• 한국통신학회논문지
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• 제32권10B호
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• pp.630-637
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• 2007

본 논문에서는 현재의 Mobile IPv6 메커니즘을 개선한 방식으로서 이동단말의 정보 공유를 통한 주소 중복 검사 생략과 2 계층에서의 이벤트를 이용한 예상된 핸드오프 기법 그리고 패킷 지연을 줄이기 위해 터널링 기법을 이용하는 방법과 효과적인 자원예약을 위해 2 계층에서의 이벤트를 이용한 anticipated-reservation 메커니즘을 제안한다. 제안한 핸드오프 메커니즘은 기존의 방식에 비해 핸드오프 시 데이터 수신 지연을 줄이고 터널링 되는 시간을 단축함으로써 라우터 간의 데이터 트래픽 양을 줄인다. 또한 anticipated-reservation 메커니즘은 자원예약을 수행하기 위해 자원을 미리 예약한다. 제안한 이동통신망에서의 핸드오프 메커니즘은 시뮬레이션을 통해 성능을 검증하였고 anticipated-reservation 메커니즘은 새로운 에이전트의 도입과 메시지 흐름을 이용하여 타당성을 입증하였다.

• JSTS:Journal of Semiconductor Technology and Science
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• 제15권4호
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• pp.506-517
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• 2015

This paper presents a 1.248 Gb/s - 2.918 Gb/s low-power receiver MIPI-DigRF M-PHY with a fully digital frequency detection loop. MIPI-DigRF M-PHY should be operated in a very short training time which is $0.01{\mu}s$ the for HS-G2B mode. Because of this short SYNC pattern, clock and data recovery (CDR) should have extremely fast locking time. Thus, the quarter rate CDR with a fully digital frequency detection loop is proposed to implement a fast phase tracking loop. Also, a low power CDR architecture, deserializer and voltage controlled oscillator (VCO) are proposed to meet the low power requirement of MIPI-DigRF M-PHY. This chip is fabricated using a $0.11{\mu}m$ CMOS process, and the die area is $600{\mu}m{\times}250{\mu}m$. The power consumption of the receiver is 16 mW from the supply voltage of 1.1 V. The measured lock time of the CDR is less than 20 ns. The measured rms and peak jitter are $35.24ps_{p-p}$ and $4.25ps_{rms}$ respectively for HS-G2 mode.

• Journal of Periodontal and Implant Science
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• 제35권3호
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• pp.675-685
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• 2005

Bone resorption involves sequential stages of osteoclast precursor migration and differentiation of osteoclast precursors into multinucleated osteoclasts. Stromal cell derived factor (SDF)-1 is a chemotactic factor for osteoclast precursor migration. Matrix metalloproteinase (MMP)-9 is involved in migration of osteoclast precursors and activation of $interleukin(IL)-1{\beta}$. Alveolar bone destruction is a characteristic feature of periodontal disease. Treponema lecithinolyticum is a oral spirochete isolated from the periodontal lesions. The effect of lipopolysaccharide(LPS) from T. lecithinolyticum on expression of SDF-1 and MMP-9 was examined in cocultures of bone marrow cells and osteblasts derived from mouse calvariae. T. lecithinolyticum LPS increased expression of MMP-9 in the coculture. Polymyxin B, an inhibitor of LPS, abolished the increase of MMP-9 mRNA expression by LPS. LPS did not increase the expression of SDF-1, $IL-1{\beta}$ and tumor necrosis $factor(TNF)-{\alpha}$ mRNA in cocultures. Prostaglandin $E_2(PGE_2)$ up-regulated the expression of MMP-9 and NS398, an inhibitor of $PGE_2$ synthesis, down-regulated the induction of MMP-9 expression by T. lecitbinolyticm LPS. These results suggest that T. lecitbinolyticm LPS increases MMP-9 expression in bone cells via $PGE_2$ and that the induction of MMP-9 expression by T. lecitbinolyticm LPS is involved in alveolar bone destruction of periodontitis patients by the increase of osteoclast precursor migration and the activation of bone resorption-inducing cytokine.

