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Ecological Risk Assessment of Pharmaceuticals in the Surface Water Near a Pharmaceutical Manufacturing Complex in Korea (제약단지 인접 지역 지표수의 잔류 의약물질 생태위해성평가)

  • Park, Suhyun;Kang, Habyeong;Shin, Hyesoo;Ryoo, Ilhan;Choi, Kyungho;Kho, Younglim;Park, Kyunghwa;Kim, Kyungtae;Ji, Kyunghee
    • Journal of Environmental Health Sciences
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    • v.46 no.1
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    • pp.45-64
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    • 2020
  • Objectives: Limited information is available on the presence and associated ecological risks of pharmaceutical residues in aquatic environments near pharmaceutical manufacturing areas in Korea. In this study, we investigated the current state of pharmaceutical contamination and its associated ecological risks in streams near a pharmaceutical manufacturing complex. Methods: Seven pharmaceuticals (acetaminophen, clarithromycin, diclofenac, diphenhydramine, ibuprofen, mefenamic acid and roxithromycin) were measured in water samples collected from the streams near a pharmaceutical manufacturing complex. A predicted no-effect concentration (PNEC) was derived using either the assessment factor method or species sensitivity distribution method. In addition, a hazard quotient for each pharmaceutical was calculated by dividing its measured environmental concentration by its PNEC. Results: Samples collected downstream from the wastewater treatment plant (WWTP) had higher concentrations of pharmaceuticals than those collected from the reference site (upstream). Moreover, pharmaceutical concentrations were greater in ambient water than in the final effluent from the WWTP, which suggested that non-point sources were contributing to the contamination of the ambient water environment. Some of the target pharmaceuticals exhibited a hazard quotient >1, indicating that their potential ecological effects on the aquatic environment near the pharmaceutical industrial area should not be ignored. Conclusion: This study demonstrated that the pharmaceutical manufacturing area was contaminated with residual drugs, and that there was a possible non-point source near the WWTP effluent discharge area. The results of this study will aid in the development of management plans for pharmaceuticals, particularly in hotspots such as pharmaceutical industrial sites and their vicinities.

Change of Binocular Vision Induced by Longitudinal Chromatic Aberration during Near Work (근거리 작업 시 종색수차에 따른 양안시의 변화)

  • Kim, Se-il;Park, Mijung;Kim, So Ra
    • Journal of Korean Ophthalmic Optics Society
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    • v.20 no.2
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    • pp.219-228
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    • 2015
  • Purpose: The current study was performed to compare the difference in binocular visual function depending on variable background colors at near work. Method: Fifty four adults (18 males, 34 females) who consented to the present study and had no ocular disease, ocular surgery history, strabismus and amblyopia with normal binocular vision were participated into this study. The subjects were asked to read the novels with black letter printed on white, red, green and blue background for 15 min. Then, their heterophoria, AC/A ratio, near point of convergence, accommodation facility, relative accommodation and vergence were measured before and after reading. The difference of measurements were compared. Result: Overall heterophoria was tended to decrease with regardless of background color. AC/A ratio showed a tendency of increase after reading the novels with all backgrounds except white background. Near point of convergence was significantly increased compared to before reading at all background color. Accommodative facility of dominant and non-dominant eyes were also significantly increased after reading however, binocular accommodative facility showed a tendency of decrease. Negative relative accommodation also decreased at all background colors however, the change of positive relative accommodation was not significantly different. In case of vergence, there was significant difference in break point of far BO and recovery point of far BI by the wavelength of background color. Conclusions: From the results, it was known there is convergence change depending on the wavelength of light even though same amount of accommodation and convergence is required when doing near work for certain period. Thus, it can be suggested that the adjustment of the near working environment which perception of various color was required, should be conducted according to the main wavelength.

