• Journal of Genetic Medicine
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• v.17 no.1
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• pp.27-33
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• 2020

Purpose: Duchenne muscular dystrophy (DMD) is the most common lethal muscular dystrophy and is caused by the genetic variants of DMD gene. Because DMD is X-linked recessive and shows familial aggregates, prenatal diagnosis is an important role in the management of DMD family. We present our experience of prenatal molecular diagnosis and carrier detection based on multiplex polymerase chain reaction (PCR), multiplex ligation-dependent probe amplification (MLPA), and linkage analysis. Materials and Methods: During study period, 34 cases of prenatal diagnosis and 21 cases of carrier detection were performed at the Seoul National University Hospital. Multiplex PCR and MLPA was used to detect the exon deletions or duplications. When the DMD pathogenic variant in the affected males is unknown and no DMD pathogenic variant is detected in atrisk females, linkage analysis was used. Results: The prenatal molecular diagnosis was offered to 34 fetuses. Twenty-five fetuses were male and 6 fetuses (24.0%) were affected. Remaining cases had no pathogenic mutation. We had 24 (80.0%) cases of known proband results; exon deletion mutation in 19 (79.2%) cases and duplication in 5 (20.8%) cases. Linkage analysis was performed in 4 cases in which 2 cases (50.0%) were found to be affected. In the carrier testing, among 21 cases including 15 cases of mother and 6 cases of female relative, 9 (42.9%) cases showed positive results and 12 (57.1%) cases showed negative results. Conclusion: Prenatal molecular diagnosis and carrier detection of DMD are effective and feasible. They are useful in genetic counseling for DMD families.

• Journal of Ocean Engineering and Technology
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• v.32 no.5
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• pp.372-379
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• 2018

High-pressure gas injection engines (HPGI) took center stage in LNG carrier propulsion systems after their advent. The HPGI engine system can be easily modified to include a re-liquefaction system by adding several devices, which can significantly increase the economic feasibility of the total system. This paper suggests the optimal operating conditions and capacity for a re-liquefaction system for an LNG carrier, which can minimize increases in the total annualized cost. The installation of a re-liquefaction system can save 0.23 million USD per year when the cost of LNG is 5 USD/Mscf. A sensitivity analysis with different LNG costs showed that the re-liquefaction system is profitable when the LNG cost is higher than 3.5 USD/Mscf.

• 한국정보디스플레이학회:학술대회논문집
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• 2008.10a
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• pp.239-242
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• 2008

We have investigated the reliability of short channel ($L=1.5{\mu}m$) p-type ELA poly-Si TFTs under hot carrier stress. Threshold voltage of short channel TFT was significantly more shifted to positive direction than that of long channel TFT under the same stress. This result may be attributed to electron trapping at the interface between poly-Si film and gate oxide layer.

• Proceedings of the KIPE Conference
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• 2010.11a
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• pp.183-185
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• 2010

In this paper, carrier comparison SVPWM method for voltage control of vienna rectifier is proposed. Two carrier waves are used to compare voltage commands. The feasibility of the proposed PWM method is proven by the simulation. In the simulation results, it is shown that vienna rectifier can be controlled easily by the proposed method.

• International Journal of Aeronautical and Space Sciences
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• v.13 no.2
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• pp.250-259
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• 2012

The need for position information in indoor environments has been growing lately. Several indoor navigation systems have been studied. Among them, pseudolite-based indoor positioning systems are one of the best systems to obtain precise position measurements. However, the installation of such systems is very difficult because the calibration of pseudolite antenna position is complicated. For precise calibration, the use of carrier phase measurements is necessary, and whenever carrier phase measurements are considered, problems with cycle ambiguity appear. In this paper, a new approach to calibrate the positions of pseudolite antennas is proposed. By using a multi-antenna, the ambiguity can be eliminated, epoch by epoch, for every single carrier phase measurement. Moreover, the number of calibration points can be reduced down to 3 by use of measurements collected at unknown positions. Using the proposed methods, the process of the collection of carrier phase measurements becomes considerably simple and convenient. Simulation results are presented to verify the proposed algorithms.

