• 한국임상약학회지
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• 제22권4호
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• pp.304-315
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• 2012

Today, suicide by self-poisoning of prescribed or non-prescribed drugs on purpose has been increasing and is a major cause of mortality. It is very important to treat promptly and properly for saving the lives from those suicides. There is neither an organization such as poison control center nor measurement in S. Korea, though. The object of this study was to evaluate information of frequently used substances for suicide attempt in S. Korea. Our results also can provide healthcare provider including pharmacists and doctors, etc and contribute to increasing health and welfare for Korean. From June $1^{st}$ 2006 to April $30^{th}$ 2012, we retrospectively studied patients visiting emergency room due to suicide attempt. We collected information of underlying disease, history of past medical condition and suicide attempt, ingredient and getting route of ingesting substances, emergency treatment, and outcome by reviewing electronic medical record. We also evaluated actual treatment of self-poisoning and made guide information about antidote medication for S. Korean healthcare provider. Among total 242 cases of suicidal attempts, cases ingesting substances including prescription, non-prescription drugs and agricultural chemicals were 86.4%. The most frequently used drugs for suicide attempt were sedatives-hypnotics (53.6%), followed by analgesics (16.7%) and antidepressants (12.4%). Analgesics including acetaminophen and aspirin were most in teenagers but sedatives-hypnotics including benzodiazepines, non-benzodiazepine (zolpidem) and antihistamine were most in other ages including elderly people. Most frequently used antidote was activated charcoal (62.7%) and specific antidotes for some substances (acetaminophen, aspirin, agricultural chemicals) were also treated properly, accompanying with medication for supportive care. In conclusion, the most used substances for suicide attempt were sedatives-hypnotics and treatments for self-poisoning in emergency room were appropriate based on existing references. Therefore, information of frequently used substances and antidote reflecting these results will be useful for South Korean healthcare provider.

• Toxicological Research
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• 제21권4호
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• pp.325-332
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• 2005

The developmental toxicity of water extract of licorice (Glycyrrhiza glabra) was evaluated in rats. Licorice extract (500, 1,000 or 2,000 mg/kg) was dissolved in drinking water and orally administered to male rats from 9 weeks before mating to the day of copulation, and to females from 2 weeks before mating to gestational day 19. On gestational day 20, the animals were sacrificed for Cesarian section, and maternal and fetal abnormalities were examined. Licorice extract neither induce clinical signs, nor affect the body weight gain, feed and water intake, estrous cycle, copulation and fertility rates, blood $17\beta-estradiol$ level and organ weights of dams. Also, the implantation and development including body weights, absorption and death of embryos and fetuses were not influenced by in utero exposure to licorice. In addition, there were no increases in external, visceral and skeletal abnormalities of fetuses. Taken together, it is suggested that no observed adverse effect level of licorice extract is higher than 2,000 mg/kg, and that long-term in utero exposure to licorice might not cause developmental toxicities of embryos and fetuses.

• Pediatric Infection and Vaccine
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• 제17권2호
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• pp.114-121
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• 2010

목적 : 고막체온계는 신체내의 점막과 접촉 없이 고막을 통해 심부체온을 신속히 간편한 방법으로 측정할 수 있어 영아와 소아들에서 많이 사용된다. 본 연구에서는 한쪽에만 중이염, 귀지가 있는 경우 양쪽 고막체온이 어떻게 달라지는지 연구하였다. 방법 : 2008년 6월부터 9월까지, 2010년 1월부터 5월까지 본원 소아청소년과 외래에 내원한 소아 중 비디오 이경을 통해 중이염과 귀지가 없는 정상군 50명, 한쪽에만 고막이 안보이게 귀지가 가득 있는 군 50명, 한쪽에만 중이염을 가진 군 186명의 3개 군을 대상으로 하였다. 고막체온은 Braun Thermoscan을 이용해 양쪽 귀에서 2초간 측정하였고, 15분 뒤 다시 측정하였다. 중이염을 가진 군은 비디오 이경으로 확인하여 염증정도에 따라 분류하여 비교하였다. 통계처리는 SPSSWIN 12.0을 사용하였고 paired T-test와 one way anova를 이용하여 분석하였다. 결과 : 정상 군과 한쪽에만 귀지가 있는 군에서는 양쪽 고막체온의 통계적인 차이는 없었다. 한쪽에만 중이염이 있는 군에서는 중이염이 있는 쪽의 고막이 평균 $0.13{\pm}0.20^{\circ}C$ 높았고 통계적인 차이가 있었다($36.99{\pm}0.54^{\circ}C$ vs $36.86{\pm}0.52^{\circ}C$ P<0.001). 중이염의 단계에 따른 양쪽 고막의 체온차이는 통계적으로 유의하지 않았다. 결론 : 고막체온계는 스트레스 없이 쉽고 빠르게 체온을 측정할 수 있다. 적절한 방법으로 측정한다면 양측 고막체온에는 큰 차이가 없을 것으로 생각되나, 중이염이 있을 때엔 양쪽 고막체온에 차이가 있을 수 있음을 주의 해야겠다.