Intestinal Nematodes from Small Mammals Captured near the Demilitarized Zone, Gyeonggi Province, Republic of Korea

  • Kim, Deok-Gyu;Park, Jae-Hwan;Kim, Jae-Lip;Jung, Bong-Kwang;Jeon, Sarah Jiyoun;Lim, Hyemi;Lee, Mi Youn;Shin, Eun-Hee;Klein, Terry A.;Kim, Heung-Chul;Chong, Sung-Tae;Song, Jin-Won;Baek, Luck-Ju;Chai, Jong-Yil
    • Parasites, Hosts and Diseases
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    • v.53 no.1
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    • pp.135-139
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    • 2015
  • A total of 1,708 small mammals (1,617 rodents and 91 soricomorphs), including Apodemus agrarius (n = 1,400), Microtus fortis (167), Crocidura lasiura (91), Mus musculus (32), Myodes (= Eothenomys) regulus (9), Micromys minutus (6), and Tscherskia (= Cricetulus) triton (3), were live-trapped at US/Republic of Korea (ROK) military training sites near the demilitarized zone (DMZ) of Paju, Pocheon, and Yeoncheon, Gyeonggi Province from December 2004 to December 2009. Small mammals were examined for their intestinal nematodes by necropsy. A total of 1,617 rodents (100%) and 91 (100%) soricomorphs were infected with at least 1 nematode species, including Nippostrongylus brasiliensis, Heligmosomoides polygyrus, Syphacia obvelata, Heterakis spumosa, Protospirura muris, Capillaria spp., Trichuris muris, Rictularia affinis, and an unidentified species. N. brasiliensis was the most common species infecting small mammals (1,060; 62.1%) followed by H. polygyrus (617; 36.1%), S. obvelata (370; 21.7%), H. spumosa (314; 18.4%), P. muris (123; 7.2%), and Capillaria spp. (59; 3.5%). Low infection rates (0.1-0.8%) were observed for T. muris, R. affinis, and an unidentified species. The number of recovered worms was highest for N. brasiliensis (21,623 worms; mean 20.4 worms/infected specimen) followed by S. obvelata (9,235; 25.0 worms), H. polygyrus (4,122; 6.7 worms), and H. spumosa (1,160; 3.7 worms). A. agrarius demonstrated the highest prevalence for N. brasiliensis (70.9%), followed by M. minutus (50.0%), T. triton (33.3%), M. fortis (28.1%), M. musculus (15.6%), C. lasiura (13.2%), and M. regulus (0%). This is the first report of nematode infections in small mammals captured near the DMZ in ROK.

The phase angle dependences of Reflectance on Asteroid (25143) Itokawa from the Hayabusa Spacecraft Multi-band Imaging Camera(AMICA)

  • Lee, Mingyeong;Ishiguro, Masateru
    • The Bulletin of The Korean Astronomical Society
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    • v.40 no.1
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    • pp.61.3-62
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    • 2015
  • Remote-sensing observation is one of the observation methods that provide valuable information, such as composition and surface physical conditions of solar system objects. The Hayabusa spacecraft succeeded in the first sample returning from a near-Earth asteroid, (25143) Itokawa. It has established a ground truth technique to connect between ordinary chondrite meteorites and S-type asteroids. One of the scientific observation instruments that Hayabusa carried, Asteroid Multi-band Imaging Camera(AMICA) has seven optical-near infrared filters (ul, b, v, w, x, p, and zs), taking more than 1400 images of Itokawa during the rendezvous phase. The reflectance of planetary body can provide valuable information of the surface properties, such as the optical aspect of asteroid surface at near zero phase angle (i.e. Sun-asteroid-observer's angle is nearly zero), light scattering on the surface, and surface roughness. However, only little information of the phase angle dependences of the reflectance of the asteroid is known so far. In this study, we investigated the phase angle dependences of Itokawa's surface to understand the surface properties in the solar phase angle of $0^{\circ}-40^{\circ}$ using AMICA images. About 700 images at the Hayabusa rendezvous phase were used for this study. In addition, we compared our result with those of several photometry models, Minnaert model, Lommel-Seeliger model, and Hapke model. At this conference, we focus on the AMICA's v-band data to compare with previous ground-based observation researches.

