• 대한소아치과학회지
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• 제27권4호
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• pp.517-523
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• 2000

비인강폐쇄는 연구개, 인두측벽 그리고 인두후벽간의 움직임이 서로 조화되어 구강과 비강을 나누어주는 괄약근 기전으로서 연하, 호흡 및 발음 등의 생리적 기능에 중요한 역할을 한다. 이 기능에 문제가 생긴 경우를 비인강폐쇄부전이라하며 그 원인으로는 (1) 연구개의 길이 및 움직임이상, (2) 비인두강의 해부학적 공간문제, (3) 인두후벽과 측벽의 기능이상 등이 있다. 본 연구는 구개열 환자의 측면두부방사선 사진을 통해 비인두강을 해부학적으로 분석하고 동시에 산출된 각 모음의 과비음 정도를 평가하여 비인강폐쇄부전과의 연관성을 비교해 본 것이며, 얻어진 결과는 다음과 같다. 1. 연구개 길이는 정상인에 비해 현저히 짧았다. 2. adequate ratio는 정상인에 비해 작게 나타났다. 3. adequate ratio가 감소함에 따라 모음 조음시 anatomic mVPI가 점차 증가하였다. 4. 각 모음 조음시 anatomic VPI는 과비음정도와 비례관계를 보였다. 5. 고모음(/u/, /i/)의 과비음정도가 저모음(/a/)에 비하여 크게 나타났다. 결론적으로, 구개열환자에서 측면두부방사선 사진은 비인강폐쇄부전의 진단 및 평가에 유용하게 사용될 수 있으며, 비인두강의 해부학적 구조는 산출되는 과비음정도와 밀접한 연관성이 있었다.

• 대한두경부종양학회지
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• 제34권2호
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• pp.23-28
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• 2018

Background/Objectives: Adenoid cystic carcinoma is the second most common salivary carcinoma. It occurs commonly in the submandibular gland, sublingual gland and minor salivary gland. Local recurrence and distant metastasis are the leading cause of death. The aim of this study was to evaluate long-term oncologic outcomes of patients with head and neck adenoid cystic carcinoma focusing on distant metastasis. Materials & Methods: We retrospectively studied 39 patients who were diagnosed with and treated for adenoid cystic carcinoma of the head and neck from December 1996 to May 2018. The clinicopathologic characteristics of patients such as age, sex, primary site and TNM stage, and treatment methods, recurrence and distant metastasis after treatment, survival rate, and treatment method for recurrence were analyzed. Results: Of 39 patients, 18 were males and 21 were females, and the mean age was $5.9{\pm}14.4$ (28-89) years. The most common primary site was oral cavity (12 cases), and followed by sino-nasal cavity (11 cases), parotid gland (5 cases), and etc. For treatment, 17 patients underwent surgery alone, 16 received surgery with postoperative radiation therapy, and 3 patients received radiation therapy only. Three patients refused any further treatments. Recurrence occurred in 15 patients. The most common site of recurrence was the lung. The mean time to recurrence was 31.7 months. The 5 and 10 years' overall survival rate was 79.3% and 74%, respectively. The 2 and 5 years' overall survival rate was 69.6% and 62.6% in patients with distant metastasis. Conclusion: Distant metastasis is an important prognostic factor in adenoid cystic carcinoma, and eventually one third of patients have distant metastasis, especially in the lung. An appropriate treatment for lung metastasis is necessary because some patients with pulmonary metastasis survive for a quite long time.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제20권3호
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• pp.214-216
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• 1998

Midfacial degloving approach의 장점으로는 비강, 비중격, 상악동, 사골동, 접형골동, 비인두 부위 병소의 접근에 좋은 시야를 제공하며, 수술방법이 기존의 방법에 비해 수월하고, 두피관상 절개법, 측두부 절개법, 구개부 절개법과 함께 사용하여 수술시야를 넓힐 수 있으며, 안면부에 나타나는 흉터가 없어 심미적으로 만족스러우며 특히, Keloid 체질에서 유용하다는 것을 들 수 있다. 이에 저자 들은 구강악안면외과 영역에서도 중안면부 외상, 두개안면부 기형 처치, 상악골 절제술을 요하는 경우, 상악골과 비골의 동시 수술을 요하는 경우 등에 midfacial degloving approach가 유용한 수술 접근 방법으로 사료되었다.

