• Journal of Trauma and Injury
• /
• 제27권4호
• /
• pp.178-185
• /
• 2014

Purpose: The aim of this study was to assess the clinical efficacy of combined treatment with local anesthesia and ketamine procedural sedation for pediatric facial laceration repair in the Emergency Department (ED). Methods: Patients aged 1 to 5 years receiving ketamine for facial laceration repair were prospectively enrolled in a double-blind, randomized, and controlled study at an ED. All patients were to receive intravenous ketamine (2 mg/kg). The local anesthesia group (LA group) received a local anesthetic along with ketamine, whereas the no local anesthesia group (NLA group) received only ketamine. The total time of sedation, the patients' movements and groans, adverse events, and the satisfaction ratings of physicians, nurses, and parents were recorded. Results: A total of 186 patients were randomized (NLA group: 90, LA group: 96). The total time of sedation (30.5 minutes for the NLA group, 32.6 minutes for the LA group; p=0.660), patients' groans (26 (28.9%) versus 23 (24.0%); 0.446) and movements (27 (30%) versus 35 (36.5%); p=0.350) was not affected by the addition of local anesthesia. Other adverse events were similar between the two groups. Also, the satisfaction ratings of physicians (median 4 for the NLA group versus 4 for the LA group (p=0.796)), nurses (2 versus 2.5 (p=0.400)), and parents (4 versus 4 (p=0.199)) were equivalent between the two groups. Conclusion: In this study, we found that local anesthesia was not required along with ketamine sedation for pediatric facial laceration repair.

• Structural Engineering and Mechanics
• /
• 제67권1호
• /
• pp.53-67
• /
• 2018

The changes of parameters of pressure and velocity of propagation of elastic pressure and shear waves in uniformly deformed solid compressible media are studied within the nonclassically linearized approach (NLA) of nonlinear elastodynamics to create a new theoretical basis of the geomechanical interpretation of various groups of geophysical observational and experimental data. The cases of small and large deformations are considered while their describing by various elastic potentials, i.e., problems considering the physical and geometric nonlinearity. Convenient analytical formulae are obtained to calculate the indicated parameters in the deformed isotropic media within the nonclassical linear and nonlinear solution in the NLA. Specific numerical experiments are conducted in case of overall compression of various materials. It is shown that the method (generally accepted in the studies of mechanics of standard constructional materials) of additional linearization (relative to the pressure parameter) in the basic correlations of the NLA introduces substantial quantitative and qualitative errors into the results at significant preliminary deformations. The influences of the physical and geometric nonlinearity on the studied characteristics of the medium are large in various materials and differ qualitatively. The contribution of nonlinear components to the values of the considered parameters prevails over linear components at large deformations. When certain critical values of compression deformations in the medium are achieved, elastic waves with actual velocity cannot propagate in it. The values of the critical deformations for pressure and shear waves differ within different elastic potentials and variants of the theory of initial deformations.

• 생물정신의학
• /
• 제8권1호
• /
• pp.111-115
• /
• 2001

An association study with Korean alcoholic patients(n=50) and normal controls(n=53) was performed to find the relationship between catechol-O-methyltransferase(COMT) gene polymorphism and alcoholism using polymerase chain reaction-restriction fragment length polymorphism. When we compared the allele and genotype frequencies of Nla III COMT gene polymorphism in alcoholism and normal controls, there was no significant difference between two groups. Our results do not support an association between the Nla III polymorphism of COMT gene and alcoholism.

