• 혜화의학회지
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• 제25권1호
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• pp.119-132
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• 2016

Objectives : The aim of this study is to investigate the effect of natural carbonated hot spring water (NCHW) on DNCB-induced NC/Nga mice, an atopic dermatitis (AD) model. Methods :At first, NC/Nga mice were prepared and induced to have atopic lesion on their back skin by dinitrochlorobenzene (DNCB). They swam for 20 minutes everyday in tanks where the one is filled with $28^{\circ}C$ NCHW, the other is with $25^{\circ}C$ carbonated hot spring water and another is with artificial carbonated hot spring water (ACHW). After 3 weeks, We assessed the skin clinical score and macroscopic appearance, total IgE, IgG1 levels, WBC differential counting, IFN-${\gamma}$, IL-4, IL-13, TNF-${\alpha}$ production levels and histological changes. Results : There are meaningful results of improving atopic lesion-state by relieving the count of total IgE, IgG1 levels, WBC differential counting, IFN-${\gamma}$, IL-4, IL-13, TNF-${\alpha}$ production levels and recovering skin clinical score in the group with $28^{\circ}C$ NCHW in comparison with the other groups. Conclusions : The NCHW may have potential as an effective treatment for atopic dermatitis.

• 혜화의학회지
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• 제26권1호
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• pp.19-24
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• 2017

Objectives:Spring water is widely known to relax muscles by promoting blood circulation. This study was conducted to analyze theantithrombotic effect of naturally carbonated hot spring water (NCHW) to assess its influence on blood circulation. Methods:Atopic dermatitis was induced in the skin of the mice used in this experiment. NCHW was applied, and the antithrombotic effect was assessed and compared with that of other interventions. The positive control group was treated orally with aspirin. Results:After 3 weeks of exposure to NCHW, the experimental groupshowed a significant antithrombotic effect. NCHW also produced inhibitory responses to both collagen- and ADP-induced platelet aggregation, whereas the group given aspirin reacted only to collagen-induced platelet aggregation. Conclusions:The experiment demonstrated the intrinsic antithrombotic effects of NCHW compared with those of artificially carbonated water, tap water, and aspirin. This result suggests the possibility that NCHW can be used as a supportive and alternative treatment for vascular diseases.

• 지질공학
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• 제26권4호
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• pp.515-529
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• 2016

본 연구에서는 제주 서귀포지역에서 산출되는 온천수 2지점과 탄산수 2지점에 대한 화학성분, CFCs (Chlorofluorocarbons) 동위원소, ${\delta}^{18}O$, ${\delta}D$, ${\delta}^{13}C$ 동위원소, 영족기체(He, Ne) 동위원소 분석을 통하여 탄산온천수와 탄산수의 수리화학적 특성, 생성연령, 영족기체의 기원과 $CO_2$ 가스의 기원을 해석하였다. 연구지역의 탄산수의 pH는 6.21~6.84의 범위의 약산성과 매우 높은 전기전도도 값($1,928{\sim}4,720{\mu}S/cm$)의 특성을 보인다. 화학적 유형은 $Mg(Ca,Na)-HCO_3$ 내지는 $Na(Ca,Mg)-HCO_3$ 유형을 보인다. 환경추적자인 CFCs 농도를 이용하여 지하수 연령측정결과, 탄산수는 약 47.5~57.2년, 지하수는 약 30.3~49.5년으로 추정되었다. 탄산수의 ${\delta}^{13}C$값은 -1.77~-7.27‰의 범위를 보여 $CO_2$ 가스의 기원은 심부기원과 일부 심부-무기기원의 혼합 기원으로 도시되었지만, 영족기체 조성비($^3He/^4He$, $^4He/^{20}Ne$)에서 헬륨가스가 심부기원의 농도가 절대적으로 높은 값을 보여 화산활동과 관련한 심부 마그마 기원임을 보여준다.