[KSCI] Korea Science Citation Index Service

Mammalian RNA Granules

Jayabalan, Aravinth Kumar (Department of Cellular and Molecular Medicine, College of Medicine, Chosun University)
Ohn, Takbum (Department of Cellular and Molecular Medicine, College of Medicine, Chosun University)

Abstract

RNA granules such as Stress Granules (SG) and P-Bodies (PB) are aggregates of translationally stalled messenger ribonucleoprotein (mRNP) complexes induced by a wide range of stresses. Over the past decade, extensive studies described key components of RNA granules, their molecular interactions and signaling pathways require for their assembly and disassembly. However, researches defining their exact roles under stress conditions have not been performed so far, although several studies suggested their roles in neurodegenerative diseases recently. In this review, we provide an introduction about their basic properties, key components, and the dynamic nature for their assembly.

Keywords

Stress granules; Translation initiation; $eIF2{\alpha}$ phosphorylation; RNA binding proteins;

Citations & Related Records

Reference

1	Holcik M, Sonenberg N. Translational control in stress and apoptosis. Nat Rev Mol Cell Biol. 2005. 6: 318-327. DOI ScienceOn
2	Hilliker A, Parker R. Stressed out? Make some modifications! Nat Cell Biol. 2008. 10: 1129-1130. DOI ScienceOn
3	Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell. 2000a. 6: 1099-1108. DOI ScienceOn
4	Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell. 2000b. 5: 897-904. DOI ScienceOn
5	Hofmann S, Cherkasova V, Bankhead P, Bukau B, Stoecklin G. Translation suppression promotes stress granule formation and cell survival in response to cold shock. Mol Biol Cell. 2012. 23: 3786-3800. DOI
6	Jackson RJ, Hellen CU, Pestova TV. The mechanism of eukaryotic translation initiation and principles of its regulation. Nat Rev Mol Cell Biol. 2010. 11: 113-127. DOI ScienceOn
7	Kedersha N, Anderson P. Stress granules: sites of mRNA triage that regulate mRNA stability and translatability. Biochem Soc Trans. 2002. 30: 963-969. DOI
8	Buchan JR, Parker R. Eukaryotic stress granules: the ins and outs of translation. Mol Cell. 2009. 36: 932-941. DOI ScienceOn
9	Anderson P, Kedersha N. Stress granules: the Tao of RNA triage. Trends Biochem Sci. 2008. 33: 141-150. DOI ScienceOn
10	Arimoto K, Fukuda H, Imajoh-Ohmi S, Saito H,Takekawa M. Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways. Nat Cell Biol. 2008. 10: 1324-1332. DOI ScienceOn
11	Buchan JR, Kolaitis RM, Taylor JP, Parker R. Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function. Cell. 2013. 153: 1461-1474. DOI ScienceOn
12	Calkhoven CF, Muller C, Leutz A. Translational control of gene expression and disease. Trends Mol Med. 2002. 8: 577-583. DOI ScienceOn
13	de Nadal E, Ammerer G, Posas F. Controlling gene expression in response to stress. Nat Rev Genet. 2011. 12: 833-845.
14	Dolzhanskaya N, Merz G, Aletta JM, Denman RB. Methylation regulates the intracellular protein-protein and protein-RNA interactions of FMRP. J Cell Sci. 2006. 119: 1933-1946. DOI ScienceOn
15	Emara MM, Fujimura K, Sciaranghella D, Ivanova V, Ivanov P, Anderson P. Hydrogen peroxide induces stress granule formation independent of eIF2alpha phosphorylation. Biochem Biophys Res Commun. 2012. 423: 763-769. DOI ScienceOn
16	Fujimura K, Sasaki AT, Anderson P. Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules. Nucleic Acids Res. 2012. 40: 8099-8110. DOI
17	Gilks N, Kedersha N, Ayodele M, Shen L, Stoecklin G, Dember LM, Anderson P. Stress granule assembly is mediated by prion-like aggregation of TIA-1. Mol Biol Cell. 2004. 15: 5383-5398. DOI ScienceOn
18	Spriggs KA, Bushell M, Willis AE. Translational regulation of gene expression during conditions of cell stress. Mol Cell. 2010. 40: 228-237. DOI ScienceOn
19	Richter JD, Sonenberg N. Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature. 2005. 433: 477-480. DOI ScienceOn
