• Laboraroty Animal Research
• /
• v.34 no.4
• /
• pp.176-184
• /
• 2018

In this study, we observed chronological changes in the immunoreactivity and expression level of myelin basic protein (MBP), one of the most abundant proteins in the central nervous system, in the hippocampus of Zucker diabetic fatty (ZDF) rats and their control littermates (Zucker lean control; ZLC). In the ZLC group, body weight steadily increased with age; the body weight of the ZDF group, however, peaked at 30 weeks of age, and subsequently decreased. Based on the changes of body weight, animals were divided into the following six groups: early (12-week), middle (30-week), and chronic (52-week) diabetic groups and their controls. MBP immunoreactivity was found in the alveus, strata pyramidale, and lacunosum-moleculare of the CA1 region, strata pyramidale and radiatum of the CA3 region, and subgranular zone, polymorphic layer, and molecular layer of the dentate gyrus. MBP immunoreactivity was lowest in the hippocampus of 12-week-old rats in the ZLC group, and highest in 12-week-old rats in the ZDF group. Diabetes increased MBP levels in the 12-week-old group, while MBP immunoreactivity decreased in the 30-week-old group. In the 52-week-old ZLC and ZDF groups, MBP immunoreactivity was detected in the hippocampus, similar to the 30-week-old ZDF group. Western blot results corroborated with immunohistochemical results. These results suggested that changes in the immunoreactivity and expression of MBP in the hippocampus might be a compensatory response to aging, while the sustained levels of MBP in diabetic animals could be attributed to a loss of compensatory responses in oligodendrocytes.

• Journal of Digital Convergence
• /
• v.19 no.4
• /
• pp.205-215
• /
• 2021

This study was conducted to provide basic data to establish health promotion and chronic disease management education programs and educational plans for well-aging by investigating the educational needs for health promotion and chronic disease management by life cycle. This is a descriptive correlation research study, and collected and analyzed through a structured questionnaire targeting 330 adults over 19 years of age registered at Gallup Korea. The results of the study were perceived health status 3.11 points (SD=.72), health promotion behavior 2.27 points (SD=.47), and health-related quality of life 0.92 points (SD=.10). Health-related quality of life was found to have a positive correlation with perceived health status (r=.472, p<.001) and health promotion behavior (r=.122, p<.026). The priority of educational needs and contents for health promotion and chronic disease management was the highest in chronic disease management. There was a significant difference according to the life cycle (p=0.001), and it was found that the mature stage was more likely to be aware of the level of knowledge, the need for education, and the willingness to participate in education compared to the youth. Through the results of this study, it is necessary to develop a comprehensive customized program that is subdivided according to the life cycle when developing health promotion and chronic disease management education programs for well-aging.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.48 no.1
• /
• pp.42-49
• /
• 2021

This study aimed to evaluate the long-term outcomes of teeth treated with reattachment technique in children and adolescents. Twenty seven permanent anterior teeth from 21 patients treated with fragment reattachment were evaluated. Clinical photos and medical records were used to assess treatment outcomes. Effect of pulp treatment and the ratio of fragment on success rate were statistically analyzed. Detachment of fragment was observed in 17 teeth, and their duration of retention was 21.41 ± 23.39 months. Repeated trauma was found to be the most frequent causes of failure. Pulp treatment before reattachment did not affect the success rate (p > 0.05). The mean ratio of fragment was 0.482 ± 0.147, and the success rate was affected by the ratio of fragment (p = 0.018). The median retention time of the teeth was 72 months if the ratio was under 0.5, and 8 months for that of the others. A significant correlation was found between the ratio of fragment and retention time (p = 0.003). Reattachment can be a predictable treatment option for crown fracture in anterior teeth in children and adolescents when a fracture involves less than 50% of the clinical crown.

• Journal of Digital Convergence
• /
• v.20 no.5
• /
• pp.695-702
• /
• 2022

The purpose of this study was conducted with suggesting a clue to improve the perception of jobs for the elderly, and the final study subject was 110 people. As a research methods were student t-test, ⲭ²-test, one-way ANOVA(Scheffe). The result of the study are as follows. The perception and economic status of the young elderly(65-74 years old) were significantly higher. The perception of public jobs was significantly higher when married, religious, and monthly income was more than 4 million won. The perception of social service-type jobs was significantly higher when married and when there was a religion. The perception of private jobs was high when the monthly income was more than 4 million won (p<0.05). The preference for "parking order service" in the public sector, "support for elderly facilities" in the social service sector, and "fast food restaurant employees, kitchen, restaurant assistants, and food delivery service workers" in the private sector was the highest. In conclusion, there is a need for an education program to improve the perception of jobs for the elderly in order to raise the awareness of job policies for the elderly, which decrease with age. It is expected to be used as basic data for job creation and job creation that can be done according to the age of the elderly.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.49 no.1
• /
• pp.25-34
• /
• 2022