• Journal of Pharmaceutical Investigation
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• v.13 no.4
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• pp.153-172
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• 1983

The use of carrier systems for the delivery of drugs to areas in the body in need of pharmacological intervention is now the subject of intense research in many laboratories. Because of its obvious advantages (e.g. protection of drugs from hostile environments, facilitated target penetration and avoidance of side effects), drug delivery is expected to ease the pressure and expense of new drug development by making better use of drugs in existence. Generally, carrier-mediated delivery has been envisaged either as direct transport of drugs to a biological target by a carrier that will associate with it selectively, or as release of drugs from a carrier circulating in the blood or immobilized in tissues, at rates compatible with optimal action. One system that has attracted considerable attention is the use of liposomes as carriers of pharmacologically active agents. 154 references were reviewed with special emphasis on the targeting of drugs by use of liposomes in this respect. Recent advances in the other carrier systems and in methods for the preparation of liposomes were also reviewed briefly.

• Journal of Pharmaceutical Investigation
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• v.22 no.4
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• pp.289-300
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• 1992

The counter-transport phenomena in the hepatic transport of 1-anilino-8-naphthalene sulfonate (ANS) were kinetically investigated by analyzing the plasma disappearance-time profiles and the transport into the isolated hepatocytes. In vivo "counter transport phenomena" were simulated based on the perfusion model which incorporated the carrier-mediated transport and the saturable intracellular binding. The condition that the mobility of carrier-ligand complex is greater than that of free carrier is not essential for the occurrence of counter-transport phenomenon. To examine the inhibitory effects on the initial uptake of a ligand by the liver, it is necessary to judge whether the true counter-transport mechanism (trans-stimulation) is working or not. The initial plasma disappearance curves of ANS were then kinetically analyzed based on a two-compartment model, in which the ligand is eliminated only from the peripheral compartment (liver compartment). No effects on the initial plasma disappearance rates of ANS were observed after preloading of bromophenol blue (BPB) or rose bengal (RB) in the liver. Inhibitory effect of BPB or RB on the initial uptake (or efflux) rates of ANS by the isolated hepatocytes were not observed, suggesting that the true counter transport mechanism is not working. In conclusion, checking the preloading effects of transstimulation on the initial uptake of a ligand by the liver could be a useful criterion for carrier cycling and common use of the same carrier between two ligands. However, one cannot exclude those possibilities even if the preloading effects cannot be observed.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39A no.7
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• pp.380-388
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• 2014

Transmission methods for terrestrial UHDTV broadcasting have been actively studied in order to provide enhanced broadcasting service in many countries. Most of the countries are considering multi-carrier transmission methods based on OFDM and some of them have performed UHDTV experimental broadcasting by using the DVB-T2 standard with the adoption of an improved data compression technique. However, since single carrier transmission methods, which are known to be susceptible to multi-path fading, could remedy this defect by using the SC-FDE method where a frequency domain equalizer is utilized in the receiver, they may achieve a similar transmission performance with multi-carrier transmission methods. In consideration of these circumstances, we compare the transmission performances of two-type methods to provide a decision criterion on a suitable transmission method for UHDTV broadcasting.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.10 no.1
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• pp.99-108
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• 1999

In this paper, we propose $\pi$/4 QPSK scheme with block modulation algorithm, which can reduce preamble in order to transmit ATM cell efficiently in the uplink channel of LMDS, and also designed a new carrier recovery circuit which can improve carrier synchronization performance of block demodulation algorithm. The $\pi$/4 QPSK scheme employing the proposed block modulation algorithm achieved efficient frame transmission by making use of a few preamble when carrier synchronization, symbol timing synchronization and slot timing synchronization were performed by burst data of ATM cell in LMDS environment. For performance evaluation of the proposed method, a simulation analyzing the variation of carrier synchronization, symbol timing synchronization and slot timing synchronization using LMDS environment and burst mode condition was executed. In the simulation, the proposed method showed a good performance even though the reduced preamble as a few aspossible when carrier synchronization, symbol timing synchronization and slot timing synchronization is performed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.10
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• pp.4561-4568
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• 2011

In this paper, carrier comparison PWM method for voltage control of Vienna rectifier is discussed. In general, in industrial and communications applications, the two-level rectifier is used. However, this two-level rectifier has the limit of high THD and low efficiency. So, the studies of three-level rectifier has been carried out so far, and the Vienna rectifier circuit is the representative. The space vector pulse width modulation(SVPWM) method is generally used for Vienna rectifier, in which voltage vectors and duration time are calculated from the voltage reference. However, this method require very sophisticated and complex calculations, so realizing this method by software is very difficult. To overcome this disadvantage, simple carrier comparison PWM method for Vienna rectifier is proposed which is modified from the carrier comparison method for 3 level inverter. Furthermore, to verify the usefulness of the Vienna rectifier carrier comparison PWM the simulation and experiment are carried out.