• 대한치과교정학회지
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• 제47권6호
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• pp.353-364
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• 2017

Objective: The objective of this study was to investigate the effects of miniscrew-assisted rapid palatal expansion (MARPE) on changes in airflow in the upper airway (UA) of an adult patient with obstructive sleep apnea syndrome (OSAS) using computational fluid-structure interaction analysis. Methods: Three-dimensional UA models fabricated from cone beam computed tomography images obtained before (T0) and after (T1) MARPE in an adult patient with OSAS were used for computational fluid dynamics with fluid-structure interaction analysis. Seven and nine cross-sectional planes (interplane distance of 10 mm) in the nasal cavity (NC) and pharynx, respectively, were set along UA. Changes in the cross-sectional area and changes in airflow velocity and pressure, node displacement, and total resistance at maximum inspiration (MI), rest, and maximum expiration (ME) were investigated at each plane after MARPE. Results: The cross-sectional areas at most planes in NC and the upper half of the pharynx were significantly increased at T1. Moreover, airflow velocity decreased in the anterior NC at MI and ME and in the nasopharynx and oropharynx at MI. The decrease in velocity was greater in NC than in the pharynx. The airflow pressure in the anterior NC and entire pharynx exhibited a decrease at T1. The amount of node displacement in NC and the pharynx was insignificant at both T0 and T1. Absolute values for the total resistance at MI, rest, and ME were lower at T1 than at T0. Conclusions: MARPE improves airflow and decreases resistance in UA; therefore, it may be an effective treatment modality for adult patients with moderate OSAS.

• Parasites, Hosts and Diseases
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• 제55권4호
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• pp.433-437
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• 2017

Pentastomiasis, a zoonotic parasite infection, is typically found in the respiratory tract and viscera of the host, including humans. Here, we report for the first time an extremely rare case of intraosseous pentastomiasis in the human maxilla suffering from medication related osteonecrosis of the jaw (MRONJ). A 55-year-old male had continuously visited the hospital for MRONJ which had primarily developed after bisphosphonate and anti-neoplastic administration for previous bone metastasis of medullary thyroid cancer. Pain, bone exposure, and pus discharge in the right mandible and left maxilla were seen. Osteolysis with maxillary cortical bone perforation at the left buccal vestibule, palate, nasal cavity, and maxillary sinus was observed by radiologic images. A biopsy was done at the left maxilla and through pathological evaluation, a parasite with features of pentastome was revealed within the necrotic bone tissue. Further history taking and laboratory evaluation was done. The parasite was suspected to be infected through maxillary open wounds caused by MRONJ. Awareness of intraosseous pentastomiasis should be emphasized not to be missed behind the MRONJ. Proper evaluation and interpretation for past medical history may lead to correct differential diagnosis and therapeutic intervention for parasite infections.

• 대한소아치과학회지
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• 제34권3호
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• pp.519-525
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• 2007

과잉치는 정상 치판의 과도한 증식의 결과로 발생하고, 주로 상악 전방부에서 많이 발견되며 이것을 정중과잉치라 칭한다. 정중과잉치의 존재 시 영구 전치의 위치 이상, 정중이개, 낭종의 형성, 구강 및 비강 내로의 맹출 등과 같은 다양한 문제가 존재하게 되므로 발거하는 것이 일반적이다. 본 증례는 외상으로 인해 편측 상악 중절치를 조기에 상실하였고, 매복된 상악 정중과잉치를 가지고 있는 9세 8개월된 남아로, 정중과잉치를 상실된 상악 중절치 부위에 자가이식한 후 보철적으로 수복하여 치조골 흡수를 막고 심미적인 수복을 도모한 증례이다. 이 증례에서 과잉치는 총 길이 14mm로 지대치로 사용하기에는 크기가 작고 치관/치근 비율도 좋지 않아 예후가 불량할 것으로 예상하였으나, 시술 후 8개월의 관찰 기간 동안 양호한 결과를 나타내어 이에 보고하는 바이다.

• 대한두경부종양학회지
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• 제1권1호
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• pp.21-34
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• 1985

