• Journal of Nutrition and Health
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• 제29권8호
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• pp.874-880
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• 1996

The effects of an anabolic steroid, nandrolone phenylpropionate(NPP), on body weight gain and body protein, and muscle protein metabolism were inestigated in adrenocorticotrophic hormone(ACTH)-treated male and female rats. Daily injections of 100ug/day of ACTH for 7-8 days caused a cessation of growth in females and a net loss of body weight in males which were associated with significant reductions in body protein content. However, food intake was not affected by ACTH in either sex. The weight, protein content and fractional rate of protein synthesis, measured in vivo, of gastrocnemius muscle were all significantly reduced in both sexes. NPP at a dose of 4mg/kg body weight prevented the reduction in body weight gain in ACTH-treate females but not in males. However, boy protein content was increased by NPP in both sexes which was associated with increases in the weight, protein content and fractional rate of protein synthesis of gastrocnemius muscle. ACTH treatment caused a marked increase in plasma concentrations of corticosterone in both sexes. NPP suppressed much of the increases in corticosterone concentrations in both sexes. The results of the present study suggest that NPP exerts at least part of its anabolic effect by reducing plasma concentrations of catabolic glucocorticoid hormones, through suppressing the response of the adrenals to ACTH.

• Nuclear Engineering and Technology
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• 제46권5호
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• pp.699-706
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• 2014

The probabilistic seismic performance of a standard Korean nuclear power plant (NPP) with an idealized isolation is investigated in the present work. A probabilistic seismic hazard analysis (PSHA) of the Wolsong site on the Korean peninsula is performed by considering peak ground acceleration (PGA) as an earthquake intensity measure. A procedure is reported on the categorization and selection of two sets of ground motions of the Tohoku earthquake, i.e. long-period and common as Set A and Set B respectively, for the nonlinear time history response analysis of the base-isolated NPP. Limit state values as multiples of the displacement responses of the NPP base isolation are considered for the fragility estimation. The seismic risk of the NPP is further assessed by incorporation of the rate of frequency exceedance and conditional failure probability curves. Furthermore, this framework attempts to show the unacceptable performance of the isolated NPP in terms of the probabilistic distribution and annual probability of limit states. The comparative results for long and common ground motions are discussed to contribute to the future safety of nuclear facilities against drastic events like Tohoku.

• Earthquakes and Structures
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• 제13권6호
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• pp.561-572
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• 2017

Seismic base isolation has been accepted as one of the most popular design procedures to protect important structures against earthquakes. However, due to lack of information and experimental data the application of base isolation is quite limited to nuclear power plant (NPP) industry. Moreover, the effects of inelastic behavior of soil beneath base-isolated NPP have raised questions to the effectiveness of isolation device. This study applies the wavelet analysis to investigate the effects of soil-structure interaction (SSI) on the seismic response of a base-isolated NPP structure. To evaluate the SSI effects, the NPP structure is modelled as a lumped mass stick model and combined with a soil model using the concept of cone models. The lead rubber bearing (LRB) base isolator is used to adopt the base isolation system. The shear wave velocity of soil is varied to reflect the real rock site conditions of structure. The comparison between seismic performance of isolated structure and non-isolated structure has drawn. The results show that the wavelet analysis proves to be an efficient tool to evaluate the SSI effects on the seismic response of base-isolated structure and the seismic performance of base-isolated NPP is not sensitive to the effects in this case.

• Nuclear Engineering and Technology
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• 제52권5호
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• pp.975-983
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• 2020

Since the Fukushima Daiichi accident in 2011, concerns for the safety of multi-unit Nuclear Power Plant (NPP) sites have risen. This is because more than 70% of NPP sites are multi-unit sites that have two or more NPP units and a multi-unit accident occurred for the first time. After this accident, Probability Safety Assessment (PSA) has been considered in many countries as one of the tools to quantitatively assess the safety for multi-unit NPP sites. One of the biggest concerns for a multi-unit accident such as Fukushima is that the consequences (health and economic) will be significantly higher than in the case of a single-unit accident. However, many studies on multi-unit PSA have focused on Level 1 & 2 PSA, and there are many challenges in terms of public acceptance due to various speculations without an engineering background. In this study, two kinds of multi-unit Level 3 PSA for multi-unit site have been carried out. The first case was the estimation of multi-unit risk with conservative assumptions to investigate the margin between multi-unit risk and QHO, and the other was to identify the effect of time delays in releases between NPP units on the same site. Through these two kinds of assessments, we aimed at investigating the level of multi-unit risk and understanding the characteristics of risk in a multiunit context.

