• The Korean Journal of Physiology and Pharmacology
• /
• v.21 no.1
• /
• pp.133-140
• /
• 2017

Conflicting evidence has been obtained regarding whether transient receptor potential cation channels (TRPC) are store-operated channels (SOCs) or receptor-operated channels (ROCs). Moreover, the Ca/Na permeability ratio differs depending on whether the current-voltage (I-V) curve has a doubly rectifying shape or inward rectifying shape. To investigate the calcium permeability of TRPC4 channels, we attached GCaMP6s to TRPC4 and simultaneously measured the current and calcium signals. A TRPC4 specific activator, (-)-englerin A, induced both current and calcium fluorescence with the similar time course. Muscarinic receptor stimulator, carbachol, also induced both current and calcium fluorescence with the similar time course. By forming heteromers with TRPC4, TRPC1 significantly reduced the inward current with outward rectifying I-V curve, which also caused the decrease of calcium fluorescence intensity. These results suggest that GCaMP6s attached to TRPC4 can detect slight calcium changes near TRPC4 channels. Consequently, TRPC4-GCaMP6s can be a useful tool for testing the calcium permeability of TRPC4 channels.

• Korean Chemical Engineering Research
• /
• v.49 no.2
• /
• pp.263-270
• /
• 2011

The aim of this paper is, through the experiment of Lithium-Ammonia solutions $(Li(NH_3)_n)$, to analyze and verify a thermoelectric-conversion property at near Ammonia-boiling point ($-40^{\circ}C$). The experiment results show that the solutions with 0.58 MPM~1.87 MPM generate thermoelectric power at temperature difference $({\Delta}T=0{\sim}15^{\circ}C)$ where Current is constantly proportional to Voltage. This paper provides a new insight into the development of a thermoelectric material.

• Atmosphere
• /
• v.22 no.2
• /
• pp.175-186
• /
• 2012

In this study, we investigate the effects of elliptical shape of Asian dust particles on the estimation of aerosol optical depth by implementing T-matrix method into WRF/Chem Dust Model. The phase function calculated by assuming elliptical particle shape near $110{\sim}160^{\circ}$ of scattering angle showed about 20 times larger than that calculated by assuming spherical particle shape. Significant difference of extinction efficiency was found with an increase of size parameter and aspect ratio. From the simulations of two Asian dust events occurred on 1 April 2007 and 16 March 2010, we found that the difference of extinction efficiency between elliptical and spherical particle shape was about 5~8%. The aerosol optical depth calculated by assuming elliptical particle shape with 1.6, 1.4 and 1.2 of aspect ratio was about $4.0{\pm}0.5%$, $2.0{\pm}0.2%$, and $1.0{\pm}0.1%$ larger than those estimated by assuming spherical particle shape.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.25 no.6
• /
• pp.751-757
• /
• 2001

An experimental study of impinging jet-flow structure has been carried out for a fully developed single circular jet impingement cooling on a flat plate, and the effect of the wall thickness at nozzle exit edge is investigated. Impinging jet flow structures have been measured by Laser-Doppler Velocimeter to interpret the heat transfer results presented previously by Yoon et al.(sup)(10) The peaks of heat transfer rate are observed near the nozzle edge owing to the radial acceleration of jet flow when the nozzle locates close to the impingement plate. The growth of the velocity fluctuations in the wall jet flow is induced by the vortices which originate in the jet shear layer, and consequently the radial distribution of local Nusselt numbers has a secondary peak at the certain radial position. As a wall of circular pipe nozzle becomes thicker for small nozzle-to-target distance, the entrainment can be inhibited, consequently, the acceleration of wall jet flow is reduced and the heat transfer rate decreases.

• Bulletin of the Korean Chemical Society
• /
• v.35 no.8
• /
• pp.2453-2459
• /
• 2014

Five novel cyanine dyes containing julolidine and indole moieties were synthesized. Several color compensating films for plasma display panels (PDP) were prepared using these dyes. The spectroscopic and physicochemical properties of the synthesized dyes in both solution and film state were evaluated. For each color compensating film, the optimum ratio of dye to binder was determined on the basis of transmittance, half band width, and photo-stability of the color compensating film. The five synthesized dyes showed sharp absorption peaks near 590 nm (orange light) and had molar extinction coefficients above $1{\times}10^5M^{-1}cm^{-1}$. The melting point of the dyes was above $200^{\circ}C$ and photo-stability of the color compensating films was improved by introducing substituents at the 5th position on the indole derivatives.