• 대한임상검사과학회지
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• 제42권1호
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• pp.1-15
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• 2010

Swine influenza virus (SIV) or swine-origin influenza virus (S-OIV) is endemic in swine, and classified into influenza A and influenza C but not influenza B. Swine influenza A includes H1N1, H1N2, H3N1, H3N2 and H2N3 subtypes. Infection of SIV occurs in only swine and that of S-OIV is rare in human. What human can be infected with S-OIV is called as zoonotic swine flu. Pandemic 2009 swine influenza H1N1 virus (2009 H1N1) was emerged in Mexico, America and Canada and spread worldwide. The triple-reassortant H1N1 resulting from antigenic drift was contained with HA, NA and PB1 of human or swine influenza virus, PB2 and PA polymerase of avian influenza virus, and M, NP and NS of swine influenza virus, The 2009 H1N1 enables to transmit to human and swine. The symptoms and signs in human infected with 2009 H1N1 virus are fever, cough and sore throat, pneumonia as well as diarrhea and vomiting. Co-infection with other viruses and bacteria such as Streptococcus pneumoniae can occur high mortality in high-risk population. 2009 H1N1 virus was easily differentiated from seasonal flu by real time RT-PCR which contributed rapid and confirmed diagnosis. The 2009 H1N1 virus was treated with NA inhibitors such as oseltamivir (Tamiflu) and zanamivir (Relenza) but not with adamantanes such as amantadine and rimantadine. Evolution of influenza virus has continued in various hosts. Development of a more effective vaccine against influenza prototypes is needed to protect new influenza infection such as H5 and H7 subtypes to infect to multi-organ and cause high pathogenicity.

• 한국미생물·생명공학회지
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• 제49권2호
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• pp.157-166
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• 2021

The probiotic market is constantly continuing to grow, concomitantly with a widening in the range and diversity of probiotic products. Probiotics are defined as live microorganisms that provide a benefit to the host when consumed at a proper dose; the viability of a probiotic is therefore of crucial importance for its efficacy. Many products undergo lyophilization for maintaining their shelf-life. Unfortunately, this procedure may damage the integrity of the cells due to stress conditions during both the freezing and (vacuum-) drying process, thereby impacting their functionality. We propose a lysine-based mixture for rehydration of freeze-dried probiotics for improving their viability during in vitro simulated gastric and duodenum stress conditions. Measurement of the zeta potential served as an indicator of cell integrity and efficacy of this mixture, while functionality was estimated by adhesion to a human enterocyte-like Caco-2 cell-line. The freeze-dried bacteria exhibited a significantly different zeta potential compared to fresh cultures; however, this condition could be restored by rehydration with the lysine mixture. Recovery of the surface charge was found to influence adhesion ability to the Caco-2 cell-line. The optimum lysine concentration of the formulation, designated "Zeta-bio", was found to be 0.03 M for improving the viability of Lactiplantibacillus plantarum Lp-115 by up to 13.86% and a 7-strain mixture (400B) to 41.99% compared to the control rehydrated with distilled water. In addition, the lysine Zeta-bio formulation notably increased the adherence ability of lyophilized Lp-115 to the Caco-2 cell-line after subjected to the in vitro stress conditions of the simulated gastrointestinal tract passage.

• 원예과학기술지
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• 제32권6호
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• pp.879-886
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• 2014

