• 벤처창업연구
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• 제5권2호
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• pp.1-31
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• 2010

Biotechnology has strategic importance related to the development of start-up companies, industries and nations in the near future. Therefore, many countries have promoted and developed biotechnology. The United States has led the world in promoting biotechnology. American biotechnology policies are diverse, and thus no comprehensive systematic studies have been done on it. In our paper, we will discuss American biotechnology policy in detail. For effective analysis, we will rely on the concept of a national innovation system, which emphasizes the institutional settings of innovation actors and their interaction. This paper deals with the American national innovation system for biotechnology. We will analyze the role of major actors, academia, public research institutes, and venture companies and their interactions. The American biotechnological innovation system is composed of diverse actors and numerous start-up companies in the biotechnology industry. In addition, there are many diverse policy programs for promoting biotechnology. Because of country-specific frame conditions, every country has different institutional settings and policies for promoting biotechnology. Our paper will render meaningful implications for various countries. We also think that this paper will be of interest for international readers.

• 한국보건간호학회지
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• 제29권2호
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• pp.312-324
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• 2015

Purpose: This study addressed the relationship among nutritional risk, stress, and health related quality of life for older women with a foreign daughter-in-law. Methods: A descriptive research design was used for this study. The subjects of this study were 112 older women with a foreign daughter-in-law all of whom were over 65 years and living in D city. Personal interview was used for data collection. Nutritional risk, stress, and health related quality of life were measured using Nutrition Screening Initiative (NSI), Family Inventor of Life Events and Changes (FILE), and Medical Outcome Study (MOS) Short-form 36-Item Health Survey (SF-36), respectively. Results: Older women with a foreign daughter-in-law showed negative correlation between quality of life related health and nutritional risk, stress and age, and positive correlation between Activities of Daily Living (ADL); 46% of variance in health related quality of life of older women with a foreign daughter-in-law was explained by nutritional risk, ADL, stress and occupation. Conclusion: Based on the results of this study, we suggested that specialized programs should be established to help in development of social relationship networks for older women who have a foreign daughter-in-law.

• 패션비즈니스
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• 제16권1호
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• pp.41-51
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• 2012

Polyester is mainly used as a bedding filler material. PLA fiber as an eco-friendly material for substituting polyester has a low melting temperature and therefore a hardening process is impossible. This study is to develop the oil for feather touch that can treat at the melting temperature of PLA. The slippery and soft aminosilicone emulsion, and the bulky epoxysilicone emulsion were used. They had proper viscosity and particle size for flexibility and elasticity. When using methoxy aminosilane [$H_2NSi(OCH_3)_3$] as an aminosilane and [$Zn(OCOCH_3)_2$] as a catalyst, the hardening reaction was fast and effective. Feather touch process were treated by 2 steps. At first step, aminosilicone emulsion, epoxysilicone emulsion and methylaminosilane were mixed and homogenized, and at second step, 5% blened solution of the first step, Zn catalyst 1%, distilled water 94% were treated at PLA fiber. After treatment the static friction coefficient and dynamic friction coefficient were reduced to 23.5-60.8% and 30.0-61.3% respectively, and the laundry and sun light fastnesses have not shown any decrease.

• 지역사회간호학회지
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• 제16권4호
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• pp.392-403
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• 2005

Purpose: This study was to evaluate the nutritional status of low-income elders in urban areas and factors affecting their nutritional risk. Methods: A cross-sectional analysis was conducted. The subjects were 300 elders selected from home visiting clients of DongJack Public Health Center. Data were collected using a questionnaire containing questions on socio-demographic characteristics. health behavior and disease. dietary pattern. Nutritional Screening Initiative. Geriatric Depression Scale and Barthel Index for ADL. Collected data were analyzed through descriptive statistics. $X^2-test$ and multiple regression analysis using SPSS. Results: Of the subjects, 63% had high nutritional risk, 21.3% moderate nutritional risk, and 15.7% good nutritional risk. NSI score was significantly different according to economic status, subjective health condition, medication, dental health, depression. regularity of diet and meal with family. Multiple regression analysis revealed that depression, subjective health condition, dental health and regularity of diet and meal with family explain 38.1% of nutritional risk. Conclusion: It is necessary to evaluate nutrition status and to control nutritional risk factors such as depression, dental health, regularity of diet and meal with family for improving the health of the low-income elderly.

