• Title/Summary/Keyword: NEAT1

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Upregulation and Clinicopathological Significance of Long Non-coding NEAT1 RNA in NSCLC Tissues

  • Pan, Lin-Jiang;Zhong, Teng-Fei;Tang, Rui-Xue;Li, Ping;Dang, Yi-Wu;Huang, Su-Ning;Chen, Gang
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.7
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    • pp.2851-2855
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    • 2015
  • Background: Recent reports have shown that nuclear enriched abundant transcript 1 (NEAT1), a long noncoding RNA (lncRNA), contributes to the precise control of gene expression and is related to several human malignancies. However, limited data are available on the expression and function of NEAT1 in lung cancer. The major objective of the current study was to profile the expression and clinicopathological significance of NEAT1 in non-small cell lung cancers (NSCLCs). Materials and Methods: NEAT1 expression in 125 NSCLC cases and paired adjacent non-cancer tissues was assessed by real-time quantitative reverse transcription-PCR (qRT-PCR). Relationships between NEAT1 and clinicopathological factors were also investigated. Results: The relative level of NEAT1 was $6.98{\pm}3.74$ in NSCLC tissues, significantly elevated as compared to that of the adjacent non-cancer lung tissues ($4.83{\pm}2.98$, p<0.001). The area under curve (AUC) of high expression of NEAT1 to diagnose NSCLC was 0.684 (95% CI: 0.619~0.750, p<0.001). NEAT1 expression was positively correlated with patient age (r=-2.007, p=0.047), lymphatic metastasis (r=-2.731, p=0.007), vascular invasion (r=-3.617, p=0.001) and clinical TNM stage (r=-4.134, p<0.001). Conclusions: This study indicates that NEAT1 might be associated with oncogenesis and progression in NSCLC, and suggests application in molecular targeted therapy.

Prediction of non-exercise activity thermogenesis (NEAT) using multiple linear regression in healthy Korean adults: a preliminary study

  • Jung, Won-Sang;Park, Hun-Young;Kim, Sung-Woo;Kim, Jisu;Hwang, Hyejung;Lim, Kiwon
    • Korean Journal of Exercise Nutrition
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    • v.25 no.1
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    • pp.23-29
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    • 2021
  • [Purpose] This preliminary study aimed to develop a regression model to estimate the non-exercise activity thermogenesis (NEAT) of Korean adults using various easy-to-measure dependent variables. [Methods] NEAT was measured in 71 healthy adults (male n = 29; female n = 42). Statistical analysis was performed to develop a NEAT estimation regression model using the stepwise regression method. [Results] We confirmed that ageA, weightB, heart rate (HR)_averageC, weight × HR_averageD, weight × HR_sumE, systolic blood pressure (SBP) × HR_restF, fat mass ÷ height2G, gender × HR_averageH, and gender × weight × HR_sumI were important variables in various NEAT activity regression models. There was no significant difference between the measured NEAT values obtained using a metabolic gas analyzer and the predicted NEAT. [Conclusion] This preliminary study developed a regression model to estimate the NEAT in healthy Korean adults. The regression model was as follows: sitting = 1.431 - 0.013 × (A) + 0.00014 × (D) - 0.00005 × (F) + 0.006 × (H); leg jiggling = 1.102 - 0.011 × (A) + 0.013 × (B) + 0.005 × (H); standing = 1.713 - 0.013 × (A) + 0.0000017 × (I); 4.5 km/h walking = 0.864 + 0.035 × (B) + 0.0000041 × (E); 6.0 km/h walking = 4.029 - 0.024 × (C) + 0.00071 × (D); climbing up 1 stair = 1.308 - 0.016 × (A) + 0.00035 × (D) - 0.000085 × (F) - 0.098 × (G); and climbing up 2 stairs = 1.442 - 0.023 × (A) - 0.000093 × (F) - 0.121 × (G) + 0.0000624 × (E).

Isoconversional Cure Kinetics of Modified Urea-Formaldehyde Resins with Additives

