• Journal of Ginseng Research
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• v.46 no.1
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• pp.62-70
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• 2022

Background: Maternal Toxoplasma gondii (T. gondii) infection during pregnancy has been associated with various mental illnesses in the offspring. Ginsenoside Rh2 (GRh2) is a major bioactive compound obtained from ginseng that has an anti-T. gondii effect and attenuates microglial activation through toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) signaling pathway. GRh2 also alleviated tumor-associated or lipopolysaccharide-induced depression. However, the effects and potential mechanisms of GRh2 on depression-like behavior in mouse offspring caused by maternal T. gondii infection during pregnancy have not been investigated. Methods: We examined GRh2 effects on the depression-like behavior in mouse offspring, caused by maternal T. gondii infection during pregnancy, by measuring depression-like behaviors and assaying parameters at the neuronal and molecular level. Results: We showed that GRh2 significantly improved behavioral measures: sucrose consumption, forced swim time and tail suspended immobility time of their offspring. These corresponded with increased tissue concentrations of 5-hydroxytryptamine and dopamine, and attenuated indoleamine 2,3-dioxygenase or enhanced tyrosine hydroxylase expression in the prefrontal cortex. GRh2 ameliorated neuronal damage in the prefrontal cortex. Molecular docking results revealed that GRh2 binds strongly to both TLR4 and high mobility group box 1 (HMGB1). Conclusion: This study demonstrated that GRh2 ameliorated the depression-like behavior in mouse offspring of maternal T. gondii infection during pregnancy by attenuating the excessive activation of microglia and neuroinflammation through the HMGB1/TLR4/NF-κB signaling pathway. It suggests that GRh2 could be considered a potential therapy in preventing and treating psychiatric disorders in the offspring mice of mothers with prenatal exposure to T. gondii infection.

• The Journal of the Korea Contents Association
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• v.16 no.10
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• pp.108-129
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• 2016

The purpose of this study was to develop a natural object configuration items of art education programs for children and hade verify compliance. To this end, through the literature review and analysis of previous research and the Delphi investigation of natural objects art activities were developed natural objects of art education programs. The program was applied consisting of a total of 24 times periods for 12 weeks to five year olds, represented through the art skills of children and nature-friendly attitude tests were proven the effectiveness of the program. The results showed that the natural objects of art education programs for children in the study developed effective representation in art and nature-friendly attitude, the ability of young children. This study natural objects for the art education in early childhood development programs could be provided as a basis to help plan and practice the art education activities utilize the natural objects of children in early childhood education.

• Bulletin of the Korean Chemical Society
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• v.34 no.5
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• pp.1537-1540
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• 2013

• Hwankyungkyoyuk
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• v.25 no.2
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• pp.135-148
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• 2012

This research was aimed at developing the program using the natural circumstances in Jeju Oreum as the basis of environmental education. The students were inquired about how these activities influence the environmental literacy of elementary students. The result of this study were as follows; First, the experimental group applied experience activities to the developed program to contribute to the improvement of environmental literacy. This was then compared to the control group to which theoretical classes were conducted. Second, Jeju Oreum Experience learning program has evenly influenced the elements of environmental literacy divided by the four goal levels of environmental education. As a result of the research, the Natural Experience Activities on the basis of natural circumstance is considered to affect the elementary students' environmental literacy in positive, effective manner. Consequently, the Environmental Education in a school or society should develop programs that apply to natural circumstances as a field of Environmental Education.

• Journal of the Korean Institute of Landscape Architecture
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• v.28 no.3
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• pp.39-52
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• 2000

The purpose of this paper is to investigate the difference in facilities of natural recreation forests developed by public and private body to answer the research that what is the difference in development of natural recreation forest between public and private developer\ulcorner After reviewing the literatures, developer's decision-making and motivation of investment, and the planning process of natural recreation forest, we had constructed th conceptual framework and have found the hypothesis of this research. Using data on development status of natural recreation forests and questionnaire surveying of 625 visitors from 9 among 72 natural recreation forests in Korea, We analyzed the data through the comparison of quantity of facilities per 1000 visitors and logistic regression method for quality of facilities. We have found that 1) the six facilities have been turned out to be statistically significant in determining the difference of public and private recreation forests. i.e., infrastructure including roads, maintenance and information and lodging and evacuation, indoor education, outdoor education, and shopping, 2) public recreation forests are well equipped such basic facility as roads, maintenance and information, lodging and evacuation while private recreation forests are well equipped such facility as indoor education, outdoor education, and shopping, and 3) the importance of such facility as roads, maintenance and information, lodging and evacuation, outdoor education, and shopping have been turned out to have 1.99, 2.26, 1.99, 3.01 and 2.24 times more important than that of indoor education, respectively. We can conclude that public recreation forest seems to be equipped with the facilities for sound recreational opportunities for general public, and private recreation forest turned out to have more facilities for pursuit of profits, installed basic facilities for user convenience and service, and special facilities for attracting user and raising revenue. Using the results of this research, we can make a guideline for a market positioning, and standards and provisions of natural recreation forests. We suggest that the relationship between user-satisfaction and recreation facility is needed to be examined in the future research.