This study aimed to investigate a quantitative analysis of the anatomical characteristics of the maxillary supernumerary lateral incisor and its relationship with lateral incisors. Forty-four supernumerary lateral incisors from 43 patients were evaluated for analyzing the position, shape, direction, and relationship between the supernumerary lateral incisor and the normal lateral incisors, using cone-beam computed tomography (CBCT). To compare the size of crown, the mesio-distal width was measured and the Nolla stage was used for evaluating the degree of root development to compare tooth maturity. The supernumerary lateral incisors were in the normal direction at a rate of 90.9%, and in a supplemental shape at a rate of 84.1%. The supernumerary lateral incisor was smaller in size compared to the adjacent lateral incisor and opposite lateral incisor (p < .0001). There was no statistically significant difference in the development stage of root. Based on these results, the supernumerary lateral incisor is similar with the lateral incisor, but has a difference in the size of crown. It is necessary to distinguish the supernumerary lateral incisor from the lateral incisor precisely to reduce clinical complications.

• Journal of The Korean Society of Clinical Toxicology
• /
• v.20 no.1
• /
• pp.15-21
• /
• 2022

Purpose: Acute pesticide poisoning is lethal and can lead to death. A few studies about the effects of acute pesticide poisoning have focused on the immune system. In the current study, we preliminarily investigated the changes in blood inflammatory cytokine levels in acute pesticide poisoning patients. Methods: In this study, we prospectively investigated the inflammatory cytokines in patients with acute pesticide poisoning. This study included patients admitted from February 2021 to November 2021 with a diagnosis of intentional poisoning by pesticide ingestion. The inflammatory cytokines measured were IFN-γ, IL-1β, IL-6, and TNF-α. Results: Totally, 27 patients were enrolled in this study. The types of pesticide ingested were glufosinate (n=6), glyphosate (n=8), organophosphate (n=4), pyrethroid (n=2), and others (n=7). The levels of inflammatory cytokines obtained were as follows: IFN-γ 2.78±8.03 pg/ml, IL-1β 2.62±2.03 pg/ml, IL-6 44.58±80.16 pg/ml, and TNF-α 11.80±15.60 pg/ml. The overall mortality rate was 11.1% (3/27), and levels of IL-1β and TNF-α were significantly higher in the death group compared to the survival group. Conclusion: Increased levels of IL-6 and TNF-α were observed in patients with acute pesticide poisoning. IL-1β and TNF-α were significantly higher in the death group as compared to the survival group. Our results indicate the occurrence of an inflammatory response due to the activation of immune cells by pesticide poisoning. Future large-scale studies need to be conducted to investigate the application of inflammatory cytokines as predictors and therapeutic targets.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.26 no.1A
• /
• pp.75-89
• /
• 2006

This paper presents a practical and realistic Life-Cycle Cost (LCC) optimum design methodology of steel bridges considering time effect of bridge reliability under environmental stressors such as corrosion and heavy truck traffics. The LCC functions considered in the LCC optimization consist of initial cost, expected life-cycle maintenance cost and expected life-cycle rehabilitation costs including repair/replacement costs, loss of contents or fatality and injury losses, road user costs, and indirect socio-economic losses. For the assessment of the life-cycle rehabilitation costs, the annual probability of failure which depends upon the prior and updated load and resistance histories should be accounted for. For the purpose, Nowak live load model and a modified corrosion propagation model considering corrosion initiation, corrosion rate, and repainting effect are adopted in this study. The proposed methodology is applied to the LCC optimum design problem of an actual steel box girder bridge with 3 continuous spans (40 m+50 m+40 m=130 m), and various sensitivity analyses of types of steel, local corrosion environments, average daily traffic volume, and discount rates are performed to investigate the effects of various design parameters and conditions on the LCC-effectiveness. From the numerical investigation, it has been observed that local corrosion environments and the number of truck traffics significantly influence the LCC-effective optimum design of steel bridges, and thus realized that these conditions should be considered as crucial parameters for the optimum LCC-effective design.

