• 생약학회지
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• 제28권4호
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• pp.286-292
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• 1997

We studied the screening condition for immune regulatory responsor. We focused on the T-lymphocytes leer this purpose. Mouse fetal thymic organ culture (FTOC) system and flow cytometric analysis were mainly used in this experiment. Even if FTOC is carried out in vivo condition, the pattern of thymic development in the condition of FTOC is similar to that of in vivo condition. In this regard, FTOC system might be very powerful tool to screen the immune regulator, especially concerning on T cells. To establish the optimum condition of FTOC to screen the Immune regulator, we focused on the optimum amount of dose and culture period. The cell number and surface antigens on T cells were also analysed by using hemacytometer and flow cytometer. To monitor the differentiation event, anti-CD3, anti-CD4 and anti-CD8 antibodies were used. Alkoxyglycerol and Phellodendri Cortex were used fur positive and negative control, respectively. Astragalus membranceus was used as test sample. From our analysis, we reached to conclusions that the best dose of extract is $50\;{\mu}g/ml$ of culture medium, the best culture period is for 9 days, and ethanol used as solvent has no toxicity to FTOC.

• Nuclear Engineering and Technology
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• 제53권5호
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• pp.1429-1435
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• 2021

The temperature distribution of an electromagnetic pump was analyzed with a flow rate of 1380 L/min and a pressure of 4 bar designed for the sodium thermo-hydraulic test in the Sodium Test Loop for Safety Simulation and Assessment-Phase 1 (STELLA-1). The electromagnetic pump was used for the circulation of the liquid sodium coolant in the Intermediate Heat Transport System (IHTS) of the Prototype Gen-IV Sodium-cooled Fast Reactor (PGSFR) with an electric power of 150 MWe. The temperature distribution of the components of the electromagnetic pump was numerically analyzed to prevent functional degradation in the high temperature environment during pump operation. The heat transfer was numerically calculated using ANSYS Fluent for prediction of the temperature distribution in the excited coils, the electromagnet core, and the liquid sodium flow channel of the electromagnetic pump. The temperature distribution of operating electromagnetic pump was compared with cooling of natural and forced air circulation. The temperature in the coil, the core and the flow gap in the two conditions, natural circulation and forced circulation, were compared. The electromagnetic pump with cooling of forced circulation had better efficiency than natural circulation even considering consumption of the input power for the air blower. Accordingly, this study judged that forced cooling is good for both maintenance and efficiency of the electromagnetic pump.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
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• pp.108-108
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• 2003

The current study was performed to observe the effects of Panax ginseng (PG) and P. quinquefolia (PQ) on hemodynamics such as blood flow rate (BF), blood flow velocity (BV), heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP, and body temperature (BT) in healthy young men. After testing equality of variance, Student's t-test using PROC TTEST was examined to. prove statistical differences between control and ginseng conditions at each time point. It was found that the BF data were fluctuated by personal deviation. In order to minimize the deviation, the results obtained for 6 hrs were reconstituted after dividing them into two periods of the first half from 1 to 3 hrs and of the latter half from 3.5 to 6 hrs. And then the reconstitution data and dose-response curves were obtained. Blood flow such as BF and BV shows significant increases both two periods in the dose of PG 2.25 and PG 9.0, whereas significant decrease in the dose of PG 4.5. However, in the PQ groups, the middle dose PQ 4.5 shows the highest significant increase among the three doses. Except for PG 2.25 in HR, other doses show significant decreases both in the first half and latter half. SBP of PQ 9.0 shows only a significant decrease in the first half; on the other hand, in the latter half, PG 4.5, PG 9.0 and PQ 9.0 significantly increase SBP. In addition, DBP of PG 2.25 and PG 4.5 show significant increase in the both periods. In the BT, PQ groups show gradual decrease from PQ 2.25 to PQ 9.0; however, PG groups show differently. PG 4.5 shows significant decrease, but PG 9.0 shows a increase without statistical meanings. In summary, PG is more effective in respect to keeping homeostasis of hemodynamics.

• Journal of Computational Design and Engineering
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• 제3권4호
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• pp.349-362
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• 2016

The numerical solutions of unsteady hydromagnetic natural convection Couette flow of a viscous, incompressible and electrically conducting fluid between the two vertical parallel plates in the presence of thermal radiation, thermal diffusion and diffusion thermo are obtained here. The fundamental dimensionless governing coupled linear partial differential equations for impulsive movement and uniformly accelerated movement of the plate were solved by an efficient Finite Element Method. Computations were performed for a wide range of the governing flow parameters, viz., Thermal diffusion (Soret) and Diffusion thermo (Dufour) parameters, Magnetic field parameter, Prandtl number, Thermal radiation and Schmidt number. The effects of these flow parameters on the velocity (u), temperature (${\theta}$) and Concentration (${\phi}$) are shown graphically. Also the effects of these pertinent parameters on the skin-friction, the rate of heat and mass transfer are obtained and discussed numerically through tabular forms. These are in good agreement with earlier reported studies. Analysis indicates that the fluid velocity is an increasing function of Grashof numbers for heat and mass transfer, Soret and Dufour numbers whereas the Magnetic parameter, Thermal radiation parameter, Prandtl number and Schmidt number lead to reduction of the velocity profiles. Also, it is noticed that the rate of heat transfer coefficient and temperature profiles increase with decrease in the thermal radiation parameter and Prandtl number, whereas the reverse effect is observed with increase of Dufour number. Further, the concentration profiles increase with increase in the Soret number whereas reverse effect is seen by increasing the values of the Schmidt number.

