• 대한치과교정학회지
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• 제47권6호
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• pp.353-364
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• 2017

Objective: The objective of this study was to investigate the effects of miniscrew-assisted rapid palatal expansion (MARPE) on changes in airflow in the upper airway (UA) of an adult patient with obstructive sleep apnea syndrome (OSAS) using computational fluid-structure interaction analysis. Methods: Three-dimensional UA models fabricated from cone beam computed tomography images obtained before (T0) and after (T1) MARPE in an adult patient with OSAS were used for computational fluid dynamics with fluid-structure interaction analysis. Seven and nine cross-sectional planes (interplane distance of 10 mm) in the nasal cavity (NC) and pharynx, respectively, were set along UA. Changes in the cross-sectional area and changes in airflow velocity and pressure, node displacement, and total resistance at maximum inspiration (MI), rest, and maximum expiration (ME) were investigated at each plane after MARPE. Results: The cross-sectional areas at most planes in NC and the upper half of the pharynx were significantly increased at T1. Moreover, airflow velocity decreased in the anterior NC at MI and ME and in the nasopharynx and oropharynx at MI. The decrease in velocity was greater in NC than in the pharynx. The airflow pressure in the anterior NC and entire pharynx exhibited a decrease at T1. The amount of node displacement in NC and the pharynx was insignificant at both T0 and T1. Absolute values for the total resistance at MI, rest, and ME were lower at T1 than at T0. Conclusions: MARPE improves airflow and decreases resistance in UA; therefore, it may be an effective treatment modality for adult patients with moderate OSAS.

• Tuberculosis and Respiratory Diseases
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• 제67권2호
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• pp.140-144
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• 2009

The majority of flexible bronchoscopies are performed under topical anesthesia with lidocaine being the most commonly used agent. Anaphylaxis rarely occurs after local administration of lidocaine, but can be a fatal complication. We experienced a case of unexpected anaphylaxis. A 66-year-old woman was scheduled for flexible bronchoscopy to evaluate a tracheal mass and stenosis. The oral and nasal mucosa were pretreated with lidocaine. About 2~3 minutes later, the patient developed hypotension and we treated for anaphylaxis in the emergency room. Then, we decided to perform rigid bronchoscopy in this patient, under conditions of general anesthesia. A rigid bronchoscopy was performed in this patient, safely and successfully. The tracheal mass was determined to be squamous cell carcinoma.

• Archives of Plastic Surgery
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• 제40권6호
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• pp.676-686
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• 2013

Background To overcome the potential drawbacks of a short half-life and dose-related adverse effects of using active transforming growth factor-beta 1 for cartilage engineering, a cell-mediated latent growth factor activation strategy was developed incorporating latent transforming growth factor-${\beta}$1 (LTGF) into an electrospun poly(L-lactide) scaffold. Methods The electrospun scaffold was surface modified with NH3 plasma and biofunctionalised with LTGF to produce both random and orientated biofunctionalised electrospun scaffolds. Scaffold surface chemical analysis and growth factor bioavailability assays were performed. In vitro biocompatibility and human nasal chondrocyte gene expression with these biofunctionalised electrospun scaffold templates were assessed. In vivo chondrogenic activity and chondrocyte gene expression were evaluated in athymic rats. Results Chemical analysis demonstrated that LTGF anchored to the scaffolds was available for enzymatic, chemical and cell activation. The biofunctionalised scaffolds were non-toxic. Gene expression suggested chondrocyte re-differentiation after 14 days in culture. By 6 weeks, the implanted biofunctionalised scaffolds had induced highly passaged chondrocytes to re-express Col2A1 and produce type II collagen. Conclusions We have demonstrated a proof of concept for cell-mediated activation of anchored growth factors using a novel biofunctionalised scaffold in cartilage engineering. This presents a platform for development of protein delivery systems and for tissue engineering.

• Imaging Science in Dentistry
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• 제45권4호
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• pp.213-220
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• 2015

Purpose: The aim this study was to compare the accuracy of orthodontists and dentomaxillofacial radiologists in identifying 17 commonly used cephalometric landmarks, and to determine the extent of variability associated with each of those landmarks. Materials and Methods: Twenty digital lateral cephalometric radiographs were evaluated by two groups of dental specialists, and 17 cephalometric landmarks were identified. The x and y coordinates of each landmark were recorded. The mean value for each landmark was considered the best estimate and used as the standard. Variation in measurements of the distance between landmarks and measurements of the angles associated with certain landmarks was also assessed by a subset of two observers, and intraobserver and interobserver agreement were evaluated. Results: Intraclass correlation coefficients were excellent for intraobserver agreement, but only good for interobserver agreement. The least reliable landmark for orthodontists was the gnathion (Gn) point (standard deviation [SD], 5.92 mm), while the orbitale (Or) was the least reliable landmark (SD, 4.41 mm) for dentomaxillofacial radiologists. Furthermore, the condylion (Co)-Gn plane was the least consistent (SD, 4.43 mm). Conclusion: We established that some landmarks were not as reproducible as others, both horizontally and vertically. The most consistently identified landmark in both groups was the lower incisor border, while the least reliable points were Co, Gn, Or, and the anterior nasal spine. Overall, a lower level of reproducibility in the identification of cephalometric landmarks was observed among orthodontists.

