• Title/Summary/Keyword: Nano 입자

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Electrospraying of Micro/Nano Particles for Protein Drug Delivery (단백질 약물 전달을 위한 마이크로/나노 입자의 전기분무 제조법)

  • Yoo, Ji-Youn;Kim, Min-Young;Lee, Jong-Hwi
    • Polymer(Korea)
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    • v.31 no.3
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    • pp.215-220
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    • 2007
  • The control of the surface energy by electrohydrodynamic force provides electrospraying with various potential advantages such as simple particle size control, mono-dispersity, high recovery, and mild processing conditions. The advantages are quite helpful to improve the stability of protein drug and control its release. Herein, the nano-encapsulation of protein drugs using electrospraying was investigated. Albumin as a model protein was processed using uniaxial and co-axial electrospraying, and chitosan, polycaporlactone (PCL), and poly (ethylene glycol) (PEG) were used as encapsulation materials. The major processing parameters such as the conductivity of spraying liquids, flow rate, the distance of electrical potential gradient, etc were measured to obtain the maximum efficiency. In the chitosan systems, mean particles size decreases as flow rate and the distance between nozzle and the collecting part decreases. In the uniaxial technique of the PCL systems, mean particles size decreases as flow rate decreases. In the coaxial technique of the PCL systems, it was found that the particles size gets larger under the application of the higher ratio of inner-to-outer liquid flow rates. The primary particles formed out of an electrospraying nozzle showed narrow particle size distribution, but once they arrived to the collecting part, aggregation behavior was observed obviously. Efficient nano-encapsulation of albumin with PCL, PEG, and chitosan was conveniently achieved using electrospraying at above 12 kV.

Manufacturing and Antibacterial Characteristics of Non-woven Fabrics Including Nano-silver Particles (은나노 입자를 함유한 부직포 제조와 항균특성)

  • No, Deok-Gil
    • Proceedings of the Korean Society of Dyers and Finishers Conference
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    • 2008.04a
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    • pp.63-65
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    • 2008
  • The functional non-woven fabrics have been applied in various industry fields, such as clothing, hygiene, environment, medical and so forth. The functional non-woven fabrics were manufactured by meltblown and finishing processes. These functional non-woven fabrics were made of 2,000ppm nano-silver resin composite and polypropylene resin. Silver is one of the most universal antimicrobial substances. Nano-technology enables us to expand the surface area of silver particles markedly. Nano-silver particles were successfully produced less than 10nm in size. The functional non-woven fabrics including nano-silver particles showed excellent antibacterial activities against Staphylococcus aureus(ATCC 6538) and Klebsieila pneumoniae (ATCC 4352). From the results, nano-silver particels probably will be available as a good and safe antibiotic alternative.

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Study on Fabricating Bead Mill for Manufacturing Nano Powders (나노 파우더 제조용 비드밀 제작에 관한 연구)

  • Son, Jae-Yub;Nam, Kwon-Sun;Kim, Byeong-Hee
    • Journal of Industrial Technology
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    • v.25 no.B
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    • pp.127-133
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    • 2005
  • Manufacturing methods of Nano particles can be distinguished by top-down technology as physical method and bottom-up technology as chemical synthetic method. Top-down technology is a kind of method for making microstructure as like carving after forming a macroscopic structure in advance and its typical methods are ball milling, gas condensation method and so on. Nano Particles synthesized by bottom-up method have got to do dispersing process for using them as actual nano particles because their viscosity are very strong and so easy to shape cohesive substances. Therefore, this study is about a particle separating device which separates a certain constant size of grains processed already in mill and mixer because we mostly use media agitating mill as a device of milling and dispersing and we necessarily use very slight balls as media for manufacturing nano particles in the machine. The centrifugal device has been designed for passing and separating below a certain type of grain size after final process of particles in the mill.

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A Study on Fire-Resistant Performance of Concrete Using Nano-Silica Perticles (나노 실리카 분말을 혼입한 콘크리트의 내화성능연구)

  • Jo Byung-Wan;Park Jong-Bin;Park Jong-Hwa
    • Journal of the Korea Concrete Institute
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    • v.17 no.2 s.86
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    • pp.247-254
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    • 2005
  • Recently, since the advanced nano technology develops unique physical and chemical properties different from those of the conventional materials. Normal concretes mixed with nano - $SiO_2$ have been studied to improve the fire-resistance with high strength and lower heat conductivity. In this pilot study, the nano-particle contents in the specimens (${\Phi}100{\times}200 mm$) were 0, 2, 4, and $6\%$ by weight of cement, and fire-temperatures $200^{\circ}C$, $500^{\circ}C$, and $800^{\circ}C$ were considered. The results show that as the nano-particle contents increases, the weight loss of concrete gradually decreases, and the compressive strength after fire-attack increases effectively.