• Journal of Gastric Cancer
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• 제21권2호
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• pp.191-202
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• 2021

Purpose: A near-infrared (NIR) fluorescence imaging is a promising tool for cancer-specific image guided surgery. Human epidermal receptor 2 (HER2) is one of the candidate markers for gastric cancer. In this study, we aimed to synthesize HER2-specific NIR fluorescence probes and evaluate their applicability in cancer-specific image-guided surgeries using an animal model. Materials and Methods: An NIR dye emitting light at 800 nm (IRDye800CW; Li-COR) was conjugated to trastuzumab and an HER2-specific affibody using a click mechanism. HER2 affinity was assessed using surface plasmon resonance. Gastric cancer cell lines (NCI-N87 and SNU-601) were subcutaneously implanted into female BALB/c nu (6-8 weeks old) mice. After intravenous injection of the probes, biodistribution and fluorescence signal intensity were measured using Lumina II (Perkin Elmer) and a laparoscopic NIR camera (InTheSmart). Results: Trastuzumab-IRDye800CW exhibited high affinity for HER2 (K_D=2.093(3) pM). Fluorescence signals in the liver and spleen were the highest at 24 hours post injection, while the signal in HER2-positive tumor cells increased until 72 hours, as assessed using the Lumina II system. The signal corresponding to the tumor was visually identified and clearly differentiated from the liver after 72 hours using a laparoscopic NIR camera. Affibody-IRDye800CW also exhibited high affinity for HER2 (K_D=4.71 nM); however, the signal was not identified in the tumor, probably owing to rapid renal clearance. Conclusions: Trastuzumab-IRDye800CW may be used as a potential NIR probe that can be injected 2-3 days before surgery to obtain high HER2-specific signal and contrast. Affibody-based NIR probes may require modifications to enhance mobilization to the tumor site.

• Proceedings of the KOSOMBE Conference
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• 대한의용생체공학회 1996년도 추계학술대회
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• pp.65-67
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• 1996

Optical property of tissue is characterized by its high scattering of light. In near infrared range$(800{\sim}1200nm)$ scattering is dominant than absorption. Communication using NIR through tissue is applicable to immplantable device. In this paper, simulation of unit impulse response of light in tissue is carried out to estimate the amplitude, phaselength and phaselength deviation.

• Clinics in Shoulder and Elbow
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• 제22권1호
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• pp.40-45
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• 2019

Ultrasound diathermy is widely used for the treatment of musculoskeletal disorders and other soft tissue injuries. Its use as a therapeutic modality is believed to be safe, with very few reported complications. Here, we report two patients who developed focal bone marrow abnormalities after receiving ultrasound diathermy. Both patients' magnetic resonance (MR) evaluations revealed linear subchondral bone lesions of the superolateral humeral head similar to those in osteonecrosis. The patients' symptoms subsequently improved, and available follow-up MR evaluation revealed near complete resolution of bone lesions. These findings suggest that ultrasound diathermy, and its interaction with bone tissue through thermal mechanisms, can cause focal bone marrow abnormalities. Furthermore, the bone marrow abnormalities seem to be transient, resolving upon cessation of ultrasound diathermy, therefore osteonecrosis should be differentiated from this temporal lesion.

• Journal of the Korean Wood Science and Technology
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• 제43권3호
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• pp.311-319
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• 2015

Near infrared (NIR) reflectance spectroscopy was employed to develop moisture content prediction model of pitch pine (Pinus rigida), red pine (Pinus densiflora), Korean pine (Pinus koraiensis), yellow poplar (Liriodendron tulipifera) wood below fiber saturation point. NIR reflectance spectra of specimens ranging from 1000 nm to 2400 nm were acquired after humidifying specimens to reach several equilibrium moisture contents. To determine the optimal moisture contents prediction model, 5 mathematical preprocessing methods (moving average (smoothing point: 3), baseline, standard normal variate (SNV), mean normalization, Savitzky-Golay $2^{nd}$ derivatives (polynomial order: 3, smoothing point: 11)) were applied to reflectance spectra of each specimen as 8 combinations. After finishing mathematical preprocessings, partial least squares (PLS) regression analysis was performed to each modified spectra. Consequently, the mathematical preprocessing methods deriving optimal moisture content prediction were 1) moving average/SNV for pitch pine and red pine, 2) moving average/SNV/Savitzky-golay $2^{nd}$ derivatives for Korean pine and yellow poplar. Every model contained three principal components.