• Journal of Pharmaceutical Investigation
• /
• 제29권2호
• /
• pp.87-92
• /
• 1999

Drug delivery to the brain may be achieved by producing chimeric peptide, attaching the drug to protein 'vectors' which are transported into the brain from the blood by a receptor-mediated transcytosis through the blood-brain barrier (BBB). Since the BBB expresses high concentrations of transferrin receptor, and it was reported that anti-transferrin receptor mouse monoclonal antibody (OX26) undergoes transcytosis through the BBB, it is logical to assume that a drug delivery system via transferrin receptor-mediated transcytosis is a promising strategy. In the present study, therefore, we tested feasibility of several OX26 based vectors for the brain delivery of a model drug. Avidin-based delivery vectors such as OX26-streptavidin (OX26-SA), OX26-neutralite avidin (OX26-NLA) were chemically synthesized vectors and OX26 immunoglobulin G 3 type $C_{H}3$ fusion avidin $(OX26\;IgG3C_H3-AV)$ was genetically engineered. To improve the efficiency of producing chimeric peptide, we used avidin-biotin technology. Pharmacokinetics of $[^3H]biotin$ bound to OX26-SA, OX26-NLA and $OX26\;IgG3C_H3-AV$ was determined by intravenous injection technique, and their stabilities in plasma were analyzed using HPLC. The brain delivery of $[^3H]biotin$ bound to OX26-SA, OX26-NLA and OX26\;$IgG3C_{H}3-AV$ (expressed as %ID/g brain) was $0.22{\pm}0.01$, $0.18{\pm}0.01$ and $0.25{\pm}0.09$, respectively. The areas under the plasma concentration versus time curve (AUC) for OX26-SA, OX26-NLA, $OX26\;IgG3C_H3-AV$ from time zero to 60 min were $209{\pm}10$, $195{\pm}9$, $134{\pm}29\;%ID\;min/ml$ respectively and their total clearances $(CL_{tot})$ were $1.00{\pm}0.09$, $1.08{\pm}0.07$ and $1.54{\pm}0.29\;ml/min/kg$, espectively. These results showed that these vectors possess preferable pharmaceutical (e.g., resonable stability) and pharmacokinetics (e.g., significant brain uptake and enhanced AUC) for brain delivery. Therefore, these vectors may be broadly useful in the brain delivery of drugs that are not transported into the brain to a significant extent.

• 한국도서관정보학회지
• /
• 제42권2호
• /
• pp.85-103
• /
• 2011

그동안 서지네트워크는 도서관간 협력을 통하여 종합목록을 구축하고 이를 기반으로 자원 공유를 지원하는 한편, 온라인 공동목록을 통해 목록 작성 업무의 경제성을 추구해왔다. 그러나 다양한 매체를 수용하는 새로운 자원발견시스템에 대한 요구가 대두되고 지금까지와는 다른 차원의 규모의 경제를 이룩할 수 있는 기술적 환경이 조성되면서, 새로운 개념의 협력 모델 발굴이 필요하게 되었다. 본 연구에서는 먼저 서지네트워크 기능 요건의 변화 요인을 다각도로 분석하고, 차세대 서비스를 준비하고 있는 LC(미국), NII(일본), OCLC(미국), NLA(호주), NDL(일본)의 전략을 분석하였다. 이를 기반으로 도서관 운영 효율화를 위한 새로운 협력 모델과 새로운 자원 발견 시스템 개발을 주요 내용으로 하는 한국 차세대 서지네트워크의 방향을 모색하였다.

• 한국도서관정보학회지
• /
• 제35권3호
• /
• pp.175-204
• /
• 2004

디지털 정보자원은 장기적 보존 및 다음 세대로의 접근을 보장하기 위한 상세한 베타데이터를 필요로 한다. 본 연구는 먼저 디지털 정보자원의 특성과 디지털 보존의 개념, 디지털 정보자원의 장기 보존과 접근을 위한 메타데이터의 필요성을 조명하였다. 디지털 정보자원을 위한 상호운용적인 보존 베타데이터 개발에 근거가 되고 있는 OAIS 참조 모형을 살펴보았다. 이어 실제 OAIS 참조 모형을 적용한 CEDARS, NLA, NEDLIB, OCLC/RLG 디지털 정보자원의 보존 메타데이터를 대상으로 하여 그 개발 과정, 목적 및 메타데이터 요소 세트를 각각 구체적으로 비교 분석하였다. 본 분석 결과를 기초로 하여, 향후 우리나라의 디지털정보자원의 장기 보존과 접근을 위한 상호운용성을 갖춘 보존 메타데이터의 기본적인 요소 세트 설정 방안을 제시하였다.