• 한국안광학회지
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• 제17권4호
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• pp.469-476
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• 2012

목적: 본 연구의 목적은 각막의 직경과 방향에 따른 비구면계수 변화를 알아보고자 하였다. 방법: 시력에 영향을 줄 수 있는 안과적 질환이 없고 굴절교정 수술 경험이 없는 성인 57명(평균 $27.0{\pm}4.8$세, 남 20명, 여37명)을 대상으로 각막비구면계측기(Pentacam, Oculus Co., Germany)을 이용하여 각막의 직경과 방향에 따른 비구면계수 변화를 측정하였다. 결과: 각막정점을 기준으로 모든 방향에서 직경이 증가함에 따라 비구면계수가 통계적으로 유의하게 증가하였으며(p<0.05), 측정된 모든 직경에서 방향별 비구면계수의 크기는 상측> 비측> 하측> 이측 순으로 나타났다. 강주경선과 약주경선에 따른 비구면계수와 변화량은 강주경선에서 높게 측정되었으며 이는 통계적으로 유의한 것으로 나타났다(p<0.05). 결론: 각막의 비구면계수는 각막의 직경이 증가함에 따라 유의하게 증가하였고, 각막정점을 기준으로 모든 방향에서 측정된 수치나 증가량이 다르게 나타나므로 각막형상을 이해하는데 도움이 되고 RGP 렌즈 제조와 피팅시 고려되어야 할 부분이라 생각된다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제21권2호
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• pp.189-197
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• 1999

The use of osseointegrated implant has been reported that is an acceptable procedure for the restoration of totally or partially edentulous patient and that offers good predictability of long term success. It is difficult to get high success rate in edentulous maxillae with inadequate bony quality and quantity, and anatomic limitations such as pneumatic maxillary sinus and nasal floor. The various trials such as sinus lifting, bone grafting, guided bone regeneration, trabecular condensation with osteotome, and the use of wide-diameter implant have been introduced to solve these problems. This study was undertaken to assess the evaluation of clinical prognosis of the implant restorations with these various implantation techniques in the maxillary edentulous area. One hundred eight patients were treated with a total of 386 endosseous implants from March 1994 to January 1998 at Dept. of Dentistry, Korea Veterans Hospital in Seoul Korea. The various techniques for implantation in the edentulous maxillae were supplied to overcome the limitations of implant fixation. These techniques consist of sinus lifting, guided bone regeneration, onlay bone grafting, and osteotome trabecular condensation technique. The total success rate of implant restoration of this study was 93% in the maxillae. The success rate of implant restorations with conventional technique was 94.6%, with osteotome trabecular condensation technique was 94.1%, with guided bone regeneration technique was 93.3%, with bone grafting technique was 92.9%, with sinus lifting technique was 83.8%. The success rate on the maxillary anterior area was 95.2% and that on the posterior area was 91.9%. The failures were associated not only with surgical installation techniques but also bony quality and quantity, characteristics of implant, and stress distribution when in function.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1983년도 제17차 학술대회연제순서 및 초록
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• pp.14.3-14
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• 1983

최근 급속히 증가 추세에 있는 각종 산업재해와 교통사고로 인한 심한 신체적 손상, 심혈관계수술 및 호흡계수술등을 받은 환자에서 기도유지를 위해 사용되는 기관내삽관과 기관절개위의 후유증 또는 두부외상으로 발생하는 외상성 기관협착의 빈도가 점차 높아짐에 따라서 이에 대한 치료로 기관성형술이 주목할만한 관심을 보여주고 있다. 기관성형술의 방법으로는 손상된 기관의 위치나 크기에 따라 여러 가지가 있으나 부분절제 및 단단문합술, 경부피변과 자가이식물질등을 이용한 재건술을 들 수 있다. 1965년 Grillo가 개에서 환상절제후 기관성형술을 시행한 이래 환상기관협착의 경우에는 부분절제및 단단문합술이 많이 이용되고 있다. 또한 자가이식물질로는 비중격, 늑골, 이개의 연골이 많이 사용되고 있으며, Consiglio와 Caputo가 이개연골을 이용하여 기관성형술을 시행한 이래 Morgenstein은 기관결손이 있는 환자에서 이개연골을 사용하여 혼합이식을 시행하여 성공적인 재건을 보고하였다. 이개연골이식은 이비인후과의사에게는 쉽게 채취하여 활용할 수 있고 친근감이 있는 장점이 있다. 최근 본교실에서는 5예의 기관협착증 환자에서 이개연골이식(2예), 부분절제후 단단문합술(3예)에 의한 기관성형술을 시행하여 좋은 결과를 얻었기에 문헌고찰과 함께 보고하는 바이다.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1983년도 제17차 학술대회연제순서 및 초록
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• pp.18.3-19
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• 1983