가축분뇨액비의 토양전염성 잔디병해들의 억제능력을 알아보고자 군위, 논산, 무안, 여주, 이천, 익산, 합천, 횡성 등 8개 지역의 가축분뇨액비생산시설에서 생산된 액비를 이용하여 기내에서 수행하였다. 가축분뇨액비와 병원균주들과의 대치배양을 통해 총 110종의 길항미생물을 선발하였으며, 각 병원균주별로 길항능력이 우수한 한 종씩을 선발하였다. 선발된 각각의 미생물은 16s rRNA 서열분석을 통해 brown patch에 길항력을 보인 ICIIIB60은 Alcaligenes sp., large patch에 길항력을 나타낸 GWIV70은 Bacillus licheniformis Ab2, dollar spot에 길항력을 보인 ISSH20은 B. subtilis C7-3으로 동정되었다. 이들의 최적배양조건은 NB 배지(ICIIIB60)와 TSB 배지(GWIV70, ISSH20)에서 온도는 $29.5^{\circ}C-31.4^{\circ}C$의 범위에서, pH는 6.5-7.3의 범위에서 잘 자라는 것으로 확인되었다. 또한 각 균주를 5종의 살균제와 혼용한 결과, ICIIIB60 균주는 테부코나졸 제제, GWIV70와 ISSH20 균주는 토클로포스메틸 제제에서 생존율이 높아 혼용처리가 가능할 것으로 판단되었다. 이러한 결과를 통해 가축분뇨액비는 비료로서의 역할뿐만이 아니라 잔디 병해를 줄일 수 있는 친환경적인 소재로 이용이 가능함을 확인하였다.

• KSBB Journal
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• 제17권1호
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• pp.100-105
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• 2002

중합도 n$\leq$10을 갖는 N-아세틸-D-글루코사민(GlcNAc)을 미생물 Serratia marcesce-ns QM B14f6의 최소배지 회분식 발효를 이용하여 키틴 및 키토산을 분해하는 효소 키티나제(1.5 unit/mL) [키토바이아제(3.48 unit/mL)가 포함됨]를 생성시킨다. 효소 반응에 의한 키토올리고당의 생성 활성을 규명하기 위하여 부분적으로 탈아세틸화된 키토산을 효소적 가수분해 반응시킴으로써 생성된 N-아세틸-D-글루코사민과 D-글루코사민의 키토올리고당의 생성 패턴을 확인 조사한다. 이 혼합 올리고머로부터 CM-Sephadex의 컬럼 크로마토그래피에 의하여 당별로 분획시켜 추출한 헤테로 키토 올리고당들을 각각 N-아세틸화하고 이 최종 생성물을 전기투석 장치로서 정제하여 키토올리고 1-7당을 제조하였다. 부분적으로 탈아세틸화 키토산(환원당으로서 2697 mg/mL)을 효소반응에 의해 생성시킨 키토올리고당은 1당으로서 GlcNAc=4.25%, 2당 $(GlcNAc)_2$=4.49%, 3당 $(GlcNAc)_3$=11.1%, 4당 $(GlcNAc)_4$=2.5%, 5당 $(GlcNAc)_{5}$ =0.64%, 6당$(GlcNAc)_{6}$=2.12%, 7당 $(GlcNAc)_{7}$=1.21%가 각각 제조되었다.

• 대한전자공학회논문지
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• 제25권9호
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• pp.1115-1124
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• 1988

A two-dimensional systolic array for fast Fourier transform, which has a regular and recursive VLSI architecture is presented. The array is constructed with identical processing elements (PE) in mesh type, and due to its modularity, it can be expanded to an arbitrary size. A processing element consists of two data routing units, a butterfly arithmetic unit and a simple control unit. The array computes FFT through three procedures` I/O pipelining, data shuffling and butterfly arithmetic. By utilizing parallelism, pipelining and local communication geometry during data movement, the two-dimensional systolic array eliminates global and irregular commutation problems, which have been a limiting factor in VLSI implementation of FFT processor. The systolic array executes a half butterfly arithmetic based on a distributed arithmetic that can carry out multiplication with only adders. Also, the systolic array provides 100% PE activity, i.e., none of the PEs are idle at any time. A chip for half butterfly arithmetic, which consists of two BLC adders and registers, has been fabricated using a 3-um single metal P-well CMOS technology. With the half butterfly arithmetic execution time of about 500 ns which has been obtained b critical path delay simulation, totla FFT execution time for 1024 points is estimated about 16.6 us at clock frequency of 20MHz. A one-PE chip expnsible to anly size of array is being fabricated using a 2-um, double metal, P-well CMOS process. The chip was layouted using standard cell library and macrocell of BLC adder with the aid of auto-routing software. It consists of around 6000 transistors and 68 I/O pads on 3.4x2.8mm\ulcornerarea. A built-i self-testing circuit, BILBO (Built-In Logic Block Observation), was employed at the expense of 3% hardware overhead.

