• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
• /
• v.22 no.2
• /
• pp.99-102
• /
• 2011

The laws of physics that govern actions of all moving bodies apply to sound. Because sound and all acoustic conditions consistently behave as described by the law of physics, we are able to predict and analyze the nature of a sound and its interaction. A fundamental understanding of the nature of the sound and terms used to describe it is essential to comprehend the language of otolaryngologists, audiologists, music acousticians, and engineers. Moreover, studying the basic physics of the sound helps one recognize complexities and potential pitfalls in measuring describing sound. We will talk about the structure of sound and its components, and we will see the various qualities of sound that make it interesting and useful to understand.

• Tuberculosis and Respiratory Diseases
• /
• v.75 no.4
• /
• pp.170-173
• /
• 2013

Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is rare, with a more favorable prognosis compared with that of other types of non-small cell lung cancers. Herein, we describe an interesting case of primary pulmonary LELC confirmed postoperatively, which had been initially diagnosed as poorly differentiated adenocarcinoma. We suggest that despite the rarity of pulmonary LELC, it should be included as one of the differential diagnoses for lung malignancies. Physicians should consider taking a larger biopsy, especially when histologic examination shows undifferentiated nature.

• Clinical and Experimental Reproductive Medicine
• /
• v.45 no.4
• /
• pp.149-153
• /
• 2018

Stem cells are undifferentiated cells capable of self-renewal and differentiation into various cell lineages. Stem cells are responsible for the development of organs and regeneration of damaged tissues. The highly regenerative nature of the human endometrium during reproductive age suggests that stem cells play a critical role in endometrial physiology. Bone marrow-derived cells migrate to the uterus and participate in the healing and restoration of functionally or structurally damaged endometrium. This review summarizes recent research into the potential therapeutic effects of bone marrow-derived stem cells in conditions involving endometrial impairment.

• The Korean Journal of Nuclear Medicine
• /
• v.34 no.1
• /
• pp.1-9
• /
• 2000

The rapid progress of molecular genetic methods over the past two decades has necessitated the development of methods to detect and quantify genetic activity within living bodies. Reporter genes provide a rapid and convenient tool to monitor gene expression by yielding a readily measurable phenotype upon expression when introduced into a biological system. Conventional reporter systems, however, are limited in their usefulness for in vivo experiments or human gene therapy because of its invasive nature which requires cell damage before assays can be performed. This offers an unique opportunity for nuclear imaging techniques to develope a novel method for imaging both the location and amount of gene expression noninvasively. Current developments to achieve this goal rely on utilizing either reporter enzymes that accumulate radiolabeled substrates or reporter receptors that bind specific radioligands. This overview includes a brief introduction to the background for such research, a summary of published results, and an outlook for future directions.

• Biomedical Science Letters
• /
• v.20 no.1
• /
• pp.1-7
• /
• 2014

RNA granules such as Stress Granules (SG) and P-Bodies (PB) are aggregates of translationally stalled messenger ribonucleoprotein (mRNP) complexes induced by a wide range of stresses. Over the past decade, extensive studies described key components of RNA granules, their molecular interactions and signaling pathways require for their assembly and disassembly. However, researches defining their exact roles under stress conditions have not been performed so far, although several studies suggested their roles in neurodegenerative diseases recently. In this review, we provide an introduction about their basic properties, key components, and the dynamic nature for their assembly.

• Journal of TMJ Balancing Medicine
• /
• v.2 no.1
• /
• pp.17-19
• /
• 2012

Objectives: Therapeutic effect of Yinyang Balancing Appliance of functional cerebrospinal therapy (FCST) for meridian and neurologic yinyang balance was observed in Tourette's Disorder. Methods: Two Tourette's Disorder cases were managed with the Yinyang Balancing Appliance on temporomandibular joint (TMJ), combined with acupuncture. Clinical outcome measurement was based on subjective measures and clinical observations. Results: The patients showed positive changes even after the initial treatment and this effect maintained over the follow-up period. Conclusions: Although it is not clear the effect is a sustaining or temporary in its nature, a positive effect was observed and further clinical and biological research on FCST is expected.

• Journal of TMJ Balancing Medicine
• /
• v.4 no.1
• /
• pp.17-20
• /
• 2014

Therapeutic effect of Yinyang Balancing Appliance of functional cerebrospinal therapy (FCST) for meridian and neurologic yinyang balance was observed in primary dysmenorrhea cases. Two primary dysmenorrhea cases were managed with the Yinyang Balancing Appliance on temporomandibular joint (TMJ), combined with acupuncture. Clinical outcome measurement was based on subjective measures and clinical observations. The patients showed positive changes even after the initial treatment and this effect maintained over the follow-up period. Although it is not clear the effect is a sustaining or temporary in its nature, a positive effect was observed and further clinical and biological research on FCST is expected.