• Nuclear Engineering and Technology
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• 제54권2호
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• pp.749-763
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• 2022

The fulcrum of economic development is a sustainable supply of electricity. Nigeria is plagued with blackouts, with one of the lowest per capita electricity consumption in the world (circa. 120 kWh per capita). Hence, policies have been instigated to integrate electricity generation from nuclear power plants (NPP) on or before 2027. However, a critical requirement for NPP generation is the implementation of robust human resource development (HRD) programs. This paper presents the perspective of Nigeria in assessing human resources needs over the entire NPP lifecycle following the milestone approach and employing the IAEA's Nuclear Power Human Resource (NPHR) modeling tool. Three workforce organizations are in focus including the owner/operator, regulators, and construction workers following three decades timeframe (2015-2045). The results indicate that for the study period, a maximum of approximately 9045 personnel (73% construction workers, 24% owner/operator, and 3% regulators) should be directly involved in the NPP program just before the commissioning of the third NPP in 2033. However, this number decreases by about 73% (2465 personnel including 94% operator and 6% regulator) at the end of the study timeframe. The results can potentially provide clarity and guidance in HRD decision-making programs.

• Nuclear Engineering and Technology
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• 제54권4호
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• pp.1363-1373
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• 2022

The recent seismic events that occurred in South Korea have increased the interest in the re-evaluation of the seismic capacity of nuclear power plant (NPP) equipment, which is often conservatively estimated. To date, various approaches-including the Bayesian method proposed by the United States (US) Electric Power Research Institute -have been developed to quantify the seismic capacity of NPP equipment. Among these, the Bayesian approach has advantages in accounting for both prior knowledge and new information to update the probabilistic distribution of seismic capacity. However, data availability and region-specific issues exist in applying this Bayesian approach to Korean NPP equipment. Therefore, this paper proposes to construct an earthquake experience database by combining available earthquake records at Korean NPP sites and the general location of equipment within NPPs. Also, for the better representation of the seismic demand of Korean earthquake datasets, which have distinct seismic characteristics from those of the US at a high-frequency range, a broadband frequency range optimization is suggested. The proposed data construction and seismic demand optimization method for seismic capacity re-evaluation are demonstrated and tested on a 480 V motor control center of a South Korea NPP.

• 정보처리학회 논문지
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• 제13권5호
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• pp.227-235
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• 2024

원자력발전소에서 디지털 계측제어 시스템 비중이 높아지면서 원자력발전소에 대한 확률론적 안정성 평가 시 소프트웨어에 대한 신뢰도 평가가 중요해졌다. 원전 소프트웨어 신뢰도 추정을 위한 방법들이 몇 가지 제안 되었지만 해당 방법의 효과적 적용을 지원하는 도구 지원이 미비하였다. 본 연구에서는 소프트웨어 개발 품질 및 검증 품질과 같은 정성적 정보와 통계적 시험 결과와 같은 정량적 정보를 활용하여 원전 소프트웨어 신뢰도를 정량적으로 측정할 수 있는 자동화 도구를 설계하였고 구현하였다. 개발된 도구를 산업용 원자로 보호 시스템 사례에 적용한 결과, 개발된 도구가 원전 소프트웨어의 신뢰성 평가를 효과적으로 지원할 수 있음을 확인하였다.

• 대한약침학회지
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• 제27권1호
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• pp.38-46
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• 2024

Objectives: Genotoxicity is evaluated through a chromosomal aberration test using cultured mammalian cells to determine the toxicity of no-pain pharmacopuncture (NPP), which has recently been used to treat musculoskeletal pain disorders in Korean medical clinical practice. Methods: An initial test was performed to determine the dosage range of the NPP, followed by the main test. In this study, NPP doses of 10.0, 5.0, and 2.5%, and negative and positive controls were tested. An in vitro chromosome aberration test was performed using Chinese hamster lung cells under short-term treatment with or without metabolic activation and under continuous treatment without metabolic activation. Results: Compared with the saline negative control group, NPP did not significantly increase the frequency of chromosomal abnormalities in Chinese hamster lung cells, regardless of the presence or absence of metabolic activation. Additionally, the number of cells with structural chromosomal abnormalities was significantly higher in the positive control group than that in the negative control group that received saline. Conclusion: Based on the above results, the chromosomal abnormality-producing effect of NPP was determined to be negative under these test conditions.