• 정보처리학회논문지B
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• 제9B권5호
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• pp.571-578
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• 2002

인터넷을 통해 동영상을 전송할 때, 네트워크의 상태에 따라 패킷 손실이 발생할 수 있다. 패킷 손실이 발생하면 해당 프레임 뿐 아니라, 그 프레임을 참조하는 다른 프레임의 화질에도 영향을 미치는 오류전파가 발생한다. 본 논문에서는 전송 중 패킷 손실로 인한 오류전파를 최소화하기 위한 부호화 기법인 AMV(Auxiliary Motion Vector)를 제안한다. AMV 기법에서 부호기는 한 개의 매크로블록을 압축하기 위해 여러 프레임과의 움직임 예측을 수행한 후, 상위 두 개의 매칭블록을 선택한다. 두 블록 중 압축 대상 매크로블록과 더 유사한 블록을 움직임 보상에 이용하며 이 블록을 참조블록 또는 기본블록이라 한다. 나머지 블록을 보조블록이라 하며 참조블록이 손실된 경우 복호기가 참조블록의 대체용으로 이용한다. 보조블록의 정보는 압축된 매크로블록의 헤더에 블록의 모션벡터와 프레임 번호를 삽입함으로써 전송된다. 이 기법은 다른 기법에 비해 압축에 이용되는 참조블록의 수를 최소화하고 보조블록을 이용하여 오류를 요구함으로써 오류전파가 발생하는 범위와 그 강도를 줄이는 장점이 있다. 제안된 기법의 코덱을 구현하기 위해 H.263 표준 소스를 수정하였으며, 다양한 패킷 손실율의 트레이스를 생성하기 위해 시뮬레이션 툴인 NS-2를 이용하였다. 실험 결과 제안된 기법은 전체적으로 H.253 표준에 비하여 높은 성능을 나타냈으며 특히 화면의 변화가 적은 경우 패킷 손실율이 높을수록, 변화가 심한 경우 패킷 손실율이 낮을수록 높은 성능을 나타내었다.

• 한국통신학회논문지
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• 제29권1B호
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• pp.86-100
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• 2004

To provide the end-to-end service differentiation for assured services, the random early demotion and promotion (REDP) marker in the edge router at each domain boundary monitors the aggregate flow of the incoming in-profile packets and demotes in-profile packets or promotes the previously demoted in-profile packets at the aggregate flow level according to the negotiated interdomain service level agreement (SLA). The REDP marker achieves UDP fairness in demoting and promoting packets through random and early marking decisions on packets. But, TCP fairness of the REDP marker is not obvious as for UDP sources. In this paper, to improve TCP fairness of the REDP marker, we propose a modified REDP marker where we combine a dropper, meters and a token filling rate configuration component with the REDP marker. To make packet transmission rates of TCP flows more fair, at the aggregate flow level the combined dropper drops incoming excessive in-profile packets randomly with a constant probability when the token level in the leaky bucket stays in demotion region without incoming demoted in-profile packets. Considering the case where the token level cannot stay in demotion region without the prior demotion, we propose a token filling rate configuration method using traffic meters. By using the token filling rate configuration method, the modified REDP marker newly configures a token filling rate which is less than the negotiated rate determined by interdomain SLA and larger than the current input aggregate in-profile traffic rate. Then, with the newly configured token filling rate, the token level in the modified REDP marker can stay in demotion region pertinently fir the operation of the dropper to improve TCP fairness. We experiment with the modified REDP marker using ns2 simulator fur TCP sources at the general case where the token level cannot stay in demotion region without the prior demotion at the negotiated rate set as the bottleneck link bandwidth. The simulation results demonstrate that through the combined dropper with the newly configured token filling rate, the modified REDP marker also increases both aggregate in-profile throughput and link utilization in addition to TCP fairness improvement compared to the REDP marker.