• Journal of Preventive Medicine and Public Health
• /
• v.54 no.3
• /
• pp.166-172
• /
• 2021

Traditional epidemiological assessments, which mainly focused on evaluating the statistical association between two major components-the exposure and outcome-have recently evolved to ascertain the in-between process, which can explain the underlying causal pathway. Mediation analysis has emerged as a compelling method to disentangle the complex nature of these pathways. The statistical method of mediation analysis has evolved from simple regression analysis to causal mediation analysis, and each amendment refined the underlying mathematical theory and required assumptions. This short guide will introduce the basic statistical framework and assumptions of both traditional and modern mediation analyses, providing examples conducted with real-world data.

• Journal of Sasang Constitutional Medicine
• /
• v.4 no.1
• /
• pp.5-29
• /
• 1992

In this study, the author researched the process in which the philosophical basis of 'Sa Sang Medicine (四象醫學)' and its methodology build up the principles of Sa Sang Medicine, and then, examined how the principles were applied to the theoretical system of Sa Sang Medicine. The conclusion would be summarized as follows. 1. 'Nae Kyung Medicine (內經醫學)' was developed under the concept that the cosmos's order and its moving rule could be directly applied to that of human body, which corresponded to the 'Theory of Hwang-No (黃老之學)'. On the contrary, Sa Sang Medicine is a thoroughly human-oriented theory formed in the Confucianism system. 2. Lee Jae-Ma's Substantialism can be briefed into 'Mind 心' (Tae Keuk 太極), 'Mind-Body 心身' (Yang Eui 兩儀) and 'Activity-Mind-Body-Matter 事心身物' (Sa Sang 四象), which respectively represents one-elemented substance, two-elemented substance and four-elemented substance. Especially, Sa Sang was used as a basic framework in which he recognized all the objects and phenomena. So, most critical significance of his substantialism consists in the intention of Sa Sang type classifying. 3. By the method of Sa Sang type classifying, Lee Jae-Ma not only redefined the main concepts of confucianism and developed a unique philosophy of his own, but also, in the field of medical science, resystemized and re-explained the structure and function of human body. 4. From the recognition that Activity-Mind-body-Matter (Sa Sang) are four different existence forms of energy 氣 (or four variation types of energy), Yi Jae-Ma thinks that the viscera of human body have a vertical structure of 'four parts 四焦' (upper, mid-upper, mid-lower and lower parts) and its physiological function is operated by the rising and falling action of four energy presentations (sorrow 哀, anger 怒, joy 喜 and pleasure 樂). 5. In "Gyuk Chi Go 格致藁", Lee Jae-Ma understood the concept of joy, anger, sorrow and pleasure on the basis of nature-emotion theory 性情論 from the philosophical viewpoint. But, from the medical viewpoint of "Dong Eui Su Se Bo Won 東醫壽世保元", he understood them on the basis of vital energy theory. That is, sorrow, anger, joy and pleasure are expression of advance or reverse of nature vital-energy 性氣 and emotion vital-energy 情氣. 6. The rising and falling action principle of four energy presentations (sorrow, anger, joy and pleasure) which produces and helps each other is an identical principles of Sa Sang Medicine, distinguished from the Oh-Haeng 五行 circulating principle in Nae Kyung Medicine. Through this principle, Lee Jae-Ma explained the viscera physiology of human body, pathology & diagnosis and pharmacology.

• Journal of Oriental Neuropsychiatry
• /
• v.30 no.3
• /
• pp.119-128
• /
• 2019

Objectives: This study suggests the application of philosophical counseling in the clinical field of Korean medicine and analyze the specific case. Methods: Through the analysis of coexisting factors of Korean medicine and philosophical counseling, we establish the area of philosophical counseling that Korean medicine practitioner can apply in the medical field. We described effects of philosophical counseling on the patient's symptom and the progress after discharge through a counseling approach based on philosophical questions. Results: During philosophical counseling, the Korean medical doctor asks questions about the nature of suffering and encourages patients to gain insight into their problems. In answering the vital philosophical questions, the patient leads to a creative interpretation of future life directions. We described the method of specific approaches through the description of the two cases. Conclusions: The philosophical counseling is compatible with the concept of Korean medicine, therefore, a Korean medicine practitioner can induce the recovery of mind and body through the creative interpretation of the patient by asking the patient the appropriate question which causes reflective thinking.