20	Riedl SJ, Shi Y. Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol. 2004. 5: 897-907. DOI ScienceOn
21	Sonenberg N, Hinnebusch AG. Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell. 2009. 136: 731-745. DOI ScienceOn
22	Stoecklin G, Kedersha N. Relationship of GW/P-bodies with stress granules. Adv Exp Med Biol. 2013. 768: 197-211. DOI ScienceOn
23	Stoecklin G, Stubbs T, Kedersha N, Wax S, Rigby WF, Blackwell TK, Anderson P. MK2-induced tristetraprolin: 14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO J. 2004. 23: 1313-1324. DOI ScienceOn
24	Mollet S, Cougot N, Wilczynska A, Dautry F, Kress M, Bertrand E, Weil D. Translationally repressed mRNA transiently cycles through stress granules during stress. Mol Biol Cell. 2008. 19: 4469-4479. DOI ScienceOn
25	Tourriere H, Chebli K, Zekri L, Courselaud B, Blanchard JM, Bertrand E, Tazi J. The RasGAP-associated endoribonuclease G3BP assembles stress granules. J Cell Biol. 2003. 160: 823-831. DOI ScienceOn
26	Wek RC, Jiang HY,Anthony TG. Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans. 2006. 34: 7-11. DOI
27	Wippich F, Bodenmiller B, Trajkovska MG, Wanka S, Aebersold R, Pelkmans L. Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling. Cell. 2013. 152: 791-805. DOI ScienceOn
28	Kwon S, Zhang Y, Matthias P. The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response. Genes Dev. 2007. 21: 3381-3394. DOI ScienceOn
29	Li CH, Ohn T, Ivanov P, Tisdale S, Anderson P. eIF5A promotes translation elongation, polysome disassembly and stress granule assembly. PloS One. 2010. 5: e9942. DOI ScienceOn
30	McEwen E, Kedersha N, Song B, Scheuner D, Gilks N, Han A, Chen JJ, Anderson P, Kaufman RJ. Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure. J Biol Chem. 2005. 280: 16925-16933. DOI ScienceOn
31	Ohn T, Kedersha N, Hickman T, Tisdale S, Anderson P. A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly. Nat Cell Biol. 2008. 10: 1224-1231. DOI ScienceOn
32	Parker F, Maurier F, Delumeau I, Duchesne M, Faucher D, Debussche L, Dugue A, Schweighoffer F, Tocque B. A Ras- GTPase-activating protein SH3-domain-binding protein. Mol Cell Biol. 1996. 16: 2561-2569. DOI
33	Ramaswami M, Taylor JP,Parker R. Altered ribostasis: RNAprotein granules in degenerative disorders. Cell. 2013. 154: 727-736. DOI ScienceOn
34	Kedersha N, Ivanov P, Anderson P. Stress granules and cell signaling: more than just a passing phase? Trends Biochem Sci. 2013. 38: 494-506. DOI ScienceOn
35	Reineke LC, Dougherty JD, Pierre P, Lloyd RE. Large G3BPinduced granules trigger eIF2alpha phosphorylation. Mol Biol Cell. 2012. 23: 3499-3510. DOI
36	Kedersha N, Anderson P. Mammalian stress granules and processing bodies. Methods Enzymol. 2007. 431: 61-81. DOI ScienceOn
37	Kedersha N, Cho MR, Li W, Yacono PW, Chen S, Gilks N, Golan DE, Anderson P. Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granules. J Cell Biol. 2000. 151: 1257-1268. DOI ScienceOn
38	Kedersha N, Stoecklin G, Ayodele M, Yacono P, Lykke-Andersen J, Fritzler MJ, Scheuner D, Kaufman RJ, Golan DE, Anderson P. Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol. 2005. 169: 871-884. DOI
39	Kedersha NL, Gupta M, Li W, Miller I, Anderson P. RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules. J Cell Biol. 1999. 147: 1431-1442. DOI
40	Kim WJ, Back SH, Kim V, Ryu I, Jang SK. Sequestration of TRAF2 into stress granules interrupts tumor necrosis factor signaling under stress conditions. Mol Cell Biol. 2005. 25: 2450-2462. DOI ScienceOn
41	Ohn T, Anderson P. The role of posttranslational modifications in the assembly of stress granules. Wiley Interdiscip Rev RNA. 2010. 1: 486-493. DOI
42	Anderson P, Kedersha N. Stress granules. Curr Biol. 2009. 19: R397-398. DOI ScienceOn
43	Srivastava SP, Kumar KU, Kaufman RJ. Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNAdependent protein kinase. J Biol Chem. 1998. 273: 2416-2423. DOI ScienceOn