  • Park, Byung-Dae
    • Current Research on Agriculture and Life Sciences
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    • v.30 no.1
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    • pp.41-50
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    • 2012
  • As a part of abating formaldehyde emission of urea-formaldehyde resin, this study was conducted to investigate the rmalcure kinetics of both neat and modified urea-formaldehyde resins using differential scanning calorimetry. Neat urea-formaldehyde resins with three different formaldehyde/urea mol ratios (1.4, 1.2 and 1.0) were modified by adding three different additives (sodium bisulfite, sodium hydrosulfite and acrylamide) at two different levels (1 and 3wt%). An isoconversional method at four different heating rates was employed to characterize thermal cure kinetics of these urea-formaldehyde resins to obtain activation energy ($E{\alpha}$) dependent on the degree of conversion (${\alpha}$). The $E{\alpha}$ values of neat urea-formaldehyde resins (formaldehyde/urea = 1.4 and 1.2) consistently changed as the ${\alpha}$ increased. Neat and modified urea-formaldehyde resins of these two F/U mol ratios did show a decrease of the $E{\alpha}$ at the final stage of the conversion while the $E{\alpha}$ of neat urea-formaldehyde resin (formaldehyde/urea = 1.0) increased as the ${\alpha}$ increased, indicating the presence of incomplete cure. However, the change of the $E{\alpha}$ values of all urea-formaldehyde resins was consistent to that of the Ea values. The isoconversional method indicated that thermal cure kinetics of neat and modified urea-formaldehyde resins showed a strong dependence on the resin viscosity as well as diffusion control reaction at the final stage of the conversion.

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Synchrotron X-Ray Diffraction Studies on Crystalline Domains in Urea-Formaldehyde Resins at Low Molar Ratio

  • WIBOWO, Eko Setio;PARK, Byung-Dae;CAUSIN, Valerio;HAHN, Dongyup
    • Journal of the Korean Wood Science and Technology
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    • v.50 no.5
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    • pp.353-364
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    • 2022
  • The crystalline domain of thermosetting urea-formaldehyde (UF) resins at low formaldehyde-to-urea (F/U) molar ratios (≤ 1.0) is known to be responsible for their poor performance as wood adhesives. Crystallization has been observed in 1.0 F/U UF resins during the addition reaction stage and at the end of the synthesis process (neat UF resins). The crystallinity and X-ray diffraction (XRD) spectra of the uncured neat UF resins, on the other hand, differed significantly from those of the cured neat UF resins, raising the possibility that their crystal structures were also different. This study demonstrates for the first time that the crystalline domains in 1.0 F/U UF resins generated from uncured and cured samples are identical. Despite having a lower crystallinity value, the synchrotron XRD patterns of purified neat UF resins were equivalent to the XRD patterns of cured neat UF resins. Transmission electron microscope images of the cured UF resins showed that the crystals were lamellar structures. This finding suggests that the crystal at low molar ratio UF resins are isotropic polycrystals with random orientation.

Study of Molecular Reorientation in Liquid with Raman Spectroscopy (Ⅱ) Anisotropic Rotation of$C_6F_6$ in Neat Liquid

  • Wan-In Lee;Kook-Joe Shin;Myung-Soo Kim
    • Bulletin of the Korean Chemical Society
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    • v.4 no.1
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    • pp.10-14
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    • 1983
  • Anisotropic rotation of C$_{6}$F$_{6}$ in neat liquid is investigated by the analysis of the ν$_{1}$ and ν$_{15}$ (both C-F stretching) bands of Raman spectrum and diffusion constants for the spinning (D$_{II}$) and tumbling (D$_{⊥}$) motions are obtained by the rotational dffusion theory. The same analysis is also carried out for the ν$_{2}$ and ν$_{16}$ (both C-C stretching) bands and both results are compared with the results obtained for benzene in neat liquid. The results show that the reorientation of C$_{6}$F$_{6}$ is highly anisotropic and the anisotropy is greater for C$_{6}$F$_{6}$ than benzene. This is due to the fact that the spinning rate is about the same but the tumbling rate is sharply reduced for C$_{6}$F$_{6}$.

Locomotion Control of 4 Legged Robot Using HyperNEAT (HyperNEAT를 이용한 4족 보행 로봇의 이동 제어)

  • Jang, Jae-Young;Hyun, Soo-Hwan;Seo, Ki-Sung
    • Journal of the Korean Institute of Intelligent Systems
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    • v.21 no.1
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    • pp.132-137
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    • 2011
  • The walking mobility with stability of 4 legged robots is the distinguished skills for many application areas. Planning gaits of efficient walking for quadruped robots is an important and challenging task. Especially, autonomous generation of locomotion is required to manage various robot models and environments. In this paper, we propose an adaptive locomotion control of 4 legged robot for irregular terrain using HyperNEAT. Generated locomotion is executed and analysed using ODE based Webots simulation for the 4 legged robot which is built by Bioloid.