• The Korean Journal of Ecology
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• 제13권3호
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• pp.173-180
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• 1990

The contents of Pb and CD measured with the barks of Pinus densiflora in Seoul area, Yangjaedong area near the Kyungbu-highway, Mt. Keryong and Mt. Seolak area, from Sep. to Ock. in 1988. Pb contents in Seoul area were 17.8 ppm at Changkyungkung, 17.1 ppm at Chongamdong, 13.2 ppm at Mt. Kwanak, 7.6 ppm at Mt. Dobong and 3.7 ppm at Mt. Surak. Except Mt. Kwanak, the difference between areas of central and mountains in Seoul were high significant. Mt Seolak area also showed variations in Pb contents from 16.8 ppm to 32.1 ppm according to studied sites. Cd contents in Seoul area were 0.47 ppm at Changkyungkung, 0.65 ppm at Chongamdong, 0.61 ppm at Mt. Kwanak, 0.52 ppm at Mt. Dobong, 0.47 ppm at Mt. Surak. Therefore, Cd contents in Seoul area exhibited more variations between sampling plots than between the areas of central and mountains in Seoul. Mt Seolak area also showed variations from 0.20 ppm to 0.34 ppm in Cd contents, and it was the lowest in all the studied area.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 한국지하수토양환경학회 2005년도 INTERNATIONAL SYMPOSIUM ON SOIL & GROUNDWATER ENVIRONMENT
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• pp.245-246
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• 2005

• Proceedings of the Korean Environmental Sciences Society Conference
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• 한국환경과학회 1996년도 가을 학술발표회 초록집
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• pp.17-17
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• 1996

• Journal of Preventive Medicine and Public Health
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• 제43권2호
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• pp.159-165
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• 2010

Objectives: We evaluated the reliability of the possible covariates of the baseline survey data collected for the Epidemiological Investigation on Cancer Risk Among Residents Who Reside Near the Nuclear Power Plants in Korea. Methods: Follow-up surveys were conducted for 477 participants of the cohort at less than 1 year after the initial survey. The mean interval between the initial and follow-up surveys was 282.5 days. Possible covariates were identified by analyzing the correlations with the exposure variable and associations with the outcome variables for all the variables. Logistic regression analysis with stepwise selection was further conducted among the possible covariates to select variables that have covariance with other variables. We considered that these variables can be representing other variables. Seven variables for the males and 3 variables for the females, which had covariance with other possible covariates, were selected as representative variables. The Kappa index of each variable was calculated. Results: For the males, the Kappa indexes were as follow; family history of cancer was 0.64, family history of liver diseases in parents and siblings was 0.56, family history of hypertension in parents and siblings was 0.51, family history of liver diseases was 0.50, family history of hypertension was 0.44, a history of chronic liver diseases was 0.53 and history of pulmonary tuberculosis was 0.36. For females, the Kappa indexes were as follow; family history of cancer was 0.58, family history of hypertension in parents and siblings was 0.56 and family history of hypertension was 0.47. Conclusions: Most of the possible covariates showed good to moderate agreement.

• The Korean Journal of Ecology
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• 제25권3호
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• pp.131-137
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• 2002

This study was conducted to clarify the characteristics of bird community and habitat types in Mangyeong River area from Aug. 1999 to Jun. 2000. Paddy field was the most dominant land use type. Water area, mudflat, shrub field, urban area and green house were also dominant land use types in study area. Eighty-eight bird species were recorded during study period. Maximum number of species and individuals were shown as 58 species and 7,084 individuals in Oct. and Jan., respectively. There were low number of diving ducks and clumped pattern of waterfowl distribution of bird community in Mangyeong River area. Dabbling ducks distributed at upper reaches near Samrye Bridge, and plovers and sandpipers at lower reaches near estuary. Those results suggest that creation of pools over one meter water-depth and restoration of paddy field into riparian zone with diverse shrubs are required to increase the bird diversity in the Mangyeong rived.

• Journal of the Society of Naval Architects of Korea
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• 제52권5호
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• pp.387-394
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• 2015

Before salvaging a wrecked ship, the physics-based simulation is needed to predict lifting force before real operation by floating crane or barge. Procedures affecting lifting force for the salvage can be divided into three stages. At the first stage, the bottom breakout force for the wrecked ship to escape from seabed sediment should be calculated. At the second step, the current force acting on the wrecked ship while lifting from the seabed to near sea surface should be considered. Finally, buoyancy change near at the sea surface when the wrecked ship start to escape from the water should be considered. In the previous studies, only the breakout force at the first stage was calculated based on simple assumption of embedment depth and contact area of the wrecked ship. Therefore, we develop a program for salvage simulation including whole stages. It is composed of four modules such as the equations of motion, time integration, force calculation, and visualization. As a result, it is applied to simulate lifting the wrecked ship according to various environmental loads including seabed sediments.