• Hwankyungkyoyuk
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• v.20 no.3
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• pp.89-101
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• 2007

The purpose of this study was to analysis natural disasters which can be applied environmental education for elementary students. For this study, the elementary society and science textbooks were selected. The results of this study are as follows. the society textbooks contain 2 units of the natural disaster in the 4th and 5th grades. In the science textbooks, 5 units of the natural disaster were showed in 3rd, 5th and 6th grades. The learning quantities were 4 hours in society textbooks and 7 hours in science textbooks. In society textbooks, the contents relating meteorological disasters were dominance. But the science textbooks were showed both meteorological and geological disasters. In aims of learning, while the society textbooks were focused as damages, prevention, counter-plan and restoring plan of the natural disaster, the science textbooks were emphasized damages. the photos in society textbooks, meteorological disasters were superiority in number; especially the flood and heavy rain were 76%. In science textbooks, the photos about earthquake were prominent as 40%. For activating environmental education in elementary school based on these results, it can be suggested that the effects of natural damage as tsunami and global warming should add to elementary textbooks. And the elementary teachers need to understand contents and photos relating environment problem in the elementary textbooks.

• Journal of Science Education
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• v.33 no.2
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• pp.237-247
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• 2009

The purpose of this research is to investigate the participant satisfaction of public educational programs being carried out in Natural History Museum and the contribution of these programs to normal school education and to suggest an improved framework for public education programs in Natural History Museum. For this study, we choose Seodaemun Museum of Natural History in Seodaemungu, Seoul, in which more than 30,000 students have participated in the educational programs for the last 6 years. This museum has been providing more than 60 science education programs every year. Based on a public census among participating students and accompanying parents, we investigated the satisfaction ratings of education programs provided by Natural History Museum and their contribution to school science education. The result of this study can be summarized as follows: (1) It is desired to have the education program contents well connected to the exhibits of the Museum and to increase time for experiments and practice. (2) It is required to improve the ease of access and to enhance the public awareness about the program itself. (3) The biggest consensus among participants is that the education programs by Natural History Museum should be focused on strengthening the research ability and scientific attitude rather than on acquiring knowledge, which will contribute to school education more significantly in the end.

• Journal of Ginseng Research
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• v.48 no.2
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• pp.202-210
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• 2024

Background: Panax ginseng Meyer polysaccharides exhibit various biological functions, like antagonizing galectin-3-mediated cell adhesion and migration. Galectin-8 (Gal-8), with its linker-joined N- and C-terminal carbohydrate recognition domains (CRDs), is also crucial to these biological processes, and thus plays a role in various pathological disorders. Yet the effect of ginseng-derived polysaccharides in modulating Gal-8 function has remained unclear. Methods: P. ginseng-derived pectin was chromatographically isolated and enzymatically digested to obtain a series of polysaccharides. Biolayer Interferometry (BLI) quantified their binding affinity to Gal-8, and their inhibitory effects on Gal-8 was assessed by hemagglutination, cell migration and T-cell apoptosis. Results: Our ginseng-derived pectin polysaccharides consist mostly of rhamnogalacturonan-I (RG-I) and homogalacturonan (HG). BLI shows that Gal-8 binding rests primarily in RG-I and its β-1,4-galactan side chains, with sub-micromolar K_D values. Both N- and C-terminal Gal-8 CRDs bind RG-I, with binding correlated with Gal-8-mediated function. Conclusion: P. ginseng RG-I pectin β-1,4-galactan side chains are crucial to binding Gal-8 and antagonizing its function. This study enhances our understanding of galectin-sugar interactions, information that may be used in the development of pharmaceutical agents targeting Gal-8.

• Bulletin of the Korean Chemical Society
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• v.30 no.3
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• pp.556-560
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• 2009

Aggregation behavior of three kinds of benzindocarbocyanine dyes in aqueous methanol solution was studied by UV-Vis absorption spectrum. The results indicated that the three dyes all existed monomer-dimer equilibrium in aqueous methanol solution (concentration range $10^{−5}\;to\;10^{−6}$ M) at 25.0$\sim$41.0 ${^{\circ}C}$ for Dye 1, 28.0$\sim$49.0 ${^{\circ}C}$ for Dye 2 and 26.0$\sim$47.0 ${^{\circ}C}$ for Dye 3. The fundamental property of the three dyes as the dimeric association constant KD, the dimeric free energy ${\Delta$}G_D, the dimeric entropy ${\Delta$}S_D, and the dimeric enthalpy ${\Delta$}H_D were determined. The ${\Delta$}H_D of three dyes: Dye 1, Dye 2 and Dye 3 was -42.5, -15.1 and -18.9 kJ/mol, respectively. The experimental observations were the subject of a theoretical study including the ground-state geometries which were fully optimized using DFT at B3LYP/6-31G level. The effect of dye molecule structure on ${\Delta$}H_D was discussed by theoretical calculations.

• Journal of The Korean Association For Science Education
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• v.27 no.6
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• pp.477-487
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• 2007

Previous studies show that students have difficulties in understanding and using molecular visualization tools. This study focuses on the ways in which first year chemistry undergraduates use ball-and-stick molecular models to explain the concept of addition reaction and the difficulties that they face using the models. Video recordings of interviews with undergraduates manipulating ball-and-stick models to solve problems related to reaction mechanisms are analysed to determine if they are able to elucidate their understanding with use of models. The results showed that students have difficulties with viewing the ball-and-stick models from the proper perspective and understanding the relationship between the various structures that they have created using the models. They also find the use of ball-and-stick models tedious and prefer drawing molecular structures on paper to explain their ideas. Implications for the teaching using ball-and-stick molecular models are discussed.