Non-energy Use and $CO_2$ Emissions: NEAT Results for Korea

  • Park, Hi-chun
    • Journal of Energy Engineering
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    • v.11 no.1
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    • pp.34-46
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    • 2002
  • Carbon accounting is a key issue in the discussions on global warming/CO$_2$mitigation. This paper applies both the IPCC Approach and the NEAT (Non-Energy use Emission Accounting Tables) model, a bottom-up approach, to estimate the potential CO$_2$ emissions (carbon storage) originating from the non-energy use as to assess the actual CO$_2$ emissions (carbon release) from the use of fossil fuels in Korea. The current Korean carbon accounting seems to overestimate the potential CO$_2$ emissions and with it to underestimate the actual CO$_2$ emissions. The estimation shows that the potential CO$_2$ emissions calculated according to the IPCC Approach are lower than those calculated using the NEAT model. This is because the IPCC default storage fraction for naphtha seems to be low for the Korean petrochemical production structure, on the one hand and because the IPCC Approach does not consider the trade with short life petrochemical products, on the other hand. This paper shows that a bottom-up approach like the NEAT model can contribute to overcome some of limitations of the IPCC guidelines, especially by considering the international trade with short life petrochemical products and by estimating the storage fractions of fossil fuels used as feedstocks for the country in consideration. This paper emphasizes the importance of accurate energy statistics for carbon accounting.

PHOTOCHEMICAL REACTION OF CHLOROFORM

  • Park, Hyoung-Ryun;Jeong, Young-Tae;Ko, Song-Kyong;Oh, Jong-Hoon;Ham, Heui-Suk
    • Journal of Photoscience
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    • v.4 no.1
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    • pp.17-21
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    • 1997
  • The photochemical reactions of the neat chloroform and the aqueous chloroform in the absence (saturated with argon) and presence of 02 (saturated with air or oxygen) have been investigated using 184.9 nm UV light. The irradiation of the deoxygenated neat chloroform causes the formation of hexachloroethane, pentachloroethane, and 1, 1, 2, 2-tetrachloroethane. The initial quantum yields of the products were determined to be 6.37 x 10$^{-4}$, 4.04 x 10$^{-4}$ and 1.76 x 10$^{-4}$, respectively. In the irradiation of aqueous chloroform, chloride ion was also formed along with the products listed above and 1, 1, 2, 2-tetrachloroethane was the predominant product among the chlorinated organic products, which contrasts to the case of the neat chloroform. The presence of oxygen during the irradiation of aqueous chloroform had an effect on the yield of the products. With increasing the concentration of oxygen, the formation of the products was decreased. Probable reaction mechanisms for the photochemical reaction were presented on the basis of products analysis.

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Visual Effects of Design Variations in Tailored Jackets Length of Collar, Number of Buttons and Single/Double Variation (테일러드 자켓 디자인 변화에 따른 시각적 효과 -칼라길이, 단추 수, Single/Double변화를 중심으로-)

  • 한정숙;류숙희
    • Journal of the Korean Society of Clothing and Textiles
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    • v.21 no.8
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    • pp.1376-1386
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    • 1997
  • The purpose of this study is to investigate how one's visual evaluations are affected by variations in internal designs of tailored jackets. Major findings are: 1. Of the 35 pairs of adjectives, the factor analysis singled out the following five major factors (total variance of 55.62%): elegance, maturity, neatness, hard/softness, and evaluation. 2. The image of tailored jackets were found to be significantly affected by the length of its collar: jackets with long collar were perceived elegant, graceful, neat, mature and slim. 3. The number of buttons was also found to have significant impact on the image of tailored jackets: A one-button jacket, single or double, was perceived graceful, mature, formal, neat, natural, brisk, slim and so on. Its image deteriorated as the number of buttons increased. 4. Single jackets were found to be significantly different from Double jacket in their images. The former were perceived elegant, neat, and natural.

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Cure Kinetics of Cycloaliphatic Epoxy/Silica System for Electrical Insulation Materials in Outdoor Applications

  • Lee, Jae-Young;Park, Jae-Jun;Kim, Jae-Seol;Shin, Seong-Sik;Yoon, Chan-Young;Cheong, Jong-Hoon;Kim, Young-Woo;Kang, Geun-Bae
    • Transactions on Electrical and Electronic Materials
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    • v.16 no.2
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    • pp.74-77
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    • 2015
  • The cure kinetics of a neat epoxy system and epoxy/silica composite were investigated by DSC analysis. A cycloaliphatic type epoxy resin was diglycidyl 1,2-cyclohexanedicarboxylate and curing agent was anhydride type. To estimate kinetic parameters, the Kissinger equation was used. The activation energy of the neat epoxy system was 88.9 kJ/mol and pre-exponential factor was 2.64×1012 min−1, while the activation energy and pre-exponential factor for epoxy/silica composite were 97.4 kJ/mol and 9.21×1012 min−1, respectively. These values showed that the silica particles have effects on the cure kinetics of the neat epoxy matrix.