• 여성건강간호학회지
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• 제4권2호
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• pp.173-186
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• 1998

In this study, both the literary survey as well as empirical research has been executed to test the validity of the scales that measure the construct of self-monitoring scale could not be classified into five factors as Snyder suggested. Many other scholars (Briggs, Cheek and Buss, 1980) suggested 3 different classifications which was accepted by Snyder and Gangestad (1986). John, Cheek and Klohnen (1996) claimed a two-factor classification. As has been discussed, factor analysis is used to prove convergent validity within the factor and discriminant validity between the factors. However, depending on the researchers, many variations in classification of the factors were found and a lack of content and discriminant validity was found in the previous research findings. It is also important to note that Snyder's self-monitoring scale, did not factor-load at over 30 for all 25 items, regardless of how many factors could be classified. According to findings of this study, the self-monitoring scale neither classified as five, three or two factors nor factor loaded as hypothesized. It is also clear that Snyder's self-monitoring scale lack convergent validity as the sub-factors of the scale fail to prove its uni-dimensionality. The A self-monitoring scale not only fail to overcome the problems of Snyder's self-monitoring scale but even lost the attractiveness of the self-monitoring scale. In this study, it was also found that the A self-monitoring scale was not classified as hypothesized in either in a two or three-factor classification. It is, of course, not desirable to use any scale that lacks convergent and discriminant validity even though it has been widely used but also has held a great deal of influence on the field of social psychology. To overcome the shortcomings of Snyder's self-monitoring scale, Lennox and Wolfe(1984) suggested 13 items. This study 1. was dedicated to test the validity and reliability of the scale, in which we found that the data presented in validity as the two factors were classified and loaded as expected. Reliability was also proven by checking Cronbach's alpha for each factor and for the total items. In addition, a confirmatory factor analysis was executed for the 13 items using LISREL 8.12 program to confirm convergent validity in a two-factor classification. The model was fitting and sound ; however, the self-monitoring scale was unfitted and not validated. Thus, it is recommended to use not the original or the abbreviated self-monitoring scale but the 13 items in future studies. It should also be noted that items 7 and 13 should be removed to obtain better uni-dimensionality for the 13 items. These items loaded at over .30, too high for the two factors in the test results of factor analysis. In addition, it is necessary to double-check the cause of two-hold loading at over .30 for the two factors. It could be a problem caused by data or by the scale itself. Therefore, additional studies should follow to better clarify this matter.

• Asian-Australasian Journal of Animal Sciences
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• 제15권10호
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• pp.1469-1474
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• 2002

This study was designed to evaluate the influence of a single or double dose of Fe dextran with organic trace mineral supplementation on the performance of piglets from dams fed diets with either inorganic (ITM) or organic trace minerals (OTM). It also determined the effect of the source of the trace minerals on the reproductive performance of sows. The trace mineral premixes were prepared using metal proteinates and the corresponding inorganic salts for the OTM and the ITM, respectively. Each mineral premix provided 100 ppm Fe/175 ppm Fe, 35 ppm Cu/170 ppm Cu, 90 ppm Zn/120 ppm Zn, and 40 ppm Mn/35 ppm Mn when added at 0.20% in sows /weaned pigs' diets, respectively. The first dose of Fe dextran was administered to piglets at 3 d and the second dose at 10 d after birth. One dose of Fe dextran supplied 100 mg of Fe. A total of 16 gestating sows (Landrace${\times}$Yorkshire) in parities 2 to 4 were randomly allocated to four treatments: 1) diet with ITM/one dose of Fe dextran to piglets, 2) diet with ITM/two doses of Fe dextran to piglets, 3) diet with OTM/one dose of Fe dextran to piglets, and 4) diet with OTM/two doses of Fe dextran to piglets. The total born alive, weaned, body weight at birth and at weaning were not affected by the sow's dietary treatment. Although organic trace mineral supplementation tended to increase the milk Fe content (p<0.10) at 7 d postpartum, piglets in all treatments performed equally from birth to weaning. The double doses of Fe dextran neither improved the average daily gain (ADG) nor influenced the survival of piglets from birth to weaning (21 d). Results suggest that a single dose of Fe dextran given to suckling pigs is adequate to sustain their needs for growth throughout the lactation period (21 d). Furthermore, there was a 21% improvement in both the ADG and the average daily feed intake (ADFI) (p<0.05) in weaned pigs fed diets with OTM. Cu and Fe in the liver (p<0.01), and Zn in both the bone (p<0.01) and the serum (p<0.01) were higher in piglets fed OTM than in those fed ITM. It would be concluded that single dose of Fe dextran administration with organic trace mineral supplementation show similar growth performance compared to 2 dose Fe dextran administration with inorganic mineral supplementation in young pigs.