• 정보관리연구
• /
• 제43권3호
• /
• pp.139-160
• /
• 2012

원문제공서비스는 변화하는 디지털 정보환경과 저작권법에 영향을 받아왔다. 본 논문은 국내외 원문제공서비스 기관인 BL(영국), NLA(호주), subito(독일어권), JST(일본), KERIS와 KISTI(국내)의 동향을 분석하고 각국의 저작권법을 비교한 후, 시사점을 도출하였다. 본 논문은 원문제공서비스 기관이 이용자의 요구를 만족시키는 새로운 전략을 수립하는데 도움이 되고자 하였다.

• International Journal of Knowledge Content Development & Technology
• /
• 제10권4호
• /
• pp.47-64
• /
• 2020

The study investigated the role of libraries in curtailing the spread of COVID-19 pandemic in Nigeria. Six research objectives were raised to guide the conduct of the study. The survey type of the descriptive research design was employed. The population of the study comprised of 139 selected librarians in Nigeria. The complete enumerative sampling technique was adopted to study the entire 139 librarians. The instrument for data collection was an online survey questionnaire designed by the researchers using SurveyMonkey and administered to the respondents via the Nigerian Library Association (NLA) WhatsApp group and the NLA Google group. The data collected were analyzed using descriptive statistics. The study revealed that among the services delivered by Nigerian libraries amidst the global pandemic are COVID-19 awareness and sensitization creation, provision of digital contents to patron, organizing online streaming programs and connecting patrons/citizens to accurate and reliable data on COVID-19 cases around the world. The study further revealed that these services are delivered frequently despite the low level of Nigerian libraries' preparedness for global pandemic. The study concluded that, Nigerian libraries, through their services, are potent weapon for promoting positive change, development, orientation, and re-orientation in the society. By creating COVID-19 awareness/sensitization (especially in rural areas), libraries are able to contribute significantly to the fight against the pandemic.

• 대한치과교정학회지
• /
• 제19권1호
• /
• pp.169-185
• /
• 1989

정상교합 및 안모가 단정한 성인(남자 60명, 여자 62명)을 대상으로 악교정수술을 위한 한국인 기준치를 얻고자 측모 두부방사선 규격사진을 이용하여 계측 분석과 결과 다음과 같은 결론을 얻었다. 카 계측항목의 평균치, 표준편차를 구하였다. 골격계측 항목중 각도계측치에서는 FH-SN과 SN-MP가 여자에서 더 크며, 거리계측치에서는 전 항목에서 남자가 더 큰 것으로 나타났다. 치아계측 항목에서는 수직적 관계를 나타내는 항목에서만 남녀간에 유의한 차를(P<0.05) 보였는데 ADH, PDH, overbite에서는 여자가 더 크고 Incisor exposure에서는 여자가 더 크게 나타났다. 연조직계측 항목에서는 NLA를 제외한 전 항목 즉 FCA, UFH, ULL, LLL에서 남자가 여자보다 더 크게 나타났다.

• 한국통신학회논문지
• /
• 제38A권1호
• /
• pp.79-87
• /
• 2013

전력 및 대역폭 제한적 디지털통신 시스템을 위한 새로운 변조 기술인 상관부호화 FSK (CEFSK) 시스템의 성능을 단일 및 다중 반송파 비선형 채널 환경에서 분석하였다. CEFSK는 심볼간 간섭이 없으며 인접하는 두 심볼간의 진폭과 위상 사이에 상관관계를 유지함으로써 부드럽고 연속적인 위상천이와 함께 적은 포락선 변동을 갖는 출력신호를 생성한다. 따라서 CEFSK 시스템은 기존의 GFSK와 비교하여 비선형 왜곡에 대한 인접심볼간섭(ISI)과 혼변조(IM)에 의한 영향을 적게 받는다. 본 논문에서는 AWGN과 ISI 그리고 IM 성분을 갖는 비선형 증폭 채널 환경에서 CEFSK 시스템의 성능을 전산모의실험을 통해서 분석하였다. 단일채널에 대한 실험에서는 고출력증폭기의 입력 차단 (IBO)가 -1.0dB와 -3.0dB일 때, 단일 비트 차동검파 (1DD) CEFSK가 $BER=1{\times}10^{-4}$을 유지하기 위해서 1DD-GFSK 보다 1.2dB와 0.8dB 우수하고 다중채널의 경우에서는 IBO의 값과 무관하게 약 1.1dB 우수하였다.