• Bulletin of the Korean Chemical Society
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• v.32 no.7
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• pp.2325-2331
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• 2011

Human CDX1 and CDX2 genes play important roles in the regulation of cell proliferation and differentiation in the intestine. Hox genes clustered on four chromosomal regions (A-D) specify positional signaling along the anterior-posterior body axis, including intestinal development. Using glutathione S-transferase (GST) pulldown assays, molecular interaction measurements, and fluorescence measurements, we found that the homeodomains (HDs) of CDX1 and CDX2 directly interact with that of HOXD8 in vitro. CDX1 showed significant affinity for HOXD8, but CDX2 showed weak affinity for HOXD8. Thus far, three-dimensional structures of CDX1/2 and HOXD8 have not been determined. In this study, we developed a molecular docking model by homology modeling based on the structures of other HD members. Proteins with mutations in the HD of CDX1 (S185A, N190A, T194A, and V212A) also bound to the HD of HOXD8. Our study suggests that the HDs of CDX1/2 resemble those of HOXD8, and we provide the first insight into the interaction between the HDs of CDX1/2 proteins and those of HOXD8.

• BMB Reports
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• v.50 no.5
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• pp.269-274
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• 2017

The biological activities of macrophage migration inhibitory factor (MIF) might be mediated through a classical receptor-mediated or non-classical endocytic pathway. JAB1 (C-Jun activation domain-binding protein-1) promotes the degradation of the tumor suppressor, p53, and the cyclin-dependent kinase inhibitor, p27. When MIF and JAB1 are bound to each other in various intracellular sites, MIF inhibits the positive regulatory effects of JAB1 on the activity of AP-1. The intestinal parasite, Anisakis simplex, has an immunomodulatory effect. The molecular mechanism of action of As-MIF and human JAB1 are poorly understood. In this study, As-MIF and hJAB1 were expressed and purified with high solubility. The structure of As-MIF and hJAB1 interaction was modeled by homology modeling based on the structure of Ace-MIF. This study provides evidence indicating that the MIF domain of As-MIF interacts directly with the MPN domain of hJAB1, and four structure-based mutants of As-MIF and hJAB1 disrupt the As-MIF-hJAB1 interaction.

• Journal of Magnetics
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• v.6 no.4
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• pp.119-121
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• 2001

Monte Carlo simulation was employed to study the phase transition in the classical Heisenberg ferromagnet with variable interlayer interactions. The measured transition temperatures show a strong logarithmic dependence on J/J'where J and J'are the intralayer and the interlayer exchange interaction, respectively. The results were compared with the theoretical expectations and an empirical formula for the critical coupling was stained.

• 한국전산유체공학회:학술대회논문집
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• 2003.10a
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• pp.167-169
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• 2003

This paper presents a theoretical study concerning multibubble dynamics in a sound field and the numerical validation for it by employing our new CFD code MTS-DiCUP. In recent papers, the author has shown theoretically that an unknown characteristic frequency, named 'transition frequency,' exists in a multibubble system. For a N -bubble case, up to 2N -1 transition frequencies per bubble have been predicted, only N ones of them correspond to the natural frequencies of the system. The transition frequencies that do not correspond to the natural frequencies give rise to the phase reversal of bubbles' pulsation without resonant response. In this paper, it has been suggested theoretically that those transition frequencies may cause the sign reversal of the secondary Bjerknes force, which is an interaction force acting between acoustically coupled gas bubbles. This theoretical result has been validated by the direct numerical simulation, at least in a qualitative sense.

• Development and Reproduction
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• v.21 no.4
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• pp.449-456
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• 2017

The germline stem cells of the Drosophila ovary continuously produce eggs throughout the life-span. Intricate regulation of stemness and differentiation is critical to this continuous production. The translational regulator Nos is an intrinsic factor that is required for maintenance of stemness in germline stem cells. Nos expression is reduced in differentiating cells at the post-transcriptional level by diverse translational regulators. However, molecular mechanisms underlying Nos repression are not completely understood. Through three distinct protein-protein interaction experiments, we identified specific molecular interactions between translational regulators involved in Nos repression. Our findings suggest a model in which protein complexes assemble on the 3' untranslated region of Nos mRNA in order to regulate Nos expression at the post-transcriptional level.