• Asian-Australasian Journal of Animal Sciences
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• 제13권4호
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• pp.497-505
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• 2000

Thirty piglets weaned at 24.5 d of age ($6.9{\pm}0.5kg$) randomly alloted to 3 treatments were used to investigate the effect of dietary tallow on average performance, digestibility of nutrients, metabolic utilization of energy and body composition at 25 kg. Weaned piglets respond to increasing levels of dietary tallow from 0 to 4% and 8% by digestive and metabolic adaptation. Apparent fecal digestibility of fat (AFDf) was highly correlated with the level of dietary tallow (X as % of fat extracted after HCl hydrolysis) by the following curvilinear equation of regression: $AFDf=33.8+6.9X-0.3X^2$. Feed intake expressed as DE was only significantly increased at the higher inclusion level of tallow. But neither average daily gain, nor feed conversion was affected by the addition of fat. On the other hand, body composition at 25 kg was equally affected, by both levels of supplementary fat; dry matter and energy content in the body were significantly higher (p<0.01) in piglets receiving tallow. As a consequence, the energy cost of the live weight gain was also increased from 23 to 24.7 MJ DE/kg (p<0.02) and the efficiency of energy deposition was decreased from 3.2 to 2.8 MJ DE/MJ deposited energy (p<0.01) in the presence of dietary tallow. An increase in the level of fat stimulated the activity of pancreatic lipase up to a constant value of $22{\pm}1.4IU/mg$ protein but conversely depressed the activity of amylase from 300 to 100 IU/mg of protein. The activity of liver acetyl CoA carboxylase and malic enzyme in the perirenal fat were low lind not affected by dietary fat; the activity of glucose-6-phosphate dehydrogenase was high. Opposite to that, the activity of acetyl CoA carboxylase and malic enzyme in the perirenal and backfat were higher than in the liver and both were significantly reduced by the inclusion of fat in the diet. A direct deposition of dietary fat has been demonstrated by increasing the energy and lipid content of the empty body weight gain between 7 and 25 kg of live weight, and decreasing the efficiency of digestible energy utilization.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7459-7465
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• 2014

Background: A prior study showed blood type A/AB to be associated with an increased risk of nasopharyngeal carcinoma (NPC) compared to subjects with blood type O. However, the relationship between ABO blood groups and prognosis of NPC patients is still questionable. In addition, whether Epstein-Barr virus (EBV) infection is associated with prognosis of NPC patients with different ABO blood groups is unclear. Materials and Methods: We conducted univariate and multivariable Cox regression analyses based on a consecutive cohort of 1,601 patients to investigate the above issues. Results: There was no significant difference in overall survival (OS) between different ABO blood groups (p=0.629), neither between A vs. non-A blood groups (p=0.895) nor AB vs. non-AB blood group (p=0.309) in univariate analyses and after adjusting for other factors. Interaction tests revealed that high immunoglobulin A against Epstein-Barr virus viral capsid antigen (VcA-IgA) level was associated with a favorable prognosis in male patients with UICC stage II disease who had an A blood type (p=0.008), compared with those with non-A blood type. In addition, male patients with an A blood group with a high blood lymphocyte level showeda tendency towards better survival in UICC stage III (p=0.096). Conclusions: ABO blood group status is not associated with the prognosis of patients with NPC. Additionally, blood group A male NPC patients with high VcA-IgA level or high blood lymphocyte counts might be correlated with a favorable prognosis in UICC stage II or III, respectively.

