alpha}_1-adrenoceptor$ antagonist. On the other hand, when the heart rate was decreased by the infusion of bethanechol, a muscarinic parasympathetic stimulant, clonidine had no effect on the bethanechol-induced heart rate decrease. These results suggest that clonidine inhibits vagally induced negative chronotropic response by activation of presynaptic ${\alpha}-adrenoceptors$ located on the parasympathetic cholinergic nerve terminal in the heart and this effect of clonidine is more related to ${\alpha}_2-adrenoceptors$ than ${\alpha}_1-adrenoceptors$.

• 한국전기전자재료학회논문지
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• 제13권4호
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• pp.332-336
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• 2000

We have developed a novel vertical-alignment(VA) -$\pi$ cell mode that provides a wide viewing angle and fast response times for nematic liquid crystal(NLC) with negative dielectric anisotropy on a homeotropic polymide(PI) surfaces. Good voltage-transmittance curves and low driving voltages were achieved with the new VA-$\pi$ cell mode without a negative compensation film. Iso-viewing angle characteristics using the new VA-$\pi$ cell mode without a negative compensation film was also successfully observed. As well a fast response time of 31.7 ms for a new VA-$\pi$ mode was measured. Consequently the iso-viewing angel fast response time and low driving voltage characteristics using a VA-$\pi$ cell can be achieved.

• 한국산학기술학회논문지
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• 제18권1호
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• pp.388-394
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• 2017

본 연구는 보건계열 대학생의 부정정서 극복력과 대학생활 스트레스, 스트레스 반응 관계에서 매개효과를 검증하고자 시행하였다. 연구의 방법으로는 경상남도 소재의 보건계열 대학생 284명을 대상으로 설문조사를 시행하였다. 자료의 분석은 SPSS 22.0 프로그램을 이용하여 빈도분석, 상관분석, 회귀분석을 실시하였다. 연구 결과는 다음과 같이 나타났다. 보건계열 학생의 부정정서 극복력은 평균 4.49로 나타났으며 대학생활 스트레스는 2.74로 나타났다. 스트레스 반응에 대해서는 공격성 반응이 1.76으로 가장 낮았고, 피로반응이 2.71로 가장 높았다. 부정정서 극복력과 스트레스 반응, 대학생활 스트레스의 관계를 상관분석 한 결과, 부정정서 극복력은 대학생활 스트레스, 스트레스 반응과 부적상관을 이루는 것으로 나타났다. 부정정서 극복력은 스트레스 반응을 완화시키는 과정을 통해 대학생활 스트레스를 해소하는 것으로 나타났으며 스트레스 반응 하위요인에서도 매개효과를 가지는 것으로 나타났다. 따라서 본 연구에서는 극복력은 대학생활 스트레스와 그에 따른 반응에 영향을 미치고 있는 것으로 보인다. 그러므로 보건계열 대학생 중 대학생활 스트레스에 노출되어 있는 학생에게는 부정정서 극복력이 스트레스 반응을 완화시키는 방법이 될 수 있으며, 스트레스 반응의 하위요인에 받는 적절한 스트레스 완화방법이 요구되어 진다.