• 한국수자원학회논문집
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• 제38권9호
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• pp.727-736
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• 2005

본 연구에서는 McCormack 기법의 2차 정확도 및 단순성의 장점과 불연속 흐름을 해석할 수 있는 상류이송기법의 장점을 결합하여 상류이송형 McCormack 기법을 새로이 개발하였다. 이 기법은 생성항을 효과적으로 처리할 수 있는 장점도 지니고 있다. 본 연구에서 개발된 기법을 해석해를 가진 가상적인 하도에 적용한 결과 기존 McCormack 기법에서 발생하던 수치진동없이 해석해를 잘 재현할 수 있는 것으로 나타났다. 또한 실제 하천에 대한 적용을 위해 하상과 하폭의 변화가 매우 심한 한강 하류구간에 적용한 결과 기존 McCormack 기법이 해석할 수 없는 정상류나 부정류를 모두 잘 해석할 수 있는 것으로 나타났다. 본 연구에서 개발한 상류이송형 McCormack 기법은 복잡한 자연하도의 흐름해석을 위해 효과적으로 사용될 수 있을 것으로 판단된다.

• 한국수자원학회논문집
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• 제52권spc2호
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• pp.823-833
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• 2019

This study presents the impact of natural flow patterns on downstream fish habitat and economic outcomes in the Dal Stream, Korea. The study reach is 3.35 km long, located downstream form the Goesan Dam. To assess such impact, this study performed physical habitat simulations. The River2D model was used for the computation of the flow and the HSI model for the habitat simulation. Two physical habitat variables, flow depth and velocity, were used. The Zacco platypus, Zacco temminckii, Coreoleuciscus splendidus, and Opsariichthys bidens were selected as the target species in the study area. Using the building block approach (BBA), the scenarios for the hydropeaking mitigation were presented. Scenario 1 and scenario 2 were proposed by using the magnitude - duration concept and averaged the hydrologic data over the each month, respectively. Simulation results indicated that the scenarios effects significantly increased by about 18.6% for the weighted usable area (WUA). In addition, hydroelectric power benefits with both scenarios were investigated. It was revealed that the change of storing and releasing water decreased by about 27% for hydroelectric power benefits. In order to increase economic benefits, the scenario was modified with the discharges corresponding to the hydropeaking condition except the flood season. As a result, the hydroelectric power benefits were almost the same, however the aquatic habitat for the target species increased by about 5%. The change of dam re-operations through natural flow patterns provides an opportunity to minimize environmental and economic benefits in order to balance water management.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회B
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• pp.2194-2199
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• 2007

An experimental study is performed to investigate the thermal and flow characteristics of subcooled liquid nitrogen in a natural circulation loop. Experimental apparatus is designed and constructed such that a closed loop is cooled at the top by a cryocooler and heated nearly at the bottom by cartridge heaters. Steady state is obtained by controlling the heating power to the cartridge heaters and a thin-film heater to reduce the cooling power of the cryocooler. Temperature is measured at several locations of the loop and the mass flow rate through the loop is estimated from the energy balance in terms of the measured temperatures. Experiment is repeated for various values of the vertical height between the cooling and heating parts. The results show that the heat transfer capability of the loop has a maximum at a certain value of height. The optimal height to maximize the heat transfer is in a good agreement with analytical prediction to take into account the buoyancy and viscous forces in the loop.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집D
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• pp.483-488
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• 2001

In the present study a numerical simulation is performed on a natural convection inside a square cavity with a vibrating wall. The study has been conducted varying the heat transfer rate, wall excitation frequency and also the orientation of the cavity. The temperature and velocities inside the cavity was observed and also, the heat transfer coefficients on the heating wall was seen. From the results, it can be seen that the temperature inside the cavity decreases when excited with the proper frequency and the heat transfer coefficient increased with cavity inclination angle, ${\theta}$. It is also found from the results that flow resonance is occurred near the inclination angle ${\theta}=90^{\circ}$.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1997년도 춘계학술발표회논문집(1)
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• pp.514-519
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• 1997

The MRX is an integral type ship reactor with 100 MWt power, which is designed by Japan Atomic Energy Research Institute. It is characterized by integral type PWR, in-vessel type control roe drive mechanism, water-filled containment vessel and passive decay heat removal system. Marine reactor should have high passive safety. Therefore, in this study, we simulated the loss of flow accident to verify the passive decay heat removal by natural circulation using RETRAN-03 code. auxiliary feed water systems are used for decay heat removal mechanism and results are compared with the loss of flow accident analysis using emergency decay heat removal system by JAERI. Results are very similar to case of EDRS 1 loop operation in JAERI analysis and decay heat is successfully removed by natural circulation.

• Journal of Mechanical Science and Technology
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• 제18권4호
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• pp.718-730
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• 2004

The solution for the natural convection in internally finned horizontal annuli is obtained by using a numerical simulation of time-dependent and two-dimensional governing equations. The fins existing in annuli influence the flow pattern, temperature distribution and heat transfer rate. The variations of the On configuration suppress or accelerate the free convective effects compared to those of the smooth tubes. The effects of fin configuration, number of fins and ratio of annulus gap width to the inner cylinder radius on the fluid flow and heat transfer in annuli are demonstrated by the distribution of the velocity vector, isotherms and streamlines. The governing equations are solved efficiently by using a parallel implementation. The technique is adopted for reduction of the computation cost. The parallelization is performed with the domain decomposition technique and message passing between sub-domains on the basis of the MPI library. The results from parallel computation reveal in consistency with those of the sequential program. Moreover, the speed-up ratio shows linearity with the number of processor.