• 재활복지
• /
• v.15 no.2
• /
• pp.147-173
• /
• 2011

The purpose of this study was to develop a stuttering therapy device to aid in stutter therapy. The research method used for this study was as follows: First, the stuttering therapy device based on analysis of the prolonged speech method used at home and abroad was designed to achieve the goal of research. Second, the stuttering therapy device was to be developed to maintain a vocalization state, to use bio-feedback visualization, to have enough inspiration, to use Korean language in this device, and to use transfer and maintenance training in daily life. Third, the stuttering therapy device effectiveness was to be verified through use in clinical cases. The results of subjects receiving speech therapy and using the breathing control prolonged speech device and SI(stuttering Interview) evaluation programs for 3 months were as follows: For subject A, the stuttered word rate was reduced from 3.20 SW/M to 0.5 SW/M. For subject B, the stuttered word rate was reduced from 1.90 SW/M to 0.75 SW/M. For subject C, the stuttered word rate was reduced from 3.37 SW/M to 0.34 SW/M. For Subject D, the stuttered word rate was reduced from 0.51 SW/M to 0 SW/M. Follow-up evaluations verified the effectiveness of how the stuttering therapy device can reduce subjects' SW/M.

• Korean Journal of Radiology
• /
• v.23 no.3
• /
• pp.333-342
• /
• 2022

Objective: Intracranial atherosclerotic stroke occurs through various mechanisms, mainly by artery-to-artery embolism (AA) or branch occlusive disease (BOD). This study evaluated the spatial relationship between middle cerebral artery (MCA) plaques and perforating arteries among different MCA territory infarction types using vessel wall magnetic resonance imaging (VW-MRI). Materials and Methods: We retrospectively enrolled patients with acute MCA infarction who underwent VW-MRI. Thirty-four patients were divided into three groups according to infarction pattern: 1) BOD, 2) both BOD and AA (BOD-AA), and 3) AA. To determine the factors related to BOD, the BOD and BOD-AA groups were combined into one group (with striatocapsular infarction [BOD+]) and compared with the AA group. To determine the factors related to AA, the BOD-AA and AA groups were combined into another group (with cortical infarction [AA+]) and compared with the BOD group. Plaque morphology and the spatial relationship between the perforating artery orifice and plaque were evaluated both quantitatively and qualitatively. Results: The plaque margin in the BOD+ group was closer to the perforating artery orifice than that in the AA group (p = 0.011), with less enhancing plaque (p = 0.030). In the BOD group, plaques were mainly located on the dorsal (41.2%) and superior (41.2%) sides where the perforating arteries mainly arose. No patient in the AA group had overlapping plaques with perforating arteries at the cross-section where the perforator arose. Perforating arteries associated with culprit plaques were most frequently located in the middle two-thirds of the M1 segment (41.4%). The AA+ group had more stenosis (%) than the BOD group (39.73 ± 24.52 vs. 14.42 ± 20.96; p = 0.003). Conclusion: The spatial relationship between the perforating artery orifice and plaque varied among different types of MCA territory infarctions. In patients with BOD, the plaque margin was closer and blocked the perforating artery orifice, and stenosis degree and enhancement were less than those in patients with AA.

• Journal of dental hygiene science
• /
• v.24 no.1
• /
• pp.62-70
• /
• 2024

Background: This study aimed to evaluate ChatGPT's performance accuracy in responding to questions from the national dental hygienist examination. Moreover, through an analysis of ChatGPT's incorrect responses, this research intended to pinpoint the predominant types of errors. Methods: To evaluate ChatGPT-3.5's performance according to the type of national examination questions, the researchers classified 200 questions of the 49th National Dental Hygienist Examination into recall, interpretation, and solving type questions. The researchers strategically modified the questions to counteract potential misunderstandings from implied meanings or technical terminology in Korea. To assess ChatGPT-3.5's problem-solving capabilities in applying previously acquired knowledge, the questions were first converted to subjective type. If ChatGPT-3.5 generated an incorrect response, an original multiple-choice framework was provided again. Two hundred questions were input into ChatGPT-3.5 and the generated responses were analyzed. After using ChatGPT, the accuracy of each response was evaluated by researchers according to the types of questions, and the types of incorrect responses were categorized (logical, information, and statistical errors). Finally, hallucination was evaluated when ChatGPT provided misleading information by answering something that was not true as if it were true. Results: ChatGPT's responses to the national examination were 45.5% accurate. Accuracy by question type was 60.3% for recall and 13.0% for problem-solving type questions. The accuracy rate for the subjective solving questions was 13.0%, while the accuracy for the objective questions increased to 43.5%. The most common types of incorrect responses were logical errors 65.1% of all. Of the total 102 incorrectly answered questions, 100 were categorized as hallucinations. Conclusion: ChatGPT-3.5 was found to be limited in its ability to provide evidence-based correct responses to the Korean national dental hygiene examination. Therefore, dental hygienists in the education or clinical fields should be careful to use artificial intelligence-generated materials with a critical view.