Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Inflammatory cytokines in patients with pesticide poisoning: a pilot study

농약 중독에 의한 혈중 염증성 사이토카인의 영향에 대한 예비 연구

  • Kim, Hyun Joon (Department of Emergency Medicine, Soonchunhyang University Cheonan Hospital) ;
  • Kim, Wook-Joon (Esoo clinics) ;
  • Lee, Dong Wook (Department of Emergency Medicine, Soonchunhyang University Cheonan Hospital) ;
  • Jung, Seung-Hyun (Department of Internal Medicine, Soonchunhyang University Cheonan Hospital) ;
  • Cho, Nam-Jun (Department of Internal Medicine, Soonchunhyang University Cheonan Hospital) ;
  • Park, Samel (Department of Internal Medicine, Soonchunhyang University Cheonan Hospital) ;
  • Lee, Eun Young (Department of Internal Medicine, Soonchunhyang University Cheonan Hospital) ;
  • Gil, Hyo-Wook (Department of Internal Medicine, Soonchunhyang University Cheonan Hospital)
  • 김현준 (순천향대학교부속 천안병원 응급의학과) ;
  • 김욱준 (이수내과의원) ;
  • 이동욱 (순천향대학교부속 천안병원 응급의학과) ;
  • 정승현 (순천향대학교부속 천안병원 신장내과) ;
  • 조남준 (순천향대학교부속 천안병원 신장내과) ;
  • 박삼엘 (순천향대학교부속 천안병원 신장내과) ;
  • 이은영 (순천향대학교부속 천안병원 신장내과) ;
  • 길효욱 (순천향대학교부속 천안병원 신장내과)
  • Received : 2022.04.07
  • Accepted : 2022.06.27
  • Published : 2022.06.30
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Abstract

Purpose: Acute pesticide poisoning is lethal and can lead to death. A few studies about the effects of acute pesticide poisoning have focused on the immune system. In the current study, we preliminarily investigated the changes in blood inflammatory cytokine levels in acute pesticide poisoning patients. Methods: In this study, we prospectively investigated the inflammatory cytokines in patients with acute pesticide poisoning. This study included patients admitted from February 2021 to November 2021 with a diagnosis of intentional poisoning by pesticide ingestion. The inflammatory cytokines measured were IFN-γ, IL-1β, IL-6, and TNF-α. Results: Totally, 27 patients were enrolled in this study. The types of pesticide ingested were glufosinate (n=6), glyphosate (n=8), organophosphate (n=4), pyrethroid (n=2), and others (n=7). The levels of inflammatory cytokines obtained were as follows: IFN-γ 2.78±8.03 pg/ml, IL-1β 2.62±2.03 pg/ml, IL-6 44.58±80.16 pg/ml, and TNF-α 11.80±15.60 pg/ml. The overall mortality rate was 11.1% (3/27), and levels of IL-1β and TNF-α were significantly higher in the death group compared to the survival group. Conclusion: Increased levels of IL-6 and TNF-α were observed in patients with acute pesticide poisoning. IL-1β and TNF-α were significantly higher in the death group as compared to the survival group. Our results indicate the occurrence of an inflammatory response due to the activation of immune cells by pesticide poisoning. Future large-scale studies need to be conducted to investigate the application of inflammatory cytokines as predictors and therapeutic targets.

Keywords

Acknowledgement

이 논문은 과학기술정보통신부의 재원으로 한국연구재단 바이오 의료기술개발사업의 지원을 받아 수행된 연구임(No. NRF-2019M3E5D1A02069073).

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