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FISS and SDO Observation of a Brightening Event Near a Pore

  • Kang, Juhyeong;Chae, Jongchul
    • The Bulletin of The Korean Astronomical Society
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    • v.42 no.2
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    • pp.61.2-61.2
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    • 2017
  • We report a fine scale transient brightening event near a pore boundary with the Fast Imaging Solar Spectrograph (FISS) of the 1.6m Goode Solar Telescope (GST), the Atmospheric Imaging Assembly (AIA) aboard the Solar Dynamics Observatory (SDO), and Helioseismic and Magnetic Imager (HMI) aboard SDO. The event appears in all AIA extreme ultraviolet bands, also in the two FISS lines, $H{\alpha}$ and Ca II $8542{\AA}$, and lasted for a minute. The brightening occurred at a footpoint of a loop. The conjugate brightening occurred at the other foot point outside the FISS field of view. The brightening near the pore exhibit a redshift of 4.3 km s-1 in the $H{\alpha}$ and about 2.3 km s-1 in Ca II line. Differential emission measure derived from 6 AIA EUV passbands and cloud model fitting of the two FISS lines indicate the temperature increase of between 10,000 and 20 MK at the main event. After the brightening, the upward mass motion appears in the AIA images. We discuss the physical implication of this brightening in the context of magnetic reconnection and coronal heating.

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High-resolution near-IR Spectral Mapping of Multiple Outflows around LkHα 234 in NGC 7129 Star Forming Region

  • Oh, Heeyoung;Pyo, Tae-Soo;Koo, Bon-Chul;Yuk, In-Soo;Park, Byeong-Gon
    • The Bulletin of The Korean Astronomical Society
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    • v.42 no.1
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    • pp.38.2-38.2
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    • 2017
  • We present the observational study toward the multiple outflows around $LkH{\alpha}$ 234 star formation region. The high-resolution, near-IR spectral mapping using the Immersion Grating Infrared Spectrograph (IGRINS) allowed us to distinguish at least four separate outflows with the molecular hydrogen ($H_2$) and forbidden iron ([Fe II]) emission lines. The outflow associated with the radio continuum source VLA 3B is detected in both H2 and [Fe II] emission, while the outflows driven by MM 1, VLA 2 sources were only detected in $H_2$, indicating the different physical conditions of outflows. We confirm the axis of VLA 3B jet, the position angle of ${\sim}240^{\circ}$. We firstly identified the redshifted, near-IR H2 outflow associated with VLA 2, which is coincident with the previous detections of $H_2O$ masers. From the $H_2$ line ratios, we interpret the gas properties of the shock excited blue- and redshifted components, and UV excited surrounding photodissociation region. We also discuss the origin of the high-velocity (|VLSR| > $150km\;s^{-1}$) $H_2$ emission.

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Study on the Unsteady Wakes Past a Square Cylinder near a Wall

  • Kim Tae Yoon;Lee Bo Sung;Lee Dong Ho
    • Journal of Mechanical Science and Technology
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    • v.19 no.5
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    • pp.1169-1181
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    • 2005
  • Experimental and numerical studies on the unsteady wake field behind a square cylinder near a wall were conducted to find out how the vortex shedding mechanism is correlated with gap flow. The computations were performed by solving unsteady 2-D Incompressible Reynolds Averaged Navier-Stokes equations with a newly developed ${\epsilon}-SST$ turbulence model for more accurate prediction of large separated flows. Through spectral analysis and the smoke wire flow visualization, it was discovered that velocity profiles in a gap region have strong influences on the formation of vortex shedding behind a square cylinder near a wall. From these results, Strouhal number distributions could be found, where the transition region of the Strouhal number was at $G/D=0.5{\sim}0.7$ above the critical gap height. The primary and minor shedding frequencies measured in this region were affected by the interaction between the upper and the lower separated shear layer, and minor shedding frequency was due to the separation bubble on the wall. It was also observed that the position (y/G) and the magnitude of maximum average velocity $(u/u_{\infty})$ in the gap region affect the regular vortex shedding as the gap height increases.

