• Applied Chemistry for Engineering
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• v.4 no.4
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• pp.770-775
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• 1993

Chemical structure of poly(ethylene terephthalate-co-1, 4-cyclohexylene dimethylene terephthalate), P(ET-CT) copolyesters was investigated by High Resolution NMR analysis. The copolymer composition and isomeric ratio were determined by methylene resonance peaks which were separated into three peaks corresponding to ET, trans CT and cis CT units, respectively. The copolymer sequence distribution was evaluated from the carbon resonance peaks connected to carbonyl groups in benzene, indicating died distribution. According to statistics model, these copolyesters are almost random copolymers. The copolymer sequence distribution could be simulated and its averaged length was calculated by random copolymer statistics.

• Korean Journal of Materials Research
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• v.3 no.4
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• pp.344-351
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• 1993

The crystal structunes of poly(ethylene terephthalate-eo-1, 4 cyciohexylene dimethylene terephthalate), P(ET CT), copolymers were studied by CPMAS solid state NMR spectroscopy. With the estimation of methylene resonance peaks, the bulkier CT component of the copolymer in the range of 0 20 mol% CT is excluded from the ET crystal lattice, whereas smaller ET component of the copolymer in the range of 66 100 mol% CT can be partially included into the CT crystal lattice. Those different crystallization behavior can be explained with the difference in chain bulkiness and crystal lattice dimension be tween two copolymer compurwnts.

• 전기의세계
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• v.34 no.9
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• pp.528-536
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• 1985

우리나라는 선진 대열에 올라설 수 있는 산업을 중심으로 제2의 도약을 계획하고 있다. 이의 핵심분야인 전자공업의 새로운 장을 연 NMR-CT의 국내 개발은 우리 민족의 우수성을 전세계에 알리는 계기가 됨과 동시에 과학입국으로서 세계어느 나라에도 못지 않는 능력을 과시하게 되었다. 최첨단 기술인 NMR-CT는 1980년대부터 의료진단 분야의 주역이 될 것이며, 치열한 세계경쟁 속에 뛰어 들어 선두대열에서 나아가게 될 것이다. 아울러 많은 첨단분야에서 세계 선진국들과의 경쟁대열에 뒤지지 않기 위해서는 이에 관련된 연구진들의 각고의 노력은 물론 정부와 산업체의 적극적인 지원 및 첨단분야에 대한 새로운 인식이 병행되어야 할 것이다.

• Journal of radiological science and technology
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• v.6 no.1
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• pp.3-19
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• 1983

• Journal of the Korean Magnetic Resonance Society
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• v.8 no.1
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• pp.19-27
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• 2004

C-terminal fragments of APP (APP-CTs), that contain complete Abeta sequence, are found in neuritic plaques, neurofibrillary tangles and the cytosol of lymphoblastoid cells obtained from AD patients. CT16, Lys649-Asp664 (KKQYTSIHHGVVEVD) has been known as the most toxic part in the C-terminal fragment of amyloid precursor protein (APP). The solution structure of CT16 was investigated using NMR spectroscopy in various membrane-mimicking environments. According to Circular Dichroim (CD) spectra, CT16 has a random structure in aqueous solution, while conformational change was induced by addition of TFE and SDS micelle. Tertiary structure as determined by NMR spectroscopy shows that CT16 has a ${\beta}$-turn conformation in trifluoroethanol-containing aqueous solution.

• Bulletin of the Korean Chemical Society
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• v.26 no.8
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• pp.1225-1228
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• 2005

C-terminal fragments of APP (APP-CTs), that contain A$\beta$ sequence, are found in neurotic plaques, neurofibrillary tangles and the cytosol of lymphoblastoid cells obtained from AD patients. CT26, Thr639-Asp664 (TVIVITLVMLKKKQYTSIHH GVVEVD) includes not only the transmembrane domain but also the cytoplasmic domain of APP. This sequence is produced from cleavage of APP by caspase and $\gamma$-secretase. In this study, the solution structure of CT26 was investigated using NMR spectroscopy and circular dichroism (CD) spectropolarimeter in various membrane-mimicking environments. According to CD spectra and the tertiary structure of CT26 determined in TFE-containing aqueous solution, CT26 has an α-helical structure from $Val^{2}\;to\;Lys^{11}$ in TFE-containing aqueous solution. However, according to CD data, CT26 adopts a $\beta$-sheet structure in the SDS micelles and DPC micelles. This result implies that CT26 may have a conformational transition between $\alpha$-helix and $\beta$-sheet structure. This study may provide an insight into the conformational basis of the pathological activity of the C-terminal fragments of APP in the model membrane.

• Journal of the Korean Magnetics Society
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• v.2 no.2
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• pp.132-139
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• 1992

We have designed a magnetic field gradient useful for cylindrical imaging in NMR-CT. The direc¬tion of the designed field is parallel to the axis and the gradient in the radial direction of cylindrical coordinate is monotonically increasing. The ratio of the gradient in the radial and axial direction is greater than 10 near the center of coordinate. This ratio depends on solenoid length, the number of reverse current turns at center, and the amount of the reverse current. We built a gradient coil based on the numerical simulation and tested the field generated by NMR-CT. The resulting image matches with the theoretical expectation within 10% error. Since the data acquisition time of 1-D imaging is significantly shorter than 2-D imaging, it becomes possible to image much more dynamic objects by the use of this gradient field.

• Journal of Biomedical Engineering Research
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• v.3 no.2
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• pp.119-122
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• 1982

This paper presents the principles of image formation in NMR(Nuclear Magnetic Resonance) tomography. NMR tomographic imaging is a newly emerging, noninvasive, three-dimensional imaging technique. This new technique is an interdisciplinary science which encompasses the latest technologies in electrical, electronics, computers, physics, chemistry, mathematics, and medical sciences.

• Cement
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• s.132
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• pp.16-19
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• 1993

• 전기의세계
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• v.38 no.8
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• pp.19-25
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• 1989

현재 전세계적으로 퍼져있는 NMR-CT 시스템의 수를 살펴보면 약 370여기가 설치.운영되고 있으며 앞으로 계속 늘어날 전망이다. 국내에서는 1988 한국과학기술원과 금성통신에 의해 자체 개발된 2.0 Tesla 강자장 시스템이 최초로 서울대학병원에 설치 가동된 이래 여러병원에서 시스템들이 설치중에 있다. 첨단의로 진단장치로서의 핵자기 공명 영상법은 그 영상을 통하여 기존의 진단 장치보다 우월함을 증명하고 있으며 초음파 검사나 동위원소 검사 및 X선 전산화 단층 촬영술들을 장점을 두루 지니면서 그 영상법의 다양성 때문에 앞으로의 연구 및 발전에 대한 전망은 아주 밝다고 할 수 있다. 따라서 앞으로의 종합 영상 의료 진단 장치는 이 NMR-CT가 중심이 되어 발전할 것이라고 단언해도 무리한 생각은 아닐 것이다.