• 대한의용생체공학회:의공학회지
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• 제29권2호
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• pp.89-98
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• 2008

NIRS (Near-infrared Spectroscopy) and DOI (Diffuse Optical Imaging) are relatively new, non-invasive, and non-ionizing methods that measure or image optical properties (Scattering and Absorption Coefficient) and physiological properties (Water Fraction, concentration of Oxy-, Deoxy-Hemoglobin, Cytochrome Oxidase, etc) of biological tissues. In this paper, three different types of NIRS systems, mathematical modeling, and reconstruction algorithms are described. Also, recent applications such as functional brain imaging, optical mammography, NIRS based BMI (Brain-Machine Interface), and small animal study are reviewed.

• Journal of Chest Surgery
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• 제50권6호
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• pp.448-452
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• 2017

Background: Proper monitoring of cerebral perfusion during carotid artery surgery is crucial for determining if a shunt is needed. We compared the safety and reliability of near-infrared spectroscopy (NIRS) w ith transcranial Doppler (TCD) for cerebral monitoring. Methods: This single-center, retrospective review was conducted on patients who underwent carotid endarterectomy (CEA) using selective shunt-based TCD or NIRS at Daegu Catholic University Medical Center from November 2009 to June 2016. Postoperative complications were the primary outcome, and the distribution of risk factors between the 2 groups was compared. Results: The medical records of 74 patients (45 TCD, 29 NIRS) were reviewed. The demographic characteristics were similar between the 2 groups. One TCD patient died within the 30-day postoperative period. Postoperative stroke (n=4, p=0.15) and neurologic complications (n=10, p=0.005) were only reported in the TCD group. Shunt usage was 44.4% and 10.3% in the TCD and NIRS groups, respectively (p=0.002). Conclusion: NIRS-based selective shunting during CEA seems to be safe and reliable for monitoring cerebral perfusion in terms of postoperative stroke and neurologic symptoms. It also reduces unnecessary shunt usage.

• Molecules and Cells
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• 제40권8호
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• pp.523-532
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• 2017

Functional near-infrared spectroscopy (fNIRS) is a noninvasive optical imaging technique that indirectly assesses neuronal activity by measuring changes in oxygenated and deoxygenated hemoglobin in tissues using near-infrared light. fNIRS has been used not only to investigate cortical activity in healthy human subjects and animals but also to reveal abnormalities in brain function in patients suffering from neurological and psychiatric disorders and in animals that exhibit disease conditions. Because of its safety, quietness, resistance to motion artifacts, and portability, fNIRS has become a tool to complement conventional imaging techniques in measuring hemodynamic responses while a subject performs diverse cognitive and behavioral tasks in test settings that are more ecologically relevant and involve social interaction. In this review, we introduce the basic principles of fNIRS and discuss the application of this technique in human and animal studies.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제32권3호
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• pp.99-103
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• 2021

The purpose of this review is to examine the clinical use of functional near-infrared spectroscopy (fNIRS) in children and adolescents with psychiatric disorders. Many studies have been conducted using objective evaluation tools for psychiatric evaluation, such as predicting psychiatric symptoms and treatment responses. Compared to other tools, fNIRS has the advantage of being a noninvasive, inexpensive, and portable method and can be used with patients in the awake state. This study mainly focused on its use in patients with attention-deficit/hyperactivity disorder and autism spectrum disorder. We hope that research involving fNIRS will be actively conducted in various diseases in the future.

• Journal of Radiation Protection and Research
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• 제46권2호
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• pp.39-47
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• 2021

Background: The National Institutes for Quantum and Radiological Science and Technology-National Institute of Radiological Sciences (QST-NIRS) has continuously investigated the undesired radiation exposure in ion beam radiotherapy mainly in carbon-ion radiotherapy (CIRT). This review introduces our investigations on the secondary neutron dose in CIRT with the broad and scanning beam methods. Materials and Methods: The neutron ambient dose equivalents in CIRT are evaluated based on rem meter (WENDI-II) measurements. The out-of-field organ doses assuming prostate cancer and pediatric brain tumor treatments are also evaluated through the Monte Carlo simulation. This evaluation of the out-of-field dose includes contributions from secondary neutrons and secondary charged particles. Results and Discussion: The measurements of the neutron ambient dose equivalents at a 90#x00B0; angle to the beam axis in CIRT with the broad beam method show that the neutron dose per treatment dose in CIRT is lower than that in proton radiotherapy (PRT). For the scanning beam with the energy scanning technique, the neutron dose per treatment dose in CIRT is lower than that in PRT. Moreover, the out-of-field organ doses in CIRT decreased with distance to the target and are less than the lower bound in intensity-modulated radiotherapy (IMRT) shown in AAPM TG-158 (American Association of Physicists in Medicine Task Group). Conclusion: The evaluation of the out-of-field doses is important from the viewpoint of secondary cancer risk after radiotherapy. Secondary neutrons are the major source in CIRT, especially in the distant area from the target volume. However, the dose level in CIRT is similar or lower than that in PRT and IMRT, even if the contributions from all radiation species are included in the evaluation.