• Journal of the Society of Naval Architects of Korea
• /
• v.52 no.4
• /
• pp.338-348
• /
• 2015

In this study, the added resistance of ships in short waves is systematically studied by using two different numerical methods - Rankine panel method and Cartesian grid method – and existing asymptotic and empirical formulae. Analysis of added resistance in short waves has been preconceived as a shortcoming of numerical computation. This study aims to observe such preconception by comparing the computational results, particularly based on two representative three-dimensional methods, and with the existing formulae and experimental data. In the Rankine panel method, a near-field method based on direct pressure integration is adopted. In the Cartesian grid method, the wave-body interaction problem is considered as a multiphase problem, and volume fraction functions are defined in order to identify each phase in a Cartesian grid. The computational results of added resistance in short waves using the two methods are systematically compared with experimental data for several ship models, including S175 containership, KVLCC2 and Series 60 hulls (C_B = 0.7, 0.8). The present study includes the comparison with the established asymptotic and empirical formulae in short waves.

• Archives of Pharmacal Research
• /
• v.24 no.1
• /
• pp.1-15
• /
• 2001

Gene therapy has emerged as a new concept of therapeutic strategies to treat diseases which do not respond to the conventional therapies. The principle of gene therapy is to Introduce genetic materials into patient cells to produce therapeutic proteins in these cells. Gene therapy is now at the stage where a number of clinical trials have been carried out to patients with gene-deficiency disease or cancer. Genetic materials for gene therapy are generally composed of gene expression system and gene delivery system. For the clinical application of gene therapy in a way which conventional drugs are used, researches have been focused on the design of gene delivery system which can offer high transfection efficiency with minimal toxicity. Currently, viral delivery systems generally provide higher transfection efficiency compared with non-viral delivery systems while non-viral delivery systems are less toxic, less immunogenic and manufacturable in large scale compared with viral systems. Recently, novel strategies towards the design of new non-viral delivery system, combination of viral and non-viral delivery systems and targeted delivery system have been extensively studied. The continued effort in this area will lead us to develop gene medicine as "gene as a drug" in the near future.

• The Bulletin of The Korean Astronomical Society
• /
• v.35 no.2
• /
• pp.52.1-52.1
• /
• 2010

The Japanese infrared (IR) space mission AKARI monitored the brightness in the fields very close to the north ecliptic pole (NEP) with nine wavebands in Infrared Camera (IRC), which cover the wavelength range from 2 to $24{\mu}m$. We reduced the NEP monitor observations and examined the smoothness of the sky background brightness. Our analysis shows that the background brightness is smooth over a frame of about $10'\times10'$ within about 0.1% deviation in mid-IR. Because the zodiacal light (ZL) and emission (ZE) dominate the diffuse sky brightness in the near- and mid-IR wavelengths, the background brightness varies with season through a year. We tried sinusoidal fittings to the observed NEP background brightness. The fitting analysis shows that the sine function is successful in describing the seasonal variation of the ZL and ZE within 2% deviations from the observed brightness, especially for the 15, 18, and $24{\mu}m$ bands, within 0.3%. These results will provide limits and caveats for the studies of the cosmic infrared background radiation.

• The Bulletin of The Korean Astronomical Society
• /
• v.42 no.1
• /
• pp.54.3-55
• /
• 2017

The nature and physical environments of SNRs are diverse, and for this reason, the understanding of the properties of nearby SNRs is useful in interpreting the emission from SNRs in remote galaxies where we cannot resolve them. In this regard, the LMC is a unique place to study SNRs due to its proximity, location, and composition compared with our galaxy. We carried out a multi-wavelength study of SNR N63A in the LMC, a young remnant of the SN explosion of one of the most massive (> 40 Msun) stars in a cluster. It is currently expanding within a large H II region formed by OB stars in the cluster and engulfing a molecular cloud (MC). As such, N63A is a prototypical SNR showing the impact of SN explosion on the cluster and its environment. Its morphology varies strongly across the wave bands, e.g. the size in X-ray is three times larger than in optical. However, the bright optical nebula would correspond to a MC swept up by the SNR, and consequently the interaction SNR-MC is limited to the central portion of the SNR. We aimed to study the overall structure of N63A, using near-IR imaging and spectroscopic observations to obtain the physical parameters of the atomic shocks, and also to understand how the SNR- MC interaction works and reveal the structure of the shocked cloud as well as the consequences of the impact of the SNR shock on the MC, comparing information obtained in different wavelengths.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.35 no.11A
• /
• pp.1085-1090
• /
• 2010

Ultra wideband (UWB) technologies have been developed to exploit a new spectrum resource in substances and to realize ultra-high-speed communication, high precision geolocation, and other applications. The energy of UWB signal is extremely spread from near DC to a few GHz. This means that the interference between conventional narrowband systems and UWB systems is inevitable. However, the interference effects had not previously been studied from UWB wireless systems to conventional mobile wireless systems sharing the frequency bands such as Cellular CDMA and Korean PCS. This paper experimentally evaluates the interference from two kinds of UWB sources, namely a direct-sequence spread-spectrum UWB source and an impulse radio UWB source, to a Cellular CDMA and K-PCS digital transmission system. The average frame error rate degradation of each system arc presented. From these experimental results, we show that in all practical cases UWB system can coexist with Cellular CDMA and K-PCS terminal without causing any dangerous interference.