The authors reviewed 114 cases of malignant major and minor salivary gland tumors at Presbyterian Medical Center seen from February, 1963 to December, 1983. The results were obtained as follows; 1) Overall male and female sex ratio was 2:1. The peak age of patients with major and minor salivary gland tumor were both 5 th decade. 2) The ratio of benign and malignant tumor was 83:114. The incidence of malignancy in each group was 52% in parotid (50 patients), 75% in minor salivary gland (45 patients), 49% in submaxillary gland(18 patients) and 25% in sublingual gland (1 patient). 3) The incidence according to the anatomic primary site for minor salivary cancers was 10 cases in the nasal cavity, each 8 in the palate and the maxillary antrum, 7 in the tongue, 5 in the gum, 3 in the larynx and 2 in the buccal mucosa. 4) Adenoid cystic carcinoma was the most common cancer of minor salivary gland and malignant mixed tumor was the most common in major salivary glands, each comprising 34 cases (76%) of minor and 19 cases (28%) of major salivary gland tumors. 5) The incidence of cervical lymph node metastasis was 50% in the submaxillary gland cancers, 44% in the parotid gland cancers and 21% in malignant tumors of minor salivary glands. The highest incidence of lymph node metastasis according to histopathological classification was formed in high grade of mucoepidermoid (67%). 6) Nerve invasion was common in mucoepidermoid carcinoma. According to anatomic site, nerve invasion occurred most often in adenoid cystic carcinoma of the submaxillary gland (44%). 7) The lung was the commonest site for distant metastasis comprising 12 cases among 26 cases in which distant spread occurred. 8) The recurrence rate was 50% for major salivary gland cancer and 52% in cancer of the minor salivary gland. In accordance with pathological classification, adenocarcinoma most frequently recurred after excision. This being seen in 88% of patients undergoing definitive therapy. 9) The determinate 5 year survival rate was 78% in major salivary gland tumors, but 69% in minor salivary gland tumors.

• 한국임상수의학회지
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• 제28권4호
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• pp.435-437
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• 2011

2살령, 단모종의 집고양이가 2년 동안 만성 중이염과 콧물증상을 보였다. 구강 검사시 코인두에 종괴가 발견 되었다. 추가적인 검사를 위해, 컴퓨터 단층촬영술을 시행하였고 코인두 부분에서 큰 폴립이 발견되었다. Spay hook을 이용하여 폴립의 당김제거술을 수행하였다. 종괴를 제거한 후, 호르너증후군이 나타났으나 14일 이내에 자발적으로 해소되었다.

• 대한수의학회지
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• 제29권3호
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• pp.315-324
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• 1989

In order to establish the extent of Streptococcal arthritis piglets, isolation of Streptococci from arthritic lesions of 34 piglets were undertaken from November 1987 to October 1988 in Korea. Also determined were isolation frequency of Streptococci in nasal cavity of 250 healthy sows and antibiotic susceptibilities of the isolates. Streptococci were isolated from 52.9% of 34 arthritic piglets and 20 strains isolated belonged to 4 S suis type I, 8 S suis type II, 2 Lancefield group C and 6 group E. From 28.8% of 250 healthy sows, 72 strains of Streptococci were isolated and these consisted of 9 S suis type I, 51 S suis type II and 12 group C. Streptococcal arthritis seemed to occur prominently in piglets aged 2 to 4 weeks and in male than female. No significant difference were recognized in tarsal and carpal joints as affecting site. All of 92 isolates were sensitive to ampicillin and penicillin, and all strains of S suis type I and group E Streptococcus were also sensitive to chloramphenicol and cephalothin. To cephalothin all strains of group C Streptococcus were sensitive. The 1. 7 to 100% of 92 isolates were resistant with different prevalence to colistin, erythromycin, kanamycin, tetracycline, gentamicin, chloramphenicol and cephalothin. The 92.5% of these resistant Streptococci were multiply drug-resistant strains. The drug resistant patterns most frequently encountered were Tc Cl Em Km Gm(16.3%) in quintuple pattern, Tc Cl Em Km(16.3%) in quadruple pattern, Tc Cl Em(10.9%) in triple pattern and Cl Em(14.1%) in double pattern.

• 대한수의학회지
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• 제52권4호
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• pp.213-221
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• 2012

A total of 18 Newcastle disease virus (NDV) isolates that were recovered from 1949 through 1997 were characterized and pathotyped. All viruses were highly virulent as determined by intracerebral pathogenicity indices ${\geq}1.81$ in day-old. These pathotypes are typical for viscerotropic velogenic NDV (VVNDV) pathotype viruses. Some differences were observed for the chicken red blood cell elution rate and thermostability of the hemagglutinin at $56^{\circ}C$. Three antigenic groups were identified by a hemagglutination-inhibition assay using NDV monoclonal antibodies. And the predominant gross lesions were as follows: discharge from the nasal cavity, tracheal mucus, petechial hemorrhage in the heart fat, kidney urates and hemorrhage with or without necrosis in the gastrointestinal tract. Severe hemorrhagic or necrotic lesions were also noted in the lymphoid organs and were localized primarily in the spleen and cecal tonsil. However, differences in the occurrence and frequency of the gross lesions were observed between the virus strains. Among them, NDV strains that induced neurological symptoms belonged only to genotype VI. This strain had spread throughout Korea during the late 1980s to the 1990s, which suggests that specific VVNDVs genotypes might result in neurological symptoms.