• Physical Therapy Rehabilitation Science
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• 제13권2호
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• pp.213-222
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• 2024

Objective: Stroke is a leading cause of disability worldwide, often leaving survivors with significant cognitive and motor impairments. Dual-task (DT), which involves performing cognitive and motor tasks simultaneously, can influence brain activation patterns and functional recovery in stroke patients. Design: A systematic review Methods: Following PRISMA guidelines, databases including MEDLINE, CINAHL, Embase, and Web of Science were searched for studies assessing cortical activation via functional near-infrared spectroscopy (fNIRS) during DT performance in stroke patients. Studies were selected based on predefined eligibility criteria, focusing on changes in hemodynamic responses and their correlation with task performance. Results: Eight studies met the inclusion criteria. Findings indicate that DT leads to increased activation in the prefrontal cortex (PFC), premotor cortex (PMC), and posterior parietal cortex (PPC), suggesting an integrated cortical response to managing concurrent cognitive and motor demands. However, increased activation did not consistently translate to improved functional outcomes, highlighting the complex relationship between brain activation and rehabilitation success. Conclusions: DT interventions may enhance cortical activation and neuroplasticity in post-stroke patients, but the relationship between increased brain activity and functional recovery remains complex and requires further investigation. Tailored DT programs that consider individual neurophysiological and functional capacities are recommended to optimize rehabilitation outcomes.

• 대한의용생체공학회:의공학회지
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• 제45권1호
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• pp.26-36
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• 2024

Functional brain imaging techniques have been used to diagnose psychiatric disorders such as dementia, depression, and autism. Recently, these techniques have also been actively used to study hearing loss. The present study reviewed the application of the functional brain imaging techniques in auditory research, especially those focusing on hearing loss, over the past decade. EEG, fMRI, fNIRS, MEG, and PET have been utilized in auditory research, and the number of research studies using these techniques has been increasing. In particular, fMRI and EEG were the most frequently used technique in auditory research. EEG studies mostly used event-related designs to analyze the direct relationship between stimulus and the related response, and in fMRI studies, resting-state functional connectivity and block designs were utilized to analyze alterations in brain functionality in hearing-related areas. In terms of age, while studies involving children mainly focused on congenital and pre- and post-lingual hearing loss to analyze developmental characteristics with and without hearing loss, those involving adults focused on age-related hearing loss to investigate changes in the characteristics of the brain based on the presence of hearing loss and the use of a hearing device. Overall, ranging from EEG to PET, various functional brain imaging techniques have been used in auditory research, but it is difficult to perform a comprehensive analysis due to the lack of consistency in experimental designs, analysis methods, and participant characteristics. Thus, it is necessary to develop standardized research protocols to obtain high-quality clinical and research evidence.

• 한국초지조사료학회지
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• 제43권4호
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• pp.257-267
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• 2023

본 연구는 초지 바이오매스 부문에 대한 국제적 경향과 이를 통한 국내 적용 가능성을 검토하기 위해 수행되었다. 초지 분야는 LULUCF 내 타 분야에 비해 상대적으로 연구 수준이 낮은 편으로 UNFCCC에 보고된 각 국가별 NIR을 기준으로 Approach 2 수준의 Tier 1 방법이 가장 높은 빈도로 적용되고 있었다. IPCC 가이드라인의 Tier 1 방법에서 초지 바이오매스 부문은 연 변화량을 0으로 간주하기 때문에 LULUCF 타 분야에 비해 정형화된 기본 체계가 없이 국가 상황에 따른 다양한 산정 방법을 적용하는 특징이 나타났다. 국내 초지 바이오매스에 대한 Tier 2 이상의 방법에 적용 가능한 산정 방법을 항목별로 분류하면, 인간에 의한 초지 이용 유형을 구분하는지, 초지 내 목본 식생을 포함하는지, 재해로 인한 손실량을 산정하는지, 초지 관리 방법에 따른 차이를 적용하는지 여부였다. 각 항목에서 발생하는 유의미한 차이가 국내에 적용할 수 있는지를 확인하기 위하여 국내를 대상으로 현장 조사와 활동 자료 분석을 수행하였다. 현 시점에서 국내에서 확인 가능한 항목은 초지의 정의에 따른 공간 구성과 이용 유형에 따른 탄소량 차이로 나타났다. 연구 결과, 이용 유형에 따라서 방목지, 섭식이 수행된 방목지, 채초지에서 바이오매스 탄소량의 유의미한 차이가 나타났고, 기후대, 토양형에 따른 차이도 존재하고 있었다. 따라서 IPCC 가이드라인의 기후대와 토양형을 기준으로 한 세분류가 국내에서도 타당한 초지 분류 체계로 적용될 수 있는 것으로 분석되었다. 반면, 초지 바이오매스 부문에서 활용 가능한 국가 공간 자료와 현장 자료의 불일치성이 지나치게 높아 전국 단위의 적용은 신뢰도가 낮은 상황이다. 국제 동향에서 나타난 주요 함의를 국내의 상황과 비교하였을 때, 초지 분야에 대한 더 높은 수준의 온실가스 인벤토리 작성을 위해서는 기후대-토양형 유형에 대한 국가고유계수 개발과 더불어 활용 가능한 공간자료의 마련과 이를 뒷받침할 수 있는 정책 및 제도 체계가 시급히 마련되어야 할 것이다.