• 대한간호학회지
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• 제38권1호
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• pp.122-130
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• 2008

Purpose: This study aimed to identify the associated factors of the perceived health status of the elderly in Korea and to provide basic data for developing nursing interventions for the elderly's health management. Methods: This study used a descriptive correlational research design. The subjects of this study were 335 elderly people over 60 yr living in an urban city. Data were collected through personal interviews using questionnaires from September 2006 to March 2007. Empirical indicators of perceived health status were measured by SF-36, nutritional screening initiative (NSI), activities of daily living (ADL) Index, and instrumental activities of daily living (IADL) scale. The collected data were analyzed by descriptive statistics, Pearson's correlation, and hierarchical regression. Results: The mean age of the subjects was 72.8 and 57.0% of subjects were female. 41.5% of variance in physical health was explained by nutrition, ADL, IADL, and the number of years attending school. Among them the most important factor was ADL. 13.2% of variance in mental health was explained the number of family, nutrition, and IADL. Among them the most important factor was nutrition. Conclusion: It is necessary to develop supportive interventions for improving the perceived health status of elderly people by considering the most important factors shown in this study.

• 지역사회간호학회지
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• 제19권3호
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• pp.378-387
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• 2008

Purpose: The purposes of this study were to investigate factors related to the depression of the elderly dwelling in a big city, and to explore the influence of physical health, cognitive symptom and nutritional status on the elders' depression. Methods: After the approval of the Institutional Review Board (IRB) and obtaining the participants' consent form, a face to face and private interview was conducted with each participant from Mar, 2007 to Aug, 2007 by trained graduate level students. A total of 201 elders aged over 65 years participated in the study. The questionnaire consisted of K GDS, PHQ 15 and Nutritional Screening Initiative (NSI). Collected data were analyzed with the SPSS 13.0 program, which was used for frequency, percentage, mean, standard deviation, Pearson correlation coefficients, and multiple regression. Results: The major findings of this study were as follows. 1) 28.4% of the subjects belonged to the depression group, 78.1% had one or more diseases, 85.6% had experienced somatic symptoms, and 49.7% belonged to the nutritional risk group. 2) Older age, lower educational level, more pocket money a larger number of diseases, more severe cognitive symptoms and poorer nutritional status were significantly related to a higher depression score. 3) Significant factors influencing depression were nutritional status, cognitive symptoms and the number of diseases, which explained 38.1% of the variance of elderly depression, and nutritional status was the most influencing factor. Conclusion: The finding of this study gives useful information for developing assessment tools and interventions for elders' depression.

• 한국식품영양과학회지
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• 제33권10호
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• pp.1742-1747
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• 2004

쥐치어의 이용을 다양화하기 위하여 분리대두단백과 쌀가루를 첨가하여 원료 혼합물의 수분함량을 20∼30%로 조절한 후 단축스크류 압출성형기를 이용하여 압출성형으로 조직화 단백질을 제조하기 위한 실험을 하였으며 쌀가루함량, 토출구온도 및 원료 혼합물의 수분함량이 압출성형물의 물리화학적 및 관능적특성에 미치는 영향을 반응표면분석을 이용하여 최적화하였다. 쌀가루함량이 증가하면 팽화율이 증가하므로 재흡수율은 높아지는 반면 밀도는 낮아지는 현상을 보였다. 재흡수율과 밀도는 서로 유의성 있게 반비례하는 상관관계 (p<0.01, R=-0.742)를 보였다. 육안적인 관능검사방법은 조직잔사지수와 유의성 있는 상관관계(p<0.01, R=0.489)를 보였으므로 비교적 조직화의 정도를 평가하는 방법으로 적절한 것으로 간주되었다. 그리고 관능검사와 재흡수율의 상관관계(p<0.01, R=0.507)와 밀도와의 상관관계(p<0.001, R=-0.596)가 각각 비교적 높게 나타났으며 압출공정에서 토출구의 온도가 13$0^{\circ}C$ 이상에서 최적의 조직화가 형성되었다.