Probing Cosmic Near Infrared Background using AKARI Data

  • Seo, Hyun Jong;Matsumoto, Toshio;Jeong, Woong-Seob;Lee, Hyung Mok;Matsuura, Shuji;Matsuhara, Hideo;Oyabu, Shinki;Pyo, Jeonghyun;Wada, Takehiko
    • The Bulletin of The Korean Astronomical Society
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    • v.38 no.1
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    • pp.34.1-34.1
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    • 2013
  • The first generation stars in the universe are not observed as discrete objects by using current observational facilities, but their contributions are redshifted to the near infrared wavelength bands at present universe. Therefore, investigation of background radiation at near infrared is important for the study of the first stars. In this study, we present new observations of spatial fluctuations in sky brightness toward the north ecliptic pole using data from AKARI. Among pointed observation program of AKARI, we used two pointing surveys named Monitor field and NEP wide field at three wavelength bands 2.4, 3.2, and 4.1 ${\mu}m$. To obtain spatial fluctuations from observed images, first of all, we exclude pixels affected by resolved foreground objects and then obtain diffuse map which consists of diffused radiation only. Because the diffuse map contains not only cosmological components but also various foreground components, in order to detect cosmological components, we estimate the contributions of foreground components separately. The results of this study show that there remains excess spatial fluctuation that cannot be explained by known foreground sources. This work is based on observations with AKARI, a JAXA project with the participation of ESA.

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Probing Cosmic Near Infrared Background using AKARI Data

  • Seo, Hyun Jong;Matsumoto, Toshio;Jeong, Woong-Seob;Lee, Hyung Mok;Matsuura, Shuji;Matsuhara, Hideo;Oyabu, Shinki;Pyo, Jeonghyun;Wada, Takehiko
    • The Bulletin of The Korean Astronomical Society
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    • v.38 no.1
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    • pp.35.1-35.1
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    • 2013
  • The first generation stars in the universe are not observed as discrete objects by using current observational facilities, but their contributions are redshifted to the near infrared wavelength bands at present universe. Therefore, investigation of background radiation at near infrared is important for the study of the first stars. In this study, we present new observations of spatial fluctuations in sky brightness toward the north ecliptic pole using data from AKARI. Among pointed observation program of AKARI, we used two pointing surveys named Monitor field and NEP wide field at three wavelength bands 2.4, 3.2, and 4.1 ${\mu}$. To obtain spatial fluctuations from observed images, first of all, we exclude pixels affected by resolved foreground objects and then obtain diffuse map which consists of diffused radiation only. Because the diffuse map contains not only cosmological components but also various foreground components, in order to detect cosmological components, we estimate the contributions of foreground components separately. The results of this study show that there remains excess spatial fluctuation that cannot be explained by known foreground sources. This work is based on observations with AKARI, a JAXA project with the participation of ESA.

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Near-infrared Spectroscopy of Metal-enriched Supernova Ejecta in Cassiopeia A

  • Lee, Yong-Hyun;Koo, Bon-Chul
    • The Bulletin of The Korean Astronomical Society
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    • v.44 no.1
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    • pp.44.4-44.4
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    • 2019
  • The supernova remnant Cassiopeia A (Cas A) provides a unique opportunity to observe the fine details of the explosion of core-collapse supernova (SN). Previous optical and near-infrared (NIR) observations of Cas A have shown that the spatial distribution of the metal-enriched SN ejecta is very complicated, indicating that the SN explosion should have been asymmetric and turbulent, especially near the core. Recently, we obtained a long-exposure (~10 hr) image of Cas A by using the UKIRT 3.6-m telescope with a narrow-band filter centered at [Fe II] 1.644 um emission. This 'deep [Fe II] image' provides an unprecedented panoramic view of Cas A, revealing the distribution of dense SN ejecta over the entire remnant. We have carried out NIR multi-object spectroscopic observations of the dense ejecta knots in the northeastern (NE) and eastern (E) outer regions of the remnant using the MMIRS attached on the MMT 6.5-m telescope. A total of 67 ejecta knots are detected. By analyzing their spectra, we have found that the knots in the NE area show strong [S II]/[S III] and [Fe II] lines but little or no [P II] line, while those in the E outer region show strong [Fe II] lines but weak [S II]/[S III] lines. In this talk, we present the preliminary results of our NIR spectroscopic observations and discuss the implications.

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