• Archives of Plastic Surgery
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• v.35 no.2
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• pp.121-126
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• 2008

Purpose: Poly-N-acetyl glucosamine(PGlcNAc) nanofiber-based materials, produced by a marine microalga, have been characterized as effective hemostatic and angiogenic agents. The similarity between PGlcNAc patch and the natural extracellular matrix allows it to support new healthy tissue growth in an injured area and to encourage fluid absorption. In this study, we hypothesized that a poly-N-acetyl glucosamine fiber patch(PGlcNAc patch) may enhance wound healing in the db/db mouse. Methods: PGlcNAc patches were applied on one square centimeter, full-thickness, skin wounds in the db/db mouse model. Wounds(n=15 per group) were dressed with a PGlcNAc nanofiber patch for 1 hour(1 h), 24 hours(24 h) or left untreated(NT). After the application time, patches were removed and wounds were allowed to heal spontaneously. The rate of wound closure was evaluated by digital analysis of unclosed wound area in course of time. At day 10, wounds(n=7 per group) were harvested and quantified with immunohistochemical markers of proliferation(Ki-67) and vascularization (platelet endothelial cell adhesion molecule, PECAM-1). Results: Wounds dressed with PGlcNAc patches for 1 hour closed faster than control wounds, reaching 90% closure in 16.6 days, nine days faster than untreated wounds. Granulation tissue showed higher levels of proliferation and vascularization following 1 h treatment than the 24 h and NT groups. In addition to its hemostatic properties, the PGlcNAc material also appears to accelerate wound closure in healing-impaired genetically diabetic mice. Conclusion: This material, with its combination of hemostatic and wound healing properties, has the potential to be effective agent for the treatment of complicated wounds.

• Journal of the Korean Society for Precision Engineering
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• v.32 no.8
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• pp.755-760
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• 2015

For proper wound healing, dermal contraction and remodeling are critical; during the natural healing process, differentiated fibroblasts called "myofibroblasts" typically undertake these functions. For severe wounds, however, a critical mass of dermal matrix and fibroblasts are lost, making self-regeneration impossible. To overcome this impairment, synthetic wound patches with embedded functional cells can be used to promote healing. In this study, we developed a polydioxanone (PDO)-based cell-embedded sheet on which dermal fibroblasts were cultured and induced for differentiation into myofibroblasts, whereby the following combinatorial physicochemical stimuli were also applied: aligned topology, electric field (EF), and growth factor. The results show that both the aligned topology and EF synergistically enhanced the expression of alpha smooth-muscle actin (${\alpha}$-SMA), a key myofibroblast marker. Our proof-of-concept (POC) experiments demonstrated the potential applicability of a myofibroblast-embedded PDO sheet as a wound patch.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.2
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• pp.13-21
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• 2018

The elderly are more likely to experience passive emotions such as loneliness, anxiety, and depression due to decreased physiological function and low participation in social activities. Therefore, the purpose of this study is to seek how to apply biophilic design from a healing perspective considering mental health to the residential space for the elderly. Biophilic design has a positive effect on the psychological stability of human being and the creation of a human-centered environment that provides various benefits to people's health through the combination with natural elements. The method of this study is as follows. First, survey tools are developed by reviewing literature related to biophilic design and planning factors in housing. Second, we conduct the survey around mental health status and preference of applying biophilic design patterns to the elderly and pre-elderly. Third, we propose a plan to apply biophilic design patterns in houses based on the analyzed results. The biophilic design pattern covered in this study is meaningful in that it seeks clues, the housing plan to create healing environment for the elderly with the nature friendly view.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.49 no.2
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• pp.183-192
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• 2023