• 한국지역사회생활과학회지
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• 제20권1호
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• pp.19-32
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• 2009

The purpose of this study was to examine household food insecurity and the associations of food insecurity with socioeconomic characteristics, food behaviors, health status and nutrient intake among elderly people in a rural area. This study included 191 elderly people (mean age = $72.0{\pm}7.4$) in Jeollabuk-do, Jangsu-gun. House food insecurity was measured using an adapted version of the USDA short form household food insecurity scale, and nutrient intake measured by a 24-hour dietary recall. Only 15.2% of the subjects were in food-insecure households, 84.8% of the elderly households were food-secure. The food-insecure households were significantly lower in the number of family, frequency of shopping, and perceived health status than the food-secure households. In addition, they had serious tooth problems and NSI (Nutrition Screening Index) scores. Food-insecure households were significantly lower in most areas of nutrient intake (energy, protein, fat, Ca, P, Fe, K, Na, Zn, Vit. $B_2$, niacin, Vit. E), and also lower in nutrient intake compared to dietary reference intake (energy, protein, P, Fe, K, Na, Vit. $B_1$, Vit. $B_2$, niacin, Vit. E). These results suggest that the household food insecurity measures used in this study were an important indicator of nutritional well-being among elderly persons in the rural area. Food insecurity should be considered an important issue to public health and food service programs should be expanded for food-insecure households in rural areas.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.691-695
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• 2016

Protein glycosylation is the most common posttranslational modification in mammalian cells. Aberrant protein glycosylation has been reported in various diseases, including cancer. We identified and quantified the glycan structures of O-linked glycoprotein from cholangiocarcinoma (CCA) cell lines from different histological types and compared their profiles by nanospray ionization-linear ion trap mass spectrometry (NSI-$MS^n$). Five human CCA cell lines, K100, M055, M139, M213 and M214 were characterized. The results showed that the O-linked glycans of the CCA cell lines comprised tri- to hexa-saccharides with terminal galactose and sialic acids: NeuAc1Gal1GalNAc1, Gal2GlcNAc1GalNAc1, NeuAc2Gal1GalNAc1 NeuAc1Gal2GlcNAc1GalNAc1 and NeuAc2Gal2GlcNAc1GalNAc1 All five CCA cell lines showed a similar glycan pattern, but with differences in their quantities. NeuAc1Gal1GalNAc1 proved to be the most abundant structure in poorly differentiated adenocarcinoma (K100; 57.1%), moderately differentiated adenocarcinoma (M055; 42.6%) and squamous cell carcinoma (M139; 43.0%), while moderately to poorly differentiated adenocarcinoma (M214; 40.1%) and adenosquamous cell carcinoma (M213; 34.7%) appeared dominated by $NeuA_{c2}Gal_1GalNA_{c1}$. These results demonstrate differential expression of the O-linked glycans in the different histological types of CCA. All five CCA cell lines have abundant terminal sialic acid (NeuAc) O-linked glycans, suggesting an important role for sialic acid in cancer cells. Our structural analyses of glycans may provide important information regarding physiology of disease-related glycoproteins in CCA.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.57-57
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• 2017

Chrysanthemum is one of the most important floral crop in Korea produced about 7 billion dollars (1 billion for pot and 6 billion for cutting) in 2013. However, it is difficult to breed and to do genetic study because 1) it is highly self-incompatible, 2) it is outcrossing crop having heterozygotes, and 3) commercial cultvars are hexaploid (2n = 6x = 54). Although low-density genetic map and QTL study were reported, it is not enough to apply for the marker assisted selection and other genetic studies. Therefore, we are trying to make high-density genetic mapping using GBS with about 100 $F_1s$ of C. boreale that is oHohhfd diploid (2n = 2x = 18, about 2.8Gb) instead of commercial culitvars. Since Chrysanthemum is outcrossing, two-way pseudo-testcross model would be used to construct genetic map. Also, genotype-by-sequencing (GBS) would be utilized to generate sufficient number of markers and to maximize genomic representation in a cost effective manner. Those completed sequences would be analyzed with TASSEL-GBS pipeline. In order to reduce sequence error, only first 64 sequences, which have almost zero percent error, would be incorporated in the pipeline for the analysis. In addition, to reduce errors that is common in heterozygotes crops caused by low coverage, two rare cutters (NsiI and MseI) were used to increase sequence depth. Maskov algorithm would also used to deal with missing data. Further, sparsely placed markers on the physical map would be used as anchors to overcome problems caused by low coverage. For this purpose, were generated from transcriptome of Chrysanthemum using MISA program. Among those, 10 simple sequence repeat (SSR) markers, which are evenly distributed along each chromosome and polymorphic between two parents, would be selected.