• Nuclear Engineering and Technology
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• 제56권6호
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• pp.2274-2281
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• 2024

RESRAD-ONSITE v7.2 code is used to assess the radiation effects on a farmer resident located in a hypothetical contaminated site planned for the first nuclear power plant project in Vietnam, namely Ninh Thuan 1, after decommissioning. Derived concentration guideline levels are preliminarily calculated for 17 radionuclides that are assumed to remain on a contaminated surface soil with an initial concentration of 1 pCi/g in the protected area of NPP site. For a reliable estimation, the site-specific conditions regarding the geological, hydrological, climate, and occupancy data gathered from the Feasibility Study Report (FSR) and relevant literatures for the Ninh Thuan 1 NPP site is employed as input parameters. The calculation results indicate that the peak of total exposure dose is estimated to be ca. 0.191 mSv/yr at the time of decommissioning, and then decrease over time. Furthermore, the protected site is assessed to be released at ca. 6.71 years after decommissioning under the regulation on radiation protection in Vietnam. Through this study, a radiation exposure model for residents living near the Ninh Thuan 1 NPP is preliminarily established by using the RESRAD-ONSITE code, which are expected to be useful for future implementation of the Ninh Thuan 1 NPP project in Vietnam.

• 대한원격탐사학회지
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• 제27권4호
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• pp.467-480
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• 2011

본 연구는 AVHRR(Advanced Very High Resolution Radiometer)과 MODIS(MODerate-resolution Imaging Spectroradiometer) 위성관측을 바탕으로 산출된 남한지역의 장기간(1981-2006년) 순 일차생산량(Net Primary Production, NPP)의 시공간적 변화를 분석하고 그 변화에 영향을 미치는 기후요소와의 상관성을 분석하였다. 남한지역의 AVHRR과 MODIS에서는 연간순 열차생산량이 AVHRR의 경우 893-1068 $g{\cdot}C/m^2$ /yr과 MODIS의 경우 610-695 $g{\cdot}C/m^2$/yr로 나타나고 있으며 두 자료는 통계적으로 약 325 $g{\cdot}C/m^2$/yr 의 차이를 보이고 있다. 해상도 등의 차이가 있으나 지상 관측과 비교한 결과 MODIS 센서에 의한 관측이 보다 근접한 결과를 보이는 것으로 나타났다. 위성관측자료 분석결과 NPP 값은 식생의 밀도가 높은 산림지역 및 연평균기온이 높은 지역에서 큰 것으로 나타났다. 두개의 위성센서로 산출된 순 열차생산량은 경년변화가 다소 크지만, 각각 장기간에 걸쳐 서서히 증가하고 있는 것으로 나타났으며 1981-2000년 동안 AVHRR에서 매년 평균 2.14 $g{\cdot}C/m^2$/yr, 2000-2006년 동안 MODIS에서 매년 평균 6.08 $g{\cdot}C/m^2$/yr 만큼 증가하였다. 특히 남서해안 지역은 두 위성관측결과 모두 순 일차생산량의 증가가 상대적으로 높았다. 토지피복 지도와 대조결과 그 이유는 논 밭 등의 관개와 비료시용에 의한 농작물의 생산성 증대와 관계가 있는 것으로 추정된다. NPP값은 월별 강수량 및 평균기온에 밀접한 관계가 있는 것으로 확인되었으며, 특히 남한지역의 여름몬순시기에서 강수량과 기온이 모두 가장 큰 상관관계를 보이고 있다. NPP 절대값의 차이 외에도 두 센서로 산출된 순 일차생산량과 기후요소와의 상관성 등의 차이는 두 자료의 토양호흡 등을 포함하는 등 위성자료 복원과정 및 관련 모텔의 차이에 의해 발생하는 것으로 사료된다. 또한 향후 보다 정확한 순 일차생산량을 계산하기 위해 복원과정에서 기상 실측자료 및 보다 현실적인 토지피복 등을 고려해야 할 것이다.