• Bulletin of the Korean Chemical Society
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• v.4 no.3
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• pp.123-127
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• 1983

The crystal structure of metoclopramide, $C_14H_22ClN_3O_2$, has been determined by X-ray diffraction techniques using diffractometer data obtained by the ${\omega}-2{\theta}$ scan technique with Mo $K\alpha$ radiation from a crystal with space group symmetry $P{\overline{1}}$ and unit cell parameters a = 7.500(1), b = 8.707(2), c = 13.292(2) ${\AA}$; ${\alpha}$ = 101.70(2), ${\beta}$ = 81.20(2), and ${\gamma}$ = $114.90(l)^{\circ}$. The sructure was solved by direct methods and refined by full-matrix least-squares to a final R = 0.055 for the 1524 observed reflections. The bent overall-conformation of the molecule seems to be determined mainly by the bifurcated intramolecular hydrogen bond from the amide nitrogen atom to the methoxy oxygen and the amine nitrogen atoms. The crystal packing consists of the hydrogen bonds, ${\pi}-{\pi}$ interaction and hydrophobic interaction.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2005.05a
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• pp.372-378
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• 2005

Finite element analysis of concrete slab system in apartment building was executed using the tables of orthogonal arrays, and optimal design process was proposed. At first, experimental results show that sound peak components to influence the overall level and the rating of floor impact sound insulation were coincident with natural frequencies of the reinforced concrete slab. Finite element model of concrete slab was compared with experimental results, and well corresponded with an error of less than 10%. The tables of orthogonal arrays were used for finite element analysis with 8 factors. 3 related to material properties and 5 related to slab shape parameters and its results were analyzed by statistical method, ANOVA. The most effective factor among them was slab thickness, and main effect factor from slab shape parameters was different from each natural frequency. The interaction was found in the higher mode over $3^{rd}$ natural frequency. From main effect plot and interaction plot, the optimal design factor to increase the natural frequency was determined.

• Journal of Environmental Science International
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• v.24 no.11
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• pp.1541-1546
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• 2015

The objective of this research was to evaluate the toxicity of the industial xenobiotic Aroclor 1248 (A) and natural origin substances~elemental sulfur (S80) and oleic acid (OA) and their binary mixtures to V. fischeri bioluminescence during the prolonged exposure time (up to 60 min). The bioluminescence quenching test was used to determine the toxic effects. Full factorial experiment design and multiple regression analysis and the comparison of binary mixture effect with the sum of effects of individual chemicals were used for the evaluation of combined effects of toxicants. The analysis of general trend of mixture toxicity to bioluminescence showed that mixture toxic effects were reversible up to 60 min. Data analysis revealed different joint effects, which were depended on mixture composition. S80 enhanced toxic effect of A and acted additively with synergistic interaction. Hydrophobic OA in mixture with A acted antagonistically and in mixture with sulfur caused an additive effect with antagonistic component of interaction. It was concluded that low concentrations of natural toxic substances present in environmental samples as mixtures of chemicals can define the toxicodynamic character of industrial xenobiotics.

• Korean Institute of Interior Design Journal
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• v.18 no.1
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• pp.108-116
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• 2009

As an aging society accelerates its pace for the present, providing a pleasant environment to nursing homes is such an environmental requirement with which elderly people could improve their quality of life and even acquire the effects of healing. As an optimal element of ensuring amenity, nature is a general hospital that heals human beings physically and mentally. In this vein, the investigator drew out the frame of analysis, namely emotional/healing/relating amenity, by means of theoretical examination of such natural elements as water, light, soil/stone, and plant. And on the basis of the drawn amenity, the investigator examined the application of natural elements to study subjects in order to analyze the ensured amenity. Study findings show that the existing nursing homes have ensured healing amenity sufficiently, but they are unsatisfactory in ensuring emotional and relating amenity. Based on interview survey, the investigator suggests that the introduction of natural elements into nursing homes such public space as mediation space, interaction space, and rest places to ensure emotional/healing/relating amenity must be ideally equipped with the formation of outdoor forest in which water, light, soil/stone, and plant get joined together, rather than Introducing a single element respectively. In addition, the plan of construction of nursing homes must take residing elderly people's emotional/healing/relating amenity into account on the basis of physical amenity.

• Journal of Internet Computing and Services
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• v.23 no.1
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• pp.19-29
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• 2022

Natural user interface (NUI) is used for the natural motion interface without using a specific device or tool like a mouse, keyboards, and pens. Recently, as non-contact sensor-based interaction technologies for recognizing human motion, gestures, voice, and gaze have been actively studied, an environment has been prepared that can provide more diverse contents based on various interaction methods compared to existing methods. However, as the number of sensors device is rapidly increasing, the system using a lot of sensors can suffer from a lack of computational resources. To address this problem, we proposed a real-time multi-device control system for natural interactive platform. In the proposed system, we classified two types of devices as the HC devices such as high-end commercial sensor and the LC devices such astraditional monitoring sensor with low-cost. we adopt each device manager to control efficiently. we demonstrate a proposed system works properly with user behavior such as gestures, motions, gazes, and voices.