In this study, we investigated the antioxidant activity, anti-inflammatory activity, whitening, moisturizing, wound-healing, cell proliferation and cell protective effects of 70% EtOH and hot water extract from Scutellaria baicalensis. For the anti-oxidative test, the 70% EtOH and hot water extract showed DPPH radical scavenging activities. In the anti-inflammatory tests, 70% EtOH and hot water extract inhibited the production of NO, pro-inflammatory cytokine (IL-6) and prostaglandin (PGE₂). In addition, it was confirmed that the 70% EtOH and hot water extract inhibited the melanin production, and increased production of hyaluronic acid (HA), a moisturizing factor. As a result of cell migration and proliferation assay, 70% EtOH extract promoted the cell growth in HaCaT cell. Additionally, 70% EtOH and hot water extract showed cell protective effects against UVB, and 70% EtOH extract also showed cell protective effects agianst blue light. Based on these results, it is concluded that the 70% EtOH and hot water extract from Scutellaria baicalensis could be potentially applicable as anti-oxdiative, anti-inflammation, whitening, moisturizing, wound-healing, cell proliferation and cell protective effects in cosmetic natural materials.

• Korean Institute of Interior Design Journal
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• v.24 no.1
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• pp.43-53
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• 2015

As part of alternative of elderly problems in the future super-aging society, this study aims to extract an improvement plan of interior environment design of Seoul-type day care centers to expand in future by observing day care centers as medical and healing environments, from the perspective of user experience. For this study, after selecting major activity areas of representative cases of Seoul-type day care centers, user behaviors in the space were observed and 4 seniors of baby-boom generation who are potential uses were chosen as personas by reflecting characteristics of healthy elderly, physical aging, mental aging and infirm elderly, from the perspective of user experience. Based on previous studies on healing environments, these characteristics and demands of personas were classified into environmental aspects, physical aspects and mental aspects to extract an improvement plan. The study results are as follows. First, interior environment design reflecting persona characteristics helps the elderly adapt to the environment and provides a comfortable environment like home for stability, treatment and recovery of memory. Second, interior environment design reflecting persona characteristics helps psychological healing through light entering the large windows and natural environment elements. Third, for interior environment design reflecting persona characteristics, finish materials with bright and soft colors should be used to change the images of facilities positively. Fourth, spatial composition should be remedied through division of space and built-in furniture depending on the needs of users for loitering of extra time and programs.

• Journal of Digital Convergence
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• v.18 no.7
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• pp.189-199
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• 2020

The purpose of this study was to provide basic data for the development of strategic measures for the application and growth potential of care farming as a healing for office workers. Therefore this study was investigated the relationship between supply conditions and offer programs for the activation of care farming and the intention of participants to use. The analysis results of the survey conducted for general office workers are as follows. Frist, there was a significant positive correlation between all sub-factors and intention to use. Second, the higher the awareness about the convenience of using healing facilities among supply conditions of healing farming and the necessity of medical service, the higher the intention to use. Third, the higher the awareness about the necessity of cultivation of crops, animal mediation, natural activities, and cultural activities among supply conditions of healing farming, the higher the intention to use. Based on the above analysis results, this study discussed the differences from previous studies and also derived insights for establishing a strategic plan to promote care farming.

• Journal of Korean Society of Forest Science
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• v.111 no.2
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• pp.242-250
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• 2022

Here we aimed to date the year and season of the resin collection from Korean red pines at Worak mountain and investigate the natural healing ability of the wounds using the tree-ring analysis technique. We determined the dating of the resin collection based on the synchronization between the ring-width time series from the wound surface of the experimental trees and the local master chronology, which is the mean time series from the sound surface on the opposite side of the wounds. For the dating of resin collection, we selected thirteen Korean red pines with resin wounds. For the investigation on the annual healing ability of the wounds, we sampled three dead trees out of 13 trees as disks. Through the comparison of the individual ring-width time series from the wounds with the local master chronology, it was verified that the resin collection was undertaken between the spring of 1962 and the autumn of 1975. The mean healing length of the wounds was 15.8 cm over the preceding 42 years, making their annual mean healing 0.38 cm. Through our study we successfully verified the healing ability of the wounded Korean red pines for the resin collection as well as the undocumented resin collection history.