후비공 폐쇄는 협비막의 과열부전, 협인두막의 지속적 잔존, Olfactory pit의 발생시 불완전 등의 선천성 원인과, 매독디프테리아, 수술 후 또는 외상 등으로 오는 후천성으로 나눌 수 있으며 선천성인 경우에는 두부, 심장, 소화기 계통에 여러 가지 기형이 동반되기도 한다. Johann Roedere (1755년)은 이 질환의 예를 최초로 보고하였으며 Emmert (1853년)가 골성 폐쇄를 트로카를 이용하여 처음 수술을 시도한 이래 , 비강내, 구개, 상악동, 그리고 비중격을 통한 수술 방법이 제시되어 왔으나 이중 경주개 경유법이 술후 재협착 빈도가 가장 적고 또 수술시 폐쇄부의 확인이 용이하여 가장 널리 이용되고 있다. 저자들은 선천성 양측 부분적 골부 후비공 폐쇄를 보인 11세 남아와 선친성 우측 완전 골막부 후비공 폐쇄와 좌측 부분적 골막부 후비공 폐쇄와 좌측 부분적 골막부 후비공 폐쇄를 보인 9세 여아에서 경구개 경유법으로 치험하였기에 문헌적 고찰과 함께 보고하는 바이다.

• Korean Journal of Ophthalmology
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• 제32권6호
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• pp.433-437
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• 2018

Purpose: Various absorbable anti-adhesion agents have been used to prevent postoperative synechia formation after endonasal surgery. The purpose of this study was to evaluate the anti-adhesion effects of HyFence and Mediclore after endonasal dacryocystorhinostomy (DCR) compared to a mixed solution of hyaluronic acid and sodium carboxymethylcellulose (Guardix-Sol). Methods: In this retrospective study, endonasal DCR and silicone tube intubation were performed on 198 eyes of 151 patients. Three different anti-adhesion adjuvants were applied to the osteotomy site in the nasal cavity after standard endonasal DCR procedures. The subjects were classified into three respective groups: group A (71 eyes, Guardix-Sol 1.5 g), group B (89 eyes, HyFence 1.5 mL), and group C (38 eyes, Mediclore 1 cc). The three groups were evaluated by asking patients about subjective symptoms and by performing lacrimal irrigation tests and endoscopic examinations. Results: There were no statistically significant differences in age, sex, timing of tube removal, or follow-up period among the three groups. There were no statistically significant differences in success rates among the three groups (p = 0.990, 91.5% [65 / 71], 92.1% [82 / 89], and 92.1% [35 / 38], respectively). Conclusions: HyFence and Mediclore are safe and effective adjunctive modalities following endonasal DCR compared to Guardix-Sol. Therefore, these agents can be considered good alternatives to Guardix-Sol to increase the success rate of endonasal DCR in treating patients with poor prognosis.

• Journal of Dental Anesthesia and Pain Medicine
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• 제22권6호
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• pp.427-435
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• 2022

Background: This study aimed to investigate the relationship between pharyngeal morphology and the success or failure of blind nasotracheal intubation using standard lateral cephalometric radiography and to analyze the measurement items affecting the difficulty of blind nasotracheal intubation. Methods: Assuming a line perpendicular to the Frankfort horizontal (FH) plane, the reference point (O) was selected 1 cm above the posterior-most end of the hard palate. A line passing through the reference point and parallel to the FH plane is defined as the X-axis, and a line passing through the reference point and perpendicular to the X-axis is defined as the Y-axis. The shortest length between the tip of the uvula and posterior pharyngeal wall (AW), shortest length between the base of the tongue and posterior pharyngeal wall (BW), and width of the glottis (CW) were measured. The midpoints of the lines representing each width are defined as points A, B, and C, and the X and Y coordinates of each point are obtained (AX, BX, CX, AY, BY, and CY). For each measurement, a t-test was performed to compare the tracheal intubation success and failure groups. A binomial logistic regression analysis was performed using clinically relevant items. Results: The items significantly affecting the success rate of blind nasotracheal intubation included the difference in X coordinates at points A and C (Odds ratio, 0.714; P-value, 0.024) and the ∠ABC (Odds ratio, 1.178; P-value, 0.016). Conclusion: Using binomial logistic regression analysis, we observed statistically significant differences in AX-CX and ∠ABC between the success group and the failure group.