• 한국ITS학회 논문지
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• 제15권4호
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• pp.33-43
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• 2016

수도권 통합대중교통요금제를 위해 생성되고 있는 교통카드자료는 수도권 도시철도의 환승시간 및 횟수정보를 제공하지 못하고 있다. 도시철도에는 환승게이트가 설치되어 있지 않아 노선간의 환승정보는 설문조사나 목측을 통한 거시적 추정으로 진행된다. 따라서 교통카드자료를 토대로 계산되는 수도권 대중교통의 환승시간 및 횟수는 과소평가되는 문제점을 내포한다. 환승자료의 정확한 추정을 위해서는 교통카드 태그가 이루어지는 진입 및 진출 게이트 사이에서 발생하는 통행경로에 대한 설명이 필요하다. 본 연구는 교통카드 단말기 태그자료를 기반으로 환승현황을 파악하기 위한 통행경로모형을 구축하고 수도권에서 발생하는 환승정보를 도출한다. 이를 위해 단말기 운영체계와 도시철도의 네트워크 특성을 일치시키기 위한 빅노드 개념을 도입한다. 또한 수도권 도시철도의 효과적 네트워크 구동을 위해 링크표지개념을 도입한다. 교통카드단말기의 행정구역정보를 토대로 시군구의 중죤, 서울-경기-인천의 대죤에서 발생하는 환승시간과 횟수를 도출한다. 2014년 일일 대중교통카드자료를 이용하여 전수화된 환승특성데이터를 구축하고 수도권 도시철도의 환승저항에 대한 통합적인 자료로서 활용가능성을 제시한다.

• 한국작물학회지
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• 제35권6호
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• pp.497-503
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• 1990

질소와 가리 시용량이 버어리종 잎담배(1988년; Burley 21, 1989년 ; Burley 21과 KB 101)의 생육, 수량 및 품질에 미치는 영향을 알아보기 위하여 질소 3수준(1988년 ; 17.5, 22.75, 28.0kg/10a, 1989년 ; 12.5, 17.5, 22.5kg/10a), 가리 3수준(1988년 ; 17.5, 35.0, 52.5kg/10a, 1989년 ; 25.0, 35.0, 45.0kg/10a)을 두어 포장에서 시험한 바, 그 결과를 요약하면 다음과 같다. 1. 적심기 생육에 미치는 질소 시용량의 영향은 년차간 변이가 큰 것으로 나타났으며 가리시용량은 적심기 생육에 별다른 영향을 미치지 않았다. 2. 질소나 가리 시용량이 생육기간중의 엽중 질소함량에는 비교적 큰 영향을 미쳤으나 가리함량에 미치는 영향은 비교적 작았다. 3. Burley 21에 비하여 KB 101이 다수성이었으며, 질소감비상태에서의 생산성도 높았다. 4. 질소를 22.75kg/10a까지 시용할 때는 수량과 품질이 높아졌으나, 그 이상 시용할때는 수량은 증가되지 않고 품질은 낮아졌다. 5. 가리시용량이나 가리/질소 시용비에 따른 수량, 품질 차이는 크지 않았으나, 가리/질소 시용비가 작을 때는 품질이 다소 낮아졌다 6. 질소시용량이 22.75kg/10a을 초과할 때, 잎담배 수량 및 품질면에서 유리한 점은 없었으며, 가리시용량은 35.0kg/10a이면 충분하며 그 이하로의 감비도 여지가 있을 것으로 생각된다.

• 대한후두음성언어의학회지
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• 제16권1호
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• pp.23-27
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• 2005

Background and Objectives : Voice disorders can cause problems in patients with benign vocal cord lesions emotionally, physically, economically and functionally. Neither subjective nor objective voice examinations can evaluate such factors adequately. The Voice Handicap Index (VHI) subjectively evaluates voice disorders in terms of physical, functional, emotional factors and measures the patient's perception of the impact of voice disorder. The purpose of this study is to evaluate the usefulness of VHI in the patients with benign vocal cord lesions. Materials and Method : The authors evaluated 37 patients who experienced laryngeal microsurgery for benign vocal cord lesions from september 2003 to August 2004. The VHI was used to measure the postoperative changes of the patient's perception and acoustic analysis and aerodynamic tests were also done. Statistical analysis was done using paired t-test and Pearson's correlation. Results : The VHI scores showed statistically significant reductions postoperatively. In acoustic analysis, jitter and shimmer had statistically significant reductions after surgery but noise-to-harmonics ratio did not. A statistically significant change in the average MFR and MPT perioperatively was found. The relationship between VHI and acoustic, aerodynamic analysis attained statistical significance. Conclusion : The VHI is a useful assessment tool to monitor the patient's self-perception of voice change after the surgery of benign vocal cord lesions. The VHI measurement, when combined with acoustic and aerodynamic analyses, will be helpful in comparing functional outcomes after voice surgery.