• Preventive Nutrition and Food Science
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• v.10 no.2
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• pp.198-205
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• 2005

Korean medicated diet (KMD) is not a simple combination of food and Chinese drugs, but a special carefully constructed diet made from Sasang constitutional medicines, food and condiments under the theoretical guidance of diet preparation based on differentiation of symptoms and signs of traditional Sasang medicine (TSM). It combines the functional efficacy of medicine with the delicacy of food, and can be used to prevent and cure diseases, build up one's health and prolong one's life. Korean traditional medicated diet has a long history of development. Although influenced by Chinese medicine, Korean traditional medicine has been developed into a unique system of traditional medicine that has surpassed the continental medical practice, sublimating itself into a native medical practice suitable to Korean lifestyles and physical constitutions. In the 19th century, Lee Jema's Sasang medicine (medicine of four types of energy determining the physical constitution) was introduced. It is an integration of mind and body according to the individual's physical constitution that is categorized allowing a customized method of treatment ideal for each category-making the content of Korean traditional medicated diet even richer. The characteristics of Korean medicated diet are as follows: (1) Laying stress on the wole, selecting medicated diet on the basis of differential diagnosis. (2) Suitable for prevention and treatment, outstanding in effect. (3) Good in taste, convenient for taking. KMD refers to drink and food according to certain prescriptions, by processing and cooking that can be used either for prevention and cure of diseases, or for health care and recovery. The purpose of this review is to introduce TSM and KMD based on Sasang constitutional medicines.

• Fashion & Textile Research Journal
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• v.21 no.6
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• pp.708-716
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• 2019

This study explored Jeju natural resources with healing function and tried mixed dyeing of Ecklonia cava and onion shell to improve dyeing. The results showed that silk dyed with a mixture of Ecklonia cava powder and onion shells rather than Jeju's individually dyed silk had better color power to develop fashion products. In addition, all friction lightning bolts, dry cleaning and sweat mining levels were excellent as well as excellent UV protection rates. The three baenaet jeogori worn during a birth anniversary and four rest suits that infants and children can wear comfortably maintained the dyeing and functioning of Ecklonia cava and onion shell mixture that was proven through abnormal experiments. For the three baenaet jeogori and two rest suits, the company has developed a fashion product recognized for high value-added merchandise using a variegation dyeing method made in a handmade style for expressing a person's natural sensibility through dyeing fabrics. Based on the results of the above research, it is expected that various fashion product developments will be possible by dyeing a mixture of functional and colorful extracts of the drug and colorful dye.

• Journal of the Korean Institute of Landscape Architecture
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• v.41 no.1
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• pp.82-92
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• 2013

This paper presents a landscape design proposal for the Kyeongsang National University Hospital in Changwon, Kyeongsangnam-do. The site is located at 555 Samjeongja-dong, Seongsan-gu, Changwon, Kyeongsangnam-do, and its area is approximately $79,743.1m^2$. The goal of the design was to create a landscape that helps the patients' recovery and public well-being as well as respects the surrounding environment. In order to achieve this goal, three design subjects were considered: maximizing the healing functions of the landscape, promoting ecologically regenerative landscape, and increasing the aesthetic value of the landscape based on the local context. For the healing aspect, first, therapeutic plants were carefully selected and various healing programs were introduced to the open space area such as the sensory garden, meditative space, the medicinal herb garden, outdoor acupressure treatment facilities, remedial playground etc. In addition, as the importance of patient's privacy is emphasized in research, the space and circulation patterns were divided according to the characteristics of the users. For ecological consideration, the design proposed to preserve and extend the existing ridgeline with pine forest, and recover the natural water system and recycle the water for the landscape management. For the aesthetic experience of the people, in contrast to the surrounding evergreen forest, diverse deciduous and flowering plants were introduced to arouse a sense of the season, and fruit bearing trees for wildlife to create a specific mood of being in nature so that people can listen to the songs of the birds and watch squirrels play etc. In addition, all the spaces and facilities were designed and placed according to universal design principles so that there would be no barrier for the patients to use them. Also, a sustainable management scheme was suggested to maintain the landscape in ecological and economical ways.